The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

Molecular Biology of the Cell

Volumn 8, Issue 6, 1997, Pages 1013-1023

  Blasina, Alessandra ^a   Paegle, E Sasha ^a   McGowan, Clare H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL DNA; CYCLIN B;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IRRADIATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0030921428     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.6.1013     Document Type: Article

References (37)

1. CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature 355, 368-371.
2. Cohen, G.M., Sun, X.M., Snowden, R.T., Dinsdale, D., and Skilleter, D.N. (1992). Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 286, 331-334.
3. 1-S phase protein kinase. Science 257, 1958-1961.
4. Gossen, M., and Bujard, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.
5. + protein kinase regulates entry into mitosis. Nature 342, 39-45.
6. Harlow, E., and Lane, D. (1988). Antibodies. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
7. Hartwell, L.H., and Kastan, M.B. (1994). Cell cycle control and cancer. Science 266, 1821-1828.
8. Heald, R., McLoughlin, M., and McKeon, F. (1993). Human Wee1 Maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74, 463-474.
9. 2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene 11, 2151-2156.
10. Hoffmann, I., Clarke, P.R., Marcote, M.J., Karsenti, E., and Draetta, G. (1993). Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 12, 53-63.
11. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C.C. (1991). p53 mutations in human cancers. Science 253, 49-53.
12. 2 arrest in human cells. J. Cell Biol. 134, 963-970.
13. 2 delay in HeLa cells. Cancer Res. 57, 753-758.
14. Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R.W. (1991). Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304-6311.
15. cdc2 kinase activation in vertebrates. EMBO J. 10, 3331-3341.
16. 2/M checkpoint with DNA synthesis inhibitors. Mol. Biol. Cell 6, 199-213.
17. Kumagai, A., and Dunphy, W.G. (1992). Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell 70, 139-151.
18. Lamb, N.J., Fernandez, A., Watrin, A., Labbe, J.C., and Cavadore, J.C. (1990). Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Cell 60, 151-165.
19. 2/M transition in Xenopus extracts. Proc. Natl. Acad. Sci. USA 93, 352-356.
20. 2 arrest in Chinese hamster ovary cells. Cancer Res. 50, 3761-3766.
21. Lu, K.P., and Hunter, T. (1995). Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81, 413-424.
22. Lundgren, K., Walworth, N., Booher, R., Dembski, M., Kirschner, M., and Beach, D. (1991). mik1 and weel cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64, 1111-1122.
23. Maity, A., McKenna, W.G., and Muschel, R.J. (1995). Evidence for post-transcriptional regulation of cyclin B mRNA in the cell cycle and following irradiation in HeLa cells. EMBO J. 14, 603-609.
24. McGowan, C.H., and Russell, P. (1995). Cell cycle regulation of human WEE1. EMBO J. 14, 2166-2175.
25. Mondesert, O., McGowan, C.H., and Russell, P. (1996). Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol. Cell. Biol. 16, 1527-1533.
26. cdc2 protein kinase in vertebrates. EMBO J. 10, 3321-3329.
27. Ongkeko, W., Ferguson, D.P.J., Harris, A.L., and Norbury, C. (1995). Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage. J. Cell Sci. 108, 2897-2904.
28. Osmani, A.H., McGuire, S.L., and Osmani, S.A. (1991). Parallel activation of the nimA protein kinase is required to initiate mitosis in A. nidulans. Cell 67, 283-291.
29. Poon, Y.C., Jiang, W., Toyoshima, H., and Hunter, T. (1996). Cyclin-dependent kinases are inactivated by a combination of p21 and Thr14/Tyr15 phosphorylation after UV-induced DNA damage. J. Biol. Chem. 271, 13283-13291.
30. Shi, L., Nishioka, W.K., Th'ng, J., Barbury, E.M., Litchfield, D.W., and Greenberg, A.H. (1994). Premature p34cdc2 activation required for apoptosis. Science 263, 1143-1145.
31. cdc28. Nature 355, 365-368.
32. Stueland, C.S., Lew, D.J., Cismowski, M.J., and Reed, S.I. (1993). Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 23, 3744-3755.
33. Watanabe, N., Broome, M., and Hunter, T. (1995). Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14, 1878-1891.
34. Werness, B.A., Levine, A.J., and Howley, P.M. (1990). Association of human papillomavarus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
35. Wilson, I.A., Niman, H.L., Hougten, R.A., Cherenson, A.R., Connolly, M.L., and Lerner, R.A. (1984). The structure of an antigenic determinant in a protein. Cell 37, 767-778.
36. 2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans. EMBO J. 16, 182-192.
37. Ye, X.S., Fincher, R.R., Tang, A., and Osmani, S.A. (1996). Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis. EMBO J. 15, 3599-3610.