Induction of Jak/STAT signaling by activation of the type 1 TNF receptor

Journal of Immunology

Volumn 160, Issue 6, 1998, Pages 2742-2750

  Guo, DanQun ^a   Dunbar, James D ^a   Yang, Chuan He ^b   Pfeffer, Lawrence M ^b   Donner, David B ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; ENZYME ACTIVATION; ENZYME ACTIVITY; HELA CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; DNA; DNA-BINDING PROTEINS; HUMANS; JANUS KINASE 1; JANUS KINASE 2; MICE; MILK PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RABBITS; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0032521284     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Beutler, B., and A. Cerami. 1989. The biology of cachectin/TNF primary mediator of the host response. Annu. Rev. Immunol. 7:625.
2. Sidhu, R. S., and A. P. Bollon. 1993. Tumor necrosis factor activities and cancer therapy: a perspective. Pharmacol. Ther. 57:79.
3. Loetscher, H., Y.-C. Pan, H.-W. Lahm, R. Gentz, M. Brockhaus, H. Tabuchi, and W. Lesslauer. 1990. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell 61:351.
4. Schall, T. J., M. Lewis, K. J. Koller, A. Lee, G. C. Rich, G. H. W. Wong, T. Gatanaga, G. A. Granger, R. Lentz, H. Raab, W. J. Kohr, and D. V. Goeddel. 1990. Molecular cloning and expression of a receptor for tumor necrosis factor. Cell 61:361.
5. Smith, C. A., T. Davis, D. Anderson, L. Solam, M. P. Beckman, R. Jerzy, S. K. Dower, D. Cosman, and R. G. Goodwin. 1990. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248:1019.
6. Smith, C. A., T. Farrah, and R. G. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation and death. Cell 76:959.
7. Engelmann, H., H. Holtmann, C. Barkebush, Y. S. Avni, I. Sarov, Y. Nophar, E. Hadas, O. Leitner, and D. Wallach. 1990. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. J. Biol. Chem. 265:14497.
8. Espevik, T., M. Brockhaus, H. Loetscher, U. Nonstad, and R. Shalaby. 1989. Characterization of binding and biological effects of monoclonal antibodies against a tumor necrosis factor receptor. J. Exp. Med. 171:415.
9. Tartaglia, L. A., R. F. Weber, I. S. Figari, C. Reynolds, M. A. Palladino, and D. V. Goeddel. 1991. The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl. Acad Sci. USA 88:9292.
10. Wong, G. H. W., L. A. Tartaglia, M. S. Lee, and D. V. Goeddel. 1992. Antiviral activity of tumor necrosis factor is signaled through the 55-kDa type I TNF receptor. J. Immunol. 149:3550.
11. Pfeffer, K., T. Matsuyama, T. M. Kundig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P. S. Ohashi, M. Kronke, and T. W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocylogenes infection. Cell 73:457.
12. Heller, R. A., K. Song, N. Fan, and D. J. Chang. 1992. The p70 tumor necrosis factor receptor mediates cytotoxicity. Cell 70:47.
13. Grell, M., P. Scheurich, A. Meager, and K. Pfizenmaier. 1993. TR60 and TR80 tumor necrosis factor (TNF) receptors can independently mediate cytolysis. Lymphokine Cytokine Res. 12:143.
14. Jacobsen, F. W., M. Rothe, L. Rusten, D. V. Goeddel, E. B. Smeland, O. P. Veiby, L. Skordal, and S. E. W. Jacobsen. 1994. Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis. Proc. Natl. Acad. Sci. USA 91:10695.
15. Gehr, G., R. Gentz, M. Brockhaus, H. Loetscher, and W. Lesslauer. 1992. Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation. J. Immunol. 149:911.
16. Tartaglia, L. A., D. V. Goeddel, C. Reynolds, I. S. Figari, R. F. Weber, B. M. Fendly, and M. A. Palladino. 1993. Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor. J. Immunol. 151:4637.
17. Mishra, S., R. Mathur, and A. E. Hamburger. 1994. Modulation of the cytotoxic activity of tumor necrosis factor by protein tyrosine kinase and protein tyrosine phosphatase inhibitors. Lymphokine Cytokine Res. 13:77.
18. Sasaki, C. Y., and P. Q. Patek. 1995. The involvement of protein tyrosine kinase activity in a tumor necrosis factor resistance mechanism. Proc. Soc. Exp. Biol. Med. 210:25.
19. Ji, L., G. Zhang, and Y. Hirabayashi. 1995. Tumor necrosis factor increases tyrosine phosphorylation of a 23-kDa nuclear protein in U937 cells through ceramide signaling pathway. Biochem. Biophys. Res. Commun. 215:489.
20. Ji, L., G. Zhang, and Y. Hirabayashi. 1995. Inhibition of tumor necrosis factor and ceramide-induced internucleosomal DNA fragmentation by herbimycin A in U937 cells. Biochem. Biophys. Res. Commun. 212:640.
21. Reddy, S. A. G., M. M. Chaturvedi, B. G. Darnay, H. Chan, M. Higuchi, and B. B. Aggarwal. 1994. Reconstitution of NF-κB activation induced by tumor necrosis factor requires membrane-associated components: comparison with pathway induced by ceramide. J. Biol. Chem. 269:25369.
22. Weber, C. E. Negrescu, W. Erl, A. Pietsch, M. Frankenberger, H. W. Loms Ziegler-Heitbrock, W. Siess, and P. C. Weber. 1995. Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules. J. Immunol. 155:445.
23. Guo, D., and D. B. Donner. 1996. Tumor necrosis factor promotes phosphorylation and binding of IRS-1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J. Biol. Chem. 271:615.
24. Fuortes, M., W.-W. Jin, and C. Nathan. 1993. Adhesion dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J. Cell Biol. 120:777.
25. 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor. J. Cell Biol. 127:1477.
26. Akimaru, K., T. Utsumi, E. F. Sato, J. Klostergaard, M. Inoue, and K. Utsumi. 1992. Role of tyrosine phosphorylation in neutrophil priming by tumor necrosis factor-α and granulocyte colony stimulating factor. Arch. Biochem. Biophys. 298: 703.
27. Yuo, A., S. Kitagaw, E. Azuma, Y. Natori, A. Togawa, M. Saito, and F. Takaku. 1993. Tyrosine phosphorylation and intracellular alkalinization are early events in human neutrophils treated by tumor necrosis factor, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. Biochim. Biophys. Acta 1156:197.
28. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the Jak/STAT pathway. Annu. Rev. Biochem. 64:621.
29. Ihle, J. N. 1995. Cytokine receptor signaling. Nature 377:591.
30. Wills, A. F., and A. G. Harpur. 1994. Cytokine signal transduction and the Jak family of protein tyrosine kinases. Bioessays 16:313.
31. Souza, S. C., G. P. Frick, R. Yip, R. B. Lobo, L. Tai, and H. M. Goodman. 1994. Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 269:30085.
32. Argetsinger, L. S., G. W. Hsu, M. G. Myers, Jr., N. Billestrup, M. F. White, and C. Carter-Su. 1995. Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270:14685.
33. Uddin, S., L. Yenush, X. Sun, M. E. Sweet, M. F. White, and L. C. Platanias. 1995. Interferon-α engages insulin receptor substrate-1 to associate with phosphatidylinositol 3-kinase. J. Biol. Chem. 270:15938.
34. Yin, T., S. R. Keller, F. W. Quelle, B. A. Witthuhn, M. L. Tsang, G. E. Lienhard, J. N. Ihle, and Y. C. Yang. 1995. Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via Jak tyrosine kinases. J. Biol. Chem. 270:20497.
35. Rubin, C. S., and O. M. Rosen. 1977. Acquisition of increased hormone sensitivity during in vitro adipocyte development. J. Biol. Chem. 252:3554.
36. Song, H. Y., J. D. Dunbar, Y. X. Zhang, D. Guo, and D. B. Donner. 1995. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. J. Biol. Chem. 270:3574.
37. Lewis, M., L. A. Tartaglia, A. Lee, G. L. Bennett, G. C. Rice, G. H. W. Wong, E. Y. Chen, and D. V. Goeddel. 1991. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate that one receptor is species specific. Proc. Natl. Acad. Sci. USA 88:2830.
38. Vanderkuur, J. A., X. Wang, L. Zhang, G. S. Campbell, G. Allevato, N. Billestrup, G. Norstedt, and C. Carter-Su. 1994. Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase. J. Biol. Chem. 269:21709.
39. Leaman, D. W., S. Leung, X. Li, and G. R. Stark. 1996. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J. 10:1578.
40. Pearse, R. N., R. Feinman, K. Shuai, J. E. Darnell, Jr., and J. V. Ravetch. 1993. Interferon-γ-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc. Natl. Acad. Sci. USA 90:4314.
41. Schindler, C., H. Kashleva, A. Pernis, R. Pine, and P. Rothman. 1994. STF-IL-4: a novel IL-4-induced signal transducing factor. EMBO J. 13:1350.
42. Yuan, J., U. M. Wegenka, C. Lutticken, J. Buschmann, T. Decker, C. Schindler, P. C. Heinrich, and F. Horn. 1994. The signaling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements. Mol. Cell. Biol. 14:1657.
43. Lin, J.-X., T. S. Migone, M. Tsang, M. Friedman, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. Jinn, and W. J. Leopnard. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2:331.
44. Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carver-Moore, R. N. DuBois, R. Clark, M. Aguet, and R. D. Schreiber. 1996. Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the Jak-STAT signaling pathway. Cell 84:431.
45. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse STAT1 gene results in compromised innate immunity to viral disease. Cell 84:443.
46. Zhuang, H., S. V. Patel, T. He, S. K. Sonsteby, Z. Niu, and D. M. Wojchowski. 1994. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269:21411.
47. Rui, H., J. Lebrun, R. A. Kirken, P. A. Kelly, and W. L. Farrar. 1994. Jak2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization. Endocrinology 135:1299.
48. Chin, Y. E., M. Kitagawa, W. S. Su, Z. You, Y. Iwamoto, and X. Fu. 1996. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 272:719.
49. Zhuang, H., Z. Niu, T. C. He, S. V. Patel, and D. M. Wojchowski. 1995. Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2. J. Biol. Chem. 270:14500.
50. Migone, T. S., J.-X. Lin, A. Cereseto, J. C. Mulloy, J. J. O'Shea, G. Franchini, and W. J. Leonard. 1995. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269:79.
51. Yu, C-L., D. J. Meyer, G. S. Campbell, A. C. Larner, C. Carter-Su, J. Schwartz, and R. Jove. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81.
52. Danial, N. N., A. Pernis, and P. B. Rothman. 1995. Jak-STAT signaling induced by the v-abl oncogene. Science 269:1875.
53. Marrero, M. B., B. Schieffer, W. G. Paxton, L. Heerdt, B. C. Berk, P. Delafontaine, and K. E. Bernstein. 1995. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375:247.
54. Eck, M. J., and S. R. Sprang. 1989. The structure of tumor necrosis factor alpha at 2.6 A resolution: implications for receptor binding. J. Biol. Chem. 264:17595.
55. Eck, M. J., M. Ultsch, E. Ringerknecht, A. M. DeVos, and S. R. Sprang. 1992. The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9 A resolution. J. Biol. Chem. 267:2119.
56. Loetscher, H. R., R. Gentz, M. Zulauf, A. Lustig, H. Tabuchi, E. J. Schlaeger, M. Brockhaus, H. Gallati, M. Manneberg, and W. Lesslauer. 1991. Recombinant human 55-kDa tumor necrosis factor (TNF) receptor: stoichiometry of binding to TNF-alpha and TNF-beta and inhibition of TNF activity. J. Biol. Chem. 266: 18324.
57. Banner, D. W., A. D'Arcy, W. Janes, R. Gentz, H. Schoenfeld, C. Broger, H. Loetscher, and W. Lesslauer. 1993. Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: implications for TNF receptor activation. Cell 73:431.
58. Song, H. Y., J. D. Dunbar, and D. B. Donner. 1994. Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system. J. Biol. Chem. 269:22492.
59. Boldin, M. P., I. L. Mett, E. E. Varfolomeev, I. Chumakov, Y. Shemer-Avni, J. H. Camonis, and D. Wallach. 1995. Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 promotes signaling for TNF and Fas/APO1 effects. J. Biol. Chem. 270:387.
60. Hsu, H., J. Xiong, and D. V. Goeddel. 1995. The TNF receptor 1 associated protein TRADD signals cell death and NF-κB activation. Cell 81:495.
61. Darnay, B. G., S. A. G. Reddy, and B. B. Aggarwal. 1994. Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. J. Biol. Chem. 269:20299.
62. VanArsdale, R. L., and C. F. Ware. 1994. TNF receptor signal transduction: ligand-dependent stimulation of a serine protein kinase activity associated with (CD120a) TNFR60. J. Immunol. 153:3043.
63. Hanissian, S. H., and R. S. Geha. 1997. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 6:379.
64. Lutticken, C., U. M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A. G. Harpur, A. F. Wilks, K. Yasukawa, T. Taga, T. Kishimoto, G. Barbieri, S. Pellegrini, M. Sendtner, P. C. Heinrich, and F. Horn. 1994. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89.
65. Stahl, N., T. G. Boulton, T. Farruggella, N. Y. Ip, S. Davis, B. A. Witthuhn, F. W. Quelle, O. Silvennoinen, G. Barbieri, S. Pellegrini, J. N. Ihle, and G. D. Yancopoulos. 1994. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 263:92.
66. Guschin, D., N. Rogers, J. Briscoe, B. Witthuhn, D. Watling, F. Horn, S. Pellegrini, K. Yasukawa, P. Heinrich, G. R. Stark, J. N. Ihle, and I. M. Kerr. 1995. A major role for the protein tyrosine kinase Jak1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J. 14:1421.
67. Ivashkiv, L. B., E. M. Schmitt, and A. Castro. 1996. Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway. J. Immunol. 157:1415.
68. Zhang, X. J., J. Blenis, H.-C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoler complexes. Science 267:1990.
69. Wen, Z., Z. Zhong, and J. E. Darnell. Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine phosphorylation and serine phosphorylation. Cell 82:241.
70. Boulton, T. G., Z. Zhong, Z. Wen, J. E. Darnell, Jr., N. Stahl, and G. D. Yancoupoulos. 1995. Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. USA 92:6915.
71. David, M. E., E. Petricoin III, C. Benjamin, R. Pine, M. J. Weber, and A. C. Lamer. 1996. Requirement for MAP kinase (ERK2) activity in interferon-α and interferon-β-stimulated gene expression through STAT proteins. Science 269:1721.