Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors

Science

Volumn 280, Issue 5370, 1998, Pages 1747-1749

  Feng, Weijun ^a   Ribeiro, Ralff C J ^b   Wagner, Richard L ^a   Nguyen, Hoa ^a   Apriletti, James W ^a   Fletterick, Robert J ^a   Baxter, John D ^a   Kushner, Peter J ^a   West, Brian L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; DNA; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; GLUTATHIONE TRANSFERASE; HORMONE; HYBRID PROTEIN; LIGAND; LIOTHYRONINE; PROTEIN; RALOXIFENE; STEROID RECEPTOR; THYROID HORMONE RECEPTOR;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DNA BINDING; HORMONE DEPENDENCE; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; SURFACE PROPERTY; TRANSCRIPTION REGULATION; X RAY CRYSTALLOGRAPHY;

HELA CELLS; HISTONE ACETYLTRANSFERASES; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RECOMBINANT FUSION PROTEINS; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRIIODOTHYRONINE;

EID: 0032511086     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5370.1747     Document Type: Article

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41. We thank M. Stallcup and C. Costa for providing the GST-GRIP1, GST-RXRα, and GST-TRβ expression vectors; P. Webb and M. Tsai for providing the pSG5-GRIP1 and pCMX-SRC-1a expression vectors; K. Yamamoto, P. Webb, M. G. Rosenfeld, and T. Scanlan for suggestions; and T. Chen and K. Nakamura for technical assistance. W.F. is a recipient of a postdoctoral fellowship from the National Institutes of Health (DK09516). Supported by NIH grants to J.D.B. (DK51281) and to the Computer Graphics Laboratory at the University of California, San Francisco (P41-RR01081).