The Drosophila jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye

Genes and Development

Volumn 10, Issue 21, 1996, Pages 2759-2768

  Riesgo Escovar, Juan R ^a   Jenni, Mario ^a   Fritz, Andreas ^a,b   Hafen, Ernst ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

basket; dorsal closure; Drosophila; Jun N terminal kinase; MAPK

Indexed keywords

PROTEIN KINASE;

ARTICLE; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME ANALYSIS; GENE EXPRESSION; GENE MUTATION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

MAMMALIA; VERTEBRATA;

EID: 0029834756     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.21.2759     Document Type: Article

References (63)

1. Abel, T., A.M. Michelson, and T. Maniatis. 1993. A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development 119: 623-633.
2. Affolter, M., D. Nellen, U. Nussbaumer, and K. Basler. 1994. Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGFβ homologs during Drosophila embryogenesis. Development 120: 3105-3117.
3. Basler, K., B. Christen, and E. Hafen. 1991. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64: 1069-1082.
4. Bohmann, D., M.C. Ellis, L.M. Staszewski, and M. Mlodzik. 1994. Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78: 973-986.
5. Brand, A.H. and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
6. Brunner, D., K. Dücker, N. Oellers, E. Hafen, H. Scholz, and C. Klämbt. 1994a. The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway. Nature 370: 386-389.
7. Brunner, D., N. Oellers, J. Szabad, W.H. Biggs III, S.L. Zipursky, and E. Hafen. 1994b. A gain of function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signalling pathways. Cell 76: 875-888.
8. Campos-Ortega, J. and V. Hartenstein. 1985. The embryonic development of Drosophila melanogaster. Springer-Verlag, Berlin, Germany.
9. Clegg, N.J., I.P. Whitehead, J.K. Brock, D.A. Sinclair, R. Mottus, G. Stromotich, M.J. Harrington, and T.A. Grigliatti. 1993. A cytogenetic analysis of chromosomal region 31 of Drosophila melanogaster. Genetics 134: 221-230.
10. Coso, O.A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J.S. Gutkind. 1995. The small GTP-binding proteins Racl and Cdc42 regulate the activity of the JNK/ SAPK signalling pathway. Cell 81: 1137-1146.
11. Dérijard, B., M. Hibi, I.H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R.J. Davis. 1994. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037.
12. Dickson, B. and E. Hafen. 1993. Genetic dissection of eye development in Drosophila. In The development of Drosophila melanogaster jed. A. Martinez-Arias and M. Bate), pp. 1327-1362. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
13. Domínguez, M. and E. Hafen. 1996. Genetic dissection of cell fate specification in the developing eye of Drosophila. Semin. Cell Dev. Biol. 7: 219-226.
14. Eaton, S., P. Auvinen, L.Q. Luo, Y.N. Jan, and K. Simons. 1995. CDC42 and Racl control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol. 131: 151-164.
15. Engelberg, D., C. Klein, H. Martinetto, K. Struhl, and M. Karin. 1994. The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell 77: 381-390.
16. Fehon, R.G., I.A. Dawson, and T.S. Artavanis. 1994. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 120: 545-557.
17. Fields, P.E., T.F. Gajewski, and F.W. Fitch. 1996. Blocked Ras activation in anergic CD4 + T cells. Science 271: 1276-1278.
18. Frank, L.H. and C. Rushlow. 1996. A group of genes required for the maintenance of the amnioserosa tissue in Drosophila. Development 122: 1343-1352.
19. Glise, B., H. Bourbon, and S. Noselli. 1995. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83: 451-462.
20. Harden, N., H.Y. Loh, W. Chia, and L. Lim. 1995. A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121: 903-914.
21. Heitzler, P., M. Haenlin, P. Ramain, M. Calleja, and P. Simpson. 1996. A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila. Genetics 143: 1271-1286.
22. Herskowitz, I. 1995. MAP kinase pathways in yeast: For mating and more. Cell 80: 187-197.
23. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation do- main. Genes & Dev. 7: 2135-2148.
24. Hill, C.S., J. Wynne, and R. Treisman. 1995. The Rho family GTPases RhoA, Racl, and Cdc42Hs regulate transcriptional activation by SRF. Cell 81: 1159-1170.
25. Hou, X.S., T.-B. Chou, M.B. Melnick, and N. Perrimon. 1995. The torso receptor tyrosine kinase can activate Raf in a Rasindependent pathway. Cell 81: 63-71.
26. Jürgens, G., C. Nüsslein-Volhard, and H. Kluding. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster II. Zygotic loci on the third chromosome. Roux's Arch. Dev. Biol. 193: 183-295.
27. Kallunki, T., B. Su, I. Tsigelny, H.K. Sluss, B. Dérijard, G. Moore, R. Davis, and M. Karin. 1994. INK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes & Dev. 8: 2996-3007.
28. Karin, M. and T. Hunter. 1995. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus. Curr. Biol. 5: 747-757.
29. Kayne, P.S. and P.W. Sternberg. 1995. Ras pathways in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 5: 38-43.
30. Kenyon, C. 1995. A perfect vulva every time: Gradients and signaling cascades in C. elegans. Cell 82: 171-174.
31. Keyse, S.M. and E.A. Emslie. 1992. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. Nature 359: 644-647.
32. Klemenz, R., U. Weber, and W.J. Gehring. 1987. The white gene as a marker in a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res. 15: 3947-3959.
33. Kyriakis, J.M., P. Banerjee, E. Nikolakaki, T. Dai, E.A. Rubie, M.F. Ahmad, J. Avruch, and J.R. Woodgett. 1994. The stressactivated protein kinase subfamily of c-Jun kinases. Nature 369: 156-160.
34. Li, W., C.D. Whaley, A. Mondino, and D.L. Mueller. 1996. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4 + T cells. Science 271: 1272-1276.
35. Lindsley, D.L. and G.G. Zimm. 1992. The genome of Drosophila melanogaster. Academic Press, San Diego, CA.
36. Marshall, C.J. 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4: 82-89.
37. - 1995. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185.
38. Minden, A., A. Lin, T. Smeal, B. Dérijard, M. Cobb, R. Davis, and M. Karin. 1994. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14: 6683-6688.
39. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signalling cascade and c-(un transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147-1157.
40. Mohit, A.A., J.H. Martin, and C.A. Miller. 1995. p49 3F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14: 67-78.
41. Nishida, E. and Y. Gotoh. 1993. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18: 128-131.
42. Nüsslein-Volhard, C., E. Wieschaus, and H. Kluding. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193: 267-282.
43. Pesacreta, T.C., T.J. Byers, R. Dubreuil, D.P. Kiehart, and D. Branton. 1989. Drosophila spectrin: The membrane skeleton during embryogenesis. J. Cell Biol. 108: 1697-1710.
44. Peverali, F.A., A. Isaksson, A.G. Papavassiliou, P. Plastina, L.M. Staszewski, M. Mlodzik, and D. Bohmann. 1996. Phospho- rylation of Drosophila jun by the MAP kinase tolled regulates photoreceptor differentiation. EMBO J. 15: 3943-3950.
45. Pombo, C.M., J.V. Bonventre, J. Avruch, J.R. Woodgett, J.M. Kyriakis, and T. Force. 1994. The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J. Biol. Chem. 269: 26546-26551.
46. Ramain, P., P. Heitzler, M. Haenlin, and P. Simpson. 1993. pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. Development 119: 1277-1291.
47. Ring, J.M. and A. Martinez-Arias. 1993. puckered, a gene involved in position-specific cell differentiation in the dorsal epidermis of the Drosophila larva. Development 119: 251-259.
48. Rogge, R., P.J. Green, J. Urano, S. Horn-Saban, M. Mlodzik, B.-Z. Shilo, V. Hartenstein, and U. Banerjee. 1995. The role of yan in mediating the choice between cell division and differentiation. Development 121: 3947-3958.
49. Ruperte, E., T. Marty, D. Nellen, M. Affolter, and K. Basler. 1995. An absolute requirement for both type II and type I receptors, Punt and Thick Veins, for Dpp signalling in vivo. Cell 80: 889-897.
50. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning: A laboratory manual, 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
51. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and N.Y. Ben. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727-736.
52. Sun, H., C.H. Charles, L.F. Lau, and N.K. Tonks. 1993. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75: 487-493.
53. Tautz, D. and C. Pfeifle. 1989. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81-85.
54. Treier, M., D. Bohmann, and M. Mlodzik. 1995. fun cooperates with the ETS-domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell 83: 753-760.
55. Wassarman, D.A., M. Therrien, and G.M. Rubin. 1995. The Ras signaling pathway in Drosophila. Curr. Opin. Genet, Dev. 5: 44-50.
56. Wieschaus, E., C. Nüsslein-Volhard, and G. Jürgens. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster III. Zygotic loci on the X-chromosome and the fourth chromosome. Roux's Arch. Dev. Biol. 193: 296-307.
57. Wilcox, M., A. DiAntonio, and M. Leptin. 1989. The function of PS integrins in Drosophila wing morphogenesis. Development 107: 891-897.
58. Wilson, C., D.C.I. Goberdhan, and H. Steller. 1993. Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases. Proc. Natl. Acad. Sci. 90: 7109-7113.
59. Xia, Z., M. Dickens, J. Raingeaud, R.G. Davis, and M.E. Greenberg. 1995. Opposing effects of ERK and JNK-P38 MAP kinases on apoptosis. Science 270: 1326-1331.
60. Xu, T. and G. Rubin. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
61. Young, P.E., T.C. Pesacreta, and D.P. Kiehart. 1991. Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis. Development 111: 1-14.
62. Young, P.E., A.M. Richman, A.S. Ketchum, and D.P. Kiehart. 1993. Morphogenesis in Drosophila requires nonmuscle my- osin heavy chain function. Genes & Dev. 7: 29-41.
63. Zipursky, L.S. and G.M. Rubin. 1994. Determination of neuronal cell fate: Lessons from the R7 neuron in Drosophila. Annu. Rev. Neurosci. 17: 373-397.