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Volumn 5, Issue 7, 1999, Pages 432-456

STAT signaling in the pathogenesis and treatment of cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 0032772912     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03403538     Document Type: Review
Times cited : (104)

References (245)
  • 1
    • 0023987751 scopus 로고
    • Interferon-induced nuclear factors that bind a shared promoter correlate with positive and negative transcriptional control
    • Levy DE, Kessler DS, Pine R, Reich N, Darnell JE Jr. (1988) Interferon-induced nuclear factors that bind a shared promoter correlate with positive and negative transcriptional control. Genes Dev. 2: 383-393.
    • (1988) Genes Dev. , vol.2 , pp. 383-393
    • Levy, D.E.1    Kessler, D.S.2    Pine, R.3    Reich, N.4    Darnell J.E., Jr.5
  • 2
    • 0027165321 scopus 로고
    • Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds
    • Khan KD, Shuai K, Lindwall G, Maher SE, Darnell JE Jr, Bothwell AL. (1993) Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proc. Natl. Acad. Sci. U.S.A. 90: 6806-6810.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6806-6810
    • Khan, K.D.1    Shuai, K.2    Lindwall, G.3    Maher, S.E.4    Darnell J.E., Jr.5    Bothwell, A.L.6
  • 3
    • 0026686488 scopus 로고
    • The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction
    • Fu X-Y, Schindler C, Improta T, Aebersold R, Darnell JE Jr. (1992) The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. U.S.A. 89: 7840-7843.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7840-7843
    • Fu, X.-Y.1    Schindler, C.2    Improta, T.3    Aebersold, R.4    Darnell J.E., Jr.5
  • 4
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91-kD DNA binding protein
    • Shuai K, Schindler C, Prezioso VR, Darnell JE Jr. (1992) Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258: 1808-1812.
    • (1992) Science , vol.258 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell J.E., Jr.4
  • 5
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the interferon α/β signaling pathway
    • Velazquez L, Fellous M, Stark G, Pellegrini S. (1992) A protein tyrosine kinase in the interferon α/β signaling pathway. Cell 70: 313-322.
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellous, M.2    Stark, G.3    Pellegrini, S.4
  • 6
    • 0027494653 scopus 로고
    • The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and gamma signal transduction
    • Muller M, Briscoe J, Laxton C, et al. (1993) The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and gamma signal transduction. Nature 366: 129-135.
    • (1993) Nature , vol.366 , pp. 129-135
    • Muller, M.1    Briscoe, J.2    Laxton, C.3
  • 7
    • 0027914818 scopus 로고
    • Complementation by the protein tyrosine kinase JAK-2 of a mutant cell line defective in the interferon-gamma signal transduction pathway
    • Walting D, Guschin D, Muller M. (1993) Complementation by the protein tyrosine kinase JAK-2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature 366: 166-170.
    • (1993) Nature , vol.366 , pp. 166-170
    • Walting, D.1    Guschin, D.2    Muller, M.3
  • 8
    • 0027742729 scopus 로고
    • Interferon-induced nuclear signaling by Jak protein tyrosine kinases
    • Silvennoinen O, Ihle JN, Schlessinger J, Levy DE. (1993) Interferon-induced nuclear signaling by Jak protein tyrosine kinases. Nature 366: 583-585.
    • (1993) Nature , vol.366 , pp. 583-585
    • Silvennoinen, O.1    Ihle, J.N.2    Schlessinger, J.3    Levy, D.E.4
  • 10
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
    • Heim MH, Kerr IM, Stark GR, Darnell JE Jr. (1995) Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267: 1347-1349.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell J.E., Jr.4
  • 11
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267: 1349-1353.
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell J.E., Jr.5    Yancopoulos, G.D.6
  • 12
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ
    • Shuai K, Stark GR, Kerr IM, Darnell JE Jr. (1993) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261: 1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell J.E., Jr.4
  • 13
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • Shuai K, Horvath CM, Huang LHT, Qureshi SA, Cowburn D, Darnell JE Jr. (1994) Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76: 821-828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Huang, L.H.T.3    Qureshi, S.A.4    Cowburn, D.5    Darnell J.E., Jr.6
  • 15
    • 0029767462 scopus 로고    scopus 로고
    • Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α
    • Bhattacharya S, Eckner R, Grossman S, et al. (1996) Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α. Nature 383: 344-347.
    • (1996) Nature , vol.383 , pp. 344-347
    • Bhattacharya, S.1    Eckner, R.2    Grossman, S.3
  • 17
    • 0031037363 scopus 로고    scopus 로고
    • Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
    • Horvai AE, Xu L, Korzus E, et al. (1997) Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc. Natl. Acad. Sci. U.S.A. 94: 1074-1079.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 1074-1079
    • Horvai, A.E.1    Xu, L.2    Korzus, E.3
  • 18
    • 0032579289 scopus 로고    scopus 로고
    • Differential use of CREB binding protein-coactivator complexes
    • Kurokawa R, Kalafus D, Ogliastro M-H, et al. (1998) Differential use of CREB binding protein-coactivator complexes. Science 279: 700-703.
    • (1998) Science , vol.279 , pp. 700-703
    • Kurokawa, R.1    Kalafus, D.2    Ogliastro, M.-H.3
  • 19
    • 0032579292 scopus 로고    scopus 로고
    • Transcription factor-specific requirements for coactivators and their acetyltransferase functions
    • Korzus E, Torchia J, Rose DW, et al. (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279: 703-707.
    • (1998) Science , vol.279 , pp. 703-707
    • Korzus, E.1    Torchia, J.2    Rose, D.W.3
  • 20
    • 0027443228 scopus 로고
    • A nuclear tyrosine phosphatase downregulates interferon-induced gene expression
    • David M, Grimely PM, Finbloom DS. (1993) A nuclear tyrosine phosphatase downregulates interferon-induced gene expression. Mol. Cell. Biol. 13: 5715-5721.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5715-5721
    • David, M.1    Grimely, P.M.2    Finbloom, D.S.3
  • 21
    • 0028791664 scopus 로고
    • Roles of protein-tyrosine phosphatases in Stat1 alpha-mediated cell signaling
    • Haque SJ, Flati V, Deb A, Williams BR. (1995) Roles of protein-tyrosine phosphatases in Stat1 alpha-mediated cell signaling. J. Biol. Chem. 270: 25709-25714.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25709-25714
    • Haque, S.J.1    Flati, V.2    Deb, A.3    Williams, B.R.4
  • 22
    • 0000413462 scopus 로고    scopus 로고
    • Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway
    • Kim TK, Maniatis T. (1996) Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 273: 1717-1719.
    • (1996) Science , vol.273 , pp. 1717-1719
    • Kim, T.K.1    Maniatis, T.2
  • 23
    • 0029972194 scopus 로고    scopus 로고
    • The rapid inactivation of nuclear tyrosine phosphoryloted Stat1 depends upon a protein tyrosine phosphatase
    • Haspel RL, Salditt-Georgieff M, Darnell JE Jr. (1996) The rapid inactivation of nuclear tyrosine phosphoryloted Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15: 6262-6268.
    • (1996) EMBO J. , vol.15 , pp. 6262-6268
    • Haspel, R.L.1    Salditt-Georgieff, M.2    Darnell J.E., Jr.3
  • 24
    • 0030983549 scopus 로고    scopus 로고
    • Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
    • Yu CL, Burakoff SJ. (1997) Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J. Biol. Chem. 272: 14017-14020.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14017-14020
    • Yu, C.L.1    Burakoff, S.J.2
  • 25
    • 0030956715 scopus 로고    scopus 로고
    • CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
    • Matsumoto A, Masuhara M, Mitsui K, et al. (1997) CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89: 3148-3154.
    • (1997) Blood , vol.89 , pp. 3148-3154
    • Matsumoto, A.1    Masuhara, M.2    Mitsui, K.3
  • 26
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signaling
    • Starr R, Willson TA, Viney EM, et al. (1997) A family of cytokine-inducible inhibitors of signaling. Nature 387: 917-921.
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1    Willson, T.A.2    Viney, E.M.3
  • 27
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • Endo TA, Masuhara M, Yokouchi M, et al. (1997) A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387: 921-924.
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1    Masuhara, M.2    Yokouchi, M.3
  • 28
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • Naka T, Narazaki M, Hirata M, et al. (1997) Structure and function of a new STAT-induced STAT inhibitor. Nature 387: 924-928.
    • (1997) Nature , vol.387 , pp. 924-928
    • Naka, T.1    Narazaki, M.2    Hirata, M.3
  • 29
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • Chung CD, Liao J, Liu B, et al. (1997) Specific inhibition of Stat3 signal transduction by PIAS3. Science 278: 1803-1805.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3
  • 30
    • 0032169599 scopus 로고    scopus 로고
    • Inhibition of Stat1-mediated gene activation by PIAS1
    • Liu B, Liao J, Rao X, et al. (1998) Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. U.S.A. 95: 10626-10631.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 10626-10631
    • Liu, B.1    Liao, J.2    Rao, X.3
  • 31
    • 0028029813 scopus 로고
    • Activation of JAK kinases and STAT proteins by interleukin-2 and Interferon α, but not the T cell antigen receptor, in human T lymphocytes
    • Beadling C, Guschin D, Witthuhn BA, et al. (1994) Activation of JAK kinases and STAT proteins by interleukin-2 and Interferon α, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 13: 5605-5615.
    • (1994) EMBO J. , vol.13 , pp. 5605-5615
    • Beadling, C.1    Guschin, D.2    Witthuhn, B.A.3
  • 32
    • 0028596154 scopus 로고
    • Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes
    • Nielsen M, Svejgaard A, Skov S, Odum N. (1994) Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes. Eur. J. Immunol. 24: 3082-3086.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3082-3086
    • Nielsen, M.1    Svejgaard, A.2    Skov, S.3    Odum, N.4
  • 34
    • 0028964916 scopus 로고
    • Identification and purification of human Stat proteins activated in response to interleukin-2
    • Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL. (1995) Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2: 321-329.
    • (1995) Immunity , vol.2 , pp. 321-329
    • Hou, J.1    Schindler, U.2    Henzel, W.J.3    Wong, S.C.4    McKnight, S.L.5
  • 35
    • 0032960199 scopus 로고    scopus 로고
    • IL-2 induces STAT4 activation in primary NK cells and NK cell lines but not in T cells
    • Wang KS, Ritz J, Frank DA. (1999) IL-2 induces STAT4 activation in primary NK cells and NK cell lines but not in T cells. J. Immunol. 162: 299-304.
    • (1999) J. Immunol. , vol.162 , pp. 299-304
    • Wang, K.S.1    Ritz, J.2    Frank, D.A.3
  • 36
    • 0027446710 scopus 로고
    • Tyrosine phosphorylation of DNA binding proteins by multiple cytokines
    • Larner AC, David M, Feldman GM, et al. (1993) Tyrosine phosphorylation of DNA binding proteins by multiple cytokines. Science 261: 1730-1733.
    • (1993) Science , vol.261 , pp. 1730-1733
    • Larner, A.C.1    David, M.2    Feldman, G.M.3
  • 37
    • 0027688778 scopus 로고
    • Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4
    • Kotanides H, Reich NC. (1993) Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262: 1265-1267.
    • (1993) Science , vol.262 , pp. 1265-1267
    • Kotanides, H.1    Reich, N.C.2
  • 38
    • 0028262965 scopus 로고
    • STF-IL-4: A novel IL-4-induced signal transducing factor
    • Schindler C, Kashleva H, Pernis A, Pine R, Rothman P. (1994) STF-IL-4: a novel IL-4-induced signal transducing factor. EMBO J. 13: 1350-1356.
    • (1994) EMBO J. , vol.13 , pp. 1350-1356
    • Schindler, C.1    Kashleva, H.2    Pernis, A.3    Pine, R.4    Rothman, P.5
  • 39
    • 0027441586 scopus 로고
    • Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
    • Wegenka UM, Buschmann J, Lutticken C, Heinrich PC, Horn F. (1993) Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 13: 276-288.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 276-288
    • Wegenka, U.M.1    Buschmann, J.2    Lutticken, C.3    Heinrich, P.C.4    Horn, F.5
  • 40
    • 0028211553 scopus 로고
    • The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements
    • Yuan J, Wegenka UM, Lutticken C, et al. (1994) The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements. Mol. Cell. Biol. 14: 1657-1668.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1657-1668
    • Yuan, J.1    Wegenka, U.M.2    Lutticken, C.3
  • 41
    • 0029116336 scopus 로고
    • Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes
    • Bacon CM, Petricoin EFI, Ortaldo JR, et al. (1995) Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 92: 7307-7311.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 7307-7311
    • Bacon, C.M.1    Petricoin, E.F.I.2    Ortaldo, J.R.3
  • 42
    • 0028274299 scopus 로고
    • The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family
    • Wegenka UM, Lutticken C, Buschmann J, et al. (1994) The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol. Cell. Biol. 14: 186-196.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 186-196
    • Wegenka, U.M.1    Lutticken, C.2    Buschmann, J.3
  • 43
    • 0028819918 scopus 로고
    • Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts
    • Lowe C, Gillespie GA, Pike JW. (1995) Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts. J. Bone Min. Res. 10: 1644-1650.
    • (1995) J. Bone Min. Res. , vol.10 , pp. 1644-1650
    • Lowe, C.1    Gillespie, G.A.2    Pike, J.W.3
  • 44
    • 0028785045 scopus 로고
    • Differences in nuclear signaling by leukemia inhibitory factor and interferon-gamma: The role of STAT proteins in regulating vasoactive intestinal peptide gene expression
    • Symes AJ, Corpus L, Fink JS. (1995) Differences in nuclear signaling by leukemia inhibitory factor and interferon-gamma: the role of STAT proteins in regulating vasoactive intestinal peptide gene expression. J. Neurochem. 65: 1926-1933.
    • (1995) J. Neurochem. , vol.65 , pp. 1926-1933
    • Symes, A.J.1    Corpus, L.2    Fink, J.S.3
  • 45
    • 0029091195 scopus 로고
    • STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
    • Boulton TG, Zhong Z, Wen Z, Darnell JE Jr, Stahl N, Yancopoulos GD. (1995) STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. U.S.A. 92: 6915-6919.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 6915-6919
    • Boulton, T.G.1    Zhong, Z.2    Wen, Z.3    Darnell J.E., Jr.4    Stahl, N.5    Yancopoulos, G.D.6
  • 46
    • 0029002074 scopus 로고
    • Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter
    • Zhao Y, Nichols JE, Bulun SE, Mendelson CR, Simpson ER. (1995) Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J. Biol. Chem. 270: 16449-16457.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16449-16457
    • Zhao, Y.1    Nichols, J.E.2    Bulun, S.E.3    Mendelson, C.R.4    Simpson, E.R.5
  • 47
    • 0029072586 scopus 로고
    • Signal transduction by the receptors for thrombopoietin (c-mpl) and interleukin-3 in hematopoietic and nonhematopoietic cells
    • Morella KK, Bruno E, Kumaki S, et al. (1995) Signal transduction by the receptors for thrombopoietin (c-mpl) and interleukin-3 in hematopoietic and nonhematopoietic cells. Blood 86: 557-571.
    • (1995) Blood , vol.86 , pp. 557-571
    • Morella, K.K.1    Bruno, E.2    Kumaki, S.3
  • 48
    • 0029010473 scopus 로고
    • Thrombopoietin activates a STAT5-like factor in hematopoietic cells
    • Pallard C, Gouilleux F, Benit L. et al. (1995) Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J. 14: 2847-2856.
    • (1995) EMBO J. , vol.14 , pp. 2847-2856
    • Pallard, C.1    Gouilleux, F.2    Benit, L.3
  • 49
    • 0029117375 scopus 로고
    • The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosinc kinases
    • Sattler M, Durstin MA, Frank DA, et al. (1995) The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosinc kinases. Exp. Hematol. 23: 1040-1048.
    • (1995) Exp. Hematol. , vol.23 , pp. 1040-1048
    • Sattler, M.1    Durstin, M.A.2    Frank, D.A.3
  • 50
    • 0027371337 scopus 로고
    • Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation
    • Silvennoinen O, Schindler C, Schlessinger J, Levy DE. (1993) Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science 261: 1736-1739.
    • (1993) Science , vol.261 , pp. 1736-1739
    • Silvennoinen, O.1    Schindler, C.2    Schlessinger, J.3    Levy, D.E.4
  • 51
    • 0029763756 scopus 로고    scopus 로고
    • Formation of STAT5-containing DNA binding complexes in response to colony-stimulating factor-1 and platelet-derived growth factor
    • Novak U, Mui A, Miyajima A, Paradiso L. (1996) Formation of STAT5-containing DNA binding complexes in response to colony-stimulating factor-1 and platelet-derived growth factor. J. Biol. Chem. 271: 18350-18354.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18350-18354
    • Novak, U.1    Mui, A.2    Miyajima, A.3    Paradiso, L.4
  • 52
    • 0028806173 scopus 로고
    • Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells
    • Tweardy DJ, Wright TM, Ziegler SF, et al. (1995) Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood 86: 4408-4416.
    • (1995) Blood , vol.86 , pp. 4408-4416
    • Tweardy, D.J.1    Wright, T.M.2    Ziegler, S.F.3
  • 53
    • 0029796380 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells
    • Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ. (1996) Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells. Blood 88: 2442-2448.
    • (1996) Blood , vol.88 , pp. 2442-2448
    • Chakraborty, A.1    White, S.M.2    Schaefer, T.S.3    Ball, E.D.4    Dyer, K.F.5    Tweardy, D.J.6
  • 54
    • 0027179365 scopus 로고
    • Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
    • Argetsinger LS, Campbell GS, Yang X, et al. (1993) Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74: 237-244.
    • (1993) Cell , vol.74 , pp. 237-244
    • Argetsinger, L.S.1    Campbell, G.S.2    Yang, X.3
  • 55
    • 0027939930 scopus 로고
    • Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor
    • Meyer DJ, Campbell GS, Cochran BH, et al. (1994) Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor. J. Biol. Chem. 269: 4701-4704.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4701-4704
    • Meyer, D.J.1    Campbell, G.S.2    Cochran, B.H.3
  • 56
    • 0028605958 scopus 로고
    • STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines
    • Symes A, Lewis S, Corpus L, Rajan P, Hyman SE, Fink JS. (1994) STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Mol. Endocrinol. 8: 1750-1763.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1750-1763
    • Symes, A.1    Lewis, S.2    Corpus, L.3    Rajan, P.4    Hyman, S.E.5    Fink, J.S.6
  • 57
    • 0029066310 scopus 로고
    • Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity
    • Gouilleux F, Pallard C, Dusanter-Fourt I, et al. (1995) Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J. 14: 2005-2013.
    • (1995) EMBO J. , vol.14 , pp. 2005-2013
    • Gouilleux, F.1    Pallard, C.2    Dusanter-Fourt, I.3
  • 58
    • 0027993605 scopus 로고
    • Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
    • Gouilleux F, Wakao H, Mundt M, Groner B. (1994) Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 13: 4361-4369.
    • (1994) EMBO J. , vol.13 , pp. 4361-4369
    • Gouilleux, F.1    Wakao, H.2    Mundt, M.3    Groner, B.4
  • 59
    • 0027941433 scopus 로고
    • Activation of receptor-associated tyrosine kinase JAK2 by prolactin
    • Rui H, Kirken RA, Farrar WL. (1994) Activation of receptor-associated tyrosine kinase JAK2 by prolactin. J. Biol Chem. 269: 5364-5368.
    • (1994) J. Biol Chem. , vol.269 , pp. 5364-5368
    • Rui, H.1    Kirken, R.A.2    Farrar, W.L.3
  • 60
    • 0027771191 scopus 로고
    • Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus
    • Bonni A, Frank DA, Schindler C, Greenberg ME. (1993) Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science 262: 1575-1579.
    • (1993) Science , vol.262 , pp. 1575-1579
    • Bonni, A.1    Frank, D.A.2    Schindler, C.3    Greenberg, M.E.4
  • 61
    • 0032521284 scopus 로고    scopus 로고
    • Induction of Jak/STAT signaling by activation of the type 1 TNF receptor
    • Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB. (1998) Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J. Immunol. 160: 2742-2750.
    • (1998) J. Immunol. , vol.160 , pp. 2742-2750
    • Guo, D.1    Dunbar, J.D.2    Yang, C.H.3    Pfeffer, L.M.4    Donner, D.B.5
  • 62
    • 0028135399 scopus 로고
    • Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the ATIA receptor activates transcription factor-Stat91 and/or a related protein
    • Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM, Baker KM. (1994) Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the ATIA receptor activates transcription factor-Stat91 and/or a related protein. J. Biol. Chem. 269: 31443-31449.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31443-31449
    • Bhat, G.J.1    Thekkumkara, T.J.2    Thomas, W.G.3    Conrad, K.M.4    Baker, K.M.5
  • 63
    • 0029019246 scopus 로고
    • Direct stimulation of Jak/STAT pathway by the angiotensin II AT, receptor
    • Marrero MB, Schieffer B, Paxton WG, et al. (1995) Direct stimulation of Jak/STAT pathway by the angiotensin II AT, receptor. Nature 375: 247-250.
    • (1995) Nature , vol.375 , pp. 247-250
    • Marrero, M.B.1    Schieffer, B.2    Paxton, W.G.3
  • 64
    • 0032473935 scopus 로고    scopus 로고
    • Src kinases and not JAKs activate STATs during IL-3 induced mycloid cell proliferation
    • Chaturvedi P, Reddy MV, Reddy EP. (1998) Src kinases and not JAKs activate STATs during IL-3 induced mycloid cell proliferation. Oncogene 16: 1749-1758.
    • (1998) Oncogene , vol.16 , pp. 1749-1758
    • Chaturvedi, P.1    Reddy, M.V.2    Reddy, E.P.3
  • 65
    • 0030697510 scopus 로고    scopus 로고
    • The Bmx tyrosine kinase induces activation of the Slat signaling pathway, which is specifically inhibited by protein kinase Cδ
    • Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. (1997) The Bmx tyrosine kinase induces activation of the Slat signaling pathway, which is specifically inhibited by protein kinase Cδ. Blood 90: 4341-4353.
    • (1997) Blood , vol.90 , pp. 4341-4353
    • Saharinen, P.1    Ekman, N.2    Sarvas, K.3    Parker, P.4    Alitalo, K.5    Silvennoinen, O.6
  • 66
    • 0032030688 scopus 로고    scopus 로고
    • Tec and Jak2 cooperate to mediate cytokine-driven activation of c-fos transcription
    • Yamashita Y, Walanabe S, Miyazato A, et al. (1998) Tec and Jak2 cooperate to mediate cytokine-driven activation of c-fos transcription. Blood 91: 1496-1507.
    • (1998) Blood , vol.91 , pp. 1496-1507
    • Yamashita, Y.1    Walanabe, S.2    Miyazato, A.3
  • 67
    • 0027372119 scopus 로고
    • Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
    • Fu X, Zhang J. (1993) Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. Cell 74: 1135-1145.
    • (1993) Cell , vol.74 , pp. 1135-1145
    • Fu, X.1    Zhang, J.2
  • 68
    • 0027385186 scopus 로고
    • Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei
    • Ruff-Jamison S, Chen K, Cohen S. (1993) Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science 261: 1733-1736.
    • (1993) Science , vol.261 , pp. 1733-1736
    • Ruff-Jamison, S.1    Chen, K.2    Cohen, S.3
  • 69
    • 0027496114 scopus 로고
    • A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
    • Sadowski HB, Shuai K, Darnell JE Jr, Gilman MZ. (1993) A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 261: 1739-1744.
    • (1993) Science , vol.261 , pp. 1739-1744
    • Sadowski, H.B.1    Shuai, K.2    Darnell J.E., Jr.3    Gilman, M.Z.4
  • 70
    • 0030447148 scopus 로고    scopus 로고
    • In vitro activation of Stat3 by epidermal growth factor receptor kinase
    • Park OK, Schaeffer TS, Nathans D. (1996) In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc. Natl. Acad. Sci. U.S.A. 93: 13704-13708.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 13704-13708
    • Park, O.K.1    Schaeffer, T.S.2    Nathans, D.3
  • 71
    • 0029656001 scopus 로고    scopus 로고
    • Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
    • Leaman DW, Pisharody S, Flickinger TW, et al. (1996) Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cel. Biol. 16: 369-375.
    • (1996) Mol Cel. Biol. , vol.16 , pp. 369-375
    • Leaman, D.W.1    Pisharody, S.2    Flickinger, T.W.3
  • 73
    • 0029891085 scopus 로고    scopus 로고
    • Antigen-receptor engagement in 8 cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site
    • Karras JG, Wang Z, Coniglio SJ, Frank DA, Rothstein TL. (1996) Antigen-receptor engagement in 8 cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site. J. Immunol. 157: 39-47.
    • (1996) J. Immunol. , vol.157 , pp. 39-47
    • Karras, J.G.1    Wang, Z.2    Coniglio, S.J.3    Frank, D.A.4    Rothstein, T.L.5
  • 74
    • 4243388647 scopus 로고    scopus 로고
    • Activation of T cells through CD2 leads to the delayed and prolonged activation of STAT1
    • Frank DA, Mahajan S, Ritz J. (1998) Activation of T cells through CD2 leads to the delayed and prolonged activation of STAT1. Blood 92: 701a.
    • (1998) Blood , vol.92
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 75
  • 76
    • 0033135256 scopus 로고    scopus 로고
    • Hematopoietic growth factors signal through the formation of reactive oxygen species
    • Sattler M, Winkler T, Verma S, et al. (1999) Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 93: 2928-2935.
    • (1999) Blood , vol.93 , pp. 2928-2935
    • Sattler, M.1    Winkler, T.2    Verma, S.3
  • 77
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong z, Darnell JE Jr. (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell J.E., Jr.3
  • 78
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of Stat-promoter complexes
    • Zhang X, Blenis J, Li H-C, Schindler C, Chen-Kiang S. (1995) Requirement of serine phosphorylation for formation of Stat-promoter complexes. Science 267: 1990-1994.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.-C.3    Schindler, C.4    Chen-Kiang, S.5
  • 79
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • Wen Z, Darnell JE Jr. (1997) Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucl. Acids Res. 25: 2062-2067.
    • (1997) Nucl. Acids Res. , vol.25 , pp. 2062-2067
    • Wen, Z.1    Darnell J.E., Jr.2
  • 80
    • 0032746702 scopus 로고    scopus 로고
    • Requirement of Rac-1 mediated p38 and JNK signaling for Stat3 transcriptional activity induced by the Src oncoprotein
    • (in press)
    • Turkson J, Bowman T, Adnane J, et al. (1999) Requirement of Rac-1 mediated p38 and JNK signaling for Stat3 transcriptional activity induced by the Src oncoprotein. Mol. Cell. Biol. (in press).
    • (1999) Mol. Cell. Biol.
    • Turkson, J.1    Bowman, T.2    Adnane, J.3
  • 81
    • 0033561559 scopus 로고    scopus 로고
    • The functional synergy between IL-12 and IL-2 involves p38 MAP kinase and is associated with the augmentation of STAT serine phosphorylation
    • Gollob JA, Schnipper CP, Murphy EA, Ritz J, Frank DA. (1999) The functional synergy between IL-12 and IL-2 involves p38 MAP kinase and is associated with the augmentation of STAT serine phosphorylation. J. Immunol. 162: 4472-4481.
    • (1999) J. Immunol. , vol.162 , pp. 4472-4481
    • Gollob, J.A.1    Schnipper, C.P.2    Murphy, E.A.3    Ritz, J.4    Frank, D.A.5
  • 82
    • 0029961352 scopus 로고    scopus 로고
    • Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony stimulating factor
    • Rajotte D, Sadowski HB, Haman A, et al. (1996) Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony stimulating factor. Blood 88: 2906-2916.
    • (1996) Blood , vol.88 , pp. 2906-2916
    • Rajotte, D.1    Sadowski, H.B.2    Haman, A.3
  • 83
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain STAT1 and STAT3 constitulively phosphorylated on serine residues
    • Frank DA, Mahajan S, Ritz J. (1997) B lymphocytes from patients with chronic lymphocytic leukemia contain STAT1 and STAT3 constitulively phosphorylated on serine residues. J. Clin. Invest. 100: 3140-3148.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 84
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle JN. (1996) STATs: signal transducers and activators of transcription. Cell 84: 331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 85
    • 0028921573 scopus 로고
    • Jaks and stats in signaling by the cytokine receptor superfamily
    • Ihle JN, Kerr IM. (1995) Jaks and stats in signaling by the cytokine receptor superfamily. Trends Genet. 11: 69-74.
    • (1995) Trends Genet. , vol.11 , pp. 69-74
    • Ihle, J.N.1    Kerr, I.M.2
  • 87
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JE Jr. (1997) STATs and gene regulation. Science 277: 1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell J.E., Jr.1
  • 88
    • 0028234529 scopus 로고
    • Jak-STAT pathway and transcription activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IM, Stark GR. (1994) Jak-STAT pathway and transcription activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1420.
    • (1994) Science , vol.264 , pp. 1415-1420
    • Darnell J.E., Jr.1    Kerr, I.M.2    Stark, G.R.3
  • 89
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: One gene encodes the 91 and 84 kDa ISGF-3 proteins that are activated by interferon-α
    • Schindler C, Fu X-Y, Improta T, Acbersold R, Darnell JE Jr. (1992) Proteins of transcription Factor ISGF-3: one gene encodes the 91 and 84 kDa ISGF-3 proteins that are activated by interferon-α. Proc. Natl. Acad. Sci. U.S.A. 89: 7836-7839.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.-Y.2    Improta, T.3    Acbersold, R.4    Darnell J.E., Jr.5
  • 90
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3
    • Schaefer TS, Sanders LK, Nathans D. (1995) Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc. Natl. Acad. Sci. U.S.A. 92: 9097-9101.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 91
    • 0029790559 scopus 로고    scopus 로고
    • Requirements for interleukin-4-induced gene expression and functional characterization of Stat6
    • Mikita T, Campbell D, Wu P, Williamson K, Schindler U. (1996) Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16: 5811-5820.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5811-5820
    • Mikita, T.1    Campbell, D.2    Wu, P.3    Williamson, K.4    Schindler, U.5
  • 92
    • 0028917885 scopus 로고
    • Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: Regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50
    • Delphin S, Stavenezer J. (1995) Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50. J. Exp. Med. 181: 181-192.
    • (1995) J. Exp. Med. , vol.181 , pp. 181-192
    • Delphin, S.1    Stavenezer, J.2
  • 94
    • 0029851231 scopus 로고    scopus 로고
    • Functional interactions between Stat5 and the glucocorticoid receptor
    • Stocklin E, Wissler M, Gouilleux F, Groner B. (1996) Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383: 726-728.
    • (1996) Nature , vol.383 , pp. 726-728
    • Stocklin, E.1    Wissler, M.2    Gouilleux, F.3    Groner, B.4
  • 95
    • 0025639009 scopus 로고
    • The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
    • Wagner BJ, Hayes TE, Hoban CJ, Cochran BH. (1990) The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9: 4477-4484.
    • (1990) EMBO J. , vol.9 , pp. 4477-4484
    • Wagner, B.J.1    Hayes, T.E.2    Hoban, C.J.3    Cochran, B.H.4
  • 96
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response 10 epidermal growth factor and imerleukin-6
    • Zhong Z, Wen Z, Darnell Jr JE. (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response 10 epidermal growth factor and imerleukin-6. Science 264: 95-98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell J.E., Jr.3
  • 97
    • 0029070907 scopus 로고
    • Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver
    • Ruff-Jamison S, Chen K, Cohen S. (1995) Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver. Proc. Natl. Acad. Sci. U.S.A. 92: 4215-4218.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 4215-4218
    • Ruff-Jamison, S.1    Chen, K.2    Cohen, S.3
  • 98
    • 0028085525 scopus 로고
    • Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver
    • Ruff-Jamison S, Zhong Z, Wen Z, Chen K, Darnell JE Jr, Cohen S. (1994) Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. J. Biol. Chem. 269: 21933-21935.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21933-21935
    • Ruff-Jamison, S.1    Zhong, Z.2    Wen, Z.3    Chen, K.4    Darnell J.E., Jr.5    Cohen, S.6
  • 99
    • 0029892399 scopus 로고    scopus 로고
    • Suppression of interleukin3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation
    • Mui AL, Wakao H, Kinoshita T, Kitamura T, Miyajima A. (1996) Suppression of interleukin3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 15: 2425-2433.
    • (1996) EMBO J. , vol.15 , pp. 2425-2433
    • Mui, A.L.1    Wakao, H.2    Kinoshita, T.3    Kitamura, T.4    Miyajima, A.5
  • 100
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stal1 activation for epidermal growth factor-mediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, et al. (1998) Requirement of Stat3 but not Stal1 activation for epidermal growth factor-mediated cell growth in vitro. J. Clin. Invest. 102: 1385-1392.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3
  • 101
    • 0029738371 scopus 로고    scopus 로고
    • Interferon-γ-mediated activation of STAT1α regulates growth factor-induced mitogenesis
    • Marra F, Choudhury GG, Abboud HE. (1996) Interferon-γ-mediated activation of STAT1α regulates growth factor-induced mitogenesis. J. Clin. Invest. 98: 1218-1230.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1218-1230
    • Marra, F.1    Choudhury, G.G.2    Abboud, H.E.3
  • 103
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • Wakao H, Gouilleux F, Groner B. (1994) Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13: 2182-2191.
    • (1994) EMBO J. , vol.13 , pp. 2182-2191
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 104
    • 0027372064 scopus 로고
    • Mechanism and regulation of immunoglobulin isotype switching
    • Coffman RL, Lebman DA, Rothman P. (1993) Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54: 229.
    • (1993) Adv. Immunol. , vol.54 , pp. 229
    • Coffman, R.L.1    Lebman, D.A.2    Rothman, P.3
  • 105
    • 0025942519 scopus 로고
    • Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsiveelement located at the promoter of germ line epsilon transcripts
    • Rothman P, Li SC, Gorham B, Glimcher L, Alt F, Boothby M. (1991) Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsiveelement located at the promoter of germ line epsilon transcripts. Mol. Cell. Biol. 11: 5551-5561.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5551-5561
    • Rothman, P.1    Li, S.C.2    Gorham, B.3    Glimcher, L.4    Alt, F.5    Boothby, M.6
  • 106
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. (1996) Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4: 313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 107
    • 0032473555 scopus 로고    scopus 로고
    • Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
    • Miller DM, Rahill BM, Boss JM, et al. (1998) Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J. Exp. Med. 187: 675-683.
    • (1998) J. Exp. Med. , vol.187 , pp. 675-683
    • Miller, D.M.1    Rahill, B.M.2    Boss, J.M.3
  • 108
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun Y-L, Hocy T, Grusby MJ. (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382: 174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hocy, T.3    Grusby, M.J.4
  • 109
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated response of natural killer and T cells
    • Thierfelder WE, van Deursen JM, Yamamoto K, et al. (1996) Requirement for Stat4 in interleukin-12-mediated response of natural killer and T cells. Nature 382: 171-174.
    • (1996) Nature , vol.382 , pp. 171-174
    • Thierfelder, W.E.1    Van Deursen, J.M.2    Yamamoto, K.3
  • 110
    • 0030708523 scopus 로고    scopus 로고
    • Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
    • Bonni A, Sun Y, Nadal-Vicens M, et al. (1997) Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278: 477-483.
    • (1997) Science , vol.278 , pp. 477-483
    • Bonni, A.1    Sun, Y.2    Nadal-Vicens, M.3
  • 112
    • 0030851722 scopus 로고    scopus 로고
    • Involvement of STAT3 in granulocyte colony-stimulating factor-induced differentiation of myeloid cells
    • Shimozaki K, Nakajima K, Hirano T, Nagata S. (1997) Involvement of STAT3 in granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J. Biol. Chem. 272: 25184-25189.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25184-25189
    • Shimozaki, K.1    Nakajima, K.2    Hirano, T.3    Nagata, S.4
  • 113
    • 0032518375 scopus 로고    scopus 로고
    • Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
    • Boccaccio C, Ando M, Tamagnone L, et al. (1998) Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391: 285-288.
    • (1998) Nature , vol.391 , pp. 285-288
    • Boccaccio, C.1    Ando, M.2    Tamagnone, L.3
  • 114
    • 0030659512 scopus 로고    scopus 로고
    • Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
    • Kumar A, Commane M, Flickinger TW, Horvath CM, Stark GR. (1997) Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278: 1630-1632.
    • (1997) Science , vol.278 , pp. 1630-1632
    • Kumar, A.1    Commane, M.2    Flickinger, T.W.3    Horvath, C.M.4    Stark, G.R.5
  • 115
    • 0032125574 scopus 로고    scopus 로고
    • IFN-γ induces cell growth inhibition by fas-mediated apoptosis: Requirement of STAT1 protein for up-regulation of Fas and FasL expression
    • Xu X, Fu X-Y, Plate J, Chong AS-F. (1998) IFN-γ induces cell growth inhibition by fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res. 58: 2832-2837.
    • (1998) Cancer Res. , vol.58 , pp. 2832-2837
    • Xu, X.1    Fu, X.-Y.2    Plate, J.3    Chong, A.S.-F.4
  • 116
    • 0032525262 scopus 로고    scopus 로고
    • Activation of Stat-3 is involved in the induction of apoptosis after ligation of major histocompatibility complex class I molecules on human Jurkat T cells
    • Skov S, Nielsen M, Bregenholt S, Odum N, Claesson MH. (1998) Activation of Stat-3 is involved in the induction of apoptosis after ligation of major histocompatibility complex class I molecules on human Jurkat T cells. Blood 91: 3566-3573.
    • (1998) Blood , vol.91 , pp. 3566-3573
    • Skov, S.1    Nielsen, M.2    Bregenholt, S.3    Odum, N.4    Claesson, M.H.5
  • 117
    • 0001504743 scopus 로고    scopus 로고
    • The chemoprotectant butyrate downregulates IL-6 induced signaling events in colorectal carcinoma cells
    • Frank DA, Mahajan S, Yuan H. (1999) The chemoprotectant butyrate downregulates IL-6 induced signaling events in colorectal carcinoma cells. Proc. Amer. Assoc. Cancer Res. 40: 318.
    • (1999) Proc. Amer. Assoc. Cancer Res. , vol.40 , pp. 318
    • Frank, D.A.1    Mahajan, S.2    Yuan, H.3
  • 118
    • 0030912739 scopus 로고    scopus 로고
    • Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes
    • Fujio Y, Kunisada K, Hirota H, Yamauchi-Takihara K, Kishimoto T. (1997) Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes. J. Clin. Invest. 99: 2898-2905.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2898-2905
    • Fujio, Y.1    Kunisada, K.2    Hirota, H.3    Yamauchi-Takihara, K.4    Kishimoto, T.5
  • 119
    • 0027957316 scopus 로고
    • Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
    • Binari R, Perrimon N. (1994) Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev. 8: 300-312.
    • (1994) Genes Dev. , vol.8 , pp. 300-312
    • Binari, R.1    Perrimon, N.2
  • 120
    • 0030040691 scopus 로고    scopus 로고
    • Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to mammalian STATs
    • Hou XS, Melnick MB, Perrimon N. (1996) marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to mammalian STATs. Cell 84: 411-419.
    • (1996) Cell , vol.84 , pp. 411-419
    • Hou, X.S.1    Melnick, M.B.2    Perrimon, N.3
  • 121
    • 0001514956 scopus 로고    scopus 로고
    • Identification of a Stat gene that functions in Drosaphila development
    • Yan R, Small S, Desplan C, Dearolf CR, Darnell JE Jr. (1996) Identification of a Stat gene that functions in Drosaphila development. Cell 84: 421-430.
    • (1996) Cell , vol.84 , pp. 421-430
    • Yan, R.1    Small, S.2    Desplan, C.3    Dearolf, C.R.4    Darnell J.E., Jr.5
  • 122
    • 0028938172 scopus 로고
    • Tum-1 Jak kinase causes leukemia-like hematopoietic defects
    • Tum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 14: 1412-1420.
    • (1995) EMBO J. , vol.14 , pp. 1412-1420
    • Luo, H.1    Hanratty, W.P.2    Dearolf, C.R.3
  • 123
    • 0029031668 scopus 로고
    • Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
    • Harrison DA, Binari R, Nahrenini TS, Gilman M, Perrimon N. (1995) Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14: 2857-2865.
    • (1995) EMBO J. , vol.14 , pp. 2857-2865
    • Harrison, D.A.1    Binari, R.2    Nahrenini, T.S.3    Gilman, M.4    Perrimon, N.5
  • 124
    • 13344279401 scopus 로고    scopus 로고
    • STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
    • Gouilleux-Gruart V, Gouilleux F, Desaint C, et al. (1996) STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87: 1692-1697.
    • (1996) Blood , vol.87 , pp. 1692-1697
    • Gouilleux-Gruart, V.1    Gouilleux, F.2    Desaint, C.3
  • 125
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt RM, Egen C, Wehinger J, et al. (1996) Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88: 809-816.
    • (1996) Blood , vol.88 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3
  • 126
    • 0032528191 scopus 로고    scopus 로고
    • Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts
    • Xia Z, Baer MR, Block AW, Baumann H, Wetzler M. (1998) Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts. Cancer Res. 58: 3173-3180.
    • (1998) Cancer Res. , vol.58 , pp. 3173-3180
    • Xia, Z.1    Baer, M.R.2    Block, A.W.3    Baumann, H.4    Wetzler, M.5
  • 127
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell PC, Hungerford DA. (1960) A minute chromosome in human chronic granulocytic leukemia. Science 132: 1497-1499.
    • (1960) Science , vol.132 , pp. 1497-1499
    • Nowell, P.C.1    Hungerford, D.A.2
  • 128
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa banding
    • Rowley JD. (1973) A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa banding. Nature 243: 290-291.
    • (1973) Nature , vol.243 , pp. 290-291
    • Rowley, J.D.1
  • 129
    • 0021674862 scopus 로고
    • An alteration of the human c-abl protein in K562 unmasks associated tyrosine kinase activity
    • Konopka JB, Watanabe SM, Witte ON. (1984) An alteration of the human c-abl protein in K562 unmasks associated tyrosine kinase activity. Cell 37: 1035-1042.
    • (1984) Cell , vol.37 , pp. 1035-1042
    • Konopka, J.B.1    Watanabe, S.M.2    Witte, O.N.3
  • 130
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukemia
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E. (1985) Fused transcript of abl and bcr genes in chronic myelogenous leukemia. Nature 315: 550-554.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 131
    • 0026608119 scopus 로고
    • Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro
    • Gishizky ML, Witte ON. (1992) Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro. Science 256: 836-839.
    • (1992) Science , vol.256 , pp. 836-839
    • Gishizky, M.L.1    Witte, O.N.2
  • 132
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. (1990) Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 247: 824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 133
    • 0001044842 scopus 로고
    • Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein
    • Daley GQ, Baltimore D. (1988) Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc. Natl. Acad. Sci. U.S.A. 85: 9312-9316.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 9312-9316
    • Daley, G.Q.1    Baltimore, D.2
  • 134
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA-binding activity of STAT proteins in hematopoietic cell lines transformed by Bcr/Abl
    • Carlesso N, Frank DA, Griffin JD. (1996) Tyrosyl phosphorylation and DNA-binding activity of STAT proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med 183: 811-820.
    • (1996) J. Exp. Med , vol.183 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 135
    • 0029796725 scopus 로고    scopus 로고
    • BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats
    • Frank DA, Varticovski L. (1996) BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 10: 1724-1730.
    • (1996) Leukemia , vol.10 , pp. 1724-1730
    • Frank, D.A.1    Varticovski, L.2
  • 136
    • 0000506439 scopus 로고    scopus 로고
    • RCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
    • RCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J. Biol. Chem. 271: 31704-31710.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31704-31710
    • Ilaria R.L., Jr.1    Van Etten, R.A.2
  • 137
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Halpern J, ten Hoevc J, Rao X, Sawyers CL. (1996) Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13: 247-254.
    • (1996) Oncogene , vol.13 , pp. 247-254
    • Shuai, K.1    Halpern, J.2    Ten Hoevc, J.3    Rao, X.4    Sawyers, C.L.5
  • 138
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
    • Chai SK, Nichols GL, Rothman P. (1997) Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J. Immunol. 159: 4720-4728.
    • (1997) J. Immunol. , vol.159 , pp. 4720-4728
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 139
    • 0023753576 scopus 로고
    • The molecular genetics of Philadelphia chromosome-positive leukemias
    • Kurzrock R, Gutterman J, Talpaz M. (1988) The molecular genetics of Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 319: 990-998.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 990-998
    • Kurzrock, R.1    Gutterman, J.2    Talpaz, M.3
  • 140
    • 4243771588 scopus 로고    scopus 로고
    • STAT5 activation by Bcr/Abl is dependent on its intact SH3 and SH2 domains and is required for leukemogenesis
    • Nieborowska-Skorska M, Wasik MA, Salomoni P, Kitamura T, Calabretta B, Skorski T. (1998) STAT5 activation by Bcr/Abl is dependent on its intact SH3 and SH2 domains and is required for leukemogenesis. Blood 92: 91a.
    • (1998) Blood , vol.92
    • Nieborowska-Skorska, M.1    Wasik, M.A.2    Salomoni, P.3    Kitamura, T.4    Calabretta, B.5    Skorski, T.6
  • 141
    • 0028822481 scopus 로고
    • Chronic lymphocytic leukernia
    • Rozman C, Montserrat E. (1995) Chronic lymphocytic leukernia. New Engl. J. Med. 333: 1052-1057.
    • (1995) New Engl. J. Med. , vol.333 , pp. 1052-1057
    • Rozman, C.1    Montserrat, E.2
  • 142
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin J-X. (1995) The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2: 331-339.
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.-X.1
  • 143
    • 0026602154 scopus 로고
    • Regulation of B-cell growth and immunoglobulin gene transcription by interleukin-6
    • Tanner JE, Tosato G. (1992) Regulation of B-cell growth and immunoglobulin gene transcription by interleukin-6. Blood 79: 452-459.
    • (1992) Blood , vol.79 , pp. 452-459
    • Tanner, J.E.1    Tosato, G.2
  • 144
    • 0030978808 scopus 로고    scopus 로고
    • Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrpbostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
    • Nielsen M, Kaltoft K, Nordahl M, et al. (1997) Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrpbostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc. Natl. Acad. Sci. U.S.A. 94: 6764-6769.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 6764-6769
    • Nielsen, M.1    Kaltoft, K.2    Nordahl, M.3
  • 145
    • 0029834676 scopus 로고    scopus 로고
    • Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
    • Zhang Q, Nowak I, Vonderheid EC, et al. (1996) Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc. Natl. Acad. Sci. U.S.A. 93: 9148-9153.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9148-9153
    • Zhang, Q.1    Nowak, I.2    Vonderheid, E.C.3
  • 146
    • 0029005549 scopus 로고
    • Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
    • Migone T-S, Lin J-X, Cereseto A, et al. (1995) Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269: 79-81.
    • (1995) Science , vol.269 , pp. 79-81
    • Migone, T.-S.1    Lin, J.-X.2    Cereseto, A.3
  • 147
    • 13144276369 scopus 로고    scopus 로고
    • Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
    • Takemoto S, Mulloy JC, Cereseto A, et al. (1997) Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc. Natl. Acad. Sci. U.S.A. 94: 13897-13902.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 13897-13902
    • Takemoto, S.1    Mulloy, J.C.2    Cereseto, A.3
  • 148
    • 0029128045 scopus 로고
    • Constitutive activation of different Jak kinases in human T cell leukemia virus type 1 (HTLV-I) tax protein or virus-transformed cells, J
    • Xu X, Kang SH, Heidenreich O, Okerholm M, O'Shea JJ, Nerenberg MI. (1995) Constitutive activation of different Jak kinases in human T cell leukemia virus type 1 (HTLV-I) tax protein or virus-transformed cells, J. Clin. Invest. 96: 1548-1555.
    • (1995) Clin. Invest. , vol.96 , pp. 1548-1555
    • Xu, X.1    Kang, S.H.2    Heidenreich, O.3    Okerholm, M.4    O'Shea, J.J.5    Nerenberg, M.I.6
  • 149
    • 0033541939 scopus 로고    scopus 로고
    • HTLV-I infected T cells evade the anti-proliferative action of IFN-beta
    • Smith D, Buckle GJ, Hafler DA, Frank DA, Hollsberg P. (1999) HTLV-I infected T cells evade the anti-proliferative action of IFN-beta. Virology 257: 314-321.
    • (1999) Virology , vol.257 , pp. 314-321
    • Smith, D.1    Buckle, G.J.2    Hafler, D.A.3    Frank, D.A.4    Hollsberg, P.5
  • 150
    • 0023849455 scopus 로고
    • Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    • Kawano M, Hirano T, Matsuda T, et al. (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332: 83-85.
    • (1988) Nature , vol.332 , pp. 83-85
    • Kawano, M.1    Hirano, T.2    Matsuda, T.3
  • 151
    • 0024391288 scopus 로고
    • Response patterns of purified myeloma cells to hematopoietic growth factors
    • Andersen KC, Jones RM, Morimoto C, Leavitt P, Barut BA. (1989) Response patterns of purified myeloma cells to hematopoietic growth factors. Blood 73: 1915-1924.
    • (1989) Blood , vol.73 , pp. 1915-1924
    • Andersen, K.C.1    Jones, R.M.2    Morimoto, C.3    Leavitt, P.4    Barut, B.A.5
  • 152
    • 0025737915 scopus 로고
    • Interleukin-6 antisense oligonucleotides inhibit the growth of human mycloma cell lines
    • Levy Y, Tsapis A, Brouct JC. (1991) Interleukin-6 antisense oligonucleotides inhibit the growth of human mycloma cell lines. J. Clin. Invest. 88: 696-699.
    • (1991) J. Clin. Invest. , vol.88 , pp. 696-699
    • Levy, Y.1    Tsapis, A.2    Brouct, J.C.3
  • 153
    • 0028921477 scopus 로고
    • Interleukin-6 in human multiple myeloma
    • Klein B, Zhang XG, Yang LZ, Bataille R. (1995) Interleukin-6 in human multiple myeloma. Blood 85: 863-874.
    • (1995) Blood , vol.85 , pp. 863-874
    • Klein, B.1    Zhang, X.G.2    Yang, L.Z.3    Bataille, R.4
  • 154
    • 0029069307 scopus 로고
    • Interleukin 6 is essential for in vivo development of B lineage neoplasms
    • Hilbert DM, Kopf M, Mock BA, Kohler G, Rudikoff S. (1995) Interleukin 6 is essential for in vivo development of B lineage neoplasms. J. Exp. Med. 182: 243-248.
    • (1995) J. Exp. Med. , vol.182 , pp. 243-248
    • Hilbert, D.M.1    Kopf, M.2    Mock, B.A.3    Kohler, G.4    Rudikoff, S.5
  • 155
    • 0030200982 scopus 로고    scopus 로고
    • Distinct tumorigenic potential of abl and raf in B cell neoplasia: Abl activates the IL-6 signaling pathway
    • Hibert DM, Migone T-S, Kopf M, Leonard WJ, Rudikoff S. (1996) Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway. Immunity 5: 81-89.
    • (1996) Immunity , vol.5 , pp. 81-89
    • Hibert, D.M.1    Migone, T.-S.2    Kopf, M.3    Leonard, W.J.4    Rudikoff, S.5
  • 156
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. (1999) Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10: 105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 157
    • 0027503920 scopus 로고
    • Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro
    • Barut B, Chauhan D, Uchiyama H, Anderson KC. (1993) Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro. J. Clin. Invest. 92: 2346-2352.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2346-2352
    • Barut, B.1    Chauhan, D.2    Uchiyama, H.3    Anderson, K.C.4
  • 158
    • 0028986492 scopus 로고
    • Serum interleukin-6 levels correlate with prognosis in diffuse large cell lymphoma
    • Seymour JF, Talpaz M, Cabanillas F, Wetzler M, Kurzrock R. (1995) Serum interleukin-6 levels correlate with prognosis in diffuse large cell lymphoma. J. Clin. Oncol. 13: 575-582.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 575-582
    • Seymour, J.F.1    Talpaz, M.2    Cabanillas, F.3    Wetzler, M.4    Kurzrock, R.5
  • 160
    • 0028923658 scopus 로고
    • Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
    • Watson CJ, Miller WR. (1995) Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer 71: 840-844.
    • (1995) Br. J. Cancer , vol.71 , pp. 840-844
    • Watson, C.J.1    Miller, W.R.2
  • 161
    • 0031443156 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
    • Garcia R, Yu C-L, Hudnall A, et al. (1997) Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 8: 1267-1276.
    • (1997) Cell Growth Differ. , vol.8 , pp. 1267-1276
    • Garcia, R.1    Yu, C.-L.2    Hudnall, A.3
  • 162
    • 0031025240 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells
    • Sartor CI, Dziubinski ML, Yu CL, Jove R, Ethier SP. (1997) Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res. 57: 978-987.
    • (1997) Cancer Res. , vol.57 , pp. 978-987
    • Sartor, C.I.1    Dziubinski, M.L.2    Yu, C.L.3    Jove, R.4    Ethier, S.P.5
  • 163
    • 0009612506 scopus 로고    scopus 로고
    • Ornithine decarboxylase (ODC) overexpression activates Src and STAT signaling in MCF-10A human breast epithelial cells
    • Manni A, Trout D, Verderame MF, Beaston-Wimmer PR. (1999) Ornithine decarboxylase (ODC) overexpression activates Src and STAT signaling in MCF-10A human breast epithelial cells. Proc. Am. Assoc. Cancer Res. 40: 99.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 99
    • Manni, A.1    Trout, D.2    Verderame, M.F.3    Beaston-Wimmer, P.R.4
  • 164
    • 0009575418 scopus 로고    scopus 로고
    • Increased Stat3 activation in head and neck tumors in vivo
    • Endo S, Zeng Q, He Y, et al. (1999) Increased Stat3 activation in head and neck tumors in vivo. Proc. Am. Assoc. Cancer Res. 40: 336.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 336
    • Endo, S.1    Zeng, Q.2    He, Y.3
  • 165
    • 0030757686 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
    • Rubin Grandis J, Chakraborty A, Mclhem MF, Zeng Q, Tweardy DJ. (1997) Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogens 15: 409-416.
    • (1997) Oncogens , vol.15 , pp. 409-416
    • Rubin Grandis, J.1    Chakraborty, A.2    Mclhem, M.F.3    Zeng, Q.4    Tweardy, D.J.5
  • 167
    • 0000364663 scopus 로고    scopus 로고
    • Src kinase mediated activation of STAT-3 plays an essential role in the proliferation and oncogenicity of human breast, prostate and ovarian carcinomas
    • Reddy MVR, Chaturvedi P, Reddy EP. (1999) Src kinase mediated activation of STAT-3 plays an essential role in the proliferation and oncogenicity of human breast, prostate and ovarian carcinomas. Proc. Am. Assoc. Cancer Res. 40: 376.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 376
    • Reddy, M.V.R.1    Chaturvedi, P.2    Reddy, E.P.3
  • 168
    • 0033047725 scopus 로고    scopus 로고
    • Systemic interferon-α (IFN-α) treatment leads to Stat3 inactivation in melanoma precursor lesions
    • Kirkwood JM, Farkas DL, Chakraborty A, et al. (1999) Systemic interferon-α (IFN-α) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol. Med. 5: 11-20.
    • (1999) Mol. Med. , vol.5 , pp. 11-20
    • Kirkwood, J.M.1    Farkas, D.L.2    Chakraborty, A.3
  • 169
    • 0025219434 scopus 로고
    • Interleukin-6 and its receptor are expressed in human intestinal epithelial cells
    • Shirota K, LeDuy L, Yuan SY, Jothy S. (1990) Interleukin-6 and its receptor are expressed in human intestinal epithelial cells. Virchows Arch B Cell Pathol 58: 303-308.
    • (1990) Virchows Arch B Cell Pathol , vol.58 , pp. 303-308
    • Shirota, K.1    LeDuy, L.2    Yuan, S.Y.3    Jothy, S.4
  • 170
    • 0015098728 scopus 로고
    • Epidemiology of cancer of the colon and rectum
    • Burkitt DP. (1971) Epidemiology of cancer of the colon and rectum. Cancer 28: 3-13.
    • (1971) Cancer , vol.28 , pp. 3-13
    • Burkitt, D.P.1
  • 171
    • 0027096262 scopus 로고
    • Dietary intake of fiber and decreased risk of cancers of the colon and rectum: Evidence from the combined analysis of 13 case-control studies
    • Howe GR, Benito E, Castelleto R, et al. (1992) Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. J. Natl Cancer Inst. 84: 1887-1896.
    • (1992) J. Natl Cancer Inst. , vol.84 , pp. 1887-1896
    • Howe, G.R.1    Benito, E.2    Castelleto, R.3
  • 172
    • 0018225255 scopus 로고
    • Metabolic epidemiology of large bowel cancer: Fecal bulk and constituents of high-risk North American and low-risk Finnish population
    • Reddy BS, Hedges AR, Laakso K, Wynder EL. (1978) Metabolic epidemiology of large bowel cancer: fecal bulk and constituents of high-risk North American and low-risk Finnish population. Cancer 42: 2832-2838.
    • (1978) Cancer , vol.42 , pp. 2832-2838
    • Reddy, B.S.1    Hedges, A.R.2    Laakso, K.3    Wynder, E.L.4
  • 173
    • 0025232254 scopus 로고
    • Dietary fiber, vegetables, and colon cancer: Critical review and meta-analyses of the cpidemiologic evidence
    • Trock B, Lanza E, Greenwald P. (1990) Dietary fiber, vegetables, and colon cancer: critical review and meta-analyses of the cpidemiologic evidence. J. Natl. Cancer Inst. 82: 650-661.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 650-661
    • Trock, B.1    Lanza, E.2    Greenwald, P.3
  • 174
    • 0028938688 scopus 로고
    • Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum(II) by anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody
    • Mizutani Y, Bonavida B, Koishihara Y, Akamatsu K, Ohsugi Y, Yoshida O. (1995) Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum(II) by anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody. Cancer Res. 55: 590-596.
    • (1995) Cancer Res. , vol.55 , pp. 590-596
    • Mizutani, Y.1    Bonavida, B.2    Koishihara, Y.3    Akamatsu, K.4    Ohsugi, Y.5    Yoshida, O.6
  • 175
    • 0028880675 scopus 로고
    • Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines
    • Borsellino N, Belldegrun A, Bonavida B. (1995) Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res. 55: 4633-4639.
    • (1995) Cancer Res. , vol.55 , pp. 4633-4639
    • Borsellino, N.1    Belldegrun, A.2    Bonavida, B.3
  • 177
    • 0021799508 scopus 로고
    • Lymphoblastic leukemia with features associated with abnormalities of the short arm of chromosome 9
    • Chilcote RR, Brown E, Rowley JD. (1985) Lymphoblastic leukemia with features associated with abnormalities of the short arm of chromosome 9. N. Engl. J. Med. 313: 286-289.
    • (1985) N. Engl. J. Med. , vol.313 , pp. 286-289
    • Chilcote, R.R.1    Brown, E.2    Rowley, J.D.3
  • 178
    • 0023637789 scopus 로고
    • Abnormalities of the short arm of chromosome 9 with partial loss of material in hematological disorders
    • Pollack C, Hagemeijer A. (1987) Abnormalities of the short arm of chromosome 9 with partial loss of material in hematological disorders. Leukemia 1: 541-548.
    • (1987) Leukemia , vol.1 , pp. 541-548
    • Pollack, C.1    Hagemeijer, A.2
  • 179
    • 0030852328 scopus 로고    scopus 로고
    • Fusion of Tel, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase Jak2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
    • Peeters P, Raynaud SD, Cools J, et al. (1997) Fusion of Tel, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase Jak2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90: 2535-2540.
    • (1997) Blood , vol.90 , pp. 2535-2540
    • Peeters, P.1    Raynaud, S.D.2    Cools, J.3
  • 180
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Della Valle V, et al. (1997) A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278: 1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Della Valle, V.3
  • 182
    • 0344517071 scopus 로고    scopus 로고
    • Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling
    • Ho JM-Y, Boattie BK, Squire JA, Frank DA, Barber DL. (1999) Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood 93: 4354-4364.
    • (1999) Blood , vol.93 , pp. 4354-4364
    • Ho, J.M.-Y.1    Boattie, B.K.2    Squire, J.A.3    Frank, D.A.4    Barber, D.L.5
  • 183
    • 0032530972 scopus 로고    scopus 로고
    • Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
    • Schwaller J, Frantsve J, Aster J, et al. (1998) Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 17: 5321-5333.
    • (1998) EMBO J. , vol.17 , pp. 5321-5333
    • Schwaller, J.1    Frantsve, J.2    Aster, J.3
  • 184
    • 0029049682 scopus 로고
    • The fusion of TEL and ABL in human acute lymphoblastic leukemia is a rare event
    • Janssen JW, Ridge SA, Papadopoulos P, et al. (1995) The fusion of TEL and ABL in human acute lymphoblastic leukemia is a rare event. Br. J. Haematol. 90: 222-224.
    • (1995) Br. J. Haematol. , vol.90 , pp. 222-224
    • Janssen, J.W.1    Ridge, S.A.2    Papadopoulos, P.3
  • 185
    • 0029898682 scopus 로고    scopus 로고
    • Oligomerization of the ABL tyrosine kinase by the ETS protein TEL in human leukemia
    • Golub TR, Goga A, Barker G, et al. (1996) Oligomerization of the ABL tyrosine kinase by the ETS protein TEL in human leukemia. Mol. Cell. Biol. 16: 4107-4116.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4107-4116
    • Golub, T.R.1    Goga, A.2    Barker, G.3
  • 186
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris SW, Kirstein MN, Valentine MB, et al. (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263: 1281-1284.
    • (1994) Science , vol.263 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3
  • 187
    • 17344373285 scopus 로고    scopus 로고
    • FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome
    • Xiao S, Nalabolu SR, Aster JC, et al. (1998) FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nat. Genet. 18: 84-87.
    • (1998) Nat. Genet. , vol.18 , pp. 84-87
    • Xiao, S.1    Nalabolu, S.R.2    Aster, J.C.3
  • 188
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG. (1994) Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77: 307-316.
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 189
    • 0030669455 scopus 로고    scopus 로고
    • Fusion of the platelet-derived growth factor receptor β to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution
    • Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H. (1997) Fusion of the platelet-derived growth factor receptor β to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood 90: 4271-4277.
    • (1997) Blood , vol.90 , pp. 4271-4277
    • Abe, A.1    Emi, N.2    Tanimoto, M.3    Terasaki, H.4    Marunouchi, T.5    Saito, H.6
  • 190
    • 0031864246 scopus 로고    scopus 로고
    • Fusion of the Huntington interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocylic leukemia with t(5;7)(q33;q11.2)
    • Ross T, Bernard O, Berger R, Gilliland DG. (1998) Fusion of the Huntington interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocylic leukemia with t(5;7)(q33;q11.2). Blood 91: 4419-4426.
    • (1998) Blood , vol.91 , pp. 4419-4426
    • Ross, T.1    Bernard, O.2    Berger, R.3    Gilliland, D.G.4
  • 191
    • 0029966664 scopus 로고    scopus 로고
    • Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins
    • Vignais ML, Sadowski HB, Walling D, Rogers NC, Gilman M. (1996) Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. 16: 1759-1769.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1759-1769
    • Vignais, M.L.1    Sadowski, H.B.2    Walling, D.3    Rogers, N.C.4    Gilman, M.5
  • 192
    • 0032576873 scopus 로고    scopus 로고
    • Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains
    • Valgeirsdottir S, Paukku K, Silvennoinen O, Heldin CH, Claesson-Welsh L. (1998) Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains. Oncogene 16: 505-515.
    • (1998) Oncogene , vol.16 , pp. 505-515
    • Valgeirsdottir, S.1    Paukku, K.2    Silvennoinen, O.3    Heldin, C.H.4    Claesson-Welsh, L.5
  • 193
    • 0029966854 scopus 로고    scopus 로고
    • The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myclomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways
    • Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG. (1996) The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myclomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 93: 14845-14850.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 14845-14850
    • Carroll, M.1    Tomasson, M.H.2    Barker, G.F.3    Golub, T.R.4    Gilliland, D.G.5
  • 194
    • 17144463437 scopus 로고    scopus 로고
    • A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein
    • Joussert C, Carron C, Boureux A, et al. (1997) A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. EMBO J. 16: 69-82.
    • (1997) EMBO J. , vol.16 , pp. 69-82
    • Joussert, C.1    Carron, C.2    Boureux, A.3
  • 196
    • 0031800697 scopus 로고    scopus 로고
    • Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
    • Garcia R, Jove R. (1998) Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J. Biomed. Sci. 5: 79-85.
    • (1998) J. Biomed. Sci. , vol.5 , pp. 79-85
    • Garcia, R.1    Jove, R.2
  • 197
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-abl oncogene
    • Danial NN, Pernis A, Rothman PB. (1995) Jak-STAT signaling induced by the v-abl oncogene. Science 269: 1875-1877.
    • (1995) Science , vol.269 , pp. 1875-1877
    • Danial, N.N.1    Pernis, A.2    Rothman, P.B.3
  • 198
    • 0031741655 scopus 로고    scopus 로고
    • Direct interaction of Jak l and v-Abl is required for vAbl-induced activation of STATs and proliferation
    • Danial NN, Losman JA, Lu T, et al. (1998) Direct interaction of Jak l and v-Abl is required for vAbl-induced activation of STATs and proliferation. Mol. Cel. Biol. 18: 6795-6804.
    • (1998) Mol. Cel. Biol. , vol.18 , pp. 6795-6804
    • Danial, N.N.1    Losman, J.A.2    Lu, T.3
  • 199
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu C, Meyer DJ, Campbell GS, et al. (1995) Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269: 81-83.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.1    Meyer, D.J.2    Campbell, G.S.3
  • 200
    • 0029916933 scopus 로고    scopus 로고
    • Activation and association of Stat3 with Src in v-Src-transformed cell lines
    • Cao X, Tay A, Guy GR, Tan YH. (1996) Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16: 1595-1603.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1595-1603
    • Cao, X.1    Tay, A.2    Guy, G.R.3    Tan, Y.H.4
  • 201
    • 0030992813 scopus 로고    scopus 로고
    • Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs
    • Chaturvedi P, Sharma S, Reddy EP. (1997) Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol. Cell. Biol. 17: 3295-3304.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3295-3304
    • Chaturvedi, P.1    Sharma, S.2    Reddy, E.P.3
  • 203
    • 0029666298 scopus 로고    scopus 로고
    • STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
    • Caldenhoven E, van Dijk TB, Solari R, et al. (1996) STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 271: 13221-13227.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13221-13227
    • Caldenhoven, E.1    Van Dijk, T.B.2    Solari, R.3
  • 204
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by src induces specific gene regulation and is required for cell transformation
    • Turkson J, Bowman T, Garcia R, Caldenhuven E, de Groot RP, Jove R. (1998) Stat3 activation by src induces specific gene regulation and is required for cell transformation. Mol. Cell. Biol. 18: 2545-2552.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2545-2552
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhuven, E.4    De Groot, R.P.5    Jove, R.6
  • 205
    • 0031018486 scopus 로고    scopus 로고
    • Constitutive activation of Jak1 in Src-transformed cells
    • Campbell GS, Yu C-L, Jove R, Carter-Su C. (1997) Constitutive activation of Jak1 in Src-transformed cells. J. Biol. Chem. 272: 2591-2594.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2591-2594
    • Campbell, G.S.1    Yu, C.-L.2    Jove, R.3    Carter-Su, C.4
  • 206
    • 0031306869 scopus 로고    scopus 로고
    • Constitutive activation of the Janus kinase-STAT pathway in T lympboma overexpressing the Lek protein tyrosine kinase
    • Yu CL, Jove R, Burakoff SJ. (1997) Constitutive activation of the Janus kinase-STAT pathway in T lympboma overexpressing the Lek protein tyrosine kinase. J. Immunol. 159: 5206-5210.
    • (1997) J. Immunol. , vol.159 , pp. 5206-5210
    • Yu, C.L.1    Jove, R.2    Burakoff, S.J.3
  • 207
    • 0030761716 scopus 로고    scopus 로고
    • Activation of STAT transcription factors by herpesvirus saimiri Tip-484 requires p56Ick
    • Lund TC, Garcia R, Medveczky MM, Jove R, Medveczky PG. (1997) Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56Ick. J. Viral. 71: 6677-6682.
    • (1997) J. Viral. , vol.71 , pp. 6677-6682
    • Lund, T.C.1    Garcia, R.2    Medveczky, M.M.3    Jove, R.4    Medveczky, P.G.5
  • 208
    • 0032927057 scopus 로고    scopus 로고
    • The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells
    • Lund TC, Prator PC, Medveczky MM, Medveczky PG. (1999) The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. J. Virol. 73: 1689-1694.
    • (1999) J. Virol. , vol.73 , pp. 1689-1694
    • Lund, T.C.1    Prator, P.C.2    Medveczky, M.M.3    Medveczky, P.G.4
  • 209
    • 0029791664 scopus 로고    scopus 로고
    • Unique signal transduction of Eyk: Constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase
    • Zong C, Yan R, August A, Darnell JE Jr, Hanafusa H. (1996) Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J. 15: 4515-4525.
    • (1996) EMBO J. , vol.15 , pp. 4515-4525
    • Zong, C.1    Yan, R.2    August, A.3    Darnell J.E., Jr.4    Hanafusa, H.5
  • 210
    • 0032962930 scopus 로고    scopus 로고
    • A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation
    • Besser D, Bromberg JF, Darnell JE Jr, Hanafusa H. (1999) A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation. Mol. Cell. Biol. 19: 1401-1409.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1401-1409
    • Besser, D.1    Bromberg, J.F.2    Darnell J.E., Jr.3    Hanafusa, H.4
  • 211
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K, van Deursen J, Sangster MY, et al. (1996) Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380: 630-633.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    Van Deursen, J.2    Sangster, M.Y.3
  • 212
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda K, Tanaka T, Shi W, et al. (1996) Essential role of Stat6 in IL-4 signalling. Nature 380: 627-630.
    • (1996) Nature , vol.380 , pp. 627-630
    • Takeda, K.1    Tanaka, T.2    Shi, W.3
  • 213
    • 0029986943 scopus 로고    scopus 로고
    • Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia
    • Robertson MJ, Cochran KJ, Cameron C, Le JM, Tantravahi R, Ritz J. (1996) Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp. Hematol. 24: 406-415.
    • (1996) Exp. Hematol. , vol.24 , pp. 406-415
    • Robertson, M.J.1    Cochran, K.J.2    Cameron, C.3    Le, J.M.4    Tantravahi, R.5    Ritz, J.6
  • 215
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cylokine responses
    • Teglund S, McKay C, Schnetz E, et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cylokine responses. Cell 93: 841-850.
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1    McKay, C.2    Schnetz, E.3
  • 216
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS, et al. (1998) Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice. Proc. Natl. Acad. Sci. U.S.A. 95: 7556-7561.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3
  • 217
    • 0030935260 scopus 로고    scopus 로고
    • Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality
    • Takeda K, Noguchi K, Shi W, et al. (1997) Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. U.S.A. 94: 3801-3804.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 3801-3804
    • Takeda, K.1    Noguchi, K.2    Shi, W.3
  • 218
    • 0029868971 scopus 로고    scopus 로고
    • Characterization of an interleukin 6 cytokine family antagonist protein from a marine sponge, Callyspongia sp
    • Peppard JV, Loo P, Sills MA, Munster D, Pomponi SA, Wright AE. (1996) Characterization of an interleukin 6 cytokine family antagonist protein from a marine sponge, Callyspongia sp. J. Biol. Chem. 271: 7281-7284.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7281-7284
    • Peppard, J.V.1    Loo, P.2    Sills, M.A.3    Munster, D.4    Pomponi, S.A.5    Wright, A.E.6
  • 219
    • 0028202123 scopus 로고
    • Generation of interleukin-6 antagonists by molecular-modeling guided mutagenesis of residues important for gpl 30 activation
    • Savino R, Lahm A, Salvati AL, et al. (1994) Generation of interleukin-6 antagonists by molecular-modeling guided mutagenesis of residues important for gpl 30 activation. EMBO J. 13: 1357-1367.
    • (1994) EMBO J. , vol.13 , pp. 1357-1367
    • Savino, R.1    Lahm, A.2    Salvati, A.L.3
  • 220
    • 0028590077 scopus 로고
    • Rational design of a receptor super-antagonist of human interleukin-6
    • Savino R, Ciapponi L, Lahm A, et al. (1994) Rational design of a receptor super-antagonist of human interleukin-6. EMBO J. 13: 5863-5870.
    • (1994) EMBO J. , vol.13 , pp. 5863-5870
    • Savino, R.1    Ciapponi, L.2    Lahm, A.3
  • 221
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M, Baumann H, Freer G, et al. (1994) Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368: 339-342.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3
  • 222
    • 0025990893 scopus 로고
    • Murine amtiinterleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia
    • Klein B, Wijdenes J, Zhang XG, et al. (1991) Murine amtiinterleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78: 1198-1204.
    • (1991) Blood , vol.78 , pp. 1198-1204
    • Klein, B.1    Wijdenes, J.2    Zhang, X.G.3
  • 223
    • 13344295097 scopus 로고    scopus 로고
    • Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
    • Meydan N, Grunberger T, Dadi H, et al. (1996) Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379: 645-648.
    • (1996) Nature , vol.379 , pp. 645-648
    • Meydan, N.1    Grunberger, T.2    Dadi, H.3
  • 224
    • 0028978269 scopus 로고
    • 4,5-bis(4-fluoroanilino)phthalimide: A selective inhibitor of the epidermal growth factor receptor signal transduction pathway with potent in vivo antitumor activity
    • Buchdunger E, Mett H, Trinks U, et al. (1995) 4,5-bis(4-fluoroanilino)phthalimide: a selective inhibitor of the epidermal growth factor receptor signal transduction pathway with potent in vivo antitumor activity. Clin. Cancer Res. 1: 813-821.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 813-821
    • Buchdunger, E.1    Mett, H.2    Trinks, U.3
  • 225
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the ABL protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Melt H, et al. (1996) Inhibition of the ABL protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56: 100-104.
    • (1996) Cancer Res. , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Melt, H.3
  • 226
    • 0033585504 scopus 로고    scopus 로고
    • In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
    • Mologni L, Cleris L, Marchesi E, et al. (1999) In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J. Natl. Cancer Inst. 91: 163-168.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 163-168
    • Mologni, L.1    Cleris, L.2    Marchesi, E.3
  • 227
    • 0031454003 scopus 로고    scopus 로고
    • CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
    • Carroll M, Ohno-Jones S, Tamura S, et al. (1997) CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 90: 4947-4952.
    • (1997) Blood , vol.90 , pp. 4947-4952
    • Carroll, M.1    Ohno-Jones, S.2    Tamura, S.3
  • 228
    • 0030008414 scopus 로고    scopus 로고
    • 4-(phenylamino)pyrrolopyrimidines: Potent and selective, ATP site directed inhibitors of the EGF-receptor tyrosine kinase
    • Traxler PM, Fyret P, Mett H, Buchdunger H, Meyer T, Lydon N. (1996) 4-(phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor tyrosine kinase. J. Med. Chem. 39: 2285-2292.
    • (1996) J. Med. Chem. , vol.39 , pp. 2285-2292
    • Traxler, P.M.1    Fyret, P.2    Mett, H.3    Buchdunger, H.4    Meyer, T.5    Lydon, N.6
  • 229
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2: 561-566.
    • (1996) Nat. Med. , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 230
    • 0033084227 scopus 로고    scopus 로고
    • TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor
    • Tomasson MH, Williams IR, Hasserjian R, et al. (1999) TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor. Blood 93: 1707-1714.
    • (1999) Blood , vol.93 , pp. 1707-1714
    • Tomasson, M.H.1    Williams, I.R.2    Hasserjian, R.3
  • 231
    • 0032950743 scopus 로고    scopus 로고
    • Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling
    • Frank DA, Mahajan S, Ritz J. (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat. Med. 5: 444-447.
    • (1999) Nat. Med. , vol.5 , pp. 444-447
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 233
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alla-2b adjuvant, therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST 1684
    • Kirkwood JM, Strawdermann MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH. (1996) Interferon alla-2b adjuvant, therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J. Clin. Oncol. 14: 7-17.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 7-17
    • Kirkwood, J.M.1    Strawdermann, M.H.2    Ernstoff, M.S.3    Smith, T.J.4    Borden, E.C.5    Blum, R.H.6
  • 234
    • 0031696748 scopus 로고    scopus 로고
    • Interferon-α-induced activation of signal transducer and activator of transcription proteins in malignant melanoma
    • Carson WE. (1998) Interferon-α-induced activation of signal transducer and activator of transcription proteins in malignant melanoma. Clin. Cancer Res. 4: 2219-2228.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2219-2228
    • Carson, W.E.1
  • 235
    • 0030712998 scopus 로고    scopus 로고
    • Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-lSGF3gamma
    • Wong LH, Krauer KG, Hatzinisiriou I, et al. (1997) Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-lSGF3gamma. J. Biol. Chem. 272: 28779-28785.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28779-28785
    • Wong, L.H.1    Krauer, K.G.2    Hatzinisiriou, I.3
  • 236
    • 0031962552 scopus 로고    scopus 로고
    • Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression
    • Sun WH, Pabon C, Alsayed Y, et al. (1998) Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression. Blood 91: 570-576.
    • (1998) Blood , vol.91 , pp. 570-576
    • Sun, W.H.1    Pabon, C.2    Alsayed, Y.3
  • 237
    • 0029799912 scopus 로고    scopus 로고
    • Transcriptionally active Stat1 is required for the antiproliferative effects of both Interferon alpha and interferon gamma
    • Bromberg JF, Horvath CM, Wen Z, Schreiber RD, Darnell JE Jr. (1996) Transcriptionally active Stat1 is required for the antiproliferative effects of both Interferon alpha and interferon gamma. Proc. Natl. Acad. Sci. U.S.A. 93: 7673-7678.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 7673-7678
    • Bromberg, J.F.1    Horvath, C.M.2    Wen, Z.3    Schreiber, R.D.4    Darnell J.E., Jr.5
  • 238
    • 0025882306 scopus 로고
    • Differentiation therapy of acute promyelocytic leukemia with triretinoin (all-trans retinoic acid)
    • Warrell RP Jr, Frankel SR, Miller WJJ, et al. (1991) Differentiation therapy of acute promyelocytic leukemia with triretinoin (all-trans retinoic acid). N. Engl. J. Med. 324: 1385-1391.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1385-1391
    • Warrell R.P., Jr.1    Frankel, S.R.2    Miller, W.J.J.3
  • 239
    • 0030899018 scopus 로고    scopus 로고
    • Stat1 is induced and activated by all-trans retinoic acid in acute promyelocylic leukemia cells
    • Gianni M, Terao M, Fortino I, et al. (1997) Stat1 is induced and activated by all-trans retinoic acid in acute promyelocylic leukemia cells. Blood 89: 1001-1012.
    • (1997) Blood , vol.89 , pp. 1001-1012
    • Gianni, M.1    Terao, M.2    Fortino, I.3
  • 240
    • 0030899367 scopus 로고    scopus 로고
    • Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid
    • Weihua X, Kolla V, Kalvakolanu DV. (1997) Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. J. Biol. Chem. 272: 9742-9748.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9742-9748
    • Weihua, X.1    Kolla, V.2    Kalvakolanu, D.V.3
  • 241
    • 0027469982 scopus 로고
    • Differentiation-dependent activation of interferon-stimulated gene factors and transcription factor NFkappa B in mouse embryonal carcinoma cells
    • Kalvakolanu DV, Sen GC. (1993) Differentiation-dependent activation of interferon-stimulated gene factors and transcription factor NFkappa B in mouse embryonal carcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 90: 3167-3171.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 3167-3171
    • Kalvakolanu, D.V.1    Sen, G.C.2
  • 242
    • 17544376424 scopus 로고    scopus 로고
    • Modulation of interferon (IFN)-inducible gene expression by retinoic acid, up-regulation of Stat1 protein in IFN-unresponsive cells
    • Kolla V, Lindner DJ, Weihua X, Borden EC, Kalvakolanu DV. (1996) Modulation of interferon (IFN)-inducible gene expression by retinoic acid, Up-regulation of Stat1 protein in IFN-unresponsive cells. J. Biol. Chem. 271: 10508-10514.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10508-10514
    • Kolla, V.1    Lindner, D.J.2    Weihua, X.3    Borden, E.C.4    Kalvakolanu, D.V.5
  • 243
    • 0030972135 scopus 로고    scopus 로고
    • Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons
    • Matikainen S, Ronni T, Lehtonen A, et al. (1997) Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons. Cell Growth Differ. 8: 687-698.
    • (1997) Cell Growth Differ. , vol.8 , pp. 687-698
    • Matikainen, S.1    Ronni, T.2    Lehtonen, A.3
  • 245
    • 0032432076 scopus 로고    scopus 로고
    • Direct suppression of Stal1 function during adenoviral infection
    • Look DC, Roswit WT, Frick AG, et al. (1998) Direct suppression of Stal1 function during adenoviral infection. Immunity 9: 871-880.
    • (1998) Immunity , vol.9 , pp. 871-880
    • Look, D.C.1    Roswit, W.T.2    Frick, A.G.3


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