IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 299-304

  Wang, Kathy S ^a   Ritz, Jerome ^a   Frank, David A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; STAT4 PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

AUTOCRINE COMMUNICATION; CELL LINE; CELLS, CULTURED; DNA; DNA-BINDING PROTEINS; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-12; INTERLEUKIN-2; INTERPHASE; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS;

EID: 0032960199     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
2. Morgan, D. A., F. W. Ruscetti, and R. Gallo. 1976. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193:1007.
3. Smith, K. A. 1988. Interleukin-2: inception, impact, and implications. Science 240:1169.
4. Nagler, A., L. L. Lanier, and J. H. Phillips. 1990. Constitutive expression of high affinity interleukin 2 receptors on human CD16-NK cells in vivo. J. Exp. Med. 171:1527.
5. Swain, S. L. 1991. Lymphokines and the immune response: the central role of interleukin-2. Curr. Opin. Immunol. 3:304.
6. Kundig, T. M., H. Schorle, M. F. Bachmann, H. Hentgartner, R. M. Zinkernagel, and I. Horak. 1993. Immune responses in interleukin-2-deficient mice. Science 262:1059.
7. Warren, H. S., B. F. Kinnear, and L. J. Skipsey. 1993. Human natural killer (NK) cells: requirements for cell proliferation and expansion of phenotypically novel subpopulations. Immunol. Cell Biol. 71:87.
8. Caligiuri, M. A., A. Zmuidzinas, T. J. Manley, H. Levine, K. A. Smith, and J. Ritz. 1990. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes: identification of a novel natural killer cell subset with high affinity receptors. J. Exp. Med. 171:1509.
9. Robertson, M. J., and J. Ritz. 1992. Role of IL-2 receptors in NK cell activation and proliferation. In NK Cell Mediated Cytotoxicity: Receptors, Signaling, and Mechanisms. E. Lotzova and R. B. Herberman, eds. CRC Press, Boca Raton, pp. 183-206.
10. Bonnema, J. D., K. A. Rivlin, A. T. Ting, R. A. Schoon, R. T. Abraham, and P. J. Leibson. 1994. Cytokine-enhanced NK cell-mediated cytotoxicity: positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J. Immunol. 152:2098.
11. Ihle, J. N. 1995. Cytokine receptor signalling. Nature 377:591.
12. Johnston, J. A., M. Kawamura, R. A. Kirken, Y.-Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151.
13. Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lai, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153.
14. Frank, D. A., M. J. Robertson, A. Bonni, J. Ritz, and M. Greenberg. 1995. Interleukin 2 signaling involves the phosphorylation of Stat proteins. Proc. Natl. Acad. Sci. USA 92:7779.
15. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251.
16. Yu, C., J. Lin, D. W. Fink, S. Akira, E. T. Bloom, and A. Yamauchi. 1996. Differential utilization of Janus kinase-signaling transducer and activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-α. J. Immunol. 157:126.
17. Sattler, M., M. A. Durstin, D. A. Frank, K. Okuda, K. Kaushansky, R. Salgia, and J. D. Griffin. 1995. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp. Hematol. 23:1040.
18. Frank, D. A., and L. Varticovski. 1996. BCR/abl leads to the constitutive activation of Stat proteins and shares an epitope with tyrosine phosphorylated Stats. Leukemia 10:1724.
19. Gollob, J. A., H. Kawasaki, and J. Ritz. 1997. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol 27:647.
20. Kornbluth, J., N. Flomenberg, and B. Dupont. 1982. Cell surface phenotype of a cloned line of human natural killer cells. J. Immunol. 129:2831.
21. Robertson, M. J., K. J. Cochran, C. Cameron, J.-M. Le, R. Tantravahi, and J. Ritz. 1996. Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp. Hematol. 24:406.
22. 42-50) is activated in human Jurkat cells undergoing apoptosis. Cell. Immunol. 165:161.
23. Bonni, A., D. A. Frank, C. Schindler, and M. E. Greenberg. 1993. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science 262:1575.
24. Cho, S. S., C. M. Bacon, C. Sudarshan, R. C. Rees, D. Finbloom, R. Pine, and J. J. O'Shea. 1996. Activation of STAT4 by IL-12 and IFN-α. J. Immunol. 157:4781.
25. Bacon, C. M., E. F. Petricoin, III, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
26. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activation of transcription (Stat) 3 and Stat4. J. Exp. Med. 181:1755.
27. Gollob, J. A., E. A. Murphy, S. Mahajan, C. P. Schnipper, J. Ritz, and D. A. Frank. 1998. Altered IL-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood 91:1341.
28. Frank, D. A., and M. E. Greenberg. 1996. Signal transduction pathways activated by ciliary neurotrophic factor and related cytokines. Perspect. Dev. Neurobiol. 4:3.
29. Yamamoto, K., F. W. Quelle, W. E. Thierfelder, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, and J. N. Ihle. 1994. Stat4, a novel γ interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14:4342.
30. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. A. Vignali, P. C. Doherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin-12-mediated response of natural killer and T cells. Nature 382:171.
31. Kaplan, M. H., Y.-L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.