Notch receptors and hematopoiesis

Experimental Hematology

Volumn 29, Issue 9, 2001, Pages 1041-1052

  Kojika, Satoru ^a   Griffin, James D ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; NOTCH RECEPTOR; PRESENILIN 1; TRANSCRIPTION FACTOR; UBIQUITIN; UNCLASSIFIED DRUG;

CELL PROLIFERATION; DEFENSE MECHANISM; DROSOPHILA; GENE DELETION; GENE MUTATION; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HUMAN; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVIEW; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; THYMOCYTE;

ANIMALS; HEMATOPOIESIS; HUMANS; LIGANDS; MAMMALS; MEMBRANE PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034876802     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00676-2     Document Type: Review

References (151)

1. Notch signaling; Cell fate control and signal integration in development
2. Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
3. Genes of the Enhancer of Split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signaling in Drosophila.
4. Lateral inhibition mediated by the Drosophila neurogenic gene Delta is enhanced by proneural proteins
5. The notch signaling pathway is required to specify muscle progenitor cells in Drosophila.
6. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
7. A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
8. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila.
9. Notch and Wingless regulate expression of cuticle patterning genes
10. Notch responds differently to Delta and Wingless in cultured Drosophila cells
11. Notch signaling and the determination of appendage identity
12. Dorsal-ventral signaling in the Drosophila eye
13. Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye
14. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye
15. Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye
16. The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1
17. Notch signaling regulates the pattern of auditory hair cell differentiation in mammals
18. Notch signalling pathway mediates hair cell development in mammalian cochlea
19. Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte
20. Notch-mediated segmentation and growth control of the Drosophila leg
21. Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch
22. Notch signalling mediates segmentation of the Drosophila leg
23. The lin-12 locus specifies cell fates in Caenorhabditis elegans.
24. Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch siganaling pathway
25. Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors
26. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
27. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2
28. The human Notch1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
29. Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3
30. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
31. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
32. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
33. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jkappa/Su(H)
34. The suppressor of hairless protein participates in notch receptor signaling
35. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis
36. Control of daughter cell fates during asymmetric division; interaction of Numb and Notch
37. Mammary tumorigenesis in feral mice; identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
38. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
39. Signaling downstream of activated mammalian Notch
40. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1
41. Suppressor of hairless-independent events in Notch signaling imply novel pathway elements
42. Oncogenic forms of Notch1 lacking either the primary binding site for RBP-Jκ or nuclear localization sequences retain the ability to associate with RBP-Jκ and activate transcription
43. Notch inhibition of E47 supports the existence of a novel signaling pathway
44. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
45. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
46. Human ligands of the Notch receptor
47. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene
48. Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components; distinct ligand-receptor interactions in intrathymic T cell development
49. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
50. Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis
51. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
52. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
53. Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
54. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
55. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
56. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
57. Maintenance of somite borders in mice requires the Delta homologue Dll1
58. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
59. Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element
60. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
61. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function
62. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
63. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
64. LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein
65. Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.
66. Evidence that Spt6p controls chromatin structure by a direct interaction with histones
67. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
68. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
69. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis
70. Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif
71. The bHLH gene HES1 is essential for expansion of early T cell precursors
72. Control of endodermal endocrine development by Hes-1
73. The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1
74. TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation
75. The bHLH gene HES6, an inhibitor of HES1, promotes neuronal differentiation
76. Structure, Chromosomal Locus, and Promoter analysis of the Gene Encoding the Mouse helix-Loop-Helix Factor HES-1
77. Human deltex is a conserved regulator of Notch signalling
78. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene; A regulator of notch signaling
79. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
80. Recognition and ubiquitination of Notch by Itch, a Hect-type E3 ubiquitin ligase
81. Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function
82. Mastermind acts downstream of notch to specify neuronal cell fates in the Drosophila central nervous system
83. MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
84. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
85. The Notch1 receptor is cleaved constitutively by a furin-like convertase
86. Presenilin structure, function and role in Alzheimer disease
87. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
88. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
89. Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1
90. Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
91. Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
92. Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A β42 secretion in mammalian cells but impaired Notch/lin-12 signaling in C. elegans.
93. Presenilin is required for proper morphology and function of neurons in C. elegans.
94. Skeletal and CNS defects in Presenilin-1-deficient mice
95. Mice lacking both presenilin genes exhibit early embryonic patterning defects
96. Presenilin-1 regulates neuronal differentiation during neurogenesis
97. Fringe is a glycosyltransferase that modifies Notch
98. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
99. Fringe forms a complex with Notch
100. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
101. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
102. The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
103. Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage
104. Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate
105. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
106. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins
107. Groucho/TLE family proteins and transcriptional repression
108. A role for Groucho tetramerization in transcriptional repression
109. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
110. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
111. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development
112. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
113. Rel/NF-κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
114. T cell leukemia-associated Human Notch/Translocation-associated Notch Homologue has IκB-like activity and physically interacts with nuclear factor-κB proteins in T cells
115. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
116. Inhibition of nuclear factor-κB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
117. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
118. Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling
119. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
120. Notch signaling is essential for vascular morphogenesis in mice
121. Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
122. Neoplastic transformation by Notch requires nuclear localization
123. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells
124. Deficient T cell fate specification in mice with an induced inactivation of Notch1
125. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells
126. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
127. The Notch pathway intermediate HES-1 silences CD4 gene expression
128. Notch activity influences the αβ vs γδ T cell lineage decision
129. Correlating notch signaling with thymocyte maturation
130. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
131. Protective effects of notch-1 on TCR-induced apoptosis
132. + T cells
133. Epstein-Barr virus immortalization; Notch2 interacts with CBF1 and blocks differentiation
134. Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promoters
135. Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2
136. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
137. Cell cycle arrest and apoptosis induced by notch1 in B cells
138. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
139. The helix-loop-helix gene E2A is required for B cell formation
140. Inhibition of granulocytic differentiation by mNotch1
141. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
142. Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by notch-1
143. Notch signaling enhances survival and alters differentiation of 32D myeloblasts
144. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells
145. Mouse Jagged2 suppresses the initial differentiation and proliferation of hematopoietic stem cells
146. Notch signalling via RBP-J promotes myeloid differentiation
147. Notch signaling via RBP-J reduces self renewal of multipotent hematopoietic progenitor cells and promotes differentiation into granulocytes, macrophages and erythroid cells
148. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
149. mNotch1 signaling reduces proliferation of myeloid progenitor cells by altering cell-cycle kinetics
150. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro
151. An activated Notch4(Int-3) affects the proliferation and differentiation of hematopoietic stem and progenitor cells