Photoaffinity labeling of the benzodiazepine binding site of α1β3γ2 γ-aminobutyric acid(A) receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the α subunit and predicts orientation of these within the benzodiazepine pharmacophore

Molecular Pharmacology

Volumn 54, Issue 1, 1998, Pages 33-43

  McKernan, Ruth M ^a   Farrar, Sophie ^a   Collins, Ian ^a   Emms, Frances ^a   Asuni, Ayodeji ^a   Quirk, Kathleen ^a   Broughton, Howard ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE; FLUNITRAZEPAM; LIGAND; PHENYL GROUP; RADIOLIGAND; RECEPTOR SUBTYPE;

ALPHA CHAIN; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PHOTOAFFINITY LABELING; PHOTOLYSIS; PREDICTION; PRIORITY JOURNAL;

EID: 0031820285     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.1.33     Document Type: Article

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