Expression of BRC repeats in breast cancer cells disrupts the BRCA2- Rad51 complex and leads to radiation hypersensitivity and loss of G2/M checkpoint control

Journal of Biological Chemistry

Volumn 274, Issue 46, 1999, Pages 32931-32935

  Chen, Chi Fen ^a   Chen, Phang Lang ^a   Zhong, Qing ^a   Sharp, Z Dave ^a   Lee, Wen Hwa ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; COMPLEX FORMATION; DNA DAMAGE; FIBROBLAST; GENE DISRUPTION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; TANDEM REPEAT; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL CYCLE; CLONE CELLS; DNA DAMAGE; DNA-BINDING PROTEINS; G2 PHASE; GAMMA RAYS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MITOSIS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM PROTEINS; PROTEIN BINDING; RAD51 RECOMBINASE; REPETITIVE SEQUENCES, NUCLEIC ACID; S PHASE; TETRACYCLINE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0032702679     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.46.32931     Document Type: Article

References (35)

1. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregrory, S., Gumbs, C., Micklem, G., Barfoot, R., Hamoudi, R., Patel, S., Rice, C., Biggs, P., Hashim, Y., Smith, A., Connor, F., Arason, A., Gudmundseon, J., Ficenec, D., Kelsell, D., Ford, D., Tonin, P., Bishop, D. T., Spurr, N. K., Ponder, B. A. J., Eeles, R., Peto, J., Devilee, P., Cornelisse, C., Lynch, H., Narod, S., Lenoir, G., Egilsson, V., Barkadottir, R. B., Easton, F. E., Bentley, D. R., Futreal, P. A., Ashworth, A., and Stratton, M. R. (1995) Nature 378, 789-792
2. Tavtigian, S. V., Simard, J., Rommens, J., Couch, F., Shattuck-Eidens, D., Neuhausen, S., Merajver, S., Thorlacius, S., Offit, K., Stoppa-Lyonnet, D., Belanger, C., Bell, R., Berry, S., Bogden, R., Chen, Q., Davis, T., Dumont, M., Frye, C., Hattier, T., Jammulapati, S., Janecki, T., Jiang, P., Kehrer, R., and Leblanc, J. F. (1996) Nat. Genet. 12, 333-337
3. Marquis, S. T., Rajan, J. V., Wynshaw-Boris, A., Xu, J., Yin, G. Y., Abel, K. J., Weber, B. L., and Chodosh, L. A. (1995) Nat. Genet. 11, 17-26
4. Rajan, J. V., Wang, M., Marquis, S. T., and Chodosh, L. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13078-13083
5. Rajan, J. V., Marquis, S. T., Gardner, H. P., and Chodosh, L. A. (1997) Dev. Biol. 184, 385-401
6. Vaughn, J. P., Cirisano, F. D., Huper, G., Berchuck, A., Futreal, P. A., Marks, J. R., and Iglehart, J. D. (1996) Cancer Res. 56, 4590-4594
7. Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D. S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P., and Bradley, A. (1997) Nature 386, 804-810
8. Patel, K. J., Vu, V. P., Lee, H., Corcoran, A., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A., and Venkitaraman, A. R. (1998) Mol. Cell 1, 347-357
9. Abbott, D. W., Freeman, M. L., and Holt, J. T. (1998) J. Natl. Cancer Inst. 90, 978-985
10. Chen, P. L., Chen, C. F., Chen, Y., Xiao, J., Sharp, Z. D., and Lee, W. H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5287-5292
11. Mizuta, R., LaSalle, J. M., Cheng, H. L., Shinohara, A., Ogawa, H., Copeland, N., Jenkins, N. A., Lalande, M., and Alt, F. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6927-6932
12. Wong, A. K. C., Pero, R., Ormonde, P. A., Tavtigian, S. V., and Bartel, P. L. (1997) J. Biol. Chem. 272, 31941-31944
13. Shinohara, A., Ogawa, H., and Ogawa, T. (1992) Cell 69, 457-470
14. Baumann, P., Benson, F. E., and West, S. C. (1996) Cell 87, 757-766
15. Baumann, P., and West, S. C. (1997) EMBO J. 16, 5198-5206
16. Lim, D. S., and Hasty, P. (1996) Mol. Cell. Biol 16, 7133-7143
17. Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Yoshimura, Y., and Morita, T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6236-6240
18. Shen, Z., Cloud, K. G., Chen, D. J., and Park, M. S. (1996) J. Biol. Chem. 271, 148-152
19. Bork, P., Blomberg, N., and Nilges, M. (1996) Nat. Genet. 13, 22-23
20. Bignell, G., Micklem, G., Stratton, M. R., Ashworth, A., and Wooster, R. (1997) Hum. Mol. Genet. 6, 53-58
21. Shan, B., Durfee, T., and Lee, W. H. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 679-684
22. Durfee, T., Becherer, K., Chen, P.-L., Yeh, S.-H., Yang, Y., Kilburn, A. E., Lee, W.-H., and Elledge, S. J. (1993) Genes Dev. 7, 555-569
23. Vidal, M., Braun, P., Chen, E., Boeke, J. D., and Harlow, E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10321-10326
24. Gossen, M., and Bujard, H. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 5547-5551
25. Evan, G. I., Lewis, G. K., Ramsay, G., and Bishop, J. M. (1985) Mol. Cell. Biol. 5, 3610-3616
26. Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., and Lee, W.-H. (1999) Science 285, 747-750
27. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7491-7495
28. Xu, X., Weaver, Z., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., and Deng, C. X. (1999) Mol. Cell 3, 389-395
29. Kastan, M. B., Zhan, Q., el-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Vogelstein, B., and Fornace, A. J., Jr. (1992) Cell 71, 587-597
30. Lu, X., and Lane, D. P. (1993) Cell 75, 765-778
31. Brugarolas, J., and Jacks, T. (1997) Nat. Med. 3, 721-722
32. Deng, C., Zhang, P., Harper, J. W., Elledge, S. J., and Leder, P. (1995) Cell 82, 675-684
33. Elledge, S. J. (1996) Science 274, 1664-1672
34. Friedman, L. S., Thistlethwaite, F. C., Patel, K. J., Yu, V. P., Lee, H., Venkitaraman, A. R., Abel, K. J., Carlton, M. B., Hunter, S. M., Colledge, W. H., Evans, M. J., and Ponder, B. A. (1998) Cancer Res. 58, 1338-1343
35. Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., and Scully, R. (1998) Mol. Cell 2, 317-328