A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea

Journal of Cell Biology

Volumn 138, Issue 5, 1997, Pages 1105-1116

  Nishijima, Hitoshi ^a   Nishitani, Hideo ^a,b   Seki, Takashi ^a,b   Nishimoto, Takeharu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B; CYCLIN DEPENDENT KINASE; HISTONE H1; HYDROXYUREA; PHOSPHOTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL GROWTH; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ESCHERICHIA COLI; HAMSTER; IMMUNOPRECIPITATION; KIDNEY CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL-FREE SYSTEM; CLONING, MOLECULAR; CRICETINAE; CYCLINS; CYCLOHEXIMIDE; ENZYME ACTIVATION; HYDROXYUREA; KIDNEY; KINETICS; MITOSIS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; S PHASE; SIGNAL TRANSDUCTION;

ANIMALIA; CRICETINAE; ESCHERICHIA COLI;

EID: 0030884275     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.5.1105     Document Type: Article

References (64)

1. cdc2 inhibitory kinases. Mol. Biol. Cell. 5:989-1001.
2. Bischoff, F.R., and H. Ponstingle. 1991. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature (Lond.). 354:80-82.
3. Cyert, M.S., and M.W. Kirschner. 1988. Regulation of MPF activity in vitro. Cell 53:185-195.
4. Dickmanns, A., F.R. Bischoff, C. Marshallsay, R. Luhrmann, H. Ponstingle, and E. Fanning. 1996. The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N. J. Cell Science. 109:1449-1457.
5. Dingwall, C., S. Kandels-Lewis, and B. Seraphin. 1995. A family of Ran binding proteins that includes nucleoporins. Proc. Natl. Acad. Sci. USA. 92:7525-7529.
6. Dunphy, W.G. 1994. The decision to enter mitosis. Trends Cell Biol. 4:202-207.
7. Evans, T., E.T. Rosenthal, J. Youngblom, D. Distel, and T. Hunt. 1983. Cyclin: a protein specified by maternal mRNA in Sea Urchin eggs that is destroyed at each cleavage division. Cell. 33:389-396.
8. Fesquet, D., J.C. Labbe, J. Derancourt, J.P. Capony, S. Galas, F. Girard, T. Lorca, J. Shuttle-worth, M. Doree, and J.C. Cavadore. 1993. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr 161 and its homologues. EMBO (Eur. Mol. Biol. Organ.) J. 12:3111-3121.
9. Featherstone, C., and P. Russell. 1991. Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature (Lond.). 349:808-811.
10. Frasch, M. 1991. The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1. EMBO (Eur. Mol. Biol. Organ.) J. 10: 1225-1236.
11. Furuno , N., M. Nishizawa, K. Okazaki, H. Tanaka, J. Iwashita, N. Nakajo, Y. Ogawa, and N. Sagata. 1994. Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes. EMBO (Eur. Mol. Biol. Organ.) J. 13:2399-2410.
12. Galaktionov, K., and D. Beach. 1991. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell. 67:1181-1194.
13. Galaktionov, K., A.K. Lee, J. Eckstein, G. Draetta, J. Meckler, M. Loda, and D. Beach. 1995. Cdc25 phosphatases as potential human oncogenes. Science (Wash. DC). 269:1575-1577.
14. Heald, R., M. McLoughlin, and F. McKeon. 1993. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase. Cell. 74:463-474.
15. Hershko, A. 1983. Ubiquitin; roles in protein modification and breakdown. Cell. 34:11-12.
16. Hoffmann, I., P.R. Clarke, M.J. Marcote, E. Karsenti, and G. Draetta. 1993. Phosphorylation and activation of human cdc25-C by cdc2/cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO (Eur. Mol. Biol. Organ.) J. 12:53-63.
17. 1/S transition. EMBO (Eur. Mol. Biol. Organ.) J. 13:4302-4310.
18. Honda, R., Y. Ohba, A. Nagata, H. Okayama, and H. Yasuda. 1993. Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase. FEBS (Fed. Eur. Biochem. Soc.) Lett. 318:331-334.
19. Izumi, T., and J.L. Maller. 1993. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol. Biol. Cell. 4:1337-1350.
20. Izumi, T., D.H. Walker, and J.L. Maller. 1992. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity. Mol. Biol. Cell. 3:927-939.
21. Jinno, S., K. Suto, A. Nagata, M. Igarashi, Y. Kanaoka, H. Nijima, and H. Okayama. 1994. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO (Eur. Mol. Biol. Organ.) J. 13:1549-1556.
22. Kumagai, A., and W.G. Dunphy. 1992. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell. 70:139-151.
23. 2/M checkpoint with DNA synthesis inhibitors. Mol. Biol. Cell. 6:199-213.
24. Kumagai, A., and W.G. Dunphy. 1996. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science (Wash. DC). 273:1377-1380.
25. 2/M transition in Xenopus extracts. Proc. Natl. Acad. Sci. USA. 93: 352-356.
26. Lee, T.H., M.J. Solomon, M.C. Mumby, and M.W. Kirschner. 1991. INH, a negative regulator of MPF, is a form of protein phosphatase 2A. Cell. 64:415-423.
27. Lee, T.H., C. Turck, and M.W. Kirschner. 1994a. Inhibition of cdc2 activation by INH/PP2A. Mol. Biol. Cell. 5:323-338.
28. cdc2 on tyrosine-15. J. Biol. Chem. 269:30530-30537.
29. cdc2 exclusively on Tyr 15. EMBO (Eur. Mol. Biol. Organ.) J. 12:75-85.
30. Makishima, T., T. Nakashima, K. Nagata-Kuno, K. Fukushima, H. Iida, M. Sakaguchi, Y. Ikehara, S. Komiyama, and T. Nishimoto. 1997. The highly conserved DAD1 protein involved in apoptosis is required for N-linked glycosylation. Genes Cells. 2:129-141.
31. Melchior, F., B. Paschal, E. Evans, and L. Gerace. 1993. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123: 1649-1659.
32. CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc. Natl. Acad. Sci. USA. 88:10500-10504.
33. Minshull, J., A. Murray, A. Colman, and T. Hunt. 1991. Xenopus oocyte maturation does not require new cyclin synthesis. J. Cell Biol. 114:767-772.
34. Morla, A., and J.Y.J. Wang. 1986. Protein tyrosine phosphorylation in the cell cycle of GALB/c 3T3 fibroblasts. Proc. Natl. Acad. Sci. USA. 83:8191-8195.
35. Moore, M.S., and G. Blobel. 1993. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature (Lond.). 365:661-663.
36. Mueller, P.R., T.R. Coleman, and W.G. Dunphy. 1995a. Cell cycle regulation of a Xenopus wee1-like kinase. Mol. Biol. Cell 6:119-134.
37. Mueller, P.R., T.R. Coleman, A. Kumagai, and W.G. Dunphy. 1995b. Myt1: a membrane-associated inhibitory kinase that phosphorylates cdc2 on both threonine-14 and tyrosine-15. Science (Wash. DC). 270:86-90.
38. + gene occurs in humans and is highly expressed in some cancer cells. New Biol. 3:959-968.
39. Nefsky, B., and D. Beach. 1996. Pub1 acts as an E6-AP-like protein ubiquitin ligase in the degradation of cdc25. EMBO (Eur. Mol. Biol. Organ.) J. 15: 1301-1312.
40. - Mutant of BHK cells. Cell. 15:475-483.
41. Nishimoto, T., R. Ishida, K. Ajiro, S. Yamamoto, and T. Takahashi. 1981. The synthesis of protein(s) for chromosome condensation may be regulated by a post-transcriptional mechanism. J. Cell. Physiol. 109:299-308.
42. Nishitani, H., M. Ohtsubo, K. Yamashita, H. Iida, J. Pines, H. Yasuda, Y. Shibata, T. Hunter, and T. Nishimoto. 1991. Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO (Eur. Mol. Biol. Organ.) J. 10:1555-1564.
43. Noguchi, E., N. Hayashi, N. Nakashima, and T. Nishimoto. 1997. Yrb2p, Nup2p-related yeast protein has functional overlap with Rna1p, yeast RanGAP protein. Mol. Cell. Biol. 17:2235-2246.
44. Norbury, C., and P. Nurse. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61:441-470.
45. Ohba, T., T. Seki, Y. Azuma, and T. Nishimoto. 1996. Premature chromatin condensation induced by loss of RCC1 is inhibited by GTP- and GTPgS-Ran, but not GDP-Ran. J. Biol. Chem. 27:14665-14667.
46. cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science (Wash. DC) 257: 1955-1957.
47. Pines, J., and T. Hunter. 1991. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell Biol. 115:1-17.
48. Pines, J., and T. Hunter. 1994. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO (Eur. Mol. Biol. Organ.) J. 13:3772-3781.
49. cdc2. EMBO (Eur. Mol. Biol. Organ.) J. 12:3123-3132.
50. 2. Proc. Natl. Acad. Sci. USA. 87:5139-5143.
51. Sagata, N., M. Oskarsson, T. Copeland, J. Brumbaugh, and G.F. Vande Woud. 1988. Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. Nature (Lond.). 335:519-525.
52. Sazer, S. 1996. The search for the primary function of the Ran GTPase continues. Trends Cell Biol. 6:81-85.
53. Seki, T., K. Yamashita, H. Nishitani, T. Takagi, P. Russell, and T. Nishimoto. 1992. Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm. Mol. Biol. Cell. 3:1373-1388.
54. Seki, T., N. Hayashi, and T. Nishimoto. 1996. RCC1 in the Ran pathway. J. Biochem. 120:207-214.
55. Schlegel, R., and A.B. Pardee. 1986. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (Wash. DC). 232:1264-1266.
56. MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes. EMBO (Eur. Mol. Biol. Organ.) J. 9:3233-3240.
57. Solomon, M.J., M. Glotzer, T.H. Lee, M. Philippe, and M.W. Kirschner. 1990. Cyclin activation of p34 cdc2. Cell. 63:1013-1024.
58. cdc2 activation: identification of an activating kinase. Mol. Biol. Cell. 3:13-27.
59. MO15. EMBO (Eur. Mol. Biol. Organ.) J. 12:3133-3142.
60. Tachibana, T., N. Imamoto, H. Seino, T. Nishimoto, and Y. Yoneda. 1994. Loss of RCC1 leads to suppression of nuclear protein import in living cells. J. Biol. Chem. 269:24542-24545.
61. Wasserman, W.J., and Y. Masui. 1975. Effects of cycloheximide on a cytoplasmic factor initiating meiotic maturation in Xenopus laevis oocytes. Exp. Cell Res. 91:381-388.
62. Wu, L., K. Shiozaki, R. Aligue, and P. Russell. 1996. Spatial organization of the Nim1-Wee1-Cdc2 mitotic control network in Schizosaccharomyces pombe. Mol. Biol. Cell 7:1749-1758.
63. Wu, L., and P. Russell. 1993. Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Nature (Lond.). 363:738-741.
64. Yew, N., M.L. Mellini, and G.F. Vande Woude. 1992. Meiotic initiation by the mos protein in Xenopus. Nature (Lond.). 355:649-652.