Th1- and Th2-cell commitment during infectious disease: Asymmetry in divergent pathways

Trends in Immunology

Volumn 22, Issue 8, 2001, Pages 450-457

  Jankovic, Dragana ^a   Liu, Zhugong ^b   Gause, William C ^b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; TRANSCRIPTION FACTOR;

CELL INTERACTION; CELL MATURATION; CELL POLARITY; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; INFECTION; INFECTION PREVENTION; NONHUMAN; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ANIMALS; CHEMOKINES; COMMUNICABLE DISEASES; CYTOKINES; DENDRITIC CELLS; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTORS;

EID: 0035424854     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)01975-5     Document Type: Review

References (87)

1. Functional diversity of helper T lymphocytes
2. Innate immune recognition: Mechanisms and pathways
3. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
4. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
5. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
6. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
7. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
8. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
9. A Toll-like receptor recognizes bacterial DNA
10. Dynamics of T-lymphocyte responses: Intermediates, effectors and memory cells
11. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin-12 by dendritic cells and their redistribution to T-cell areas
12. Reciprocal control of T helper cell and dendritic cell differentiation
13. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization
14. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo
15. Interleukin-12: A cytokine at the interface of inflammation and immunity
16. Interleukin-12 is produced in vivo during endotoxemia and stimulates synthesis of γ interferon
17. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
18. Immune responses in the absence of costimulation: Viruses know the trick
19. Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T-cell costimulatory pathway
20. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental Leishmaniasis
21. Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: Reversal of elicited T-cell cytokine profile and partial inhibition of egg granuloma formation
22. Lipopolysaccharide interferes with the induction of peripheral T-cell death
23. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
24. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
25. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
26. IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men
27. Cutting edge: IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen Toxoplasma gondii
28. IL-12 is required to maintain a Th1 response during Leishmania major infection
29. + dendritic cells
30. Macrophage-derived dendritic cells have strong Th1-polarizing potential mediated by β-chemokines rather than IL-12
31. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
32. Development of Th1-type immune responses requires the type I cytokine receptor TCCR
33. The role of IL-18 in innate immunity
34. Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii
35. Genetically resistant mice lacking the IL-18 gene develop a Th1 response and control cutaneous Leishmania major infection
36. + T cells, IL-4 and STAT6
37. Two roads diverged: Interferon α/β- and interleukin-12-mediated pathways in promoting T cell interferon γ responses during viral infection
38. Type I interferons and T helper development
39. Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox
40. Modulation of chromatin structure regulates cytokine gene expression during T-cell differentiation
41. Signaling and transcription in T-helper development
42. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-γ promoter in T cells
43. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
44. A novel transcription factor, T-bet, directs Th1 lineage commitment
45. Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-γ-producing (Th1) cells
46. The injection of deaggregated γ globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes
47. B7-CD28/CTLA-4 costimulatory pathways are required for the develoment of T helper cell type 2-mediated allergic responses to inhaled antigens
48. Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast-cell derived
49. Cutting edge: Activation of NK T cells by CD1d and α- galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype
50. + T cells provide an initial source of IL-4 during Th2 differentiation
51. + lymphocytes with a Th2 cytokine profile
52. Stat6 regulation of in vivo IL-4 responses
53. + T-cell subsets
54. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells
55. Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses
56. CD28/B7 system of T-cell costimulation
57. CD28-dependence of T-cell differentiation to IL-4 production varies with the particular type 2 immune response
58. Impaired Th2 subset development in the absence of CD4
59. Parasite dose determines the Th1/Th2 nature of the response to Leishmania major independently of infection route and strain of host or parasite
60. + T-cell responses: The alternative approaches
61. + T-cell differentiation
62. + T-cell responses in vivo and in vitro
63. Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response
64. IL-13-mediated worm expulsion is B7 independent and IFN-γ sensitive
65. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
66. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1-cell development
67. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
68. Loss of CTLA-4 leads to massive lymphoproliferations and fetal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
69. CD40-mediated costimulation contributes to lymphocyte proliferation, antibody production, eosinophilia and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production
70. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis
71. Robust B-cell immunity but impaired T-cell proliferation in the absence of CD134 (OX40)
72. The CD28-related molecule ICOS is required for effective T-cell-dependent immune responses
73. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
74. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-Atc
75. NFATc1 and NFATc2 together control both T- and B-cell activation and differentiation
76. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
77. Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene
78. IL-4 requirements for the generation of secondary in vivo IgE responses
79. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3
80. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection
81. + T cells
82. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
83. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
84. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells
85. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
86. Triggering of T-cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo
87. Stat6 activation and Th2 cell differentiation driven by CD28