Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes

Journal of Experimental Medicine

Volumn 186, Issue 6, 1997, Pages 941-953

  Nishina, Hiroshi ^a   Bachmann, Martin ^a   Oliveira dos Santos, Antonio J ^a   Kozieradzki, Ivona ^a   Fischer, Klaus D ^b,f   Odermatt, Bernhard ^d   Wakeham, Andrew ^a   Shahinian, Arda ^a   Takimoto, Hiroaki ^a   Bernstein, Alan ^c,f   Mak, Tak W ^a   Woodgett, James R ^a,e   Ohashi, Pamela S ^a   Penninger, Josef M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e Medical Research Council   (Canada)

^f Institut national du cancer du Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD40 ANTIGEN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMALS; ANTIGENS, CD28; B-LYMPHOCYTES; BASE SEQUENCE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIFFERENTIATION; CHIMERA; DNA PRIMERS; GERMINAL CENTER; IMMUNOGLOBULIN SWITCH REGION; INTERLEUKIN-2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; POLYMERASE CHAIN REACTION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0030931125     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.6.941     Document Type: Article

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