High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment

Cancer Research

Volumn 59, Issue 22, 1999, Pages 5758-5767

  Willuda, Jörg ^a,b   Honegger, Annemarie ^a   Waibel, Robert ^c   Schubiger, P August ^c   Stahel, Rolf ^b   Zangemeister Wittke, Uwe ^b   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; PROTEIN ANTIBODY; TUMOR ANTIGEN;

ANTIGEN BINDING; ARTICLE; DRUG TARGETING; GENETIC ENGINEERING; HUMAN; HUMAN CELL; LUNG TUMOR; PHAGE DISPLAY; PRIORITY JOURNAL; THERMOSTABILITY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; FEMALE; HEAT; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; ISOTOPE LABELING; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, ERBB-2; SEQUENCE ALIGNMENT; TECHNETIUM; TUMOR CELLS, CULTURED;

EID: 0033571383     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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