Effect of selective proteasome inhibitors on TNF-induced activation of primary and transformed endothelial cells

American Journal of Physiology - Cell Physiology

Volumn 276, Issue 4 45-4, 1999, Pages

  Kalogeris, Theodore J ^a   Laroux, F Stephen ^a   Cockrell, Adam ^a   Ichikawa, Hiroshi ^a   Okayama, Naotsuka ^a   Phifer, Travis J ^a   Alexander, J Steven ^a   Grisham, Matthew B ^a,b  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b Dept of Molec and Cell Physiology ^*  (United States)

Author keywords

Adhesion molecules; ECV cell line; Human umbilical vein endothelial cells; Inflammatory mediators; Leukocyte adhesion; Neutrophils; Nuclear factor B; U 937 cell line

Indexed keywords

BORONIC ACID DERIVATIVE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LACTACYSTIN; PROTEASOME; PROTEASOME INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; NEUTROPHIL; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 0032929351     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.276.4.c856     Document Type: Article

References (10)

1. Adams, J., and R. Stein. Novel inhibitors of the proteasome and their therapeutic use in inflammation. Annu. Rep. Med. Chem. 31: 279-288, 1996.
2. Bauerle, P. A., and D. Baltimore. NF-κ-B: ten years after. Cell 87: 13-20, 1996.
3. Beekhuizen, H., I. Blokland, A. J. Corsèl-Van Tilburg, F. Koning, and R. Van Furth. CD14 contributes to the adherence of human monocytes to cytokine-stimulated endothelial cells. J. Immunol. 147: 3761-3767, 1991.
4. Chen, Z. J., L. Parent, and T. Maniatis. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853-862, 1996.
5. Cobb, R. R., K. A. Felts, G. C. N. Parry, and N. Mackman. Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear transcription factor-κB. Eur. J. Immunol. 26: 839-845, 1996.
6. Conner, E. M., S. Brand, J. M. Davis, F. S. Laroux, V. J. Palombella, J. W. Fuseler, D. Y. Kang, R. E. Wolf, and M. B. Grisham. Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis. J. Pharmacol. Exp. Ther. 282: 1615-1622, 1997.
7. De Catarina, R. P. Libby, H.-B. Peng, V. J. Thannickal, T. B. Rajavashisth, M. A. Gimbrone, Jr., W. S. Shin, and J. K. Liao. Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial cell expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96: 60-68, 1995.
8. Dick, L. R., A. A. Cruikshank, L. Grenier, F. D. Melandri, S. L. Nunes, and R. L. Stein. Mechanistic studies on the inactivation of the proteasome by lactacystin. J. Biol. Chem. 271: 7273-7276, 1996.
9. Fenteany, G., R. F. Standaert, W. S. Lane, S. Choi, E. J. Corey, and S. L. Shreiber. Inhibition of proteasome activities and subunit-specific ammo-terminal threonine modification by lactacystin. Science 268: 726-731, 1995.
10. Fenteany, G., R. F. Standaert, G. A. Reichard, E. J. Corey, and S. L. Schreiber. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc. Natl. Acad. Sci. USA 91: 3358-3362, 1994.