Chronic ethanol administration regulates the expression of GABA(A) receptor α1 and α5 subunits in the ventral tegmental area and hippocampus

Journal of Neurochemistry

Volumn 68, Issue 1, 1997, Pages 121-127

  Charlton, Maura E ^a   Sweetnam, Paul M ^b   Fitzgerald, Lawrence W ^c   Terwilliger, Rosemarie Z ^a   Nestler, Eric J ^a   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER CORPORATION   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

Chronic ethanol treatment; GABA(A) receptor; Hippocampus; Ventral tegmental area

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; DOPAMINE; RECEPTOR SUBUNIT;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOL TOLERANCE; ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; COGNITIVE DEFECT; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOREACTIVITY; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; VENTRAL TEGMENTUM;

ANIMALIA;

EID: 0031020568     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68010121.x     Document Type: Article

References (37)

1. Allan A. M. and Harris R. A. (1987) Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels. Pharmacol. Biochem. Behav. 27, 665-670.
2. A receptor-operated chloride channels. II. Chronic effects of ethanol. J. Pharmacol. Exp. Ther. 253, 713-719.
3. A receptor subunits. Soc. Neurosci. Abstr. 16, 162.
4. A receptor complex: new approaches in mechanistic pharmacology, in Current Topics in Molecular Pharmacology (Mennon J., ed). pp. 155-187. Research Trends/Compilers International, India.
5. de Fiebre N. C., de Fiebre C. M., Booker T. K., Nelson S., and Collins A. C. (1994) Bioavailability of ethanol is reduced in several commonly used liquid diets. Alcohol 11, 329-335.
6. A receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis. Mol. Pharmacol. 48, 861-868.
7. Fitzgerald L. W. and Nestler E. J. (1995) Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clin. Neurosci. 3, 165-173.
8. Follesa P. and Ticku M. K. (1995) Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain. Mol. Brain Res. 29, 99-106.
9. Goldstein D. B. (1973) Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission. J. Pharmacol. Exp. Ther. 186, 1-9.
10. Grayson D. R., Bovolin P., and Santi M.-R. (1993) Absolute quantitation of γ-aminobutyric acid A receptor subunit mRNAs by competitive polymerase chain reaction. Methods Neurosci. 12, 191-208.
11. Gulya K., Grant K. A., Valverius P., Hoffman P. L., and Tabakoff B. (1991) Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res. 547, 129-134.
12. A receptors. Mol. Pharmacol. 43, 970-975.
13. Harris B. T., Charlton M. E., Costa E., and Grayson D. R. (1994) Quantitative changes in α1 and α5 γ-aminobutyric acid type A receptor subunit mRNAs and proteins after a single treatment of cerebellar granule neurons with N-methyl-D-aspartate. Mol. Pharmacol. 45, 637-648.
14. 1-adrenergic receptor mRNA and ligand binding by antidepressant treatments and norepinephrine depletion in rat frontal cortex. J. Neurochem. 60, 1335-1343.
15. Karobath M., Rogers J., and Bloom F. E. (1980) Benzodiazepine receptors remain unchanged after chronic ethanol administration. Neuropharmacology 19, 125-128.
16. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 12, 1063-1076.
17. Le A. D., Khanna J. M., Kalant H., and Grossi F. (1986) Tolerance to and cross-tolerance among ethanol, pentobarbital, and chlordiazepoxide. Pharmacol. Biochem. Behav. 24, 93-98.
18. A receptor selective for a behavioral alcohol antagonist. Nature 346, 648-651.
19. Mhatre M. and Ticku M. K. (1989) Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons. J. Pharmacol. Exp. Ther. 251, 164-168.
20. A receptor gene expression. Mol. Pharmacol. 42, 415-422.
21. 3H]RO15-4513 in rat brain. Eur. J. Pharmacol. 153, 141-145.
22. A receptor a subunits reveal that chronic alcohol treatment down-regulates α-subunit expression in rat brain regions. J. Neurochem. 61, 1620-1625.
23. A receptor a subunit mRNAs in the rat cerebral cortex. Mol. Pharmacol. 39, 157-163.
24. - uptake in cerebral cortical synaptoneurosomes. J. Pharmacol. Exp. Ther. 246, 158-164.
25. A receptor α1 and α6 subunit mRNA levels in rat cerebellum. J. Mol. Cell. Neurosci. 3, 251-258.
26. Nestler E. J., Hope B. T., and Widnell K. L. (1993) Drug addiction: a model for the molecular basis of molecular plasticity. Neuron 11, 995-1006.
27. Ortiz J., Fitzgerald L. W., Charlton M., Lane S., Trevisan L., Guitart X., Shoemaker W., Duman R. S., and Nestler E. J. (1995) Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 21, 289-298.
28. A receptor research. Synapse 21, 189-274.
29. Rastogi S. K., Thyagarajan J., Clothier J., and Ticku M. K. (1986) Effect of chronic treatment of ethanol on benzodiazepine and picrotoxin sites on the GABA receptor complex in regions of the brain of the rat. Neuropharmacology 25, 1179-1184.
30. Ritzmann R. F. and Tabakoff B. (1976) Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence. J. Pharmacol. Exp. Ther. 199, 158-170.
31. A receptor function and ethanol. FEBS Lett. 324, 140-142.
32. Tremwell M. F. and Hunter B. E. (1994) Effects of chronic ethanol ingestion on long-term potentiation remain even after a prolonged recovery from ethanol exposure. Synapse 17, 141-148.
33. Trevisan L., Fitzgerald L. W., Brose N., Gasic G. P., Heinemann S. F., Duman R. S., and Nestler E. J. (1994) Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J. Neurochem. 62, 1635-1638.
34. Ulrichsen J., Clemmesen L., Barry D., and Hemmingsen R. (1988) The GABA/benzodiazepine receptor chloride channel complex during repeated episodes of physical ethanol dependence in the rat. Psychopharmacology (Berlin) 96, 227-231.
35. A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the γ2L subunit. Neuron 7, 27-33.
36. Walker D. W. and Hunter B. E. (1978) Short-term memory impairment following chronic alcohol consumption in rats. Neuropsychologia 16, 545-553.
37. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12, 1040-1062.