Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

EMBO Journal

Volumn 17, Issue 12, 1998, Pages 3398-3412

  Huang, Ningwu ^a,b   Vom Baur, Elmar ^a,c   Garnier, Jean Marie ^a   Lerouge, Thierry ^a   Vonesch, Jean Luc ^a   Lutz, Yves ^a   Chambon, P ^a   Losson, Régine ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Activation function AF 2; Chromatin; PHD finger; SET domain; Transcriptional intermediary factor

Indexed keywords

CELL NUCLEUS RECEPTOR; REPRESSOR PROTEIN; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; COS CELLS; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRETINOIN; YEASTS;

ANIMALIA;

EID: 0032526951     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.12.3398     Document Type: Article

References (60)

1. Aasland, R., Gibson, T.J. and Stewart, A.F. (1995) The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci., 20, 56-59.
2. Alland, L., Muhle, R., Hou, H., Jr, Potes, J., Chin, L., Schreiber-Agus, N. and DePinho, R.A. (1997) Role of N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature, 387, 49-55.
3. Bannister, A.J. and Kouzarides, T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643.
4. Carrington, E.A. and Jones, R.S. (1996) The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution. Development, 122, 4073-4083.
5. Chambon, P. (1996) A decade of molecular biology of retinoic acid receptors. FASEB J., 10, 940-954.
6. Chen, J.D. and Evans, R.M. (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature, 377, 454-457.
7. Chen, H., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalski, M.L., Nakatani, Y. and Evans, R.M. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell, 90, 569-580.
8. Cross, S.H., Meehan, R.R., Nan, X. and Bird, A. (1997) A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nature Genet., 16, 256-259.
9. Danielian, P.S., White, R., Lees, L.A. and Parker, M.G. (1992) Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J., 11, 1025-1033.
10. Durand, B., Saunders, M., Gaudon, C., Roy, B., Losson, R. and Chambon, P. (1994) Activation function 2 (AF-2) of RAR and RXR: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J., 13, 5370-5382.
11. Gaub, M.P., Rochette-Egly, C., Lutz, Y., Ali, S., Matthes, H., Scheuer, I. and Chambon, P. (1992) Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation. Exp. Cell Res., 201 335-346.
12. Glass, C.K., Rose, D.W. and Rosenfeld, M.G. (1997) Nuclear receptor coactivators. Curr. Opin. Cell Biol., 9, 222-232.
13. Heery, D.M., Zacharewski, T., Pierrat, B., Gronemeyer, H., Chambon, P. and Losson, R. (1993) Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors. Proc. Natl Acad. Sci. USA, 90, 4281-4285.
14. Heery, D.M., Kalkhoven, E., Hoare, S. and Parker, M.G. (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature, 387, 733-736.
15. Heinzel, T. et al. (1997) A complex containing N-CoR, mSin3 and histone deactylase mediates transcriptional repression. Nature, 387, 43-48
16. Hobert, O., Sures, I., Ciossek, T., Fuchs, M. and Ullrich, A. (1996) Isolation and developmental expression analysis of Eux-1, a novel mouse Polycomb group gene. Mech. Devel., 55, 171-184.
17. Hörlein, A. J. et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor-corepressor. Nature 377, 397-404.
18. Jones, R.S. and Gelbart, W.M. (1993) The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol., 13, 6357-6366.
19. Kalkoven, E., Valentine, J.E., Heery, D.M. and Parker, M.G. (1998) The isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J., 17, 232-243.
20. Kastner, P. Mark, M. and Chambon, P. (1995) Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell, 83, 859-869.
21. Kastner, P., Mark, M., Ghyselinck, N., Krezel, W., Dupe, V., Grondona, J.M. and Chambon, P. (1997) Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development, 124, 313-326.
22. Kurokawa, R., Söderström, M., Hörlein, A., Halachmi, S., Brown, M., Rosenfeld, M.G. and Glass, C.K. (1995) Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature, 377, 451-454.
23. Laible, G. Wolf, A., Dorn, R., Reuter, G., Nislow, C., Lebersorger, A., Popkin, D., Pillus, L. and Jenuwein, T. (1997) Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres. EMBO J., 16, 3219-3232.
24. LaJeunesse, D. and Shearn, A. (1995) Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent small and homeotic discs 1 and 2. Mech. Devel., 53, 123-139.
25. LaJeunesse, D. and Shearn, A. (1996) E(z): a polycomb group gene or a trithorax group gene? Development, 122, 2189-2197.
26. Le Douarin, B. et al. (1995a) The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J., 14, 2020-2033.
27. Le Douarin, B., Pierrat, B., vom Baur, E., Chambon, P. and Losson, R. (1995b). A new version of the two-hybrid assay for detection of protein-protein interactions. Nucleic Acids Res., 23, 876-878.
28. Le Douarin, B., Lade Nielsen, A., Garnier, J.-M., Ichinose, H., Jeanmougin, F., Losson, R. and Chambon, P. (1996) A possible involvement of TIF1α and TIF1β in the epigenetic control of transcription by nuclear receptors. EMBO J., 15, 6701-6715.
29. Lonie, A., D'Andrea, R.D., Paro, R. and Saint, R. (1994) Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Development, 120, 2629-2636.
30. Ma, Q. et al. (1993) Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc. Natl Acad. Sci. USA, 90, 6350-6354.
31. Mangelsdorf, D.J. et al. (1995). The nuclear receptor superfamily: the second decade. Cell, 83, 835-839.
32. Milner, C.M. and Campbell, R.D. (1993) The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats. Biochem. J., 290, 811-818.
33. Nagy, L., Kao, H.-Y., Chakiavarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L. and Evans, R.M. (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell, 89, 365-380.
34. Nakajima, T., Uchida, C., Anderson, S.F., Lee, C.-G., Hurwitz, J., Parvin, J.D. and Montminy, M. (1997) RNA helicase A mediates association of CBP with RNA polymerase II. Cell, 90, 1107-1112.
35. Nislow, C., Ray, E. and Pillus, L. (1998) SET1, a yeast member of the Trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol. Biol. Cell, 8, 2421-2436.
36. Ogryzko, V.V., Schilz, R.L., Russanova, V., Howard, B.H. and Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell, 87, 953-959.
37. Paro, R. (1990) Imprinting a determined state into the chromatin of Drosophila. Trends Genet., 6, 416-421.
38. Pazin, M.J. and Kadonaga, J.T. (1997) What's up and down with histone deacetylation and transcription? Cell, 89, 325-328.
39. Perlman, T. and Evans, R.M. (1997) Nuclear receptors in Sicily: all in the famiglia. Cell, 90: 391-397.
40. Pierrat, B., Heery, D.M., Lemoine, Y. and Losson, R. (1992) Functional analysis of the human oestrogen receptor using a phenotypic transactivation assay in yeast. Gene, 119, 237-245.
41. Prasad, R. et al. (1997) Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene, 15, 549-560.
42. Reeves, R. and Nissen, M.S. (1990) The AT-DNA-binding domain of mammalian high mobility group I chrorhosomal proteins: a novel peptide motif for recognizing DNA structure. J. Biol. Chem., 265, 8573-8582.
43. Rose, M.D., Winston, F. and Hieter, P. (1990) Methods in Yeast Genetics: A Laboratory Course Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. Rost, B. and Sander, C. (1993) Secondary structure prediction of all-helical proteins in two states. Protein Eng., 6, 831-836.
45. Schumacher, A. and Magnuson, T. (1997) Murine Polycomb- and Trithorax-group genes regulate homeotic pathways and beyond. Trends Genet., 13, 167-170.
46. Spencer, T.E. et al. (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature, 389, 194-198.
47. Stassen, M.J., Bailey, D., Nelson, S., Chinvalla, V. and Harte, P.J. (1995) The Drosophila trithorax protein contains a novel variant of the nuclear receptor DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech. Devel., 52, 209-223.
48. Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignments through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
49. Tkachuk, D.C., Kohler, S. and Cleary, M.L. (1992) Involvement of a homolog of Drosophila Trithorax by 11q23 chromosomal translocations in acute leukemia. Cell, 71, 691-700.
50. Tora, L., White, J., Brou, C., Tasset, D., Webster, N., Scheer, E. and Chambon, P. (1989) The human oestrogen receptor has two independent nonacidic transcriptional activation functions. Cell, 59, 447-487.
51. Torchia, J., Rose, D.W. Inostroza, J., Kamei, Y., Westin, S., Glass, C.K. and Rosenfeld, M.G. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature, 387, 677-684.
52. Tripoulas, N., LaJeunesse, D., Gildea, J. and Shearn, A. (1996) The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger. Genetics, 143, 913-928.
53. Tschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G. and Reuter, G. (1994) The protein encoded by the Drosophila position-effect-variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J., 13, 3822-3831.
54. Vivat, V. et al. (1997) A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers. EMBO J., 16, 5697-5709.
55. Voegel, J.J., Heine, M.J.S., Tini, M., Vivat, V., Chambon, P. and Gronemeyer, H. (1998) The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J., 17, 507-519.
56. Vojtek, B.A., Hollenberg, S.M. and Cooper, J.A. (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell, 74, 205-214.
57. vom Baur, E. et al. (1996) Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J., 15, 110-124.
58. Wolffe, A.P. (1997) Transcriptional control. Sinful repression. Nature, 387, 16-17.
59. Wurtz, J.M., Bourguet, W., Renaud, J.P., Vivat, V., Chambon, P., Moras, D. and Gronemeyer, H. (1996) A canonical structure for the ligand binding domain of nuclear receptors. Nature Struct. Biol., 3, 87-94.
60. Ylikomi, T., Bocquel, M.-T., Berry, M., Gronemeyer, H. and Chambon, P. (1992) Cooperation of proto-signals for nuclear accumulation of oestrogen and progesterone receptors. EMBO J., 11, 2229-2240.