Absolute conservation of residue 6 of immunoglobulin heavy chain variable regions of class IIA is required for correct folding

Protein Engineering

Volumn 11, Issue 12, 1998, Pages 1267-1276

  De Haard, Hans J W ^a,c,e   Kazemier, Bert ^a   Van Der Bent, Arie ^b   Oudshoorn, Peter ^a   Boender, Piet ^a   Van Gemen, Bob ^a   Arends, Jan Willem ^c,d   Hoogenboom, Hennie R ^c  

^a Organon Teknika   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

Antigen binding; Bacterial expression; Folding; Framework residue; Single chain antibody

Indexed keywords

ANTIBODY; GLUTAMIC ACID; GLUTAMINE; IMMUNOGLOBULIN HEAVY CHAIN; TRYPSIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; ENZYME ACTIVITY; GENETIC CONSERVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032408704     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/11.12.1267     Document Type: Article

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