Nuclear receptors have distinct affinities for coactivators: Characterization by fluorescence resonance energy transfer

Molecular Endocrinology

Volumn 12, Issue 10, 1998, Pages 1594-1604

  Zhou, G ^a   Cummings, R ^a   Li, Y ^a   Mitra, S ^a   Wilkinson, H A ^a   Elbrecht, A ^a   Hermes, J D ^a   Schaeffer, J M ^a   Smith, R G ^a   Moller, D E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CELL NUCLEUS RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTROGEN RECEPTOR; FLUORESCENT DYE; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; STEROID RECEPTOR COACTIVATOR 1;

ARTICLE; DOSE RESPONSE; ENERGY TRANSFER; FLUORESCENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KINETICS; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION;

EUKARYOTA;

EID: 0032230368     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.10.0176     Document Type: Article

References (43)

1. The nuclear receptror superfamily: The second decade
2. Convergence of 9-cis retinoic acid and peroxisome proliferator signaling pathways through heterodimer formation of their receptors
3. RXRb: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
4. The retinoid signaling pathway: Molecular and genetic analyses
5. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
6. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
7. Interaction of proteins with transcriptionally active estrogen receptors
8. A transcriptional co-repressor that interacts with nuclear hormone receptors
9. Role of CBP/p300 in nuclear receptor signalling
10. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
11. Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor γ
12. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
13. CRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
14. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
15. The transcriptional coactivators p300 and CBP are histone acetyltransferases
16. Steroid receptor coactivator-1 is a histone acetyltransferase
17. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
18. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
19. New developments in HTS technology
20. Time-resolved detection of lanthanide luminescence for ultrasensitive bioanalytical assays
21. Time-resolved fluorescence spectroscopy
22. Europium chelate-loaded liposomes: A tool for the study of binding and integrity of liposomes
23. Rare earth cryptates and homogeneous fluoroimmuno assays with human sera
24. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ
25. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-γ: Binding and activation correlate with antidiabetic actions in db/db mice
26. Insulin mimetic and insulin-sensitizing drugs
27. 15-Deoxy-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
28. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
29. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor β
30. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β
31. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
32. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator
33. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator activated receptors by coactivator-dependent receptor ligand assay
34. The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers
35. Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens
36. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid x receptor heterodimers with ligands, coactivators, and corepressors
37. CBP-induced stimulation of c-Fos activity is abrogated by E1A
38. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling
39. Nuclear protein CBP is a coactivator for the transcription factor CREB
40. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
41. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
42. Differential use of CREB binding protein-coactivator complexes
43. Eukaryotic proteins expressed in Escherichia coil: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase