[3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABA(A) receptors which contain the α5 subunit

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1331-1335

  Quirk, K ^a   Blurton, P ^b   Fletcher, S ^b   Leeson, P ^b   Tang, F ^c   Mellilo, D ^c   Ragan, C I ^b   McKernan, R M ^a  

^a Merck Sharp & Dohme Limited   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c Department of Drug Metabolism ^*  (United States)

Author keywords

5 selective; 3H L 655,708; Benzodiazepine site; GABA(A) receptor; Radioligand

Indexed keywords

3 METHYL 6 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE RECEPTOR; FLUMAZENIL; FLUNITRAZEPAM; GABAERGIC RECEPTOR AFFECTING AGENT; L 655708; PEPTIDE ANTIBODY; PROTEIN ANTIBODY; RADIOLIGAND; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; ZOLPIDEM; IMIDAZOLE DERIVATIVE; L 655,708; LIGAND;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; CELL LINE; CONTROLLED STUDY; DRUG SELECTIVITY; GENETIC TRANSFECTION; HIPPOCAMPUS; IMMUNOPRECIPITATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; ANIMAL; DRUG EFFECT; IN VITRO STUDY; KINETICS; MEMBRANE; METABOLISM; RADIOASSAY; SERODIAGNOSIS;

ANIMALS; HIPPOCAMPUS; IMIDAZOLES; KINETICS; LIGANDS; MALE; MEMBRANES; PRECIPITIN TESTS; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A;

EID: 0030346304     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00061-5     Document Type: Article

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