Improved stability and yield of a Fv-toxin fusion protein by computer design and protein engineering of the Fv

Journal of Molecular Biology

Volumn 281, Issue 5, 1998, Pages 917-928

  Chowdhury, Partha S ^a   Vasmatzis, George ^a   Beers, Richard ^a   Lee, Byungkook ^a   Pastan, Ira ^a  

^a Lab Molec Biol Div Basic Sci N   (United States)

Author keywords

Immunotoxin; K1 antibody; Modeling; Sequence variability; Stabilization

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOTOXIN; PSEUDOMONAS EXOTOXIN;

ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA BASE; GENE MUTATION; GENETIC ENGINEERING; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; TECHNIQUE;

PSEUDOMONAS; PSEUDOMONAS EXOTOXIN;

EID: 0032483392     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1980     Document Type: Article

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