Modulation by general anaesthetics of rat GABA(A) receptors comprised of α1β3 and β3 subunits expressed in human embryonic kidney 293 cells

British Journal of Pharmacology

Volumn 120, Issue 5, 1997, Pages 899-909

  Davies, Paul A ^a   Kirkness, Ewen F ^b   Hales, Tim G ^a  

^a UCLA MEDICAL CENTER   (United States)

^b J CRAIG VENTER INSTITUTE   (United States)

Author keywords

GABA(A) receptors; General anaesthetic; Neurosteroids; Patch damp; Pentobarbitone; Propofol; Radioligand binding

Indexed keywords

3BETA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; COMPLEMENTARY DNA; PENTOBARBITAL; PICROTOXIN; PROPOFOL; RECEPTOR SUBUNIT;

ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CELL; LIGAND BINDING; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR BINDING;

ANESTHETICS, GENERAL; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TRANSFORMED; GAMMA-AMINOBUTYRIC ACID; HUMANS; PENTOBARBITAL; PREGNANOLONE; PROPOFOL; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; SULFUR RADIOISOTOPES;

EID: 0030902186     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700987     Document Type: Article

References (42)

1. A receptors of clonal murine hypothalamic GT1-7 neurones by propofol. Br. J. Pharmacol., 115, 953 - 960.
2. A receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature, 366, 565 - 569.
3. A receptor subunits, α1β1 and α1β1γ2S subunits produce unique ion channels with dissimilar single-channel properties. J. Neurosci., 13, 1429 - 1440.
4. BELELLI, D., CALLACHAN, H., HILL-VENNING, C., PETERS, P.A. & LAMBERT, J.J. (1996). Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes Br. J. Pharmacol. 118, 563 - 576.
5. A receptor form ion channels with properties of the native receptor. Science, 242, 577 - 579.
6. BORMANN, J., HAMILL, O.P. & SAKMANN, B. (1987). Mechanism of anion permeation through channels gated by glycine and γ-aminobutyric acid in mouse cultured spinal neurones. J. Physiol., 385, 243 - 286.
7. A receptor subtypes, from pharmacology to molecular biology. FASEB J., 5, 2916 - 2923.
8. A β-subunit homomeric receptors. NeuroReport, 7, 943 - 947.
9. A receptor function is different from that of benzodiazepines. Naunyn-Schmiedeberg's Arch. Pharmacol., 350, 294 - 300.
10. CONNOLLY, C.N., KRISHEK, B.J., MCDONALD, B.J., SMART, T.G. & MOSS, S.J. (1996). Assembly and cell surface expression of heteromeric and homomeric γ-aminobutyric acid type A receptors. J. Biol. Chem., 271, 89 - 96.
11. FRANKS, N.P. & LIEB, W.R. (1994). Molecular and cellular mechanisms of general anaesthesia. Nature, 367, 607 - 614.
12. HALES, T.G. & LAMBERT, J.J. (1991). The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br .J. Pharmacol., 104, 619 - 628.
13. HALES, T.G. & OLSEN, R.W. (1994). Basic pharmacology of intravenous induction agents. In The Pharmacological Basis of Anesthesiology, Basic Science and Clinical Applications (ed. Bowdle, T.A., Horita, A.H., Karasch, E.D.) pp. 295 - 306. Chichester: Churchill Livingstone Inc.
14. A receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurones of the rat. Anesthesiology, 79, 781 - 788.
15. A response in dissociated hippocampal pyramidal neurons of the rat. Anesthesiology 81, 988 - 994.
16. A receptor. Eur. J. Pharmacol., 269, 157 - 163.
17. A receptor activation. Br. J. Pharmacol., 108, 711 - 716.
18. A receptors. Br. J. Pharmacol., 114, 1040 - 1044.
19. A receptor by propofol is independent of the γ subunit. J. Pharmacol. Exp. Ther., 274, 962 - 968.
20. A receptor. Neuron, 3, 745 - 753.
21. KIRKNESS, E.F. & FRASER, C.M. (1993). A strong promoter element is located between alternative exons of a gene encoding the human γ-aminobutyric acid-type A receptor β3 subunit (GABRB3). J. Biol. Chem., 268, 4420 - 4428.
22. A receptor-ion channels, evaluation of pharmacological and physiological properties. Mol. Pharmacol., 49, 494 - 504.
23. A receptor. FEBS Lett., 246, 145 - 148.
24. MAJEWSKA, M.D., HARRISON, N.L., SCHWARTZ, R.D., BARKER, J.L. & PAUL, S.M. (1986). Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science, 232, 1004 - 1007.
25. OGURUSU, T. & SHINGAI, R. (1996). Cloning of a putative γ-aminobutyric acid (GABA) receptor subunit p3 cDNA. Biochem. Biophys. Acta, 1305, 15 - 18.
26. A receptors in cultured murine hippocampal neurons. Neuroscience, 14, 7747 - 7760.
27. A receptor subunits determines sorting and localization in polarized cells. Nature, 361, 457 - 460.
28. A receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol., 94, 1257 - 1269.
29. A receptors on bovine adrenomedullary chromaffin cells. Pflugers Archiv., 415, 95 - 103.
30. A receptor subunit for benzodiazepine pharmacology. Nature, 388, 582 - 585.
31. A chloride channels in mammalian dorsal root ganglion neurones. Br. J. Pharmacol., 98, 167 - 176.
32. SANNA, E., GARAU, F. & HARRIS, R.A. (1995). Novel properties of homomeric β1 γ-aminobutyric acid type A receptors, actions of the anesthetics propofol and pentobarbital. Mol. Pharmacol., 47, 213 - 217.
33. SCHULZ, D.W., & MACDONALD, R.L. (1981). Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance, correlation with anticonvulsant and anesthetic actions. Brain Res., 209, 177 - 188.
34. SHIMADA, S., CUTTING, G. & UHL, G.R. (1992). γ-Aminobutyric acid A or C receptor? γ-Aminobutyric acid p1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ-aminobutyric acid responses in Xenopus oocytes. Mol. Pharmacol., 41, 683 - 687.
35. A receptor on the response to a neurosteroid. Eur. J. Pharmacol., 206, 77 - 80.
36. A receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA. Febs Lett., 257, 377 - 379.
37. A receptors on channel function. Neuron, 5, 703 - 711.
38. A receptors. Eur. J. Pharmacol., 291, 99 - 105.
39. TURNER, D.M., RANSOM, R.W., YANG, J.S. & OLSEN, R.W. (1989). Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J. Pharmacol. Exp. Ther., 248, 960 - 966.
40. A receptor-channel complex composed of α1β2 and α1β3 subunits from rat brain. J. Pharmacol. Exp. Ther., 265, 985 - 991.
41. A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the γ2L subunit. Neuron, 7, 27 - 33.
42. A receptor beta subunit heterogeneity, functional expression of cloned cDNAs. EMBO J., 8, 1665 - 1670.