BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats

Leukemia

Volumn 10, Issue 11, 1996, Pages 1724-1730

  Frank, D A ^a   Varticovski, L ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BCR abl; IL 3; Phosphorylation; Stats; Transformation

Indexed keywords

BCR ABL PROTEIN; INTERLEUKIN 3;

ARTICLE; BINDING SITE; CELL TRANSFORMATION; HEMATOPOIETIC CELL; HUMAN; HYPOTHESIS; LEUKEMIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0029796725     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Rosenberg N, Witte ON. The viral and cellular forms of the Abelson (abl) oncogene. Adv Virus Res 1988; 39: 39-81.
2. Heisterkamp N, Stephenson JR, Groffen J et al. Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukemia. Nature 1983; 306: 239-242.
3. Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld C. Philadelphia chromosome breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1985; 36: 93-99.
4. Nowell PC, Hungerford DA. A minute chromosome in human chronic granulocytic leukemia. Science 1960; 132: 1497-1499.
5. Clark S, McLaughlin J, Crist WM, Champlin R, Witte ON. Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from PH1-positive ALL. Science 1987; 235: 85-87.
6. Hermans A, Heisterkamp N, von Linderen M et al. Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell 1987; 51: 33-40.
7. Ben-Neriah Y, Daley GQ, Mes-Masson A-M, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr-abl hybrid gene. Science 1986; 233: 212-214.
8. Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824-830.
9. Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J 1990; 9: 1069-1078.
10. Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 1990; 87: 6649-6653.
11. Gishizky ML, Johnson-White J, Witte ON. Efficient transplantation of BCR/ABL-induced chronic myelogenous leukemia-like syndrome in mice. Proc Natl Acad Sci USA 1993; 90: 3755-3759.
12. Palacios R, Steinmetz M. II-3-dependent mouse clones that express B-220 antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 1985; 41: 727-734.
13. Silvennoinen O, Witthuhn FW, Quelle JL, Cleveland T, Yi B, Ihle JN. Structure of the JAK2 protein tyrosine kinase and its role in IL-3 signal transduction. Proc Natl Acad Sc USA 1993; 90: 8429-8433.
14. Mui AL-F, Wakao H, O'Farrell A-M, Harada N, Miyajima A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 1995; 14: 1166-1175.
15. Rothman P, Kreider B, Azam M et al. Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors. Immunity 1994; 1: 457-468.
16. Azam M, Erdjument-Bromage H, Kreider BL et al. Interleukin-3 signals through multiple isoforms of Stat5. EMBO J 1995; 14: 1402-1411.
17. Shuai K, Schindler C, Prezioso VR, Darnell JE. Activation of transcription by IFN-γ:tyrosine phosphorylation of a 91-kD DNA binding protein. Science 1992; 258: 1808-1812.
18. Okuda K, Sanghera JS, Pelech SL et al. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 1992; 79: 2880-2887.
19. Sattler M, Salgia R, Okuda K et al. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3′ kinase pathway. Oncogene 1996; 12: 839-846.
20. Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci USA 1988; 85: 9312-9316.
21. Susa M, Keeler M, Varticovski L. Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol. Detection of enzyme activity in detergent-solubilized cell extracts. J Biol Chem 1992; 267: 22951-22956.
22. Frank DA, Robertson M, Bonni A, Ritz J, Greenberg ME. IL-2 signaling involves the phosphorylation of novel Stat proteins. Proc Natl Acad Sci USA 1995; 92: 7779-7783.
23. Shuai K, Stark GR, Kerr IM, Darnell JE. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 1993; 261: 1744-1746.
24. Mandanas RA, Leibowitz DS, Gharehbaghi K et al. Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells. Blood 1993; 82: 1838-1847.
25. ten Hoeve J, Arlinghaus RB, Guo JQ, Heisterkamp N, Groffen J. Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia. Blood 1994; 84: 1731-1736.
26. Puil L, Liu J, Gish G et al. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J 1994; 13: 764-773.
27. Sawyers CL, McLaughlin J, Witte ON. Genetic requirement for ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J Exp Med 1995; 181: 307-313.
28. Pendergast AM, Quilliam LA, Cripe LD et al. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 1993; 75: 175-185.
29. Lowenstein EJ, Daly RJ, Batzer AG et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalling. Cell 1992; 70: 431-442.
30. Skolnick EY, Batzer A, Li N et al. The function of GRB2 in linking the insulin receptor to ras signaling pathways. Science 1993; 260: 1953-1955.
31. Chardin P, Camonis JH, Gale NW et al. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 1993; 260: 1338-1343.
32. Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON. Alternative signals to Ras for hematopoietic transformation by the BCR-ABL oncogene. Cell 1995; 82: 981-988.
33. van Etten RA. Disease progression in a murine model of bcr/abl leukemogenesis. Leuk Lymphoma 1993; 1: 239-242.
34. Steegmann JL, Perez M, Vazquez L et al. Interferon alpha treatment of accelerated-phase chronic myeloid leukemia in relapse after bone marrow transplantation: a case with complete cytogenetic and molecular remission. Bone Marrow Transplant 1991; 7: 65-67.
35. Shuai K, Horvath CM, Huang LHT, Qureshi SA, Cowburn D, Darnell JE. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phospholyrosyl peptide interactions. Cell 1994; 76: 821-828.
36. Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990; 247: 1079-1082.