Mice with a targeted disruption of the Fanconi anemia homolog Franca

Human Molecular Genetics

Volumn 9, Issue 12, 2000, Pages 1805-1811

  Cheng, Ngan Ching ^a,b   Van De Vrugt, Henri J ^a   Van Der Valk, Martin A ^b   Oostra, Anneke B ^a   Krimpenfort, Paul ^b   De Vries, Yne ^a   Joenje, Hans ^a   Berns, Anton ^b   Arwert, Fré ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CLASTOGEN; MITOMYCIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DEPRESSION; CANCER SUSCEPTIBILITY; CAUSE OF DEATH; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CROSS LINKING; ERYTHROCYTE VOLUME; FANCONI ANEMIA; FEMALE; FERTILITY; FIBROBLAST; GENE DISRUPTION; GENETIC COMPLEMENTATION; GENETIC STABILITY; HYPERSENSITIVITY; HYPOGONADISM; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PANCYTOPENIA; PHENOTYPE; PRIORITY JOURNAL; THROMBOCYTE COUNT;

ANIMALS; DNA-BINDING PROTEINS; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; FEMALE; GENE TARGETING; HEMATOLOGY; HUMANS; INFERTILITY, FEMALE; INFERTILITY, MALE; MALE; MICE; MICE, KNOCKOUT; OVARY; PHENOTYPE; PROTEINS; TESTIS;

ANIMALIA;

EID: 0033852602     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

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4. Expression cloning of a cDNA for the major fanconi anemia gene, FAA
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6. The fanconi anemia group G gene FANCG is identical with XRCC9
7. The fanconi anemia gene FANCF encodes a novel protein with homology to ROM
8. Microcell mediated chromosome transfer maps the fanconi anemia group D gene to chromosome 3p
9. The fanconi anemia group E gene, FANCE, maps to chromosome 6p
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11. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
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13. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
14. Mutation of a mutL homolog in hereditary colon cancer
15. The fanconi anemia proteins, FAA and FAC interact to form a nuclear complex
16. Fanconi anemia proteins FANCA, FANCC and FANCG/XRCC9 interact in a functional nuclear complex
17. A physical complex of the fanconi anemia proteins FANCG/XRCC9 and FANCA
18. Mutations of the fanconi anemia group A gene (FAA) in Italian patients
19. Heterogeneous spectrum of mutations in the Fanconi anaemia group A gene
20. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of fanconi anaemia
21. Germ cell defects and hematopoietic hypersensitivity to y-interferon in mice with a targeted disruption of the fanconi anemia C gene
22. Loss of FancC function results in decreased hematopoietic stem cell repopulating ability
23. Bone marrow failure in the fanconi anemia group C mouse model after DNA damage
24. Fanconi's anaemia and pregnancy
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27. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
28. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
29. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
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31. Cloning and characterization of the murine fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis and ovary