Chronic intermittent ethanol treatment in rats increases GABA(A) receptor α4-subunit expression: Possible relevance to alcohol dependence

Journal of Neurochemistry

Volumn 68, Issue 6, 1997, Pages 2485-2492

  Mahmoudi, Mithra ^a   Kang, Maeng Hee ^a   Tillakaratne, Niranjala ^b   Tobin, Allan J ^a,b   Olsen, Richard W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol dependence; Chronic ethanol; GABA(A) receptor; Hippocampus; In situ hybridization; 4 subunit

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; RECEPTOR SUBUNIT;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISEASE PREDISPOSITION; HUMAN; IN SITU HYBRIDIZATION; LONG TERM EXPOSURE; MALE; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT; RECEPTOR DENSITY; SEIZURE;

EID: 0031011897     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68062485.x     Document Type: Article

References (50)

1. Allan A. M. and Harris R. A. (1987) Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels. Pharmacol. Biochem. Behav. 27, 665-670.
2. Ballenger J. C. and Post R. M. (1978) Kindling as a model for alcohol withdrawal syndrome. Br. J. Psychiatry 133, 1-14.
3. Banerjee P. K. Tillakaratne N. J. K., Brailowsky S., Olsen R. W., Snead O. C., and Tobin A. J. (1995) γ-Hydroxybutyrate (GHB)-induced absence-like seizures decrease the expression of GABA receptor α4 mRNA in thalamus. Abstr. Soc. Neurosci. 21, 1592.
4. Becker H. C. and Hale R. L. (1993) Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal "kindling." Alcohol. Clin. Exp. Res. 17, 94-98.
5. A receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine. Mol. Brain Res. 26, 309-319.
6. Cox K. H., DeLeon D. V., Angerer L. M., and Angerer R. C. (1984) Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev. Biol. 101, 485-502.
7. DeLorey T. M. and Olsen R. W. (1994) GABA and glycine, in Basic Neurochemistry (Sieger G. J., Agranoff R. W., Albers R. W., and Molinoff P. B., eds). pp. 389-399. Raven Press, New York.
8. Devaud L. L., Smith F. D., Grayson D. R., and Morrow A. L. (1995) Chronic ethanol consumption differentially alters the expression of γ-aminobutyric acid A receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis. Mol. Pharmacol. 48, 861-868.
9. A receptors to neuroactive steroids in rats during ethanol withdrawal. J. Pharmacol. Exp. Ther. 278, 510-517.
10. Dietrich R. A., Dunwiddie T. V., Harris R. A., and Erwin V. G. (1989) Mechanism of action of ethanol: initial central nervous system actions. Pharmacol. Rev. 41, 489-537.
11. Esclapez M., Tillakaratne N. J., Tobin A. J., and Houser C. R. (1993) Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods. J. Camp. Neurol. 331, 339-362.
12. Goddard G. V., McIntyre D. C., and Leech C. K. (1969) A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 25, 295-330.
13. Harrison N. L., Kugler J. L., Jones M. V., Greenblatt E. P., and Pritchett D. B. (1993) Positive modulation of human γ-aminobutyric acid type A and glycine receptor by the inhalation anesthetic isoflurane. Mol. Pharmacol. 44, 628-632.
14. A receptors in cerebellum and thalamus. Eur. J. Pharmacol. 310, 225-233.
15. A receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study. Mol Brain Res. 31, 33-47.
16. Areceptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment. Brain Res. 709, 221-228.
17. Karobath M., Rogers J., and Bloom F. E. (1980) Benzodiazepine receptors remain unchanged after chronic ethanol administration. Neuropharmacology 19, 125-128.
18. A receptors. Neuron 3, 745-753.
19. Knoflach F., Benke D., Wang Y., Scheurer L., Lüddens H., Hamilton B. J., Carter D. B., Mönler H., and Benson J. A. (1996) Pharmacological modulation of the diazepam-insensitive recombinant GABAA receptors α4β2γ2 and α6β2γ2. Mol. Pharmacol. 50, 1253-1261.
20. Kokka N., Sapp D. W., Taylor A. M., and Olsen R. W. (1993) The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol. Alcohol. Clin. Exp. Res. 17, 525-531.
21. A receptors in the actions of alcohol and in alcoholism: recent advances. Alcohol Alcohol. 26, 115-129.
22. Le A. D., Khanna J. M., Kalant H., and Grossi F. (1986) Tolerance to and cross-tolerance among ethanol, pentobarbital, and chlordiazepoxide. Pharmacol. Biochem. Behav. 24, 93-98.
23. A receptor selective for a behavioural alcohol antagonist. Nature 346, 648-651.
24. Macdonald R. L. and Olsen R. W. (1994) GABAA receptor channels. Annu. Rev. Neurosci. 17, 569-602.
25. McCown T. J. and Breese G. R. (1990) Multiple withdrawals from chronic ethanol "kindles" inferior collicular seizure activity: evidence for kindling of seizures associated with alcoholism. Alcohol. Clin. Exp. Res. 14, 394-399.
26. A-receptor subtypes really occur in the brain? Trends Neurosci. 19, 139-143.
27. Mehta A. K. and Ticku M. K. (1988) Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves γ-aminobutyric acid A gated chloride channels. J. Pharmacol. Exp. Ther. 246, 564-588.
28. Mhatre M. C. and Ticku M. K. (1992) Chronic ethanol administration alters γ-aminobutyric acid A receptor gene expression. Mol. Pharmacol. 42, 415-422.
29. A β subunit expression. Mol. Brain Res. 23, 246-252.
30. 3H] Ro15-4513 in rat brain. Eur. J. Pharmacol. 153, 141-145.
31. A receptor α subunits reveal that chronic alcohol treatment down-regulates α-subunit expression in rat brain regions. J. Neurochem. 61, 1620-1625.
32. A receptor function and expression in brain. Alcohol 7, 237-244.
33. Obenaus A., Esclapez M., and Houser C. R. (1993) Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures. J. Neurosci. 13, 4470-4485.
34. A receptors. Adv. Biochem. Psychopharmacol. 48, 57-74.
35. A receptors. FASEB J. 4, 1469-1480.
36. Olsen R. W., Sapp D. W., Bureau M. H., Turner D. M., and Kokka N. (1991a) Allosteric actions of central nervous system depressants including anesthetics on subtypes of the inhibitory γ-aminobutyric acid A receptor-chloride channel complex. Ann. NY Acad. Sci. 625, 145-154.
37. A receptor family in the mammalian brain. Neurochem. Res. 16, 317-325.
38. Pinel J. P. J., Van Oot P. H., and Mucha R. F. (1975) Intensification of the alcohol withdrawal syndrome by repeated brain stimulation. Nature 254, 510-511.
39. 3H]Ro 15-4513: a biochemical and autoradiographic study. J. Neurochem. 48, 46-52.
40. Sonnenberg J. L., Frantz G. D., Lee S., Heick A., Chu C., Tobin A. J., and Christakos S. (1991) Calcium binding protein (calbindin-D28k) and glutamate decarboxylase gene expression after kindling induced seizures. Mol. Brain Res. 9, 179-190.
41. Suzdak P. D., Glowa J. R., Crawley J. N., Schwartz R. D., Skolnick P., and Paul S. M. (1986a) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234, 1243-1247.
42. Suzdak P. D., Schwartz R. D., Skolnick P., and Paul S. M. (1986b) Ethanol stimulates γ-aminobutyric acid receptor mediated chloride transport in rat brain synaptosomes. Proc. Natl. Acad. Sci. USA 83, 4071-4075.
43. A receptor subtype that is insensitive to diazepam. J. Pharmacol. Exp. Ther. 257, 1236-1241.
44. A receptors, in Handbook of Receptors and Channels: Ligand and Voltage-Gated Ion Channels (North R. A., ed), pp. 265-290. CRC Press, Inc., Boca Raton, Florida.
45. Veatch L. M. and Gonzalez L. P. (1996) Repeated ethanol withdrawal produces site-dependent increase in EEG spiking. Alcohol. Clin. Exp. Res. 20, 262-267.
46. A receptor α4 subunit expressed in Xenopus laevis oocytes. Mol. Pharmacol. 50, 1364-1375.
47. A receptor α4 subunit. FEBS Lett. 289, 227-230.
48. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12, 1040-1062.
49. A/benzodiazepine receptor subunit mRNAs and ligand binding sites in mouse cerebellar neurons following in vivo ethanol administration: an autoradiographic analysis. J. Neurochem. 65, 1229-1239.
50. A receptors. J. Neurosci. 16, 6648-6656.