Macrophage-derived dendritic cells have strong Th1-polarizing potential mediated by β-chemokines rather than IL-12

Journal of Immunology

Volumn 165, Issue 8, 2000, Pages 4388-4396

  Zou, W ^a   Borvak, J ^a   Marches, F ^a   Wei, S ^a   Galanaud, P ^a   Emilie, D ^a   Curiel, T J ^a  

^a BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; SUPERANTIGEN;

ARTICLE; CELL MEMBRANE POTENTIAL; CYTOKINE RELEASE; DENDRITIC CELL; HELPER CELL; HUMAN; HUMAN CELL; MACROPHAGE; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0034667785     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.8.4388     Document Type: Article

References (38)

1. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α
2. Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics
3. Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells
4. + dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes
5. Dendritic cells as the terminal stage of monocyte differentiation
6. Properties of dendritic cells produced from in vitro or in vivo macrophages
7. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
8. Reciprocal control of T helper cell and dendritic cell differentiation
9. + dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
10. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development
11. + precursors
12. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice
13. 2, promote Th2 responses
14. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
15. Natural interferon α/β-producing cells link innate and adaptive immunity
16. + cytotoxic T lymphocytes specific for Toxoplasma gondii lyse tachyzoite-infected target cells
17. Cross-reactivity of human Toxoplasma-specific T cells: Implications for development of a potential immunotherapeutic or vaccine
18. + human immunodeficiency virus type 1 (HIV-1) envelope-specific cytotoxic T lymphocytes derived from the peripheral blood cells of an HIV-1-infected individual
19. Macrophage inflammatory protein-1α (MIP-1α) expression plasmid enhances DNA vaccine-induced immune response against HIV-1
20. CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines
21. Chemokines
22. + individuals: Correlation with a Th1-type cytokine response
23. Synthesis of the CC-chemokines MIP-1α, MIP-1β, and RANTES is associated with a type 1 immune response
24. Role of chemokines in the regulation of Th1/Th2 and autoimmune encephalomyelitis
25. Distinct patterns and kinetics of chemokine production regulate dendritic cell function
26. The biology of chemokines and their receptors
27. Chemokines: A new classification system and their role in immunity
28. Dendritic cells and the control of immunity
29. In vitro generation of human dendritic cells and cell therapy
30. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
31. Human CD14 mediates recognition and phagocytosis of apoptotic cells
32. 3)
33. Human macrophages induced in vitro by macropbage colony-stimulating factor are deficient in IL-12 production
34. 2, promote type 2 cytokine production in maturing human naive T helper cells
35. IL-12 induces the production of IFN-γ by neonatal human CD4 T cells
36. Immunobiology of interleukin-12
37. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
38. + peripheral blood dendritic cells are differentially regulated by cytokines