Anticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 2, 1997, Pages 543-553

  Gasior, Maciej ^a,c,d   Carter, Richard B ^b   Goldberg, Steven R ^a   Witkin, Jeffrey M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d NIDA Addiction Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA (4 ACETYLPHENYL)ETHYNYL 3ALPHA,21 DIHYDROXY 5BETA,20 ONE 21 HEMISUCCINIC ACID; 4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; CALCIUM ION; CO 21068; DIAZEPAM; DIZOCILPINE; ELTANOLONE; GANAXOLONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTETRAZOLE; PHENOBARBITAL; PREGNENOLONE; STEROID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; EPILEPSY; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SEIZURE;

ANIMALS; ANTICONVULSANTS; COCAINE; DIAZEPAM; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PHENOBARBITAL; STEROIDS;

EID: 0030838076     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. BARKER, J. L., HARRISON, N. L., LANGE, G. D. AND OWEN, D. G.: Potentiation of γ-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurons. J. Physiol. 386: 485-501, 1987.
2. BELELLI, D., BOLGER, M. B. AND GEE, K. W.: Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 166: 325-329, 1989.
3. BELELLI, D., LAN, N. C. AND GEE, K. W.: Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. Neuroscience and Biobehav. Rev. 14: 315-322, 1990.
4. BENOWITZ, N. L.: Clinical pharmacology and toxicology of cocaine. Pharmacology and Toxicology 72: 3-12, 1993.
5. BRADFORD, H. F.: Glutamate, GABA and epilepsy. Progress in Neurobiol. 47: 477-511, 1995.
6. A receptor by progesterone metabolites. Proc. R. Soc. Lond. Biol. 231: 359-369, 1987.
7. A receptor. J. Pharmacol. Exp. Ther. 280: 1284-1295, 1997.
8. COTTRELL, G. A., LAMBERT, J. J. AND PETERS, J. A.: Modulation of GABAA receptor activity by alphaxalone. Br. J. Pharmacol. 90: 491-500, 1987.
9. COUGHENOUR, L. L., MCLEAN, J. R. AND PARKER, R. B.: A new device for the rapid measurement of impaired motor function in mice. Pharmacol. Biochem. Behav. 6: 351-353, 1977.
10. CZUCZWAR, S. J., MALEK, U. AND KLEINROK, Z.: Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice. Neuropharmacology 29: 943-948, 1990.
11. DERLET, R. W. AND ALBERTSON, T. E.: Potentiation of cocaine toxicity with calcium channel blockers. Am. J. Emerg. Med. 7: 464-468, 1989.
12. DERLET, R. W., TSENG, C. C. AND ALBERTSON, T. E.: Cocaine toxicity and calcium channel blockers nifedipine and nimodipine in rats. J. Emerg. Med. 12:1-4, 1994.
13. DHUNA, A., PASCUAL-LEONE, A., LANGENDORF, F. AND ANDERSON, D. C.: Epileptogenic properties of cocaine in humans. Neurotoxicology 12: 621-626, 1991.
14. A receptor complex. J. Pharmacol. Exp. Ther. 265: 1374-1379, 1993.
15. FINN, D. A. AND GEE, K. W.: The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J. Pharmacol. Exp. Ther. 271: 164-170, 1994.
16. 2+ channel current in freshly isolated hippocampal CA1 neurons. Eur. J. Pharmacol. 202: 269-272, 1991.
17. GASIOR, M., KAMINSKI, R., BRUDNIAK, T., KLEINROK, Z. AND CZUCZWAR, S. J.: Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J. Neural Transm. Gen. Sec. 103: 819-831, 1996.
18. GEE, K. W.: Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore. Mol. Neurobiol. 2: 291-317, 1988.
19. - ionophore by steroids in rat brain. Eur. J. Pharmacol. 136: 419-423, 1987.
20. A receptor complex: The pharmacological properties and therapeutic potential of epalons. Crit. Rev. Neurobiol. 9: 207-277, 1995.
21. GINSKI, M. AND WITKIN, J. M.: Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists. Psychopharmacology 114: 573-582, 1994.
22. HARRISON, N. L. AND SIMMONDS, M. A.: Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res. 323: 287-292, 1984.
23. HEINEMANN, U. AND HAMON, B.: Calcium and epileptogenesis. Exp. Brain Res. 65: 1-10, 1986.
24. HOLMES, G. L., WEBER, D. A., KLOCZKO, N. AND ZIMMERMAN, A. W.: Relationship of endocrine function to inhibition of kindling. Brain Res. 318: 55-59, 1984.
25. ++ responses: structure activity studies. J. Pharmacol. Exp. Ther. 271: 677-682, 1994.
26. KOKATE, T. G., SVENSSON, B. E. AND ROGAWSKI, M. A.: Anticonvulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. Exp. Ther. 270: 1223-1229, 1994.
27. A receptor binding. Pharmacol. Biochem. Behav. 43: 441-447, 1992.
28. A receptor function. Trends Pharmacol. Sci. 16: 295-303, 1995.
29. LAMMERS, M. W., HEKSTER, Y. A., KEYSER, A., MEINARDI, H., RENIER, W. O. AND VAN LIER, H.: Monotherapy or polytherapy for epilepsy revisited: a quantitative assessment. Epilepsia 36: 440-446, 1995.
30. A-benzodiazepine receptor. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 188: 403-406, 1990.
31. LANDGREN, S., AASLY, J., BACKSTROM, T., DUBROVSKY, B. AND DANIELSSON, E.: The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol. Scand. 131: 33-42, 1987.
32. LEANDER, J. D., LAWSON, R. R., ORNSTEIN, P. L. AND ZIMMERMAN, D. M.: N-Methyl-D-aspartic acid-induced lethality in mice: selective antagonism be phencyclidine-like drugs. Brain Res. 448: 115-120, 1988.
33. LITCHFIELD, J. T. AND WILCOXON, F.: A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 95: 99-113, 1949.
34. LöSCHER, W. AND NOLTING, B.: The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices. Epilepsy Res. 9: 1-10, 1991.
35. LÖSCHER, W. AND SCHMIDT, D.: Which animal models should be used in the research for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2: 145-181, 1988.
36. A/benzodiazepine receptor heterogeneity: Neurophysiological implications. Neuropharmacology 34: 245-254, 1995.
37. LUNTZ-LEYBMAN, V., FREUND, R. K. AND COLLINS, A. C.: 5α-Pregnan-3α-ol-20-one blocks nicotine-induced seizures and enhances paired-pulse inhibition. Eur. J. Pharmacol. 185: 239-242, 1990.
38. A receptor channels. Annu. Rev. Neurosci. 17: 569-602, 1994.
39. MAJEWSKA, M. D., HARRISON, N. L., SCHWARTZ, R. D., BARKER, J. L. AND PAUL, S. M.: Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232: 1004-1007, 1986.
40. MCNAMARA, J. O.: Drugs effective in the therapy of the epilepsies. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, ed. by J. G. Hardman, L. E. Limbird, P. B. Molinoff and R. W. Ruddon, pp. 461-486, Pergamon Press, New York, 1996.
41. MEINARDI, H.: Use of combined antiepileptic drug therapy. In Antiepileptic Drugs, 4th ed., ed. by R. H. Levy, R. H. Mattson and B. S. Meldrum, pp. 91-97, Raven Press, Ltd., New York, 1995.
42. 2+ antagonist. Epilepsia 28: 409-414, 1987.
43. MORROW, A. L., PACE, J. R., PURDY, R. H. AND PAUL, S. M.: Characterization of steroid interactions with the GABA receptor-gated chloride ion channel: Evidence for multiple steroid recognition sites. Mol. Pharmacol. 37: 263-270, 1990.
44. MORROW, A. L., SUZDAK, P. D. AND PAUL, S. M.: Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. Eur. J. Pharmacol. 142: 483-485, 1987.
45. MURRAY, T. F., ZHANG, G. AND FRANKLIN, P. H.: Manipulation of endogenous adenosine affects seizure susceptibility. Drug Dev. Res. 28: 410-415, 1993.
46. PALMER, G. C., STAGNITTO, M. L., RAY, R. K., KNOWLES, M. A., HARVEY, R. AND GARSKE, G. E.: Anticonvulsant properties of calcium channel blockers in mice: N-methyl-D-,L-aspartate-and Bay K 8644-induced convulsions are potently blocked by the dihydropyridines. Epilepsia 34: 372-380, 1993.
47. PATSALOS, P. N. AND DUNCAN, J. S.: New antiepileptic drugs: A review of their urrent status and clinical potential. CNS Drugs 2: 40-77, 1994.
48. PAUL, S. M. AND PURDY, R. H.: Neuroactive steroids. FASEB 6: 2311-2322, 1992.
49. PLAA, G. L. AND WILLMORE, L. J.: Toxicology, In Antiepileptic Drugs, 4th ed., ed. by R. H. Levy, R. H. Mattson and B. S. Meldrum, pp. 51-60, Raven Press, Ltd., New York, 1995.
50. A receptors. Neuron 4: 759-765, 1990.
51. ROCKHOLD, R. W., ODEN, G., HO, I. K., ANDREW, M. AND FARLEY, J. M.: Glutamate ceptor antagonists block cocaine-induced convulsions and death. Brain Res. Bull. 27: 721-723, 1991.
52. ROGAWSKI, M. A. AND PORTER, R. J.: Antiepileptic drugs: Pharmacological mechaisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42: 223-286, 1990.
53. ROSCISZEWSKA, D., BUNTNER, B., Guz, I. AND ZAWISZA, L.: Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy. J. Neurol. Neurosurg. Psychiatry 49: 47-51, 1986.
54. SANDER, J. W. A. S.: Some aspects of prognosis in the epilepsies: A review. Epilepsia 34: 1007-1016, 1993.
55. SCHWARTZ-GIBLIN, S., KOROTZER, A. AND PFAFF, D. W.: Steroid hormone effects on picrotoxin-induced seizures in female and male rats. Brain Res. 476: 240-247, 1989.
56. SCHWARTZKROIN, P. A. AND WYLER, A. R.: Mechanisms underlying epileptiform burst discharge. Ann. Neurol. 7: 95-107, 1980.
57. SELYE, H.: The antagonism between anesthetic steroid hormones and pentamethylenetetrazol (metrazol). J. Lab. Clin. Med. 27: 1051-1053, 1942.
58. A receptor by steroids. Semin. Neurosci. 3: 231-239, 1991.
59. SKOLNICK, P. AND PAUL, S.: The benzodiazepine/GABA receptor chloride channel complex. ISI Atlas Pharmacol. 2: 19-22, 1988.
60. SPECKMANN, E. J., STROUB, H. AND KÖHLING, R.: Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism. Neuropsychobiology 27: 122-126, 1993.
61. 2+ currents in acutely isolated hippocampal CA1 neurons. Life Sci. 49: 235-239, 1991.
62. STABLES, J. P., BIALES, M., JOHANNESSEN, S. I., KUPFERBERG, H. J., LEVY, R. H., LOISEAU, P. AND PERUCCA, E.: Progress report on new antiepileptic drugs: A summary of the Second Eilat Conference. Epilepsy Res. 22: 235-245, 1995.
63. STARR, M. S.: The role of dopamine in epilepsy. Synapse 22: 159-194, 1996.
64. SWINYARD, E. A.: Laboratory evaluation of antiepileptic drugs. Review of laboratory methods. Epilepsia 10: 107-119, 1969.
65. TALLARIDA, R. J. AND MURRAY, R. B.: Manual of Pharmacological Calculations, 2nd ed., Spriger-Verlag, New York, 1987.
66. TORTELLA, F. C., MARLEY, M. AND WITKIN, J. M.: NMDA modulators protect against convulsions resistant to other anticonvulsants. NIDA Research Monograph, Problems of Drug Dependence 119: 290, 1992.
67. WIELAND, S., BELLUZZI, J. D., STEIN, L. AND LAN, N. C.: Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents. Psychopharmacology 115: 65-71, 1995.
68. WILSON, M. A.: Influence of gender, gonadectomy, and estrous cycle on GABA/BZ receptors and benzodiazepine responses in rats. Brain Res. Bull. 29: 165-172, 1992.
69. WITKIN, J. M. AND TORTELLA, F. C.: Modulators of N-methyl-D-aspartate protect against diazepam-or phenobarbital-resistant cocaine convulsions. Life Sci. 48: PL51-PL56, 1991.
70. VANDETTE, J. M. AND CORNISH, L. A.: Medical complications of illicit drugs use. Clin. Pharm. 8: 401-411, 1989.