Parasite dose determines the Th1/Th2 nature of the response to Leishmania major independently of infection route and strain of host or parasite

European Journal of Immunology

Volumn 28, Issue 12, 1998, Pages 4020-4028

  Menon, Juthika N ^a   Bretscher, Peter A ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Leishmaniasis; Parasite dose; Th1 Th2 decision criterion

Indexed keywords

ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DOSE RESPONSE; FEMALE; HELPER CELL; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

EID: 0031739807     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199812)28:12<4020::AID-IMMU4020>3.0.CO;2-3     Document Type: Article

References (39)

1. Kaplan, G. and Cohn, Z. A., The immunobiology of leprosy. Int. Rev. Exp. Path. 1986. 28: 45-78.
2. Surcel, H. M., Troye-Blomberg, M., Paulie, S., Andersson, G., Moreno, C., Pasvol, G. and Ivanyi, J., Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine responses of blood lymphocytes to mycobacterial antigens. Immunology 1994. 81: 171-176.
3. Ellner, J. J., Tuberculosis. In Kelley, W. W. (Ed.) Textbook of Internal Medicine. Lippincot Press, Philadelphia 1989, pp 1569-1577.
4. Pearson, R. D., Wheeler, D. A., Harrison, L. H. and Kay, H. D., The immunobiology of leishmaniasis. Rev. Infect. Dis. 1983. 5: 907-927.
5. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995. 5: 151-177.
6. Howard, J. G., Immunological regulation and control of experimental leishmaniasis. Int. Rev. Exp. Parasitol. 1980. 28: 79-114.
7. Clerici, M. and Shearer, G. M., Protective immunity against HIV infection: has nature done the experiment for us? Immunol. Today 1996. 17: 21-24.
8. Bretscher, P. A., A strategy to improve the efficacy of vaccination against tuberculosis and leprosy, Immunol. Today 1992. 13: 342-345.
9. Parish, C. R., The relationship between cell-mediated and humoral immunity. Transplant. Rev. 1972. 13: 35-66.
10. Parish, C. R. and Liew, F. Y., Immune response to chemically modified flagellin III. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J. Exp. Med. 1972. 135: 298-311.
11. Salvin, S. B., Occurrence of delayed-hypersensitivity during the development of Arthus-type hypersensitivity. J. Exp. Med. 1958. 107: 109-124.
12. Lagrange, P. H., MacKaness, G. B. and Miller, T. E., Influence of dose and route of antigen injection on the immunological induction of T cells. J. Exp. Med. 1974. 139: 528-542.
13. Sarzotti, M. D., Robbins, S. and Hoffman, P. M., Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 1996. 271: 1726-1728.
14. Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L. and Locksley, R. M., Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. J. Exp. Med. 1989. 169: 59-72.
15. Bretscher, P. A., Wei, G., Menon, J. N. and Bielefeldt-Ohmann, H., Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 1992. 257: 539-542.
16. Menon, J. N. and Bretscher, P. A., Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge. Eur. J. Immunol. 1996. 26: 243-249.
17. Doherty, T. M. and Coffman, R. L., Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice. Exp. Parasitai. 1996. 84: 124-135.
18. Preston, P. M., Behbahani, K. and Dumonde, D. C., Experimental cutaneous leishmaniasis VI. Anergy and allergy in the cellular immune response during nonhealing infection in different strains of mice. J. Clin. Lab. Immunol. 1978. 1: 207-219.
19. Pond, L. D., Wasson, L. and Hayes, C. E., Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection. J. Immunol. 1989. 143: 4232-4237.
20. + T cells. J. Exp. Med. 1995. 182: 1591-1596.
21. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J. Exp. Med. 1995. 182: 1579-1584.
22. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 1997. 15: 297-322.
23. Gammon, G., Dunn, K., Shastri, N., Oki, A., Wilbur, S. and Sercarz, E. E., Neonatal T cell tolerance to minimal immunogenic peptides is caused by clonal deletion. Nature 1986. 319: 413-415.
24. Ria, F., Chan, B. M. C., Scherer, M. T., Smith, J. A. and Gefter, M. L., Immunological activity of covalently linked T-cell epitopes. Nature 1990. 343: 381-383.
25. Clayton, J. P., Gammon, G. M., Ando, D. G., Kono, D. H., Hood, L. and Sercarz, E. E., Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J. Exp. Med. 1989. 169: 1681-1691.
26. Roman, L. M., Simons, L. F., Hammer, R. E., Sambrook, J. F. and Gething, M.-J. F., The expression of influenza virus hemagglutinin in the pancreatic beta cells of transgenic mice results in autoimmune diabetes. Cell 1990. 61: 383-396.
27. Goverman, J., Woods, A., Larson, L., Weiner, L. P., Hood, L. and Zaller, D. M., Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 1993. 72: 551-560.
28. Bretscher, P. A., Quantitative considerations in the design of vaccination strategies against pathogens uniquely susceptible to cell-mediated attack. In Kaufmann, S. H. E. (Ed.) Concepts in Vaccine Development. Walter de Gruyter, Berlin, New York 1996, pp 187-204.
29. Finkelman, F. D., Relationships among antigen presentation, cytokines, immune deviation and autoimmune disease. J. Exp. Med. 1995. 182: 279-282.
30. Guler, M. L., German, J. D., Hsieh, C., Mackey, A. J., Steen, R. G., Dietrich, W. F. and Murphy, K. M., Genetic susceptibility to leishmaniasis: IL-12 responsiveness in Th1 cell development. Science 1996. 271: 984-987.
31. Bretscher, P. A., Hypothesis: On the control between cell-mediated, IgM and IgG immunity. Cell. Immunol. 1974. 13: 171-195.
32. Bratscher, P. A., Significance and mechanisms of cellular regulation of the immune response. Fed. Proc. 1981. 40: 1473-1478.
33. + T-cell subsets in immune class regulation. Res. Immunol. 1991. 142: 45-50.
34. Bretscher, P. A., In vitro analysis of the cellular interactions between unprimed lymphocytes responsible for determining the class of response an antigen induces; specific T cells switch a cell-mediated response to a humoral response. J. Immunol. 1983. 131: 1103-1107.
35. Bretscher, P. A., Regulation of the class of immune response induced by antigen 1. Specific T cells switch the in vivo response from a cell-mediated to a humoral mode. Cell. Immunol. 1983. 81: 345-356.
36. Sacks, D., Hieny, S. and Sher, A., Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J. Immunol. 1985. 135: 564-569.
37. Scott, P., Natovitz, P., Coffman, R. L., Pearce, E. and Sher, A., Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 1988. 168: 1675-1684.
38. Mitchell, G. F., Curtis, J. M., Scollay, R. G. and Handman, E., Resistance and abrogation of resistance to cutaneous leishmaniasis in reconstituted BALB/c nude mice. Aust. J. Exp, Biol. Med. Sci. 1981. 59: 539-554.
39. Titus, R. G., Marchand, M., Boon, T. and Louis, J. A., A limiting dilution assay for quantifying Leishmania major of infected mice. Parasite Immunol. 1985. 7: 545-555.