Signals through gp130 upregulate bcl-x gene expression via STAT1- binding cis-element in cardiac myocytes

Journal of Clinical Investigation

Volumn 99, Issue 12, 1997, Pages 2898-2905

  Fujio, Yasushi ^a   Kunisada, Keita ^a   Hirota, Hisao ^a   Yamauchi Takihara, Keiko ^a   Kishimoto, Tadamitsu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

bcl 2 family; IL 6 related cytokine; Jak STAT pathway; Leukemia inhibitory factor; Signal transduction

Indexed keywords

CIS ACTING ELEMENT; DNA FRAGMENT; GAMMA INTERFERON; GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LUCIFERASE; MESSENGER RNA; ONCOPROTEIN; PROTEIN BCL X; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

EID: 0030912739     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119484     Document Type: Article

References (35)

1. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell. 76:253-262.
2. Saito, M., K. Yoshida, M. Hibi, T. Taga, and T. Kishimoto. 1992. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immnnol. 148:4066-4071.
3. Hirota, H., K. Yoshida, T. Kishimoto, and T. Taga. 1995. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc. Natl. Acad. Sci. USA. 92:4862-4866.
4. Yoshida, K., T. Taga, M. Saito, S. Suematsu, A. Kumanogoh, T. Tanaka, H. Fujiwara, M. Hirata, T. Yamagami, T. Nakahata, et al. 1996. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA. 93:407-411.
5. Pennica, D., K.L. King, K.J. Shaw, E. Luis, J. Rullamas, S.-M. Luoh, W.C. Darbonne, D.S. Knutzon, R. Yen, K.R. Chien, et al. 1995. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. USA. 92:1142-1146.
6. Pennica, D., K.J. Shaw, T.A. Swanson, M.W. Moor, D.L. Shelton, K.A. Zioncheck, A. Rosenthal, T. Taga, N.F. Proni, and W.I. Wood. 1995. Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270:10915-10922.
7. Wollert, K.C., T. Taga, M. Sailo, M. Narazaki, T. Kishimoto, C.C. Glembotski, A.B. Vernallis, J.K. Heath, D. Pennica, W.I. Wood, and K.R. Chien. 1996. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. J. Biol. Chem. 271:9535-9545.
8. Sendtner, M., G.W. Kreutzberg, and H. Thoenen. 1990. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature (Lond.). 345:440-441.
9. Hirota, H., H. Kiyama, T. Kishimoto, and T. Taga. 1996. Accelerated nerve regeneration in mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J. Exp. Med. 183:2627-2634.
10. Sheng, Z., D. Pennica, W.I. Wood, and K.R. Chien. 1996. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development (Camb.). 122:419-428.
11. Schwarze, M.M.K., and R.G. Hawley. 1995. Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL. Cancer Res. 55:2262-2265.
12. Boise, L.H., M. González-Garcia, C.E. Postema, L. Ding, T. Lindsten, L.A. Turka, X. Mao, G. Nuñez, and C.B. Thompson. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 74: 597-608.
13. Matsui, H., Y. Fujio, K. Kunisada, H. Hirota, and K. Yamauchi-Takihara. 1996. Leukemia inhibitory factor induces a hypertrophie response mediated by gp130 in murine cardiac myocytes. Res. Commun. Mol. Pathol. Pharmacol. 93:149-162.
14. Kunisada, K., H. Hirota, Y. Fujio, H. Matsui, Y. Tani, K. Yamauchi-Takihara, and T. Kishimoto. 1996. Activation of Jak-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. Circulation. 94:2626-2632.
15. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
16. Fang. W., J.J. Rivard, D.L. Mueller. and T.W. Behrens. 1994. Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. J. Immunol. 153:4388-4398.
17. Negrini, M., E. Silini, C. Kozak, Y. Tsujimoto, and C.M. Croce. 1987. Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell. 49:455-463.
18. Miller-Hance, W.C., M. LaCorbiere, S.J. Fuller, S.M. Evans, G. Lyons, C. Schmidt, J. Robbins, and K.R. Chien. 1993. In vitro chamber specification during embryonic stem cell cardiogenesis. J. Biol. Chem. 268:25244-25252.
19. Wang, Z., J.G. Karras, R.G. Howard, and T.L. Rothstein. 1995. Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J. Immunol. 155:3722-3725.
20. Shiraiwa, N., N. Inohara, S. Okada, M. Yuzaki, S. Shoji, and S. Ohta. 1996. An additional form of rat bcl-x, bcl-xβ, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J. Biol. Chem. 271:13258-13265.
21. Tamamori, M., H. Ito, S. Adachi, H. Akimoto, F. Marumo, and M. Hiroe. 1996. Endothelin-3 induces hypertrophy of cardiomyocytes by the endogenous endothelin-1-mediated mechanism. J. Clin. Invest. 97:366-372.
22. Knowlton, K.U., E. Baracchmi, R.S. Ross, A.N. Harris, S.A. Henderson, S.M. Evans, C,C. Glembotski, and K.R. Chien. 1991. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during α-adrenergic stimulation of neonatal rat ventricular cells. J. Biol. Chem. 266:7759-7768.
23. Matsusaka, T., K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira. 1993. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA. 90:10193-10197.
24. Sengupta, T.K., A. Chen, Z. Zhong, J.E. Darnell, Jr., and L.B. Ivashkiv. 1995. Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon γ. J. Exp. Med. 181:1015-1025.
25. Miyazaki, T., Z.-J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E.L. Barsoumian, R.M. Perlmutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell. 81:223-231.
26. Gerhartz, C., B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P.C. Heinrich, and L. Graeve. 1996. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. J. Biol. Chem. 271: 12991-12998.
27. Lowe, C., G.A.J. Gillespie, and J.W. Pike. 1995. Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts. J Bone Miner. Res. 10:1644-1650.
28. Seidel, H.M., L.H. Milocco, P. Lamb, J.E. Darnell, Jr., R.B. Stein, and J. Rosen. 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA. 92:3041-3045.
29. Kinoshita, T.,T. Yokota, K. Arai, and A. Miyajima. 1995. Regulation of bcl-2 expression by oncogenic Ras protein in hematopoietic cells. Oncogene. 10: 2207-2212.
30. Zhang, X., J. Blenis, H.-C. Li, C. Schindier, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complex. Science (Wash. OC). 267:1990-1994.
31. Zhuang, H., Z. Niu, T.-C. He, S.V. Patel, and D.M. Wojchowski. 1995. Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2. J. Biol. Chem. 270:14500-14504.
32. Motoyama, N., F. Wang, K.A. Roth, H. Sawa, K.-i. Nakayama, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, S. Fujii, and D.Y. Loh. 1995. Massive cell death of immature hematopoietic cells and neurons in bcl-x-deficient mice. Science (Wash. DC). 267:1506-1510.
33. Durbin, J.E., R. Hackenmiller, M.C. Simon, and D.E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 84:443-450.
34. Meraz, M.A., J.M. White, K.C.F. Sheehan, E.A. Bach, S.J. Rodig, A.S. Dighe, D.H. Kaplan, J.K. Riley, A.C. Greenlund, D. Campbell, et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 84:431-442.
35. Yamauchi-Takihara, K., Y. Ihara, A. Ogata, K. Yoshizaki, J. Azuma, and T. Kishimoto. 1995. Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation. 91:1520-1524.