The functional synergy between IL-12 and IL-2 involves p38 mitogen- activated protein kinase and is associated with the augmentation of STAT serine phosphorylation

Journal of Immunology

Volumn 162, Issue 8, 1999, Pages 4472-4481

  Gollob, Jared A ^a,b   Schnipper, Claudia P ^b   Murphy, Erin A ^b   Ritz, Jerome ^b   Frank, David A ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; STAT1 PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; CELL KILLING; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUMOR CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD18; ANTIGENS, CD8; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DNA-BINDING PROTEINS; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; INTERLEUKIN-12; INTERLEUKIN-2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; SERINE; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; TRANS-ACTIVATORS; TYROSINE;

EID: 0033561559     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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