Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

Journal of Molecular Biology

Volumn 292, Issue 1, 1999, Pages 1-9

  Kallen, J ^a   Welzenbach, K ^a   Ramage, P ^a   Geyl, D ^a   Kriwacki, R ^b   Legge, G ^b   Cottens, S ^a   Weitz Schmidt, G ^a   Hommel, U ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Leukocyte function associated antigen 1; Lovastatin, integrin activation; X ray structure

Indexed keywords

CD11 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MEVINOLIN;

ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; HUMAN; LEUKOCYTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; T LYMPHOCYTE ACTIVATION; X RAY CRYSTALLOGRAPHY;

EID: 0033543673     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3047     Document Type: Article

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