Rad-dependent response of the chk1-Encoded protein kinase at the DNA damage checkpoint

Science

Volumn 271, Issue 5247, 1996, Pages 353-356

  Walworth, Nancy C ^a,b   Bernards, Rene ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA; ATAXIA TELANGIECTASIA; EUKARYOTA; SCHIZOSACCHAROMYCES POMBE;

ADENOSINE TRIPHOSPHATASE; ATM PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; DNA BINDING PROTEIN; FUNGAL DNA; HELICASE; HYBRID PROTEIN; PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAD3 ATPASE DNA HELICASE, S CEREVISIAE; RAD3 ATPASE-DNA HELICASE, S CEREVISIAE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CYCLE G2 PHASE; CHEMISTRY; CYTOLOGY; DNA DAMAGE; DNA REPLICATION; FUNGAL GENE; GENETICS; HUMAN; METABOLISM; MITOSIS; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; RADIATION EXPOSURE; SCHIZOSACCHAROMYCES; ULTRAVIOLET RADIATION;

ADENOSINE TRIPHOSPHATASES; BASE SEQUENCE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA HELICASES; DNA REPLICATION; DNA, FUNGAL; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; G2 PHASE; GENES, FUNGAL; HUMANS; MITOSIS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECOMBINANT FUSION PROTEINS; SCHIZOSACCHAROMYCES; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

EID: 0029664616     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5247.353     Document Type: Article

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47. We thank members of the Bernards laboratory as well as M Smeets and A. Begg at the Netherlands Cancer Institute for helpful discussions, A. M. Carr for providing strains containing the radΔ alleles, and B Nefsky for critical reading of the manuscript Supported by grants to R B. from the Netherlands Organization for Scientific Research (NWO) and the NIH, and from start-up funds provided to N.W. from UMDNJ-Robert Wood Johnson Medical School