Effects of Blocking B7-1 and B7-2 Interactions during a Type 2 in Vivo Immune Response

Journal of Immunology

Volumn 158, Issue 9, 1997, Pages 4088-4096

  Greenwald, Rebecca J ^a   Lu, Pin ^a,b   Halvorson, Mark J ^a   Zhou, Xia Di ^a   Chen, Shen Jue ^a   Madden, Kathleen B ^a   Perrin, Peter J ^b   Morris, Suzanne C ^c   Finkelman, Fred D ^c   Peach, Robert ^b   Linsley, Peter S ^b   Urban Jr , Joseph F ^d   Gause, William C ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CD86 PROTEIN, MOUSE; CYTOKINE; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; EOSINOPHIL; FEMALE; GENE EXPRESSION; GENETICS; GERMINAL CENTER; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MAST CELL; MOUSE; MUCOSAL IMMUNITY; NEMATOSPIROIDES DUBIUS; PHYSIOLOGY; TH2 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; B-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; EOSINOPHILS; FEMALE; GENE EXPRESSION; GERMINAL CENTER; IMMUNITY, MUCOSAL; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MAST CELLS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; NEMATOSPIROIDES DUBIUS; TH2 CELLS;

EID: 0031132468     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:932.
2. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferations and fetal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
3. Kurt-Jones, E. A., S. Hamberg, J. Ohara, W. E. Paul, and A. K. Abbas. 1987. Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J. Exp. Med. 166:1774.
4. Greenbaum, L. A., J. B. Horowitz, A. Woods, T. Pasqualini, E. Reich, and K. Bottomly. 1988. Cloned Th2 cells will respond to IL-4 but this response is dependent on the addition of IL-1. J. Immunol. 140:1555.
5. Weaver, C. T., and E. R. Unanue. 1990. The costimulatory function of antigen-presenting cells. Immunol. Today 11:49.
6. Johnson, J. G., and M. K. Jenkins. 1992. Co-stimulatory functions of antigen-presenting cells. J. Invest. Dermatol. 99:62S.
7. McArthur, J. G., and D. H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med. 178:1645.
8. Lu, P., X. Zhou, S. J. Chen, M. Moorman, S. C. Morris, F. D. Finkelman, P. Linsley, J. F. Urban, and W. C. Gause. 1994. CTLA-4 ligands are required in an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp. Med. 180:693.
9. Lu, P., X. Zhou, S. Chen, M. Moorman, A. Schoneveld, S. Morris, F. D. Finkelman, P. Linsley, E. Claassen, and W. C. Gause. 1995. Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a systemic in vivo immune response. J. Immunol. 154:1078.
10. Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Givson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792.
11. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
12. + T cells and induce similar patterns of cytokine secretion in vitro. Int. Immunol. 7:891.
13. Lanier, L. L., S. O'Fallon, C. Somoza, J. H. Phillips, P. S. Linsley, K. Olumura, D. Ito, and M. Azuma. 1995. CD80(B7) and CD86(B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:97.
14. Natesan, M., Z. Razi-Wolf, and H. Reiser. 1996. Costimulation of IL-4 production by murine B7-1 and B7-2 molecules. J. Immunol. 156:2783.
15. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X. Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadlier. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
16. Ranger, A. M., M. Prabhu Das, V. K. Kuchroo, and L. H. Glimcher. 1997. B7-2 (CD86) is essential for; the development of interleukin-4 producing T cells. Int. Immunol. In press.
17. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
18. Racke, M. K., D. E. Scott, L. Quigley, G. S. Gray, R. Abe, C. H. June, and P. J. Perrin. 1995. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Invest. 96:2195.
19. Lenschow, D. J., S. C. Ho, H. Sattar, L. Rhee, G. Gray, N. Nababvi, K. C. Herold, and J. A. Bluestone. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1145.
20. Svetic, A., K. B. Madden, X. D. Zhou, P. Lu, I. M. Katona, F. D. Finkelman, J. F. Urban, and W. C. Gause. 1993. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and 1L-3. J. Immunol. 150:3434.
21. Urban, J. F., K. B. Madden, A. Svetic, A. Cheever, P. P. Trotta, W. C. Gause, I. M. Katona, and F. D. Finkelman. 1992. The importance of Th2 cytokines in protective immunity to nematodes. Immunol. Rev. 127:205.
22. Hathcock, K. S., G. Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. J. Hodes. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262:905.
23. Razi-Wolf, Z., Galvin, G. Gray, and H. Reiser. 1993. Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor. Proc. Natl. Acad. Sci. USA 90:11182.
24. Kappler, J. W., B. Skidmore, J. White, and P. Marrack. 1981. Antigen-inducible, H-2-restricted interleukin-2-producing T cell hybridomas. J. Exp. Med. 153:1198.
25. Dialynas, D. P., D. B. Wilde, P. Marrack, A. Pierres, K. A. Wall, W. Havran, G. Otten, M. R. Loken, M. Pierres, J. Kappler, and F. W. Fitch. 1983. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol. Rev. 74:29.
26. Chatelain, R., R. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
27. Lu, P., J. F. Urban, X. Zhou, S. Chen, S. C. Morris, F. D. Finkelman, and W. C. Gause. 1996. CD40-mediated costimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production. J. Immunol. 156:3327.
28. Svetic', A., F. D. Finkelman, Y. C. Jian, C. W. Dieffenbach, D. E. Scott, K. F. McCarthy, A. D. Steinberg, and W. C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391.
29. Han, S., K. Hathcock, B. Zheng, T. B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interactions in germinal centers. J. Immunol. 155:556.
30. Urban, J. F., I. M. Katona, W. E. Paul, and F. D. Finkelman. 1992. Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc. Natl. Acad. Sci. USA 88:5513.
31. Madden, K. B., J. F. Urban, Jr., H. J. Ziltener, J. W. Schrader, F. D. Finkelman, and I. M. Katona. 1991. Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J. Immunol. 147:1387.
32. Morris, S. C., K. B. Madden, J. J. Adamovicz, W. C. Gause, B. R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047.
33. Gause, W. C., and J. Adamovicz. 1994. The use of the PCR to quantitate gene expression. PCR Methods Applications 3:s123.
34. Peterson, V. M., J. J. Adamovicz, T. B. Elliott, M. M. Moore, G. S. Madonna, W. E. Jackson, D. Ledney, and W. C. Gause. 1994. Gene expression of hematoregulatory cytokines is elevated endogenously after sublethal gamma irradiation and is differentially enhanced by therapeutic administration of biologic response modifiers. J. Immunol. 153:2320.
35. Linsley, P. S., J. L. Greenw, W. Brady, J. Bajorath, J. A. Ledbetter, and R. Peach. 1994. Human B7-1(CD80) and B7-2(CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
36. + T cells Io effector interleukin-4 producing T helper cells. Immunol. Res. 14:176.
37. Scott, P. 1993. IL-12:initiation cytokine for cell-mediated immunity. Science 1160:496.
38. Hathcock, K. S., G. Laszlo, C. Pucillo, P. Linsley, and R. J. Hodes. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180:631.
39. Inaba, K., M. Witmer-Pack, M. Inaba, K. S. Hathcock, H. Sakuta, M. Azuma, H. Yagita, K. Okumura, P. S. Linsley, S. Ikehara, S. Muramatsu, R. J. Hodes, and R. M. Steinman. 1994. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180:1849.
40. Boussiotis, V. A., G. J. Freeman, J. G. Gribben, J. Daley, G. Gray, and L. M. Nadler. 1993. Activated human B lymphocytes express three CTLA-4 counter-receptors that costimulate T-cell activation. Proc. Natl. Acad. Sci. USA 90:11059.