Cutting edge commentary: Immune responses in the absence of costimulation: Viruses know the trick

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 5791-5794

  Bachmann, Martin F ^a   Zinkernagel, Rolf M ^b   Oxenius, Annette ^b  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; ANTIGEN; BACTERIAL DNA; CD19 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD81 ANTIGEN; CHEMOKINE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3D RECEPTOR; CYTOKINE; DOUBLE STRANDED RNA; LIPOPOLYSACCHARIDE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PEPTIDE; PROTEIN; RECEPTOR; T LYMPHOCYTE RECEPTOR; VIRUS DNA; VIRUS ANTIBODY;

ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CPG ISLAND; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VIRUS; ANIMAL; ARTICLE; BIOSYNTHESIS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOGENICITY;

ANIMALS; ANTIBODIES, VIRAL; B-LYMPHOCYTES; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES; VIRUSES;

EID: 0032437378     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (44)

1. Bachmann, M. F., and R. M. Zinkernagel. 1997. Neutralizing anti-viral B cell responses. Annu. Rev. Immunol. 15:235.
2. Bachmann, M. F., R. U. Hoffmann, T. M. Kündig, K. Bürki, H. Hengartner, and R. M. Zinkernagel. 1993. The influence of antigen organization on B cell responsiveness. Science 262:1448.
3. Justewicz, D. M., P. C. Doherty, and R. G. Webster. 1995. The B-cell response in lymphoid tissue of mice immunized with various antigenic forms of the influenza virus hemagglutinin. J. Virol. 69:5414.
4. Szomolanyi-Tsuda, E., Q. P. Le, R. L. Garcea, and R. M. Welsh. 1998. T cell independent immunoglobulin G responses in vivo are elicited by live virus infection but not by immunization with viral proteins or virus-like particles. J. Virol. 72:6665.
5. Dempsey, P. W., M. E. Allison, S. Akkaraju, C. C. Goodnow, and D. T. Fearon. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348.
6. Müller-Eberhard, H. J. 1988. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57:321.
7. Carroll, M. C., and A. P. Prodeus. 1998. Linkages of the innate and adaptive immunity. Curr. Opin. Immunol. 10:36.
8. Chan, V. W. F., I. Mecklenbräuker, I. Su, G. Texido, M. Leitges, R. Carsetti, C. A. Lowell, K. Rajewsky, K. Miyake, and A. Tarakhovsky. 1998. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J. Exp. Med. 188:93.
9. Fehr, T., R. C. Rickert, B. Odermatt, J. Roes, K. Rajewsky, H. Hengartner, and R. M. Zinkernagel. 1998. Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J. Exp. Med. 188:145.
10. Janeway, C. 1989. Approaching the Asymptote? Evolution and Revolution in Immunology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY: pp. 1-13.
11. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kündig, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
12. Schmits, R., T. M. Kündig, D. Baker, G. Shumaker, J. J. L. Smard, G. Duncan, A. Wakeham, A. Shahinian, A. van der Heiden, M. F. Bachmann, P. Ohashi, T. W. Mak, and D. D. Hickstein. 1996. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183:1415.
13. + T cell functions. J. Exp. Med. 183:2209.
14. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346:425.
15. Bachmann, M. F., K. McKall-Faienza, R. Schmits, D. Bouchard, J. Beach, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1997. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7:549.
16. Kündig, T. M., A. Shahinian, K. Kawai, H.-W. Mittrücker, E. Sebzda, M. F. Bachmann, T. W. Mak, and P. S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirements. Immunity 5:41.
17. Champagne, E., L. Scarpellino, P. Lane, and H. Acha-Orbea. 1996. CD28/ CTLA4-B7 interaction is dispensable for T cell stimulation by mouse mammary tumor virus superantigen but not for B cell differentiation and virus dissemination. Eur. J. Immunol. 26:1595.
18. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
19. Brown, D. R., J. M. Green, N. H. Moskowitz, M. Davis, C. B. Thompson, and S. L. Reiner. 1996. Limited role of CD28-mediated signals in T helper subset differentiation. J. Exp. Med. 184:803.
20. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
21. Tuosto, L., and O. Acuto. 1998. CD28 affects the earliest signaling events generated by TCR engagement. Eur. J. Immunol. 28:2131.
22. Lucas, P. J., I. Negishi, K. Nakayama, L. E. Fields, and D. Y. Loh. 1995. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154:5757.
23. Lenschow, D. J., T. L. Walunas, and J. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:259.
24. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
25. Zhou, P., and R. A. Seder. 1998. CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum. J. Exp. Med. 187:1315.
26. Campbell, K. A., P. J. Ovendale, M. K. Kennedy, W. C. Fanslow, S. G. Reed, and C. R. Maliszewski. 1996. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 4:283.
27. Kamanaka, M., P. Yu, T. Yasui, K. Yoshida, T. Kawabe, T. Horii, T. Kishimoto, and H. Kikutani. 1996. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 4:275.
28. Soong, L., J. C. Xu, I. S. Grewal, P. Kima, J. Sun, B. J. Longley, Jr., N. H. Ruddle, D. McMahon-Pratt, and R. A. Flavell. 1996. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4:263.
29. Wiley, J. A., and A. G. Harmsen. 1995. CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice. J. Immunol. 155:3525.
30. Cosyns, M., S. Tsirkin, M. Jones, R. Flavell, H. Kikutani, and A. R. Hayward. 1998. Requirement of CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice. Infect. Immun. 66:603.
31. + CTL response. J. Exp. Med. 183:2129.
32. Cella, M., F. Sallusto, and A. Lanzavecchia. 1997. Origin, maturation and antigen-presenting function of dendritic cells. Curr. Opin. Immunol. 9:10.
33. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
34. + T helper and a T killer cell. Nature 393: 474.
35. Bennett, S. R. M., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. A. P. Miller, and W. R. Heath. 1998. Help for cytotoxic T cell responses is mediated by CD40 signalling. Nature 393:478.
36. Schoenenberger, S. P., R. E. M. Toes, E. I. H. vanderVoort, R. Offringa, and C. J. M. Melief. 1998. T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.
37. Medzitov, R., and C. A. Janeway. 1997. Innate Immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4.
38. + T-cell responses. Curr. Biol. 4:499.
39. Bevan, M. J. 1987. Class discrimination in the world of immunology. Nature 325:192.
40. Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86.
41. Wong, B. R., R. Josien, S. Y. Lee, B. Sauter, H.-L. Li, R. M. Steinman, and Y. Choi. 1997. TRANCE, a new TNF family member predominantly expressed in T cells, is a dendritic cell specific survival factor. J. Exp. Med. 186:2075.
42. Anderson, D. M., E. Maraskovsky, W. L. Billingsley, W. C. Dougall, M. E. Tometsko, E. R. Roux, M. C. Teepe, R. F. DuBose, D. Cosman, and L. Galibert. 1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175.
43. Sallusto, F., D. Lenig, C. R. Mackay, and A. Lanzavecchia. 1998. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187:875.
44. Möller, G. 1975. One non-specific signal triggers B lymphocytes. Transplant Rev. 23.