An update on GABA(A) receptors

Brain Research Reviews

Volumn 29, Issue 2-3, 1999, Pages 196-217

  Mehta, Ashok K ^a   Ticku, Maharaj K ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Anticonvulsants; Anxiolytics; Ethanol; GABA(A) receptors; General anesthetics; Neurosteroids

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; ANESTHETIC AGENT; ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; NEUROSTEROID; RECEPTOR SUBUNIT;

CHICKEN; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; GABAERGIC SYSTEM; HUMAN; MOLECULAR BIOLOGY; NEUROMODULATION; NONHUMAN; PERCH; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; RETINA; REVIEW; TISSUE DISTRIBUTION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; PHYSIOLOGY;

ANIMALS; HUMANS; RECEPTORS, GABA-A;

EID: 0032935234     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(98)00052-6     Document Type: Review

References (370)

1. Allan A.M., Harris R.A. Gamma-aminobutyric acid and alcohol actions: neurochemical studies of long sleep and short sleep mice. Life Sci. 39:1986;2005-2015.
2. A receptors. Mol. Pharmacol. 51:1997;833-841.
3. A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital. Nature. 366:1993;565-569.
4. A receptors from rat brain. Eur. J. Pharmacol. 347:1998;347-353.
5. 3 subunits. J. Biol. Chem. 271:1996;27902-27911.
6. 3H ]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors Eur. J. Pharmacol. 130:1986;257-263.
7. A receptors, exhibits low tolerance and dependence liabilities in the rat. J. Pharmacol. Exp. Ther. 270:1994;1262-1269.
8. A-receptor deduced from mutation-induced rectification. NeuroReport. 5:1993;285-288.
9. Barker J.L., Ransom B.R. Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture. J. Physiol. (London). 280:1978;355-372.
10. A receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50:1998;291-313.
11. G.D. Bartoszyk, N. Meyerson, W. Reimann, G. Satzinger, A. von Hodenberg, Gabapentin, in: B.S. Meldrum, R.J. Porter (Eds.), New Anticonvulsant Drugs, John Libbey, London, 1986, pp. 147-163.
12. A receptor heterogeneity is increased by alternative splicing of a novel β-subunit gene transcript. J. Neurochem. 56:1991;1437-1440.
13. Becker H.C., Anton R.F. The benzodiazepine receptor inverse agonist Ro 15-4513 exacerbates, but does not precipitate, ethanol withdrawal in mice. Pharmacol. Biochem. Behav. 32:1989;163-167.
14. 3H ]Ro 15-4513 binding in mouse cerebellum Eur. J. Pharmacol. 296:1996;43-46.
15. Beekman M., Ungard J.T., Gasior M., Carter R.B., Dijkstra D., Goldberg S.R., Witkin J.M. Reversal of behavioral effects of pentylenetetrazole by the neuroactive steroid ganaxolone. J. Pharmacol. Exp. Ther. 284:1998;868-877.
16. A receptor subtypes differing in β-subunit variant. J. Biol. Chem. 269:1994;27100-27107.
17. A receptor subtypes differentiated by their γ-subunit variants: prevalence, pharmacology and subunit architecture. Neuropharmacology. 35:1996;1413-1423.
18. A receptor subtypes containing the δ subunit in rat brain. FEBS Lett. 283:1991;145-149.
19. 4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ. J. Neurochem. 69:1997;806-814.
20. A receptor subunits. Mol. Pharmacol. 53:1998;295-303.
21. B receptor subtypes. Trends Neurosci. 11:1988;112-116.
22. C receptors. Trends Neurosci. 18:1995;515-519.
23. Boue-Grabot E., Roudbaraki M., Bascles L., Tramu G., Bloch B., Garret M. Expression of GABA receptor ρ subunits in rat brain. J. Neurochem. 70:1998;899-907.
24. B receptor pharmacology. Annu. Rev. Pharmacol. Toxicol. 33:1993;109-147.
25. Braestrup C., Nielsen E.B., Sonnewald U., Knutsen L.J.S., Andersen K.E., Jansen J.A., Frederiksen K., Andersen P.H., Mortensen A., Suzdak P.D. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain γ-aminobutyric acid uptake carrier. J. Neurochem. 54:1990;639-647.
26. Breese G.R., Morrow A.L., Simson P.E., Criswell H.E., McCown T.J., Duncan G.E., Keir W.J. The neuroanatomical specificity of ethanol on ligand-gated ion channels: a hypothesis. Alc. Alcohol. 2:1993;309-313. Suppl.
27. Bronson M.E. Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior. Pharmacol. Biochem. Behav. 48:1994;397-401.
28. Brown S.D., Wolf H.H., Swinyard W.A., Twyman R.E. The novel anticonvulsant topiramate enhances GABA-mediated chloride flux. Epilepsia. 34(Suppl. 2):1993;122-123.
29. A receptor subunit mRNAs: relationship to genetic differences in ethanol withdrawal seizure severity. J. Neurochem. 57:1991;1452-1455.
30. A receptor affecting modulation of the channel by ligands of the benzodiazepine binding site. Mol. Pharmacol. 49:1996;1080-1084.
31. A receptors drastically alter the affinity for ligands of the benzodiazepine binding site. J. Biol. Chem. 272:1997;11799-11804.
32. A receptors influence affinities for benzodiazepine binding site ligands. Mol. Pharmacol. 52:1997;676-682.
33. 2 subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. Proc. Natl. Acad. Sci. USA. 94:1997;8824-8829.
34. A receptor subtypes: from pharmacology to molecular biology. FASEB J. 5:1991;2916-2923.
35. A receptor. J. Pharmacol. Exp. Ther. 280:1997;1284-1295.
36. A receptor subunits in label-fracture replicas of cultured rat cerebellar granule cells. Receptors Channels. 2:1994;143-153.
37. A receptor subunits in primary cultures of rat cerebellar granule cells. Neuroscience. 67:1995;583-593.
38. Chadwick D.W. An overview of the efficacy and tolerability of new antiepileptic drugs. Epilepsia. 38:1997;S59-S62.
39. A receptor. J. Neurosci. 16:1996;5415-5424.
40. A receptors. Eur. J. Pharmacol. 349:1998;115-121.
41. 5 subunits in the ventral tegmental area and hippocampus. J. Neurochem. 68:1997;121-127.
42. 3H ]Zolpidem binding in alcohol-preferring and non-preferring rat brain Neurosci. Lett. 238:1997;103-106.
43. 4 subunit to electroshock seizures. Neurosci. Lett. 250:1998;17-20.
44. A receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine. Mol. Brain Res. 26:1994;309-319.
45. 3H ]muscimol binding in rat brain Biochem. Pharmacol. 37:1988;1271-1274.
46. A receptors. Brain Res. 542:1991;225-232.
47. A currents insensitive to benzodiazepine modulation in rats CA1 hippocampus. J. Neurophysiol. 74:1995;464-469.
48. Coulter D.A., Sombati S., Delorenzo R.J. Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia. 34:1993;123.
49. Coulter D.A., Sombati S., Delorenzo R.J. Topiramate effects on excitatory amino acid mediated responses in cultured hippocampal neurons: selective blockade of kainate currents. Epilepsia. 36:1995;40.
50. Crawley J.N., Glowa J.R., Majewska M.D., Paul S.M. Anxiolytic activity of endogenous adrenal steroid. Brain Res. 339:1986;382-386.
51. A receptors: generalization to other ligand-gated ion channels. J. Pharmacol. Exp. Ther. 267:1993;522-537.
52. Criswell H.E., Simson P.E., Knapp D.J., Devaud L.L., McCown T.J., Duncan G.E., Morrow A.L., Breese G.R. Effect of zolpidem on γ-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions. J. Pharmacol. Exp. Ther. 273:1995;526-536.
53. 3 subunit of the type A γ-aminobutyric acid receptor. Proc. Natl. Acad. Sci. USA. 90:1993;5105-5109.
54. 3 subunit of the type A γ-aminobutyric acid receptor in mice. Proc. Natl. Acad. Sci. USA. 91:1994;2815-2818.
55. 1 (GABAR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 12:1992;801-806.
56. 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc. Natl. Acad. Sci. USA. 88:1991;2673-2677.
57. A receptor subunit. Nature. 385:1997;820-823.
58. 3 subunits expressed in human embryonic kidney 293 cells. Br. J. Pharmacol. 120:1997;899-909.
59. Dawson G.R., Curnow R., Bayley P., Rambridge A., Tricklebank M.D. Lack of effect of flumazenil and CGS 8216 on the anxiolytic-like properties of loreclezole. Eur. J. Pharmacol. 252:1994;325-328.
60. A receptor modulators. J. Pharmacol. Exp. Ther. 273:1995;241-247.
61. A receptors studied with subunit-specific antibodies. Mol. Neurobiol. 12:1996;55-71.
62. De Sarro G., Spagnolo C., Gareri P., Gallelli L., De Sarro A. Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice. Eur. J. Pharmacol. 349:1998;179-185.
63. A receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J. Neurochem. 69:1997;126-130.
64. A receptors to neuroactive steroids in rats during ethanol withdrawal. J. Pharmacol. Exp. Ther. 278:1996;510-517.
65. A receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis. Mol. Pharmacol. 48:1995;861-868.
66. Dewey S.L., Morgan A.E., Ashby C.R. Jr., Horan B., Kushner S.A., Logan J., Volkow N.D., Fowler J.S., Gardner E.L., Brodie J.D. A novel strategy for the treatment of cocaine addiction. Synapse. 30:1998;119-129.
67. Dodd P.R., Thomas G.J., Harper C.G., Kril J.J. Amino acid neurotransmitter receptor changes in cerebral cortex in alcoholism: effect of cirrhosis of the liver. J. Neurochem. 59:1992;1506-1515.
68. 2+. Neuron. 5:1990;781-788.
69. A-receptor α-subunit iso-oligomers. J. Biol. Chem. 266:1991;24778-24784.
70. Duncalfe L.L., Carpenter M.R., Smillie L.B., Martin I.L., Dunn S.J. The major site of photoaffinity labeling of the γ-amonobutyric acid type A receptor by flunitrazepam is histidine102 of the α subunit. J. Biol. Chem. 271:1996;9209-9214.
71. A receptors in rat brain Neuroscience. 64:1995;1113-1128.
72. A receptors reveal brain regional heterogeneity. J. Neurochem. 60:1993;1388-1398.
73. C receptor ρ subunits in the mammalian retina. J. Neurosci. 16:1996;4479-4490.
74. Epelbaum J., Doumaud P., Fodor M., Viollet C. The neurobiology of somatostatin. Crit. Rev. Neurobiol. 8:1994;25-44.
75. A receptor-coupled chloride ionophore in rat cerebral cortex J. Neurochem. 53:1989;648-651.
76. Eriksson C.J.P., Sarviharju M. Motor impairment, narcosis, and hypothermia by ethanol: separate genetic mechanisms. Alcohol. 1:1984;59-62.
77. K. Eriksson, M. Rusi, Finnish selection studies on alcohol-related behaviors: general outline, in: G.E. McClearn, R.A. Deitrich, G. Erwin (Eds.), Development of Animal Models as Pharmacogenetic Tools, NIAAA Research Monograph No. 6, U.S. Government Printing Office, Washington DC, 1981, pp. 87-117.
78. Facklam M., Schoch P., Bonetti E.P., Jenck F., Martin J.R., Moreau J.L., Haefely W.E. Relationship between benzodiazepine receptor occupancy and functional effects in vitro and in vivo of four ligands of differing intrinsic efficacies. J. Pharmacol. Exp. Ther. 261:1992;1113-1121.
79. A receptors. Eur. J. Pharmacol. 349:1998;R7-R8.
80. Faull R.L., Villiger J.W. Benzodiazepine receptors in the human hippocampal formation: a pharmacological and quantitative autoradiographic study. Neuroscience. 26:1988;783-790.
81. Faull R.L., Villiger J.W., Holford N.H. Benzodiazepine receptors in the human cerebral cortex: a quantitative autoradiographic and pharmacological study demonstrating the predominance of type I receptors. Brain Res. 411:1987;379-385.
82. Feely M., Boyland P., Picardo A., Cox A., Gent J.-P. Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812. Eur. J. Pharmacol. 164:1989;377-380.
83. - channels in rat retina bipolar cells. Nature. 361:1993;159-162.
84. A receptor function. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 247:1993;233-237.
85. A receptors composed of single or multiple β subunit subtypes. Neuropharmacology. 36:1997;1601-1610.
86. A receptor current by zinc and other divalent cations. J. Neurosci. 18:1998;2944-2953.
87. A receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol. Pharmacol. 44:1993;191-197.
88. A-receptor α-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience. 81:1997;1043-1053.
89. A-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neurosci. Lett. 249:1998;99-102.
90. A receptor subunits revealed by antigen-retrieval immunohistochemistry. J. Comp. Neurol. 390:1998;194-210.
91. A receptor complex, attenuate pain sensitivity in rats. Brain Res. 643:1994;194-203.
92. A agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. Epilepsy. 36:1995;960-965.
93. Gardner C.R., Deacon R., Guy A.P., Mann R., Budhram P., Miller P. RU 32698, a new benzodiazepine receptor ligand with anxiolytic but little sedative/myorelaxant properties. Br. J. Pharmacol. 92:1987;537P.
94. Garratt J.C., Gert J.P., Feely M., Haigh J.R.M. Can benzodiazepines be classified by characterizing their anticonvulsant tolerance-inducing potential? Eur. J. Pharmacol. 145:1988;75-80.
95. Gasior M., Carter R.B., Beekman M., Goldberg S.R., Witkin J.M. Neuroactive steroids as a treatment for epilepsy. Current status and future directions. Acta Neurobiologiae Experimentalis. 57:1997;76. Suppl.
96. Gasior M., Carter R.B., Goldberg S.R., Witkin J.M. Anticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam. J. Pharmacol. Exp. Ther. 282:1997;543-553.
97. Gee K.W., Bolger M.B., Brinton R.E., Coirini H., McEwen B.S. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 246:1988;803-812.
98. A receptor function in mice. Eur. J. Pharmacol. 254:1994;299-302.
99. A-benzodiazepine receptor ligands in membranes from the rat forebrain. Neuropharmacology. 31:1992;895-898.
100. A receptors. J. Pharmacol. Exp. Ther. 266:1993;1018-1028.
101. 2 subunit gene of γ-aminobutyric acid type A receptors. Proc. Natl. Acad. Sci. USA. 92:1995;7749-7753.
102. A receptor subunits and glutamic acid decarboxylase in the rat inferior colliculus. J. Neurosci. 14:1994;7469-7477.
103. A receptor in the rat brain. J. Neurosci. 14:1994;7168-7179.
104. A receptor subunits in the aging rat brain. Mol. Brain Res. 35:1996;91-102.
105. A receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging. Mol. Brain Res. 45:1997;59-70.
106. A receptor in the rat hippocampus. Neuroscience. 74:1996;341-348.
107. Gyenes M., Wang Q., Gibbs T.T., Farb D.H. Phosphorylation factors control neurotransmitter and neuromodulator actions at the γ-aminobutyric acid type A receptor. Mol. Pharmacol. 46:1994;542-549.
108. Hablitz J.J., Tehrani M.H.J., Barnes E.M. Jr. Chronic exposure of developing cortical neurons to GABA down-regulates GABA/benzodiazepine receptors and GABA-gated chloride currents. Brain Res. 501:1989;332-338.
109. A receptors. Mol. Pharmacol. 43:1993;970-975.
110. A receptors. Mol. Pharmacol. 44:1993;1211-1218.
111. Haigh J.R.M., Feely M. Ro 16-6028, a benzodiazepine receptor partial agonist, does not exhibit anticonvulsant tolerance in mice. Eur. J. Pharmacol. 147:1988;283-285.
112. Hales T.G., Lambert J.J. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br. J. Pharmacol. 104:1991;619-628.
113. A and glycine receptors by chlormethiozole. Eur. J. Pharmacol. 210:1992;239-246.
114. Hammond E.J., Wilder B.J. Gamma-vinyl GABA. Gen. Pharmacol. 16:1985;441-447.
115. A receptor-chloride ionophore complex in dissociated hippocampal neurons of the rat. Anesthesiology. 79:1993;781-788.
116. Harris R.A., McQuilkin S.J., Paylor R., Abeliovich A., Tonegawa S., Wehner J.M. Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors. Proc. Natl. Acad. Sci. USA. 92:1995;3658-3662.
117. Harrison N.L., Simmonds M.A. Modulation of GABA receptor complex by a steroid anaesthetic. Brain Res. 323:1984;287-292.
118. 2 subunit. J. Neurochem. 62:1994;10-16.
119. A receptor. FEBS Lett. 331:1993;211-216.
120. A receptors by neuroactive steroids. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 289:1995;249-257.
121. A receptor subunit in tissues of the reproductive system. J. Biol. Chem. 272:1997;15346-15350.
122. Hellevuo K., Kiianmaa K., Korpi E.R. Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol. Pharmacol. Biochem. Behav. 34:1989;399-404.
123. A subunit mRNA in rat brain. J. Mol. Neurosci. 2:1990;101-107.
124. A receptor complex. Brain Res. 615:1993;170-174.
125. Holzbauer M. Physiological aspects of steroid with anesthetic properties. Med. Biol. 22:1976;97-102.
126. 3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc. Natl. Acad. Sci. USA. 94:1997;4143-4148.
127. 6 subunit of the γ-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol. Pharmacol. 51:1997;588-596.
128. 2 subunit of γ-aminobutyrate type A receptor, Neuropharmacology, in press.
129. A receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice. Alcohol. Clin. Exp. Res. 22:1998;259-265.
130. A receptors. Mol. Pharmacol. 53:1998;870-877.
131. 2L subunits stably transfected into mouse L-cells. Br. J. Pharmacol. 107:1992;732-737.
132. Hu X.-J., Ticku M.K. Chronic benzodiazepine agonist treatment produces functional uncoupling of the γ-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons. Mol. Pharmacol. 45:1994;618-625.
133. A receptors in cortical neurons. J. Pharmacol. Exp. Ther. 270:1994;485-490.
134. Hu X.-J., Ticku M.K. Functional characterization of a kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure. Brain Res. 767:1997;228-234.
135. A receptors. Neurosci. Lett. 144:1992;165-168.
136. 3H ]Ro 15-4513 binding Synapse. 22:1996;106-113.
137. James V., Gardner C.R. Reversal of stress-induced arousal in sleeping rats by some imidazopyrimidine benzodiazepine receptor ligands. Drug Dev. Res. 22:1991;331-337.
138. Jensen L.H., Petersen E.N. Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. J. Neural. Transm. 58:1983;183-191.
139. 1 protein is a sensitive indicator of benzodiazepine agonist efficacy. Eur. J. Pharmacol. 348:1998;321-324.
140. 6 subunit gene inactivation inhibits δ subunit expression. J. Neurosci. 17:1997;1350-1362.
141. - currents in cultured rat hippocampal neurones by three volatile anaesthetics. J. Physiol. (London). 449:1992;279-293.
142. June H.L., Devaraju S.L., Eggers M.W., Williams J.A., Cason C.R., Greene T.L., Leveige T., Braun M.R., Torres L., Murphy J.M. Benzodiazepine receptor antagonists modulate the actions of ethanol in alcohol-preferring and -nonpreferring rats. Eur. J. Pharmacol. 342:1998;139-151.
143. 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim. Biophys. Acta. 1261:1995;134-142.
144. A receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study. Mol. Brain Res. 31:1995;33-47.
145. Kang I., Miller L.G. Decreased receptor subunit mRNA concentrations following chronic lorazepam administration. Br. J. Pharmacol. 103:1991;1285-1287.
146. 2 subunit subtype. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 291:1995;439-441.
147. 2 subunit induces loss of neurones in rat hippocampus. Neurosci. Lett. 202:1995;97-100.
148. 2S γ-aminobutyric acid type A receptor is modulated by protein kinase C via multiple sites. J. Biol. Chem. 267:1992;25660-25663.
149. A/benzodiazepine receptor. J. Neurochem. 60:1993;961-971.
150. A/benzodiazepine receptors. J. Neurochem. 63:1994;1466-1476.
151. A/benzodiazepine receptor from rat cerebellum. J. Neurochem. 63:1994;371-374.
152. A receptor maintaining their individual benzodiazepine-binding specificities. J. Neurochem. 66:1996;685-691.
153. A receptors from rat brain and retina. Neuropharmacology. 35:1996;1315-1322.
154. 3 subunit (GABRB3). J. Biol. Chem. 268:1993;4420-4428.
155. A receptor subtypes. J. Pharmacol. Exp. Ther. 266:1993;385-391.
156. 2-subunit in mice by alternative splicing. J. Neurochem. 56:1991;713-715.
157. A receptor. Nature (London). 361:1993;356-359.
158. A receptor function. J. Neurochem. 63:1994;1167-1170.
159. Korpi E.R., Kuner T., Seeburg P.H., Luddens H. Selective antagonist for the cerebellar granule cell-specific γ-aminobutyric acid type A receptor. Mol. Pharmacol. 47:1995;283-289.
160. A receptor α subunit Mol. Pharmacol. 44:1993;87-92.
161. Korpi E.R., Tuominen K., Uusi-Oukari M., Saransaari P., Oja S.S., Suzdak P.D. Mechanisms of alcohol intoxication in a rodent model: blunted alcohol-opposing reaction in 'alcohol-sensitive' rats. Anal. Med. 22:1990;253-258.
162. Krasowski M.D., Koltchine V.V., Rick C.E., Ye Q., Finn S.E., Harrison N.L. Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that for isoflurane. Mol. Pharmacol. 53:1998;530-538.
163. A receptors. J. Physiol. (London). 507:1998;639-652.
164. A receptor function by protein kinase C phosphorylation. Neuron. 12:1994;1081-1095.
165. Krusek J., Zemkova H. Effect of ivermectin on γ-aminobutyric acid-induced chloride currents in mouse hippocampal embryonic neurones. Eur. J. Pharmacol. 259:1994;121-128.
166. Kulkarni S.K., Mehta A.K., Ticku M.K. Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats. Life Sci. 46:1990;481-487.
167. 2-subunits. Brain Res. 784:1998;179-187.
168. A channels by Zn. Mol. Pharmacol. 39:1991;267-274.
169. A receptor: role of desensitization. Mol. Pharmacol. 41:1992;1116-1123.
170. Levesque T.R., Kenneth W.L. Discriminative stimulus effects of melatonin in the rat. Psychopharmacology. 116:1994;167-172.
171. Li M., De Blas A.L. Coexistence of two β subunit isoforms in the same γ-aminobutyric acid type A receptor. J. Biol. Chem. 272:1997;16564-16569.
172. A receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium. J. Pharmacol. Exp. Ther. 263:1992;569-578.
173. A receptor δ subunit mRNA level by tolerance to and withdrawal from pentobarbital. Neurosci. Lett. 202:1996;149-152.
174. Loscher W. New visions in the pharmacology of anticonvulsion. Eur. J. Pharmacol. 342:1998;1-13.
175. 1 subunit function. Brain Res. 756:1997;1-8.
176. A/benzodiazepine receptor complex. J. Receptor Res. 11:1991;535-551.
177. A/benzodiazepine receptor heterogeneity: neurophysiological implications. Neuropharmacology. 34:1995;245-254.
178. A receptor selective for a behavioural alcohol antagonist. Nature. 346:1990;648-651.
179. Lyon M.F., King T.R., Gondo Y., Gardner J.M., Nakatsu Y., Eicher E.M., Brilliant M.H. Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. Proc. Natl. Acad. Sci. USA. 89:1992;6968-6972.
180. Macdonald R.L. Ethanol, γ-aminobutyrate type A receptors, and protein kinase C phosphorylation. Proc. Natl. Acad. Sci. USA. 92:1995;3633-3635.
181. A receptor channels. Annu. Rev. Neurosci. 17:1994;569-602.
182. A-receptor. J. Neurochem. 61:1993;375-377.
183. 4-subunit expression: possible relevance to alcohol dependence. J. Neurochem. 68:1997;2485-2492.
184. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate like modulators of the GABA receptor. Science. 232:1986;1004-1007.
185. Makela R., Uusi-Oukari M., Homanics G.E., Quinlan J.J., Firestone L.L., Wisden W., Korpi E.R. Cerebellar γ-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. Mol. Pharmacol. 52:1997;380-388.
186. Maloteaux J.-M., Octave K.-N., Gossuin A., Laterre C., Trouet A. GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons. Eur. J. Pharmacol. 144:1987;173-183.
187. Marangos P.J., Patel J., Hirata F., Sondhein D., Paul S.M., Skolnick P., Goodwin F.K. Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite N-acetyl-5-methoxy kynurenamine. Life Sci. 29:1981;259-267.
188. Markowitz J.S., Finkenbine R., Myrick H., King L., Carson W. Gabapentin abuse in a cocaine user: implications for treatment? J. Clin. Psychopharmacol. 17:1997;423-424.
189. 2-subunit in situ. J. Receptor Res. 13:1993;467-477.
190. A receptor subunits expressed in human embryonic kidney cells. J. Pharmacol. Exp. Ther. 269:1994;157-163.
191. Martin J.R., Pieri L., Bonetti E.P., Schaffner R., Burkard W.P., Cumin R., Haefely W. Ro 16-6028: a novel anxiolytic acting as a partial agonist at the benzodiazepine receptor. Pharmacopsychiatry. 21:1988;360-362.
192. A receptor complex of brain. Neuroscience. 73:1996;705-713.
193. A receptors with flunitrazepam identifies a subset of ligands that interact directly with his102 of the α subunit and predicts orientation of these within the benzodiazepine pharmacophore. Mol. Pharmacol. 54:1998;33-43.
194. A receptor subtypes immunopurified from rat brain with subunit-specific antibodies have unique pharmacological properties. Neuron. 7:1991;667-676.
195. A receptor subunits in the mammalian retina. Soc. Neurosci. Abstr. 22:1996;817. (#325.11).
196. 3H ]abecarnil in the rat cerebral cortex Soc. Neurosci. Abstr. 21:1995;1345. (#531.7).
197. Mehta A.K., Shank R.P. Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS. Brain Res. 704:1995;289-297.
198. Mehta A.K., Shank R.P. Interaction of abecarnil, bretazenil, and Ro 19-8022 with diazepam-sensitive and -insensitive benzodiazepine sites in the rat cerebellum and cerebral cortex. Life Sci. 57:1995;2215-2222.
199. Mehta A.K., Ticku M.K. Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. Pharmacol. Biochem. Behav. 25:1986;1059-1065.
200. A-gated chloride channels. J. Pharmacol. Exp. Ther. 246:1988;558-564.
201. Mehta A.K., Ticku M.K. Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. Pharmacol. Biochem. Behav. 30:1988;995-1000.
202. Mehta A.K., Ticku M.K. Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites. Brain Res. 489:1989;93-100.
203. B receptors involved in the pharmacological effects of ethanol? Eur. J. Pharmacol. 182:1990;473-480.
204. Mehta A.K., Ticku M.K. Chronic GABA exposure down-regulates GABA-benzodiazepine receptor-ionophore complex in cultured cerebral cortical neurons. Mol. Brain Res. 16:1992;29-36.
205. 2+ Pharmacol. Biochem. Behav. 47:1994;355-357.
206. A receptors. Brain Res. 805:1998;88-94.
207. 5- and δ-subunit-specific immunopurification. J. Biol. Chem. 268:1993;5965-5973.
208. 3H ]Ro 15-4513 in rat brain Eur. J. Pharmacol. 153:1988;141-145.
209. 1 subunit in rat cerebral cortex. Eur. J. Pharmacol. 208:1991;171-174.
210. A receptor α subunits reveal that chronic alcohol treatment down-regulates α-subunit expression in rat brain regions. J. Neurochem. 61:1993;1620-1625.
211. A receptor subunit mRNA levels in Fischer rats. Mol. Brain Res. 14:1992;71-78.
212. A receptor gene expression. Mol. Pharmacol. 42:1992;415-422.
213. Mhatre M.C., Ticku M.K. Chronic ethanol treatment upregulates the GABA receptor β subunit expression. Mol. Brain Res. 23:1994;246-252.
214. Mihic S.J., Whiting P.J., Klein R.L., Wafford K.A., Harris R.A. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. J. Biol. Chem. 269:1994;32768-32773.
215. 3 subunit mRNA and protein expression in the frontal cortex of human alcoholics. Alcohol. Clin. Exp. Res. 22:1998;815-822.
216. A-receptor assembly in vivo: lessons from subunit mutant mice. Life Sci. 62:1998;1611-1615.
217. A receptor α subunit mRNAs in the rat cerebral cortex. Mol. Pharmacol. 39:1991;157-163.
218. Moody E.J., Skolnick P. Chlormethiozole: neurochemical actions at the γ-aminobutyric acid receptor complex. Eur. J. Pharmacol. 164:1989;153-158.
219. Moreau J.-L., Jenck F., Pieri L., Schoch P., Martin J.R., Haefely W.E. Physical dependence induced in DBA/2J mice by benzodiazepine receptor full agonists, but not by partial agonist Ro 16-6028. Eur. J. Pharmacol. 190:1990;269-273.
220. A receptor function and expression in brain. Alcohol. 7:1990;237-244.
221. Morrow A.L., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Mol. Pharmacol. 37:1990;263-270.
222. Morrow A.L., Suzdak P.D., Paul S.M. Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. Eur. J. Pharmacol. 142:1987;483-485.
223. 2L subunits of the γ-aminobutyric acid type A receptor. J. Biol. Chem. 267:1992;14470-14476.
224. A receptors by tyrosine phosphorylation. Nature. 377:1995;344-348.
225. A receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature (London). 364:1993;448-450.
226. Neumann P.E., Seyfried T.N. Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice. Behav. Genet. 20:1990;307-323.
227. 35S ]butylbicyclophosphorothionate binding in rat brain by melatonin Brain Res. Bull. 24:1990;635-638.
228. Nusser Z., Sieghart W., Benke D., Fritschy J.-M., Somogyi P. Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proc. Natl. Acad. Sci. USA. 93:1996;11939-11944.
229. A receptor α subunits after flurazepam treatment. Eur. J. Pharmacol. 226:1992;335-341.
230. Ogurusu T., Shingai R. Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Biochim. Biophys. Acta. 1305:1996;15-18.
231. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat. 3:1990;59-76.
232. A receptors. FASEB J. 4:1990;1469-1480.
233. Ozawa M., Nakada Y., Sugimachi K., Yabuuchi F., Akai T., Mizuta E., Kuno S., Yamaguchi M. Pharmacological characterization of the novel anxiolytic β-carboline abecarnil in rodents and primates. Jpn. J. Pharmacol. 64:1994;179-187.
234. Ozawa M., Sugimachi K., Nakada-Kometani Y., Akai T., Yamaguchi M. Chronic pharmacological activities of the novel anxiolytic β-carboline abecarnil in rats. J. Pharmacol. Exp. Ther. 269:1994;457-462.
235. Peoples R.W., Weight F.F. Trichloroethanol potentiation of γ-aminobutyric acid-activated chloride current in mouse hippocampal neurones. Br. J. Pharmacol. 113:1994;555-563.
236. A receptor proteins decreases GABA-stimulated chloride uptake and increases cocaine sensitivity in rats. Mol. Brain Res. 57:1998;310-320.
237. A receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol. 94:1988;1257-1269.
238. Petersen E.N., Jensen L.H., Drejer J., Honore T. New perspectives in benzodiazepine pharmacology. Pharmacopsychiatry. 19:1986;4-6.
239. Petroff O.A.C., Rothman D.L., Behar K.L., Lamoureux D., Mattson R.H. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann. Neurol. 39:1996;95-99.
240. Picardo A., Gent J.P., Feely M. Anticonvulsant tolerance and recovery during repeated administration of the GABA uptake inhibitor NO-328. Br. J. Pharmacol. 99:1990;131P.
241. Polasek R., Kubova H., Slamberova R., Mares P., Vorlicek J. Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition. Epilepsy Res. 25:1996;177-184.
242. A receptor subpopulations. J. Biol. Chem. 268:1993;3753-3757.
243. A receptors of adult rat cerebellum demonstrates two α subunits per receptor oligomer. J. Biol. Chem. 270:1995;21285-21290.
244. 1a modulation of γ-aminobutyric acid receptors in rat brain membranes. J. Neurochem. 38:1982;375-379.
245. Potier M.-C., de Carvalho L.P., Venault P., Chapouthier G., Rossier J. Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo. Eur. J. Pharmacol. 156:1988;169-172.
246. 2 subtypes Mol. Pharmacol. 43:1993;801-806.
247. 5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 54:1990;1802-1804.
248. Pritchett D.B., Seeburg P.H. γ-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site. Proc. Natl. Acad. Sci. USA. 88:1991;1421-1425.
249. Puia G., Ducic I., Vicini S., Costa E. Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc. Natl. Acad. Sci. USA. 89:1992;3620-3624.
250. A receptor subunit composition? Receptors Channels. 1:1993;135-142.
251. A receptors. Neuron. 4:1990;759-765.
252. - currents. Mol. Pharmacol. 39:1991;691-696.
253. Qian H., Dowling J.E. Novel GABA responses from rod-driven retinal horizontal cells. Nature. 361:1993;162-164.
254. C and ρ subunit receptors from the white perch retina. Vis. Neurosci. 14:1997;843-851.
255. 3 subunit of the γ-aminobutyric acid type A receptor. Anesthesiology. 88:1998;775-780.
256. 5 subunit Neuropharmacology. 35:1996;1331-1335.
257. 1 does not exist in combination with another γ subunit. Mol. Pharmacol. 45:1994;1061-1070.
258. A receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits. J. Biol. Chem. 269:1994;16020-16028.
259. A receptors from rat brain. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 290:1995;175-181.
260. C receptor antagonist. Mol. Pharmacol. 50:1996;1024-1030.
261. Ragsdale D.S., Avoli M. Sodium channels as molecular targets for antiepileptic drugs. Brain Res. Rev. 26:1998;16-28.
262. 3 subunit gene as the Angelman's syndrome gene. Lancet. 341:1993;122-123.
263. Roca D.J., Rozenberg I., Farrant M., Farb D.H. Chronic agonist exposure induces down-regulation and allosteric uncoupling of the γ-aminobutyric acid/benzodiazepine receptor complex. Mol. Pharmacol. 37:1990;37-43.
264. Ruano D., Benavides J., Machado A., Vitorica J. Aging-associated changes in the pharmacological properties of the benzodiazepine (ω) receptor isotypes in the rat hippocampus. J. Neurochem. 64:1995;867-873.
265. A/benzodiazepine receptor in rat hippocampus during aging. J. Pharmacol. Exp. Ther. 256:1991;902-908.
266. Sachdeo R.C., Sachdeo S.K., Walker S.A., Kramer L.D., Nayak R.K., Doose D.R. Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy. Epilepsia. 37:1996;774-780.
267. 3-subunit gene. Lancet. 339:1992;366-367.
268. 1 γ-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital. Mol. Pharmacol. 47:1995;213-217.
269. A receptor subunits: role of the delta subunit. J. Neurosci. 14:1994;7077-7086.
270. A receptor isoforms. Mol. Pharmacol. 49:1996;567-579.
271. Saxena N.C., Neelands T.R., Macdonald R.L. Contrasting actions of lanthanum on different recombinant γ-aminobutyric acid receptor isoforms expressed in L929 fibroblasts. Mol. Pharmacol. 51:1997;328-335.
272. A receptors affects the interaction with selected benzodiazepine binding site ligands. Eur. J. Pharmacol. 354:1998;283-287.
273. Schmidt D., Kramer G. The new anticonvulsant drugs. Implications for avoidance of adverse effects. Drug Safety. 11:1994;422-431.
274. A receptor subunits in the rat hippocampus: II. Altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience. 80:1997;1001-1017.
275. B receptors on neurones in rat brain slices. Br. J. Pharmacol. 101:1990;949-957.
276. A receptor complex after the in vivo administration of the anxioselective and anticonvulsant β-carboline derivative abecarnil. J. Pharmacol. Exp. Ther. 263:1992;1360-1368.
277. A receptor function. J. Pharmacol. Exp. Ther. 269:1994;32-38.
278. Serra M., Ghiani C.A., Motzo C., Porceddu M.L., Biggio G. Long-term treatment with abecarnil fails to induce tolerance in mice. Eur. J. Pharmacol. 259:1994;1-6.
279. Shank R.P., Gardocki J.F., Vaught J.L., Davis C.B., Schupsky J.J., Raffa R.B., Dodgson S.J., Nortey S.O., Maryanoff B.E. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia. 35:1994;450-460.
280. Shimada S., Cutting G., Uhl G.R. γ-Aminobutyric acid A or C receptor? γ-Aminobutyric acid ρ1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ-aminobutyric acid responses in Xenopus oocytes. Mol. Pharmacol. 41:1992;683-687.
281. A receptor subunits exist in distinct neuronal subpopulations. Neuron. 3:1989;327-337.
282. A receptor subtypes. Pharmacol. Rev. 47:1995;181-234.
283. A receptor in the rat brain. J. Neurochem. 60:1993;93-98.
284. A receptor channels. EMBO J. 11:1992;2017-2023.
285. A receptor function and ethanol. FEBS Lett. 324:1993;140-142.
286. Silvilotti L., Nistri A. GABA receptor mechanisms in the central nervous system. Prog. Neurobiol. 36:1991;35-92.
287. A receptors containing alpha-5 subunits J. Pharmacol. Exp. Ther. 283:1997;488-493.
288. 35S ]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of γ-aminobutyric acid type A receptors Mol. Pharmacol. 48:1995;385-391.
289. A receptor complex in cultured rat neurones. J. Physiol. (London). 447:1992;587-625.
290. A receptors are differentially sensitive to zinc-dependence on subunit composition. Br. J. Pharmacol. 103:1991;1837-1839.
291. A receptor α-subunit J. Biol. Chem. 269:1994;20380-20387.
292. 4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature. 392:1998;926-930.
293. 4 subunit in association with increased anxiety. J. Neurosci. 18:1998;5275-5284.
294. A receptor complex reveals that it may act via the picrotoxin site. J. Pharmacol. Exp. Ther. 282:1997;827-833.
295. 35S ]t-butylbicyclophosphorothionate binding sites in rat brain Brain Res. 441:1988;15-22.
296. A receptor function in hippocampal cells is maintained by phosphorylation factors. Science. 241:1988;339-341.
297. Stephens D.N., Schneider H.H., Kehr W., Andrews J.S., Rettig K.-J., Turski L., Schmiechen R., Turner J.D., Jensen L.H., Petersen E.N., Honore T., Hansen J.B. Abecarnil, a metabolically stable, anxioselective β-carboline acting at benzodiazepine receptors. J. Pharmacol. Exp. Ther. 253:1990;334-343.
298. 1-polypeptide is the principal site of the agonist benzodiazepine photoaffinity labelling reaction. J. Biol. Chem. 265:1990;21160-21165.
299. Stewart R.B., Gatto G.J., Lumeng L., Li T.-K., Murphy J.M. Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol. 10:1993;1-10.
300. Suzdak P.D., Jansen J.A. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia. 36:1995;612-626.
301. Suzdak P.D., Schwartz R.D., Paul S.M. Alcohols stimulate GABA receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency. Brain Res. 444:1987;340-344.
302. Suzdak P.D., Schwartz R.D., Skolnick P., Paul S.M. Ethanol stimulates γ-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc. Natl. Acad. Sci. USA. 83:1986;4071-4075.
303. Tassinari C.A., Michelucci R., Chauvel P., Chodkiewecz J., Shorvon S., Henriksen O., Dam M., Reife R., Pledger G., Karim R. Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy. Epilepsia. 37:1996;763-768.
304. Taylor C.P., Vartanian M.G., Andruszkiewicz R., Silverman R.B. 3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents. Epilepsy Res. 11:1992;103-110.
305. A receptor subtypes expressed in cerebellar granule cells: a developmental study. J. Neurochem. 62:1994;2037-2044.
306. Thompson D.M., Auta J., Guidotti A., Costa E. Imidazenil, a new anxiolytic and anticonvulsant drug, attenuates a benzodiazepine-induced cognition deficit in monkeys. J. Pharmacol. Exp. Ther. 273:1995;1307-1312.
307. A receptors. Br. J. Pharmacol. 114:1995;296P.
308. M. Ticku, A. Mehta, P. Lehoullier, Spinal cord cultured neurons: an in vitro model to study GABA synaptic pharmacology, in: G. Biggio, E. Costa (Eds.), Advances in Biochemical Psychopharmacology: Chloride Channels and Their Modulation by Neurotransmitters and Drugs, Vol. 45, Raven Press, New York, USA, 1988, pp. 151-159.
309. Ticku M.K., Kulkarni S.K. Molecular interactions of ethanol with GABAergic system and potential of Ro 15-4513 as an ethanol antagonist. Pharmacol. Biochem. Behav. 30:1988;501-510.
310. M.K. Ticku, S.K. Kulkarni, A.K. Mehta, Modulatory role of GABA receptor subtypes and glutamate receptors in the anticonvulsant effect of barbiturates, in: G. Avanzini, J. Engel Jr., R. Farielo, U. Heinemann (Eds.), Neurotransmitters in Epilepsy (Epilepsy Res. Suppl. 8), Elsevier, New York, USA, 1992, pp. 57-62.
311. 36Cl -influx in primary spinal cord cultured neurons Brain Res. Bull. 17:1986;123-126.
312. A receptor desensitization in mice spinal cord cultured neurons: lack of involvement of protein kinases A and C. Mol. Pharmacol. 38:1990;719-724.
313. M.K. Ticku, A.K. Mehta, Effects of alcohol on GABA-mediated neurotransmission, in: H.R. Kranzler (Ed.), Handbook of Experimental Pharmacology: The Pharmacology of Alcohol Abuse, Vol. 114, Springer-Verlag, Heidelberg, Germany, 1995, pp. 103-119.
314. B receptor pharmacology in cultured spinal cord neurons, in: G. Biggio, E. Costa (Eds.), Advances in Biochemical Psychopharmacology: GABA and Benzodiazepine Receptor Subtypes, Vol. 46, Raven Press, New York, USA, 1990, pp. 141-151.
315. M.K. Ticku, A.K. Mehta, M. Mhatre, S.K. Kulkarni, Ethanol and GABAergic transmission, in: R.A. Deitrich, A.A. Pawlowski (Eds.), National Institute on Alcohol Abuse and Alcoholism Research: Initial Sensitivity to Alcohol, Monograph-20, U.S. Government Press, Washington, DC, USA, 1990, pp. 401-418.
316. M.K. Ticku, M. Mhatre, A.K. Mehta, Modulation of GABAergic transmission by ethanol, in: G. Biggio, A. Concas, E. Costa (Eds.), Advances in Biochemical Psychopharmacology: GABAergic Synaptic Transmission, Vol. 47, Raven Press, New York, USA, 1992, pp. 255-268.
317. A receptor-operated chloride channels in frog dorsal root ganglion neurons. Brain Res. 643:1994;66-73.
318. Tran V.T. GABA receptors are increased in brains of alcoholics. Ann. Neurol. 9:1981;289-292.
319. A receptor subtype. J. Neurosci. 17:1997;2728-2737.
320. 2-subunit messenger RNA by tolerance to and withdrawal from pentobarbital - an in situ hybridization study. Life Sci. 53:1993;321-326.
321. 3-subunit mRNAs. J. Neurochem. 63:1994;301-309.
322. A receptor subunits in the rat hippocampus: III. Altered messenger RNA expression in kainic acid-induced epilepsy. Neuroscience. 80:1997;1019-1032.
323. Tuominen K., Korpi E.R. Diminished stress responses in the alcohol-sensitive ANT rat line. Pharmacol. Biochem. Behav. 40:1991;409-415.
324. Turner D.M., Ransom R.W., Yang J.S.-J., Olsen R.W. Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J. Pharmacol. Exp. Ther. 248:1989;960-966.
325. Turski L., Stephens D.N., Jensen L.H., Petersen E.N., Meldrum B.S., Patel S., Hansen J.B., Loscher W., Schneider H.H., Schmiechen R. Anticonvulsant action of the β-carboline abecarnil: studies in rodents and baboon, Papio papio. J. Pharmacol. Exp. Ther. 253:1990;344-352.
326. A receptor subunit gamma-2 long/short mRNA ratio by a mechanism distinct from receptor occupation. J. Pharmacol. Exp. Ther. 283:1997;350-357.
327. A receptor gated current depends on the subunit composition. Neurosci. Lett. 185:1995;203-206.
328. 1 subunit N-terminal extracellular domain in propofol potentiation of chloride current. Neuropharmacology. 36:1997;1611-1621.
329. 3H ]Ro 15-4513, in cerebellar membranes from two rat lines developed for high and low alcohol sensitivity J. Neurochem. 54:1990;1980-1987.
330. Verdoorn T.A. Formation of heteromeric γ-aminobutyric acid type A receptors containing two different α subunits. Mol. Pharmacol. 45:1994;475-480.
331. A receptor complex. Eur. J. Pharmacol. 344:1998;R1-R2.
332. Viollet C., Bodenant C., Prunotto C., Roosterman D., Schaefer J., Meyerhof W., Epelbaum J., Vaudry H., Leroux P. Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J. Neurochem. 68:1997;2263-2272.
333. Vollmer K.O., von Hodenberg A., Kolle E.U. Pharmacokinetics and metabolism of gabapentin in rat, dog and man. Arzneim.-Forsch./Drug Res. 36:1986;830-839.
334. A receptor β subunit. Neuron. 12:1994;775-782.
335. 2L subunit. Neuron. 7:1991;27-33.
336. 4 subunit. Mol. Pharmacol. 50:1996;670-678.
337. 3 subunit to the Angelman/Prader-Willi region of human chromosome 15. Am. J. Hum. Genet. 49:1991;330-337.
338. Waller M.B., Murphy J.M., McBride W.J., Lumeng L., Li T.-K. Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring lines of rats. Pharmacol. Biochem. Behav. 24:1986;617-623.
339. A receptor function by tyrosine phosphorylation of β subunits. J. Neurosci. 17:1997;5062-5069.
340. A receptors to postsynaptic domains by insulin. Nature. 388:1997;686-690.
341. A receptor. Brain Res. Bull. 29:1992;119-123.
342. A receptors: comparison in seizure-prone and -resistant mice and during development. J. Mol. Neurosci. 3:1992;177-184.
343. 1-subunit in seizure prone (DBA/2) and resistant (C57BL/6) mice. Brain Res. Bull. 45:1998;421-425.
344. A-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C. J. Pharmacol. Exp. Ther. 268:1994;1388-1395.
345. A antagonists. TIPS. 7:1986;421-424.
346. 2 phosphorylation site. Proc. Natl. Acad. Sci. USA. 87:1990;9966-9970.
347. A receptor subtypes. Int. Rev. Neurobiol. 38:1995;96-138.
348. A receptor. J. Med. Chem. 37:1994;4576-4580.
349. A receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267:1992;1426-1429.
350. A receptor that determine ligand binding and modulation at the benzodiazepine site. Mol. Pharmacol. 52:1997;874-881.
351. 3-subunit. Proc. Natl. Acad. Sci. USA. 91:1994;4569-4573.
352. 4 subunit. FEBS Lett. 289:1991;227-230.
353. A receptor diversity. Neuropharmacology. 35:1996;1139-1160.
354. A receptor subunit mRNAs in the rat brain: I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12:1992;1040-1062.
355. A/benzodiazepine receptors in a transfected cell line. Mol. Pharmacol. 42:1992;996-1003.
356. A receptor complex: dependence on the second transmembrane domain of beta subunits. J. Physiol. (London). 505:1997;633-640.
357. 4 subunit: identification of a unique diazepam-insensitive binding site. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 291:1995;319-325.
358. 1 mRNA in the hippocampus: differential responses of CA1 and CA3. Synapse. 29:1998;371-378.
359. A/benzodiazepine receptors. EMBO J. 9:1990;3261-3267.
360. Yu R., Follesa P., Ticku M.K. Down-regulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment. Mol. Brain Res. 41:1996;163-168.
361. A receptor complex in mammalian cortical neurons. J. Pharmacol. Exp. Ther. 275:1995;784-789.
362. Yu R., Ticku M.K. Chronic neurosteroid treatment produces functional heterologous uncoupling at the γ-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons. Mol. Pharmacol. 47:1995;603-610.
363. A-benzodiazepine receptors by immunoaffinity chromatography. FEBS Lett. 284:1991;15-18.
364. A receptors containing one, two, or three different subunits. Eur. J. Pharmacol. 301:1996;207-214.
365. Zhang D., Pan Z., Zhang X., Brideau A., Lipton S. Cloning of a γ-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proc. Natl. Acad. Sci. USA. 92:1995;11756-11760.
366. Zhang W., Koehler K.F., Zhang P., Cook J.M. Development of a comprehensive pharmacophore model for the benzodiazepine receptor. Drug Design Discovery. 12:1995;193-248.
367. 2 subunit increases convulsive threshold for β-CCM, a benzodiazepine 'inverse agonist', in rats. Eur. J. Pharmacol. 306:1996;61-66.
368. A receptors. J. Neurosci. 16:1996;6648-6656.
369. 2 subunit antisense oligodeoxynucleotides alter γ-aminobutyric acid receptor pharmacology in cerebellar granule neurons. Mol. Pharmacol. 50:1996;23-33.
370. Zona C., Ciotti M.T., Avoli M. Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci. Lett. 231:1997;123-126.