The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the fanconi anemia complex

Blood

Volumn 96, Issue 9, 2000, Pages 3224-3230

  Garcia Higuera, Irene ^a   Kuang, Yanan ^a   Denham, Jessica ^a   D'Andrea, Alan D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FANCONI ANEMIA GROUP A PROTEIN; FANCONI ANEMIA GROUP G PROTEIN; GENE PRODUCT; LEUCINE ZIPPER PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; FANCONI ANEMIA; GENE TRANSLOCATION; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

EID: 0034329325     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.9.3224     Document Type: Article

References (42)

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6. Positional cloning of the Fanconi anaemia group A gene
7. Expression cloning of a cDNA for the major Fanconi anemia gene, FAA
8. The Fanconi anemia complementation gene FANCF encodes a novel protein with homology to ROM
9. The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells
10. Microcell mediated chromosome transfer maps the Fanconi anemia group D gene to chromosome 3p
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14. Release of active oxygen radicals by leukocytes of Fanconi anemia patients
15. Fanconi anemia mutation causes cellular susceptibility to ambient oxygen
16. Spontaneous chromosomal aberrations in Fanconi anaemia, ataxia telangiectasia fibroblast and Bloom's syndrome lymphoblastoid cell lines as detected by conventional cytogenetic analysis and fluorescence in situ hybridisation (FISH) technique
17. Flow cytometric characterization of the response of Fanconi's anemia cells to mitomycin C treatment
18. Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent endometriosis in Fanconi anemia cells
19. Germ cell defects and hematopeietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
20. Inactivation of the Fanconi anemia group C gene augments interferon-gamma induced apoptotic responses in hematopoietic cells
21. Abnormal rearrangements associated with V(D)J recombination in Fanconi anemia
22. The fidelity of double strand breaks processing is impaired in complementation groups B and D of Fanconi anemia, a genetic instability syndrome
23. Fanconi anaemia forges a novel pathway
24. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
25. FANCA protein binds FANCC and FANCG proteins in an intracellular complex
26. Human α spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex
27. The Fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation
28. The Fanconi anemia proteins, FAA and FAC, interact to form a nuclear complex
29. A patient-derived mutant form of the Fanconi anemia protein, FANCA, is defective in nuclear accumulation
30. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA
31. Resistance to mitomycin C requires direct interaction between the Fanconi anemia protein FANCA and FANCG in the nucleus through an arginine-rich domain
32. Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system
33. Functional activity of the Fanconi anemia protein, FAA, requires FAC binding and nuclear localization
34. A stable human-derived packaging cell line for production of high-titer retrovirus/vesicular stomatitis virus G pseudotypes
35. Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer
36. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA
37. Sequence variation in the Fanconi anemia gene FAA
38. Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression
39. Post transcriptional cell cycle-dependent regulation of human FANCC expression
40. The carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity
41. Analysis of nuclear transport in vivo