Drosophila jun relays the jun amino-terminal kinase signal transduction pathway to the decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement

Genes and Development

Volumn 11, Issue 13, 1997, Pages 1728-1737

  Hou, X Steven ^a   Goldstein, Elliott S ^b   Perrimon, Norbert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Dorsal closure; Dpp; Drosophila Jun; JNK; jun; Signal relay

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM CELL; GENE LOCUS; GENE MUTATION; NONHUMAN; ONCOGENE C JUN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA; MAMMALIA;

EID: 0030742943     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.13.1728     Document Type: Article

References (64)

1. Affolter, M., D. Nellen, U. Nussbaumer, and K. Basler. 1994. Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGFβ homologs during Drosophila embryogenesis. Development 120: 3105-3117.
2. Angel, P., M. Imagawa, R. Chiu, B. Stein, R.J. Imbra, H.J. Rahmsdorf, C. Jonat, C. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49: 729-739.
3. Arora, K., H. Dai, S.G. Kazuko, J. Jamal, M.B. O'Connor, A. Letsou, and R. Warrior. 1995. The Drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81: 781-790.
4. Bartel, D., M. Sheng, L. Lau, and M.E. Greenberg. 1989. Growth factors and membrane depolarization activate distinct programs of early response gene expression: Dissociation of fos and jun induction. Genes & Dev. 3: 304-313.
5. Basler, K., B. Christen, and E. Hafen. 1991. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64: 1069-1081.
6. Bohmann, D., A. Admon, R. Turner, and R. Tjian. 1988. Transcriptional regulation by the AP-1 family of enhancer-binding proteins: A nuclear target for signal transduction. Cold Spring Harber Symp. Quant. Biol. 53: 695-700.
7. Bohmann, D., M.C. Ellis, L.M. Staszewski, and M. Mlodzik. 1994. Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78: 973-986.
8. Bour, B.A., M.A. O'Brien, W.L. Lockwood, E.S. Goldstein, R. Bodmer, P.H. Taghert, S.M. Abmayr, and H.T. Nguyen. 1995. Drosophila MEF2, a transcription factor that is essential for myogenesis. Genes & Dev. 9: 730-741.
9. Brand, A.H. and N. Perrimon. 1993. Targeted gene expression as a mean of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
10. Brummel, T.J., V. Twombly, G. Marqués, J.L. Wrana, S.L. Newfeld, L. Attisano, J. Massagué, M.B. O'Connor, and W.M. Gelbert. 1994. Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell 78: 251-261.
11. Brunner, D., N. Oellers, J. Szabad, W.H. Biggs III, L.H. Zipursky, and E. Hafen. 1994. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76: 875-888.
12. Calleja, M., E. Moreno, S. Pelaz, and G. Morata. 1996. Visualization of gene expression in living adult Drosophila. Science 274: 252-255.
13. Campos-Ortega, J.A. and V. Hartenstein. 1985. In The embryonic development of Drosophila melanogaster. Springer-Verlag, Berlin, Germany.
14. Chou, T.B. and N. Perrimon. 1996. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics 144: 1673-1679.
15. Coso, O.A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J.S. Gutkind. 1995. The small GTP-binding proteins rac1 and cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146.
16. Davis, R. 1995. Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42: 459-467.
17. Dickson, B., F. Sprenger, D. Morrison, and E. Hafen. 1992. Raf functions downstream of Ras1 in the sevenless signal transduction pathway. Nature 360: 600-603.
18. Duffy, J.B. and N. Perrimon. 1994. The torso pathway in Drosophila: Lessons on receptor tyrosine kinase signaling and pattern formation. Dev. Biol. 166: 380-395.
19. Fehon, R.G., I.A. Dawson, and S. Artavanis-Tsakonas. 1994. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 120: 545-557.
20. Glise, B., H. Bourbon, and S. Noselli. 1995. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83: 451-461.
21. Greenberg, M.E. and E.B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the fos proto-oncogene. Nature 311: 433-438.
22. Grieder, N.C., D. Nellen, R. Burke, K. Basler, and M. Affolter. 1995. schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell 81: 791-800.
23. Harden, N., H.Y. Loh, W. Chia, and L. Lim. 1995. A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape change in Drosophila. Development 121: 903-914.
24. Harden, N., J. Lee, H.Y. Loh, Y.M. Ong, I. Tan, T. Leung, E. Manser, and L. Lim. 1996. A Drosophila homolog of the Racand Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein the colocalizes with dynamic actin structures. Mol. Cell. Biol. 16: 1896-1908.
25. Hill, C.S. and R. Treisman. 1995. Transcriptional regulation by extracellular signals: Mechanisms and specificity. Cell 80: 199-211.
26. Hill, C.S., J. Wynne, and R. Treisman. 1995. The rho family GTPases rhoA, rac1, and Cdc42Hs regulate transcriptional activation by SRF. Cell 81: 1159-1170.
27. Hoodless, P.A., T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Connor, L. Attisano, and J.L. Wrana. 1996. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500.
28. Hou, X.S., T.B. Chou, M.B. Melnick, and N. Perrimon. 1995. The Torso receptor tyrosine kinase can activate raf in a rasindependent pathway. Cell 81: 63-71.
29. Kim, J., A. Sebring, J. Esch, M.E. Kraus, K. Vorwerk, J. Magee, and S.B. Carroll. 1996. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382: 133-138.
30. Jackson, P.D. and F.M. Hoffmann. 1994. Embryonic expression patterns of the Drosophila decapentaplegic gene: Separate regulatory elements control blastoderm expression and lateral ectodermal expression. Dev. Dynam. 199: 28-44.
31. Jügens, G., E. Wieschaus, C. Nüsslein-Volhard, and H. Kluding. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: II. Zygotic loci on the third chromosome. Wilhelm Roux's Arch. Dev. Biol. 193: 283-295.
32. Lawrence, P. and G. Struhl. 1996. Morphogens, compartments, and pattern: Lessons from Drosophila? Cell 85: 951-961.
33. Lee, W., P. Mitchell, and R. Tjian. 1987. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49: 741-752.
34. Letsou, A., K. Arora, J.L. Wrana, K. Simin, V. Twombly, J. Jamal, K. Staehling-Hampton, M.F. Hoffmann, W.M. Gelbert, J. Massagué, and M.B. O'Connor. 1995. Drosophila dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family. Cell 80: 899-908.
35. Lindsley, D. and G. Zimm. 1990. The genome of Drosophila melanogaster, 4. Genes L-Z, balancers, transposable elements. Dros. Inf. Serv. 68.
36. Lu, X., M.B. Melnick, J.C. Hsu, and N. Perrimon. 1994. Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. EMBO J. 13: 2592-2599.
37. Luo, L., Y.J. Liao, L.Y. Jan, and Y.N. Jan. 1994. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes & Dev. 8: 1787-1802.
38. Mackrell, A.J., B. Blumberg, S.R. Haynes, and J.H. Fessler. 1988. The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin b subunits. Proc. Natl. Acad. Sci. 85: 2633-2637.
39. Martinez Arias, A. 1993. Development and patterning of the larval epidermis of Drosophila. In The development of Drosophila melanogaster (ed. M. Bate and A. Martinez Arias), pp. 517-608. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
40. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling casacade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147-1157.
41. Nellen, D., M. Affolter, and K. Basler. 1994. Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78: 225-237.
42. Nüsslein-Volhard, C., E. Wieschaus, and H. Kluding. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: I. Zygotic loci on the second chromosome. Wilhelm Roux's Arch. Dev. Biol. 193: 267-282.
43. Penton, A., Y. Chen, K. Staehling-Hampton, J.L. Wrana, L. Attisano, J. Szidonya, J.A. Cassill, J. Massagué, and M.F. Hoffmann. 1994. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 78: 239-250.
44. Perkins, K.K., A. Admon, N. Patel, and R. Tjian. 1990. The Drosophila fos-related AP-1 protein is a developmentally regulated transcription factor. Genes & Dev. 4: 822-834.
45. Perrimon, N., L. Engstrom, and A.P. Mahowald. 1989. Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on X chromosome. Genetics 121: 333-352.
46. Peverali, F.A., A. Isaksson, A.G. Papavassiliou, P. Plastina, L.M. Staszewski, M. Mlodzik, and D. Bohmann. 1996. Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation. EMBO J. 15: 3943-3950.
47. Ray, R.P., K. Arora, C. Nüsslein-Volhard, and W.M. Gelbert. 1991. The control of cell fate along the dorsal-ventral axis of the Drosophila embryo. Development 113: 35-54.
48. Ray, R.P. and T. Schupbach. 1996. Intercellular signaling and the polarization of body axes during Drosophila oogenesis. Genes & Dev. 10: 1711-1723.
49. Riesgo-Escovar, J.R., M. Jenni, A. Fritz, and E. Hafen. 1996. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJUN-dependent cell fate specification in the eye. Genes & Dev. 10: 2759-2768.
50. Ruberte, E., T. Marty, D. Nellen, M. Affolter, and K. Basler. 1995. An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo. Cell 80: 890-898.
51. Rusch, J. and M. Levine. 1997. Regulation of a dpp target gene in the Drosophila embryo. Development 124: 303-311.
52. Ryder, K., L.F. Lau, and D. Nathans. 1989. A gene activated by growth factors is related to oncogene v-jun. Proc. Natl. Acad. Sci. 85: 1487-1491.
53. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
54. Sluss, H.K., Z. Han, T. Barrett, R.J. Davis, and T.Y. Ip. 1996. A INK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes & Dev. 10: 2745-2758.
55. Spradling, A.C. and G.M. Rubin. 1982. Transposition of cloned P-elements into Drosophila germ line chromosomes. Science 218: 341-347.
56. St. Johnston, R.D. and W.M. Gelbert. 1987. decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo. EMBO J. 6: 2785-2791.
57. Staehling-Hampton, K., A.S. Laughon, and M.F. Hoffmann. 1995. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBP/HIV-EP1 is required for dpp signaling. Development 121: 3393-3403.
58. Treier, M., D. Bohmann, and M. Mlodzik. 1995. Jun cooperates with the ETS domain protein Pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell 83: 753-760.
59. Wang, G.L. and E.S. Goldstein. 1994. Transcription of Djun from D. melanogaster is positively regulated by DTF-1, AP-1, and CREB binding sites. Exp. Cell Res. 214: 389-399.
60. Wieschaus, E., C. Nüsslein-Volhard, and G. Jürgens. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melamogaster: III. Zygotic loci on the X-chromosome. Wilhelm Roux's Arch. Dev. Biol. 193: 296-307.
61. Wilcox, M., A. DiAntonio, and M. Leptin. 1989. The function of PS integrins in Drosophila wing morphogenesis. Development 107: 891-897.
62. Xu, T. and G.M. Rubin. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
63. Young, P.E., A.M. Richman, A.S. Ketchum, and D.P. Kiehart. 1993. Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. Genes & Dev. 7: 29-41.
64. Zhang, K., R. Chaillet, L.A. Perkins, T.D. Halazonetis, and N. Perrimon. 1990. Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc. Natl. Acad. Sci. 87: 6281-6285.