메뉴 건너뛰기




Volumn 16, Issue 17, 1996, Pages 5415-5424

Stoichiometry of a recombinant GABA(A) receptor

Author keywords

GABA; ion channel; mutagenesis; receptor; stoichiometry

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ION CHANNEL; RECEPTOR SUBUNIT; 4 AMINOBUTYRIC ACID; LEUCINE; RECOMBINANT PROTEIN;

EID: 0029664746     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-17-05415.1996     Document Type: Article
Times cited : (373)

References (60)
  • 1
    • 0027787023 scopus 로고
    • A receptor needs two homologous domains of the β subunit for activation by GABA, but not by pentobarbital
    • A receptor needs two homologous domains of the β subunit for activation by GABA, but not by pentobarbital. Nature 366:565-569.
    • (1993) Nature , vol.366 , pp. 565-569
    • Amin, J.1    Weiss, D.S.2
  • 2
    • 0029944870 scopus 로고    scopus 로고
    • Insight into the activation mechanism of ρ1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits
    • Amin J, Weiss DS (1996) Insight into the activation mechanism of ρ1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. Proc R Soc Lond [Biol] 263:273-282.
    • (1996) Proc R Soc Lond [Biol] , vol.263 , pp. 273-282
    • Amin, J.1    Weiss, D.S.2
  • 4
    • 0025856536 scopus 로고
    • Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure
    • Anand R, Conroy WG, Schoepfer R, Whiting P, Lindstrom J (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J Biol Chem 266:11192-11198.
    • (1991) J Biol Chem , vol.266 , pp. 11192-11198
    • Anand, R.1    Conroy, W.G.2    Schoepfer, R.3    Whiting, P.4    Lindstrom, J.5
  • 8
    • 0027938035 scopus 로고
    • Distribution, prevalence, and drug binding profile of γ-aminobutyric acid type A receptor subtypes differing in the β subunit variant
    • Benke D, Fritschy J-M, Trzeciak A, Bannwarth W, Mohler H (1994) Distribution, prevalence, and drug binding profile of γ-aminobutyric acid type A receptor subtypes differing in the β subunit variant. J Biol Chem 268:27100-27107.
    • (1994) J Biol Chem , vol.268 , pp. 27100-27107
    • Benke, D.1    Fritschy, J.-M.2    Trzeciak, A.3    Bannwarth, W.4    Mohler, H.5
  • 9
    • 0024725677 scopus 로고
    • Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor
    • Blount P, Merlie JP (1989) Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor. Neuron 3:349-357.
    • (1989) Neuron , vol.3 , pp. 349-357
    • Blount, P.1    Merlie, J.P.2
  • 10
    • 0023856335 scopus 로고
    • Activation of ion channels in the frog end-plate by high concentrations of acetylcholine
    • Lond
    • Colquhoun D, Ogden DC (1988) Activation of ion channels in the frog end-plate by high concentrations of acetylcholine. J Physiol (Lond) 395:131-159.
    • (1988) J Physiol , vol.395 , pp. 131-159
    • Colquhoun, D.1    Ogden, D.C.2
  • 11
    • 0025828670 scopus 로고
    • Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
    • Cooper E, Couturier S, Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350:235-238.
    • (1991) Nature , vol.350 , pp. 235-238
    • Cooper, E.1    Couturier, S.2    Ballivet, M.3
  • 12
    • 0025719155 scopus 로고
    • Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor: A negatively charged region of the δ subunit within 0.9 nm of the alpha subunit binding site disulfide
    • Czajkowski C, Karlin A (1991) Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor: a negatively charged region of the δ subunit within 0.9 nm of the alpha subunit binding site disulfide. J Biol Chem 266:22603-22612.
    • (1991) J Biol Chem , vol.266 , pp. 22603-22612
    • Czajkowski, C.1    Karlin, A.2
  • 13
    • 0026357484 scopus 로고
    • A receptor alpha-subunit iso-oligomers: Demonstration of receptor populations containing α1, α2:α1α3, and α2α3 subunit pairs
    • A receptor alpha-subunit iso-oligomers: demonstration of receptor populations containing α1, α2:α1α3, and α2α3 subunit pairs. J Biol Chem 266:24778-24784.
    • (1991) J Biol Chem , vol.266 , pp. 24778-24784
    • Duggan, M.J.1    Pollard, S.2    Stephenson, F.A.3
  • 14
    • 0029123899 scopus 로고
    • The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
    • Filatov GN, White MM (1995) The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating. Mol Pharmacol 48:379-384.
    • (1995) Mol Pharmacol , vol.48 , pp. 379-384
    • Filatov, G.N.1    White, M.M.2
  • 16
    • 0028788140 scopus 로고
    • Chloride channel expression with the tandem construct of α6-β2 GABAA receptor subunit requires a monomeric subunit of α6 or γ2
    • Im WB, Pregenzer JF, Binder JA, Dillon GH, Alberts GL (1995) Chloride channel expression with the tandem construct of α6-β2 GABAA receptor subunit requires a monomeric subunit of α6 or γ2. J Biol Chem 270:26063-26066.
    • (1995) J Biol Chem , vol.270 , pp. 26063-26066
    • Im, W.B.1    Pregenzer, J.F.2    Binder, J.A.3    Dillon, G.H.4    Alberts, G.L.5
  • 19
    • 0027716526 scopus 로고
    • Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry
    • Kuhse J, Laube B, Magalei D, Betz H (1993) Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 11:1049-1056.
    • (1993) Neuron , vol.11 , pp. 1049-1056
    • Kuhse, J.1    Laube, B.2    Magalei, D.3    Betz, H.4
  • 20
    • 0023192395 scopus 로고
    • Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations
    • Kurosaki T, Fukuda K, Konno T, Mori Y, Tanaka K, Mishina M, Numa S (1987) Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations. FEBS Lett 214:253-258.
    • (1987) FEBS Lett , vol.214 , pp. 253-258
    • Kurosaki, T.1    Fukuda, K.2    Konno, T.3    Mori, Y.4    Tanaka, K.5    Mishina, M.6    Numa, S.7
  • 21
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca C, Nowak MW, Zhang H, Tang L, Deshpande P, Lester HA (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376:514-516.
    • (1995) Nature , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.W.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 22
    • 0001202076 scopus 로고
    • Conserved Quaternary structure of ligand-gated ion channels: The postsynaptic glycine receptor is a pentamer
    • Langosch D, Thomas L, Betz H (1988) Conserved Quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer. Proc Natl Acad Sci USA 85:7394-7398.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7394-7398
    • Langosch, D.1    Thomas, L.2    Betz, H.3
  • 24
    • 0018655548 scopus 로고
    • Biochemical properties of acetylcholine receptor subunits from Torpedo californica
    • Lindstrom J, Merlie J, Yogeeswaran G (1979) Biochemical properties of acetylcholine receptor subunits from Torpedo californica. Biochemistry 18:4465-4470.
    • (1979) Biochemistry , vol.18 , pp. 4465-4470
    • Lindstrom, J.1    Merlie, J.2    Yogeeswaran, G.3
  • 26
    • 0026008983 scopus 로고
    • More than one α-variant may exist in a GABA/benzodiazepine receptor complex
    • Luddens H, Killisch I, Seeburg PH (1991) More than one α-variant may exist in a GABA/benzodiazepine receptor complex. J Recept Res 11:535-551.
    • (1991) J Recept Res , vol.11 , pp. 535-551
    • Luddens, H.1    Killisch, I.2    Seeburg, P.H.3
  • 30
    • 0025961741 scopus 로고
    • Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat
    • Lond
    • Newland CF, Colquhoun D, Cull-Candy SG (1991) Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat. J Physiol (Lond) 432:203-233.
    • (1991) J Physiol , vol.432 , pp. 203-233
    • Newland, C.F.1    Colquhoun, D.2    Cull-Candy, S.G.3
  • 31
    • 0025308169 scopus 로고
    • D-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor
    • Pedersen SE, Cohen JB (1990) D-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 87:2785-2789.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2785-2789
    • Pedersen, S.E.1    Cohen, J.B.2
  • 32
    • 0028982279 scopus 로고
    • Quantitative characterization of α6 and α1α6 subunit-containing native γ-aminobutyric acid A receptors of adult rat cerebellum demonstrates two alpha subunits per receptor oligomer
    • Pollard S, Thompson CL, Stephenson FA (1995) Quantitative characterization of α6 and α1α6 subunit-containing native γ-aminobutyric acid A receptors of adult rat cerebellum demonstrates two alpha subunits per receptor oligomer. J Biol Chem 270:21285-21290.
    • (1995) J Biol Chem , vol.270 , pp. 21285-21290
    • Pollard, S.1    Thompson, C.L.2    Stephenson, F.A.3
  • 33
    • 0026100433 scopus 로고
    • γ-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site
    • Pritchett DB, Seeburg PH (1991) γ-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site. Pro Natl Acad Sci USA 88:1421-1425.
    • (1991) Pro Natl Acad Sci USA , vol.88 , pp. 1421-1425
    • Pritchett, D.B.1    Seeburg, P.H.2
  • 35
    • 0028174520 scopus 로고
    • γ-aminobutyric acid type A receptors in the rat brain can contain both γ2 and γ3 subunits, but γ1 does not exist in combination with another γ subunit
    • Quirk K, Gillard NP, Ragan CI, Whiting PJ, McKernan RM (1994) γ-aminobutyric acid type A receptors in the rat brain can contain both γ2 and γ3 subunits, but γ1 does not exist in combination with another γ subunit. Mol Pharmacol 45:1061-1070.
    • (1994) Mol Pharmacol , vol.45 , pp. 1061-1070
    • Quirk, K.1    Gillard, N.P.2    Ragan, C.I.3    Whiting, P.J.4    McKernan, R.M.5
  • 38
    • 0017826395 scopus 로고
    • Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica
    • Reynolds JA, Karlin A (1978) Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. Biochemistry 17:2035-2038.
    • (1978) Biochemistry , vol.17 , pp. 2035-2038
    • Reynolds, J.A.1    Karlin, A.2
  • 46
    • 0027482551 scopus 로고
    • Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of residues that determine curare selectivity
    • Sine SM (1993) Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity. Proc Natl Acad Sci USA 90:9436-9440.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9436-9440
    • Sine, S.M.1
  • 47
    • 0026045588 scopus 로고
    • γ- and δ-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor
    • Sine SM, Claudio T (1991) γ- and δ-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor. J Biol Chem 266:19369-19377.
    • (1991) J Biol Chem , vol.266 , pp. 19369-19377
    • Sine, S.M.1    Claudio, T.2
  • 48
    • 0023162262 scopus 로고
    • Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist
    • Lond
    • Sine SM, Steinbach JH (1987) Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist. J Physiol (Lond) 385:325-359.
    • (1987) J Physiol , vol.385 , pp. 325-359
    • Sine, S.M.1    Steinbach, J.H.2
  • 50
    • 0025257507 scopus 로고
    • A receptor main conductance state of mouse spinal cord neurones in culture
    • Lond
    • A receptor main conductance state of mouse spinal cord neurones in culture. J Physiol (Lond) 423:193-220.
    • (1990) J Physiol , vol.423 , pp. 193-220
    • Twyman, R.E.1    Rogers, C.J.2    Macdonald, R.L.3
  • 51
    • 0027506299 scopus 로고
    • Nicotinic acetylcholine receptors at 9 A resolution
    • Unwin N (1993) Nicotinic acetylcholine receptors at 9 A resolution. J Mol Biol 229:1101-1124.
    • (1993) J Mol Biol , vol.229 , pp. 1101-1124
    • Unwin, N.1
  • 52
    • 0028921479 scopus 로고
    • Acetylcholine receptor channel imaged in the open state
    • Unwin N (1995) Acetylcholine receptor channel imaged in the open state. Nature 373:37-43.
    • (1995) Nature , vol.373 , pp. 37-43
    • Unwin, N.1
  • 53
    • 0028176043 scopus 로고
    • Formation of heteromeric γ-aminobutyric acid type A receptors containing two different α subunits
    • Verdoorn TA (1994) Formation of heteromeric γ-aminobutyric acid type A receptors containing two different α subunits. Mol Pharmacol 45:475-480.
    • (1994) Mol Pharmacol , vol.45 , pp. 475-480
    • Verdoorn, T.A.1
  • 55
    • 0024600566 scopus 로고
    • Gating scheme for single GABA-activated chloride channels determined from stability plots, dwell-time distributions, and adjacent interval durations
    • Weiss DS, Magleby KL (1989) Gating scheme for single GABA-activated chloride channels determined from stability plots, dwell-time distributions, and adjacent interval durations. J Neurosci 9:1314-1324.
    • (1989) J Neurosci , vol.9 , pp. 1314-1324
    • Weiss, D.S.1    Magleby, K.L.2
  • 56
  • 57
    • 0026612363 scopus 로고
    • A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    • A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040-1062.
    • (1992) J Neurosci , vol.12 , pp. 1040-1062
    • Wisden, W.1    Laurie, D.J.2    Monyer, H.3    Seeburg, P.H.4
  • 59
    • 0027194134 scopus 로고
    • Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
    • Yakel J L, Lagrutta A, Adelman JP, North RA (1993) Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proc Natl Acad Sci USA 90:5030-5033.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5030-5033
    • Yakel, J.L.1    Lagrutta, A.2    Adelman, J.P.3    North, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.