A signature motif in transcriptional co-activators mediates binding to nuclear receptors

Nature

Volumn 387, Issue 6634, 1997, Pages 733-736

  Heery, David M ^a   Kalkhoven, Eric ^a   Hoare, Susan ^a   Parker, Malcolm G ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR;

ALPHA HELIX; ARTICLE; CONFORMATIONAL TRANSITION; DRUG RECEPTOR BINDING; GENE TARGETING; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; CREB-BINDING PROTEIN; DNA; HISTONE ACETYLTRANSFERASES; HUMANS; LIGANDS; MICE; NUCLEAR PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0030986236     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/42750     Document Type: Article

References (27)

1. Beato, M., Herrlich, P. & Shutz, G. Steroid-hormone receptors-many actors in search of a plot. Cell 83, 851-857 (1995).
2. Mangelsdorf, D. J. et al. The nuclear receptor superfamily: the second decade. Cell 83, 835-839 (1995).
3. Onate, S. A., Tsai, S. Y., Tsai, M.-J. & O'Malley, B. W. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-1357 (1995).
4. Kamei, Y. et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414 (1996).
5. Yao, T.-P., Ku, G., Zhou, N., Scully, R. & Livingston, D. M. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl Acad. Sci. USA 93, 10626-10631 (1996).
6. Voegel, J. J., Heine, M. J. S., Zechel, C., Chambon, P. & Gronemeyer, H. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15, 101-108 (1996).
7. Hong, H., Kohli, K., Trivedi, A., Johnson, D. L. & Stallcup, M. R. Grip1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone-binding domains of steroid-receptors. Proc. Natl Acad. Sci. USA 93, 4948-4952 (1996).
8. Chakravarti, D. et al. Role of CBP/p300 in nuclear receptor signalling. Nature 383, 99-103 (1996).
9. Hanstein, B. et al. p300 is a component of an estrogen receptor coactivator complex. Proc. Natl Acad. Sci. USA 93, 11540-11545 (1996).
10. Cavaillès, V. et al. Nuclear factor RIP 140 modulates transcriptional activation by the estrogen receptor. EMBO J. 14, 3741-3751 (1995).
11. Le Douarin, B. et al. The N-terminal part of TIFI, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptor, is fused to B-raf in the oncogenic protein T18. EMBO J. 14, 2020-2033 (1995).
12. Lee, J. W., Ryan, F., Swaffield, J. C., Johnston, S. A. & Moore, D. D. Interaction of thyroid-hormone receptor with a conserved transcription mediator. Nature 374, 91-94 (1995).
13. vom Baur, E. et al. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIFI. EMBO J. 15, 110-124 (1996).
14. Danielian, P. S., White, R., Lees, L. A. & Parker, M. G. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11, 1025-1033 (1992).
15. L'Horset, F., Dauvois, S., Heery, D. M., Cavailles, V. & Parker, M. G. RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol. Cell. Biol. 16, 6029-6036 (1996).
16. Rost, B. & Sander, C. Improved prediction of protein secondary structure by use of sequence profiles and neural network. Proc. Natl Acad. USA 90, 7558-7562 (1993).
17. Kwok, R. P. S. et al Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370, 223-226 (1994).
18. Arias, J. et al. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370, 226-229 (1994).
19. o for the androgen receptor in human prostate cells. Proc. Natl Acad. Sci. USA 93, 5517-5521 (1996).
20. Yoshinaga, S. K., Peterson, C. L., Herskowitz, I. & Yamamoto, K. R. Roles of SW11, SW12, and SW13 proteins for transcriptional enhancement by steroid receptors. Science 258, 1598-1604 (1992).
21. Stein, B. & Yang, M. X. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κ and C/EBPβ. Mol. Cell. Biol. 15, 4971-4979 (1995).
22. Mettger, D., Losson, R., Bornert, J.-M., Lemoine, Y. & Chambon, P. Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast. Nucleic Acids Res. 20, 2813-2817 (1992).
23. Le Douarin, B., Pierrat, B., vom Baur, E., Chambon, P. & Losson, R. A new version of the two-hybrid assay for detection of protein-protein interactions. Nucleic Acids Res. 23, 876-878 (1995).
24. Cavailles, V., Dauvois, S., Danielian, P. S. & Parker, M. G. Interaction of proteins with transcriptionally active estrogen receptors. Proc. Natl Acad. Sci. USA 91, 10009-10013 (1994).
25. Montano, M. M., Ekena, K., Kruegcr, K. D., Keller, A. L. & Katsenellenbogen, B. S. Human estrogen-receptor ligand activity inversion mutants - receptors that interpret antiestrogens as estrogens and estrogens as antiestrogens and discriminate among different antiestrogens. Mol. Endocrinol. 10, 230-242 (1996).
26. Eckner, R. et al. Molecular cloning and functional analysis of the adenovirus El A associated 300 kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8, 869-884 (1994).
27. Le Douavin, B. et al. A possible involvement of TIFlα and TIF1β in the epigenetic control of transcription by nuclear receptors. EMBO J. 15, 6701-6715 (1996).