Treatment with an antisense oligodeoxynucleotide to the GABA(A) receptor γ2 subunit increases convulsive threshold for β-CCM, a benzodiazepine 'inverse agonist', in rats

European Journal of Pharmacology

Volumn 306, Issue 1-3, 1996, Pages 61-66

  Zhao, Tai Jun ^a   Rosenberg, Howard C ^a   Chiu, Ted H ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

3 carboxylate; antisense oligodeoxynucleotide; convulsion; GABA(A) receptor; methyl carboline; picr otoxin; strychnine; 2 subunit

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; PICROTOXIN; RECEPTOR SUBUNIT; STRYCHNINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE THRESHOLD;

EID: 0030582088     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00205-1     Document Type: Article

References (38)

1. Adams, J., X. Chen, J.K. DeRiel, M.W. Adler and L. Y. Liu-Chen, 1994, Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats, Brain Res. 667, 129.
2. Baldwin, B.A., I.S. Ebenezer and C. De La Riva, 1990, Effects of intracerebroventricular injection of muscimol or GABA on operant feeding in pigs, Physiol. Behav. 48, 417.
3. Borden, L.A., C. Czajkowski, C.Y. Chan and D.H. Farb, 1984, Benzodiazepine receptor synthesis and degradation by neurons in culture, Science 226, 857.
4. A receptor α subunits in cultured visual cortex slices reduces amplitude of evoked inhibitory postsynaptic currents, Neurosci. Lett. 191, 111.
5. Cooper, S.J. and D.B. Gilbert, 1985, Clonazepam-induced hyperphagia in nondeprived rats: tests of pharmacological specificity with Ro5-4864, Ro5-3663, Ro15-1788 and CGS 9896, Pharmacol. Biochem. Behav. 22, 753.
6. 2 subunit gene of γ-aminobutyric acid type A receptors, Proc. Natl. Acad. Sci. USA 92, 7749.
7. A receptor subunit mRNA concentrations following chronic Iorazepam administration, Br. J. Pharmacol. 103, 1285.
8. 2 subunit subtype, Eur. J. Pharmacol. 291, 439.
9. A receptor heterogeneity, Nature 335, 76.
10. Listerud, M., A.B. Brussaard, P. Devay, D.R. Colman and L.W. Role, 1991, Functional contribution of neuronal AChR subunits revealed by antisense oligonucleotides, Science 254, 1518.
11. A receptor channels, Annu. Rev. Neurosci. 17, 569.
12. Mhatre, M. and M.K. Ticku, 1994, Chronic ethanol treatment upregulates the GABA receptor β subunit expression. Mol. Brain Res. 23, 246.
13. 2 subunit determines benzodiazepine efficacy, J. Biol. Chem. 269, 32768.
14. A receptor α subunit messenger RNAs in embryonic chick neurons in culture, J. Biol. Chem. 266, 6011.
15. Morley, J.E., A.S. Levine and J. Kneip, 1981, Muscimol induced feeding: a model to study the hypothalamic regulation of appetite, Life Sci. 29, 1213.
16. A receptor subunit mRNA in rat brain following flurazepam treatment, J. Psychopharmacol. 6, 364.
17. Olgiati, V.R., C. Netti, F. Guidobono and A. Pecile, 1980, The central GABAergic system and control of food intake under different experimental conditions, Psychopharmacology 68, 163.
18. Olsen, R.W., 1981, GABA-benzodiazepine-barbiturate receptor interactions, J. Neurochem. 37, 1.
19. Paxinos, G. and C. Watson, 1986, The Rat Brain in Stereotaxic Coordinates (Academic Press, San Diego, CA).
20. Pole, P., 1988, Electrophysiology of benzodiazepine receptor ligands: multiple mechanisms and sites of action, Prog. Neurobiol. 31, 349.
21. Potier, M.-C, L. Prado de Carvalho, R.H. Dodd, R. Besselievre and J. Rossier, 1988, In vivo binding of β-carbolines in mice: regional differences and correlation of occupancy to pharmacological effects, Mol. Pharmacol. 34, 124.
22. A receptor subunit mRNA levels are differentially influenced by chronic FG 7142 and diazepam exposure, Eur. J. Pharmacol. 226, 21.
23. A receptor subunits, Science 242, 1306.
24. A receptor subunit for benzodiazepine pharmacology, Nature 338, 582.
25. Rosenberg, H.C. and T.H Chiu, 1981a, Tolerance during chronic benzodiazepine treatment associated with decreased receptor binding, Eur. J. Pharmacol. 70, 453.
26. Rosenberg, H.C. and T.H. Chiu, 1981b, Regional specificity of benzodiazepine receptor down-regulation during chronic treatment of rats with flurazepam, Neurosci. Lett. 24, 49.
27. Rosenberg, H.C., E.I. Tietz, H. Zhang and T.H. Chiu, 1989, Tolerance to diazepam and methyl-β-carboline-3-carboxylate measured in substantia nigra of benzodiazepine tolerant rats, Life Sci. 46, 519.
28. A receptor subunits exist in distinct neuronal subpopulations, Neuron 3, 327.
29. A receptors on channel function, Neuron 5, 703.
30. A receptors, Trends Pharmacol. Sci. 16, 162.
31. Tietz, E.I., H.C. Rosenberg and T.H. Chiu, 1986, Autoradiographic localization of benzodiazepine receptor down-regulation, J. Pharmacol. Exp. Ther. 236, 284.
32. A receptor subunit mRNAs measured in situ in rat hippocampus and cortex following chronic flurazepam administration, J. Mol. Neurosci. 4, 277.
33. Tseng, L.F., K.A. Collins and J.P. Kampine, 1994, Antisense oligodeoxynucleotide to a δ-opioid receptor selectively blocks the spinal antinociception induced by δ-, but not μ-or κ-opioid receptor agonists in the mouse, Eur. J. Pharmacol. 258, R1.
34. A receptors depend upon subunit composition, Neuron 4, 919.
35. Whalestedt, C., E.M. Pich, G.F. Koob, F. Yee and M. Heilig, 1993, Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides, Science 259, 528.
36. A receptor subunit mRNAs during chronic treatment of rats with diazepam, J. Mol. Neurosci. 5, 105.
37. 5 subunit mRNAs in brain regions of flurazepam-treated rats, Mol. Pharmacol. 45, 657.
38. Zhao, T.-J., T.H. Chiu and H.C. Rosenberg, 1994b, Decreased expression of γ-aminobutyric acid type A/benzodiazepine receptor beta subunit mRNAs in brain of flurazepam treated rats, J. Mol. Neurosci. 5, 181.