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Volumn 5, Issue 4, 2016, Pages

Endothelial to Mesenchymal Transition (EndoMT) in the pathogenesis of human fibrotic diseases

Author keywords

Collagen; EndoMT; Endothelial cell; Endothelial mesenchymal transition; Extracellular matrix; Fibrosis; Fibrotic diseases; Idiopathic pulmonary fibrosis; Myofibroblast; Systemic sclerosis; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CAVEOLIN 1; CD31 ANTIGEN; CD34 ANTIBODY; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; FIBRILLAR COLLAGEN; FIBRONECTIN; IMATINIB; IMMUNOGLOBULIN G4; INTERLEUKIN 1; ISOPRENALINE; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; MICRORNA; NOTCH RECEPTOR; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; ROTTLERIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR ENDOTHELIAL CADHERIN; VON WILLEBRAND FACTOR;

EID: 85114281020     PISSN: None     EISSN: 20770383     Source Type: Journal    
DOI: 10.3390/jcm5040045     Document Type: Review
Times cited : (225)

References (176)
  • 1
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis-A common pathway to organ injury and failure
    • [PubMed]
    • Rockey, D. C.; Bell, P. D.; Hill, J. A. Fibrosis-A common pathway to organ injury and failure. N. Engl. J. Med. 2015, 372, 1138-1149. [PubMed]
    • (2015) N. Engl. J. Med , vol.372 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 2
    • 75749131647 scopus 로고    scopus 로고
    • Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies
    • [PubMed]
    • Rosenbloom, J.; Castro, S. V.; Jimenez, S. A. Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies. Ann. Int. Med. 2010, 152, 159-166. [PubMed]
    • (2010) Ann. Int. Med , vol.152 , pp. 159-166
    • Rosenbloom, J.1    Castro, S.V.2    Jimenez, S.A.3
  • 3
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • [CrossRef] [PubMed]
    • Wynn, T. A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 2007, 117, 524-529. [CrossRef] [PubMed]
    • (2007) J. Clin. Invest , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 4
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • [CrossRef] [PubMed]
    • Varga, J.; Abraham, D. Systemic sclerosis: A prototypic multisystem fibrotic disorder. J. Clin. Invest. 2007, 117, 557-567. [CrossRef] [PubMed]
    • (2007) J. Clin. Invest , vol.117 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 6
    • 84903694364 scopus 로고    scopus 로고
    • Fibrosis-A lethal component of systemic sclerosis
    • [CrossRef] [PubMed]
    • Ho, Y. Y.; Lagares, D.; Tager, A. M.; Kapoor, M. Fibrosis-A lethal component of systemic sclerosis. Nat. Rev. Rheumatol. 2014, 10, 390-402. [CrossRef] [PubMed]
    • (2014) Nat. Rev. Rheumatol , vol.10 , pp. 390-402
    • Ho, Y.Y.1    Lagares, D.2    Tager, A.M.3    Kapoor, M.4
  • 10
    • 84856773788 scopus 로고    scopus 로고
    • IgG4-related disease
    • [CrossRef] [PubMed]
    • Stone, J. H.; Zen, Y.; Deshpande, V. IgG4-related disease. N. Engl. J. Med. 2012, 366, 539-551. [CrossRef] [PubMed]
    • (2012) N. Engl. J. Med , vol.366 , pp. 539-551
    • Stone, J.H.1    Zen, Y.2    Deshpande, V.3
  • 11
    • 84928700021 scopus 로고    scopus 로고
    • IgG4-related disease
    • [CrossRef]
    • Kamisawa, T.; Zen, Y.; Pillai, S.; Stone, J. H. IgG4-related disease. Lancet 2015, 385, 1460-1471. [CrossRef]
    • (2015) Lancet , vol.385 , pp. 1460-1471
    • Kamisawa, T.1    Zen, Y.2    Pillai, S.3    Stone, J.H.4
  • 12
    • 84887904057 scopus 로고    scopus 로고
    • Molecular mechanisms and treatment of radiation-induced lung fibrosis
    • [CrossRef] [PubMed]
    • Ding, N. H.; Li, J. J.; Sun, L. Q. Molecular mechanisms and treatment of radiation-induced lung fibrosis. Curr. Drug Targets 2013, 14, 1347-1356. [CrossRef] [PubMed]
    • (2013) Curr. Drug Targets , vol.14 , pp. 1347-1356
    • Ding, N.H.1    Li, J.J.2    Sun, L.Q.3
  • 13
    • 0034961744 scopus 로고    scopus 로고
    • Radiation-induced and chemotherapy-induced pulmonary injury
    • [CrossRef] [PubMed]
    • Abid, S. H.; Malhotra, V.; Perry, M. C. Radiation-induced and chemotherapy-induced pulmonary injury. Curr. Opin. Oncol. 2001, 13, 242-248. [CrossRef] [PubMed]
    • (2001) Curr. Opin. Oncol , vol.13 , pp. 242-248
    • Abid, S.H.1    Malhotra, V.2    Perry, M.C.3
  • 14
    • 84930741570 scopus 로고    scopus 로고
    • Getting to the heart of the matter: New insights into cardiac fibrosis
    • [CrossRef] [PubMed]
    • Leask, A. Getting to the heart of the matter: New insights into cardiac fibrosis. Circ. Res. 2015, 116, 1269-1276. [CrossRef] [PubMed]
    • (2015) Circ. Res , vol.116 , pp. 1269-1276
    • Leask, A.1
  • 16
    • 84923312360 scopus 로고    scopus 로고
    • Contemporary assessment of hepatic fibrosis
    • [CrossRef] [PubMed]
    • Bonder, A.; Tapper, E. B.; Afdhal, N. H. Contemporary assessment of hepatic fibrosis. Clin. Liver Dis. 2015, 19, 123-134. [CrossRef] [PubMed]
    • (2015) Clin. Liver Dis , vol.19 , pp. 123-134
    • Bonder, A.1    Tapper, E.B.2    Afdhal, N.H.3
  • 17
    • 84902179695 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms in kidney fibrosis
    • [CrossRef] [PubMed]
    • Duffield, J. S. Cellular and molecular mechanisms in kidney fibrosis. J. Clin. Invest. 2014, 124, 2299-2306. [CrossRef] [PubMed]
    • (2014) J. Clin. Invest , vol.124 , pp. 2299-2306
    • Duffield, J.S.1
  • 18
    • 14044276311 scopus 로고    scopus 로고
    • Basic pathogenetic mechanisms in silicosis: Current understanding
    • [CrossRef] [PubMed]
    • Rimal, B.; Greenberg, A. K.; Rom, W. N. Basic pathogenetic mechanisms in silicosis: Current understanding. Curr. Opin. Pulm. Med. 2005, 11, 169-173. [CrossRef] [PubMed]
    • (2005) Curr. Opin. Pulm. Med , vol.11 , pp. 169-173
    • Rimal, B.1    Greenberg, A.K.2    Rom, W.N.3
  • 19
    • 0036147411 scopus 로고    scopus 로고
    • Diseases caused by asbestos: Mechanisms of injury and disease development
    • [CrossRef]
    • Manning, C. B.; Vallyathan, V.; Mossman, B. T. Diseases caused by asbestos: Mechanisms of injury and disease development. Int. Immunopharmacol. 2002, 2, 191-200. [CrossRef]
    • (2002) Int. Immunopharmacol , vol.2 , pp. 191-200
    • Manning, C.B.1    Vallyathan, V.2    Mossman, B.T.3
  • 22
    • 84907257199 scopus 로고    scopus 로고
    • Chagas disease cardiomyopathy: Immunopathology and genetics
    • [CrossRef] [PubMed]
    • Cunha-Neto, E.; Chevillard, C. Chagas disease cardiomyopathy: Immunopathology and genetics. Mediat. Inflamm. 2014, 2014, 683230. [CrossRef] [PubMed]
    • (2014) Mediat. Inflamm , vol.2014 , pp. 683230
    • Cunha-Neto, E.1    Chevillard, C.2
  • 26
    • 0028854277 scopus 로고
    • Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1
    • [PubMed]
    • Kirk, T. Z.; Mark, M. E.; Chua, C. C.; Chua, B. H.; Mayes, M. D. Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1. J. Biol. Chem. 1995, 270, 3423-3428. [PubMed]
    • (1995) J. Biol. Chem , vol.270 , pp. 3423-3428
    • Kirk, T.Z.1    Mark, M.E.2    Chua, C.C.3    Chua, B.H.4    Mayes, M.D.5
  • 28
    • 84927722050 scopus 로고    scopus 로고
    • Emerging cellular and molecular targets in fibrosis: Implications for scleroderma pathogenesis and targeted therapy
    • [CrossRef] [PubMed]
    • Castelino, F. V.; Varga, J. Emerging cellular and molecular targets in fibrosis: Implications for scleroderma pathogenesis and targeted therapy. Curr. Opin. Rheumatol. 2014, 26, 607-614. [CrossRef] [PubMed]
    • (2014) Curr. Opin. Rheumatol , vol.26 , pp. 607-614
    • Castelino, F.V.1    Varga, J.2
  • 29
    • 84953343033 scopus 로고    scopus 로고
    • Systemic sclerosis: From pathogenesis to targeted therapy
    • [PubMed]
    • Denton, C. P. Systemic sclerosis: From pathogenesis to targeted therapy. Clin. Exp. Rheumatol. 2015, 33 (Suppl. 92), S3-S7. [PubMed]
    • (2015) Clin. Exp. Rheumatol , vol.33 , pp. S3-S7
    • Denton, C.P.1
  • 30
    • 0019438740 scopus 로고
    • The myofibroblast: A key cell for wound healing and fibrocontractive diseases
    • [PubMed]
    • Gabbiani, G. The myofibroblast: A key cell for wound healing and fibrocontractive diseases. Prog. Clin. Biol. Res. 1981, 54, 183-194. [PubMed]
    • (1981) Prog. Clin. Biol. Res , vol.54 , pp. 183-194
    • Gabbiani, G.1
  • 31
    • 33847392947 scopus 로고    scopus 로고
    • New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma
    • [CrossRef] [PubMed]
    • Abraham, D. J.; Eckes, B.; Rajkumar, V.; Krieg, T. New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma. Curr. Rheumatol. Rep. 2007, 9, 136-143. [CrossRef] [PubMed]
    • (2007) Curr. Rheumatol. Rep , vol.9 , pp. 136-143
    • Abraham, D.J.1    Eckes, B.2    Rajkumar, V.3    Krieg, T.4
  • 32
    • 84879298794 scopus 로고    scopus 로고
    • Scleroderma pathogenesis: A pivotal role for fibroblasts as effector cells
    • [CrossRef] [PubMed]
    • Gilbane, A. J.; Denton, C. P.; Holmes, A. M. Scleroderma pathogenesis: A pivotal role for fibroblasts as effector cells. Arthritis Res. Ther. 2013, 15, 215. [CrossRef] [PubMed]
    • (2013) Arthritis Res. Ther , vol.15 , pp. 215
    • Gilbane, A.J.1    Denton, C.P.2    Holmes, A.M.3
  • 33
    • 84904615422 scopus 로고    scopus 로고
    • Fibroblasts in fibrosis: Novel roles and mediators
    • [CrossRef] [PubMed]
    • Kendall, R. T.; Feghali-Bostwick, C. A. Fibroblasts in fibrosis: Novel roles and mediators. Front. Pharmacol. 2014, 5, 123. [CrossRef] [PubMed]
    • (2014) Front. Pharmacol , vol.5 , pp. 123
    • Kendall, R.T.1    Feghali-Bostwick, C.A.2
  • 35
    • 84871197760 scopus 로고    scopus 로고
    • Myofibroblasts
    • [CrossRef] [PubMed]
    • Hu, B.; Phan, S. H. Myofibroblasts. Curr. Opin. Rheumatol. 2013, 25, 71-77. [CrossRef] [PubMed]
    • (2013) Curr. Opin. Rheumatol , vol.25 , pp. 71-77
    • Hu, B.1    Phan, S.H.2
  • 36
    • 41649106542 scopus 로고    scopus 로고
    • Matrix elasticity, cytoskeletal tension, and TGF-beta: The insoluble and soluble meet
    • [CrossRef] [PubMed]
    • Wells, R. G.; Discher, D. E. Matrix elasticity, cytoskeletal tension, and TGF-beta: The insoluble and soluble meet. Sci. Signal 2008, 1. [CrossRef] [PubMed]
    • (2008) Sci. Signal , pp. 1
    • Wells, R.G.1    Discher, D.E.2
  • 37
    • 65549160523 scopus 로고    scopus 로고
    • Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis
    • [CrossRef]
    • Hinz, B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis. Curr. Rheumatol. 2009, 11, 120-126. [CrossRef]
    • (2009) Curr. Rheumatol , vol.11 , pp. 120-126
    • Hinz, B.1
  • 39
    • 33847676783 scopus 로고    scopus 로고
    • Fibroblasts and myofibroblasts: Their source, function and role in disease
    • [CrossRef] [PubMed]
    • McAnulty, R. J. Fibroblasts and myofibroblasts: Their source, function and role in disease. Int. J. Biochem. Cell. Biol. 2007, 39, 666-671. [CrossRef] [PubMed]
    • (2007) Int. J. Biochem. Cell. Biol , vol.39 , pp. 666-671
    • McAnulty, R.J.1
  • 41
    • 84925678297 scopus 로고    scopus 로고
    • Diverse origins of the myofibroblast-implications for kidney fibrosis
    • [CrossRef] [PubMed]
    • Falke, L. L.; Gholizadeh, S.; Goldschmeding, R.; Kok, R. J.; Nguyen, T. Q. Diverse origins of the myofibroblast-implications for kidney fibrosis. Nat. Rev. Nephrol. 2015, 11, 233-244. [CrossRef] [PubMed]
    • (2015) Nat. Rev. Nephrol , vol.11 , pp. 233-244
    • Falke, L.L.1    Gholizadeh, S.2    Goldschmeding, R.3    Kok, R.J.4    Nguyen, T.Q.5
  • 42
    • 7044224913 scopus 로고    scopus 로고
    • Cellular origins of fibroblasts: Possible implications for organ fibrosis in systemic sclerosis
    • [CrossRef]
    • Poslethwaite, A. E.; Shigemitsu, H.; Kanagat, S. Cellular origins of fibroblasts: Possible implications for organ fibrosis in systemic sclerosis. Curr. Opin. Rheumatol. 2004, 16, 733-738. [CrossRef]
    • (2004) Curr. Opin. Rheumatol , vol.16 , pp. 733-738
    • Poslethwaite, A.E.1    Shigemitsu, H.2    Kanagat, S.3
  • 43
    • 70350738517 scopus 로고    scopus 로고
    • The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    • [CrossRef] [PubMed]
    • Strieter, R. M.; Keeley, E. C.; Hughes, M. A.; Burdick, M. D.; Mehrad, B. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J. Leukoc. Biol. 2009, 86, 1111-1118. [CrossRef] [PubMed]
    • (2009) J. Leukoc. Biol , vol.86 , pp. 1111-1118
    • Strieter, R.M.1    Keeley, E.C.2    Hughes, M.A.3    Burdick, M.D.4    Mehrad, B.5
  • 44
    • 77953544771 scopus 로고    scopus 로고
    • Fibrocytes in health and disease
    • [CrossRef] [PubMed]
    • Herzog, E. L.; Bucala, R. Fibrocytes in health and disease. Exp. Hematol. 2010, 38, 548-556. [CrossRef] [PubMed]
    • (2010) Exp. Hematol , vol.38 , pp. 548-556
    • Herzog, E.L.1    Bucala, R.2
  • 45
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Lamouille, S.; Xu, J.; Derynck, R. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell. Biol. 2014, 15, 178-196. [CrossRef] [PubMed]
    • (2014) Nat. Rev. Mol. Cell. Biol , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 48
    • 33845937474 scopus 로고    scopus 로고
    • Does transformation of microvascular endothelial cells into myofibroblasts play a key role in the etiology and pathology of fibrotic disease? Med
    • [CrossRef] [PubMed]
    • Karasek, M. A. Does transformation of microvascular endothelial cells into myofibroblasts play a key role in the etiology and pathology of fibrotic disease? Med. Hypotheses 2007, 68, 650-655. [CrossRef] [PubMed]
    • (2007) Hypotheses , vol.68 , pp. 650-655
    • Karasek, M.A.1
  • 49
    • 0345600104 scopus 로고    scopus 로고
    • Molecular markers of cardiac endocardial cushion development
    • [CrossRef] [PubMed]
    • Gitler, A. D.; Lu, M. M.; Jiang, Y. Q.; Epstein, J. A.; Gruber, P. J. Molecular markers of cardiac endocardial cushion development. Dev. Dyn. 2003, 228, 643-650. [CrossRef] [PubMed]
    • (2003) Dev. Dyn , vol.228 , pp. 643-650
    • Gitler, A.D.1    Lu, M.M.2    Jiang, Y.Q.3    Epstein, J.A.4    Gruber, P.J.5
  • 50
    • 27744464592 scopus 로고    scopus 로고
    • Endothelial-mesenchymal transition occurs during embryonic pulmonary artery development
    • [CrossRef] [PubMed]
    • Arciniegas, E.; Neves, C. Y.; Carrillo, L. M.; Zambrano, E. A.; Ramírez, R. Endothelial-mesenchymal transition occurs during embryonic pulmonary artery development. Endothelium 2005, 12, 193-200. [CrossRef] [PubMed]
    • (2005) Endothelium , vol.12 , pp. 193-200
    • Arciniegas, E.1    Neves, C.Y.2    Carrillo, L.M.3    Zambrano, E.A.4    Ramírez, R.5
  • 52
    • 63449110274 scopus 로고    scopus 로고
    • Transforming growth factor β-induced endothelial-to-mesenchymal transition: A switch to cardiac fibrosis? Trends Cardiovasc
    • [CrossRef] [PubMed]
    • Goumans, M. J.; van Zonneveld, A. J.; ten Dijke, P. Transforming growth factor β-induced endothelial-to-mesenchymal transition: A switch to cardiac fibrosis? Trends Cardiovasc. Med. 2008, 18, 293-298. [CrossRef] [PubMed]
    • (2008) Med , vol.18 , pp. 293-298
    • Goumans, M.J.1    van Zonneveld, A.J.2    Ten Dijke, P.3
  • 53
    • 55249103431 scopus 로고    scopus 로고
    • Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    • [CrossRef] [PubMed]
    • Zeisberg, E. M.; Potenta, S. E.; Sugimoto, H.; Zeisberg, M.; Kalluri, R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J. Am. Soc. Nephrol. 2008, 19, 2282-2287. [CrossRef] [PubMed]
    • (2008) J. Am. Soc. Nephrol , vol.19 , pp. 2282-2287
    • Zeisberg, E.M.1    Potenta, S.E.2    Sugimoto, H.3    Zeisberg, M.4    Kalluri, R.5
  • 54
    • 77955071008 scopus 로고    scopus 로고
    • Review: Endothelial-Myofibroblast Transition, a new player in diabetic renal fibrosis
    • [CrossRef] [PubMed]
    • Li, J.; Bertram, J. F. Review: Endothelial-Myofibroblast Transition, a new player in diabetic renal fibrosis. Nephrology 2010, 15, 507-512. [CrossRef] [PubMed]
    • (2010) Nephrology , vol.15 , pp. 507-512
    • Li, J.1    Bertram, J.F.2
  • 55
    • 80052851503 scopus 로고    scopus 로고
    • Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders
    • [CrossRef] [PubMed]
    • Piera-Velazquez, S.; Li, Z.; Jimenez, S. A. Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders. Am. J. Pathol. 2011, 179, 1074-1084. [CrossRef] [PubMed]
    • (2011) Am. J. Pathol , vol.179 , pp. 1074-1084
    • Piera-Velazquez, S.1    Li, Z.2    Jimenez, S.A.3
  • 56
    • 84865345444 scopus 로고    scopus 로고
    • The role of endothelial-mesenchymal transition in development and pathological process
    • [CrossRef] [PubMed]
    • Lin, F.; Wang, N.; Zhang, T. C. The role of endothelial-mesenchymal transition in development and pathological process. IUBMB. Life 2012, 64, 717-723. [CrossRef] [PubMed]
    • (2012) IUBMB. Life , vol.64 , pp. 717-723
    • Lin, F.1    Wang, N.2    Zhang, T.C.3
  • 58
    • 84873344021 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
    • [CrossRef] [PubMed]
    • Zeisberg, M.; Kalluri, R. Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am. J. Cell. Physiol. 2013, 304, C216-C225. [CrossRef] [PubMed]
    • (2013) Am. J. Cell. Physiol , vol.304 , pp. C216-C225
    • Zeisberg, M.1    Kalluri, R.2
  • 60
    • 84880412454 scopus 로고    scopus 로고
    • Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fibrosis
    • [CrossRef] [PubMed]
    • Yoshimatsu, Y.; Watabe, T. Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fibrosis. Int. J. Inflam. 2011, 2011, 724080. [CrossRef] [PubMed]
    • (2011) Int. J. Inflam , vol.2011 , pp. 724080
    • Yoshimatsu, Y.1    Watabe, T.2
  • 62
    • 68449088473 scopus 로고    scopus 로고
    • Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension
    • [CrossRef] [PubMed]
    • Kitao, A.; Sato, Y.; Sawada-Kitamura, S.; Harada, K.; Sasaki, M.; Morikawa, H.; Shiomi, S.; Honda, M.; Matsui, O.; Nakanuma, Y. Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Am. J. Pathol. 2009, 175, 616-626. [CrossRef] [PubMed]
    • (2009) Am. J. Pathol , vol.175 , pp. 616-626
    • Kitao, A.1    Sato, Y.2    Sawada-Kitamura, S.3    Harada, K.4    Sasaki, M.5    Morikawa, H.6    Shiomi, S.7    Honda, M.8    Matsui, O.9    Nakanuma, Y.10
  • 64
    • 84952064198 scopus 로고    scopus 로고
    • Endothelial cells expressing endothelial and mesenchymal cell gene products in Systemic Sclerosis-associated interstitial lung disease lung tissues
    • [CrossRef] [PubMed]
    • Mendoza, F.; Piera-Velazquez, S.; Farber, J.; Feghali-Bostwick, C.; Jimenez, S. A. Endothelial cells expressing endothelial and mesenchymal cell gene products in Systemic Sclerosis-associated interstitial lung disease lung tissues. Arthritis Rheum. 2016, 68, 210-217. [CrossRef] [PubMed]
    • (2016) Arthritis Rheum , vol.68 , pp. 210-217
    • Mendoza, F.1    Piera-Velazquez, S.2    Farber, J.3    Feghali-Bostwick, C.4    Jimenez, S.A.5
  • 66
    • 84931431692 scopus 로고    scopus 로고
    • Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension
    • [CrossRef] [PubMed]
    • Good, R. B.; Gilbane, A. J.; Trinder, S. L.; Denton, C. P.; Coghlan, G.; Abraham, D. J.; Holmes, A. M. Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension. Am. J. Pathol. 2015, 185, 1850-1858. [CrossRef] [PubMed]
    • (2015) Am. J. Pathol , vol.185 , pp. 1850-1858
    • Good, R.B.1    Gilbane, A.J.2    Trinder, S.L.3    Denton, C.P.4    Coghlan, G.5    Abraham, D.J.6    Holmes, A.M.7
  • 68
    • 84922337355 scopus 로고    scopus 로고
    • A role for partial endothelial-mesenchymal transitions in angiogenesis? Arterioscler
    • [CrossRef] [PubMed]
    • Welch-Reardon, K. M.; Wu, N.; Hughes, C. C. A role for partial endothelial-mesenchymal transitions in angiogenesis? Arterioscler. Thromb. Vasc. Biol. 2015, 35, 303-308. [CrossRef] [PubMed]
    • (2015) Thromb. Vasc. Biol , vol.35 , pp. 303-308
    • Welch-Reardon, K.M.1    Wu, N.2    Hughes, C.C.3
  • 71
    • 0022471924 scopus 로고
    • Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • [CrossRef] [PubMed]
    • Roberts, A. B.; Sporn, M. B.; Assoian, R. K.; Smith, J. M.; Roche, N. S.; Wakefield, L. M.; Heine, U. I.; Liotta, L. A.; Falanga, V.; Kehrl, J. H.; et al. Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. PNAS 1986, 83, 4167-4171. [CrossRef] [PubMed]
    • (1986) PNAS , vol.83 , pp. 4167-4171
    • Roberts, A.B.1    Sporn, M.B.2    Assoian, R.K.3    Smith, J.M.4    Roche, N.S.5    Wakefield, L.M.6    Heine, U.I.7    Liotta, L.A.8    Falanga, V.9    Kehrl, J.H.10
  • 72
    • 84907501988 scopus 로고    scopus 로고
    • Signaling mechanisms of the epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Gonzalez, D. M.; Medici, D. Signaling mechanisms of the epithelial-mesenchymal transition. Sci. Signal 2014, 7. [CrossRef] [PubMed]
    • (2014) Sci. Signal , pp. 7
    • Gonzalez, D.M.1    Medici, D.2
  • 73
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • [PubMed]
    • Border, W. A.; Noble, N. A. Transforming growth factor beta in tissue fibrosis. N. Engl. J. Med. 1994, 331, 1286-1292. [PubMed]
    • (1994) N. Engl. J. Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 74
    • 76649142440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in systemic sclerosis (scleroderma)
    • [CrossRef]
    • Varga, J.; Whitfield, M. L. Transforming growth factor-beta in systemic sclerosis (scleroderma). Front. Biosci. 2009, 1, 226-235. [CrossRef]
    • (2009) Front. Biosci , vol.1 , pp. 226-235
    • Varga, J.1    Whitfield, M.L.2
  • 75
    • 78649346798 scopus 로고    scopus 로고
    • Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis
    • [CrossRef] [PubMed]
    • Jiménez, S. A.; Castro, S. V.; Piera-Velázquez, S. Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. Curr. Rheumatol. Rev. 2010, 6, 283-294. [CrossRef] [PubMed]
    • (2010) Curr. Rheumatol. Rev , vol.6 , pp. 283-294
    • Jiménez, S.A.1    Castro, S.V.2    Piera-Velázquez, S.3
  • 76
    • 84927176114 scopus 로고    scopus 로고
    • Transforming growth factor β-At the centre of systemic sclerosis
    • [CrossRef] [PubMed]
    • Lafyatis, R. Transforming growth factor β-At the centre of systemic sclerosis. Nat. Rev. Rheumatol. 2014, 10, 706-719. [CrossRef] [PubMed]
    • (2014) Nat. Rev. Rheumatol , vol.10 , pp. 706-719
    • Lafyatis, R.1
  • 79
    • 58149230979 scopus 로고    scopus 로고
    • TGF-beta signaling in vascular biology and dysfunction
    • [CrossRef] [PubMed]
    • Goumans, M. J.; Liu, Z.; ten Dijke, P. TGF-beta signaling in vascular biology and dysfunction. Cell Res. 2009, 19, 116-127. [CrossRef] [PubMed]
    • (2009) Cell Res , vol.19 , pp. 116-127
    • Goumans, M.J.1    Liu, Z.2    Ten Dijke, P.3
  • 80
    • 79960217559 scopus 로고    scopus 로고
    • Transforming growth factor-β2 promotes Snail-mediated endothelial mesenchymal transition through convergence of Smad-dependent and Smad-independent signaling
    • [CrossRef] [PubMed]
    • Medici, D.; Potenta, S.; Kalluri, R. Transforming growth factor-β2 promotes Snail-mediated endothelial mesenchymal transition through convergence of Smad-dependent and Smad-independent signaling. Biochem. J. 2011, 433, 515-520. [CrossRef] [PubMed]
    • (2011) Biochem. J , vol.433 , pp. 515-520
    • Medici, D.1    Potenta, S.2    Kalluri, R.3
  • 81
    • 84857824476 scopus 로고    scopus 로고
    • Regulation of endothelial cell plasticity by TGF-β
    • [CrossRef] [PubMed]
    • Van Meeteren, L. A.; ten Dijke, P. Regulation of endothelial cell plasticity by TGF-β. Cell Tissue Res. 2012, 347, 177-186. [CrossRef] [PubMed]
    • (2012) Cell Tissue Res , vol.347 , pp. 177-186
    • Van Meeteren, L.A.1    Ten Dijke, P.2
  • 82
    • 63049101157 scopus 로고    scopus 로고
    • The role of the ZEB family of transcription factors in development and disease
    • [CrossRef] [PubMed]
    • Vandewalle, C.; Van Roy, F.; Berx, G. The role of the ZEB family of transcription factors in development and disease. Cell Mol. Life Sci. 2009, 66, 773-787. [CrossRef] [PubMed]
    • (2009) Cell Mol. Life Sci , vol.66 , pp. 773-787
    • Vandewalle, C.1    Van Roy, F.2    Berx, G.3
  • 83
    • 84872694870 scopus 로고    scopus 로고
    • Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases
    • Piera-Velazquez, S.; Jimenez, S. A. Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases. Fibrogenesis Tissue Repair 2012, 5 (Suppl. 1), S7.
    • (2012) Fibrogenesis Tissue Repair , vol.5
    • Piera-Velazquez, S.1    Jimenez, S.A.2
  • 84
    • 79961120675 scopus 로고    scopus 로고
    • Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro
    • [CrossRef] [PubMed]
    • Li, Z.; Jimenez, S. A. Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. Arthritis Rheum. 2011, 63, 2473-2483. [CrossRef] [PubMed]
    • (2011) Arthritis Rheum , vol.63 , pp. 2473-2483
    • Li, Z.1    Jimenez, S.A.2
  • 85
    • 84926432474 scopus 로고    scopus 로고
    • Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD.J
    • [CrossRef] [PubMed]
    • Xavier, S.; Vasko, R.; Matsumoto, K.; Zullo, J. A.; Chen, R.; Maizel, J.; Chander, P. N.; Goligorsky, M. S. Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD. J. Am. Soc. Nephrol. 2015, 26, 817-829. [CrossRef] [PubMed]
    • (2015) Am. Soc. Nephrol , vol.26 , pp. 817-829
    • Xavier, S.1    Vasko, R.2    Matsumoto, K.3    Zullo, J.A.4    Chen, R.5    Maizel, J.6    Chander, P.N.7    Goligorsky, M.S.8
  • 86
    • 84940791235 scopus 로고    scopus 로고
    • Interactions of DPP-4 and integrin β1 influences endothelial-to mesenchymal transition
    • [CrossRef] [PubMed]
    • Shi, S.; Srivastava, S. P.; Kanasaki, M.; He, J.; Kitada, M.; Nagai, T.; Takagi, S.; Kanasaki, K.; Koya, D. Interactions of DPP-4 and integrin β1 influences endothelial-to mesenchymal transition. Kidney Int. 2015, 88, 479-489. [CrossRef] [PubMed]
    • (2015) Kidney Int , vol.88 , pp. 479-489
    • Shi, S.1    Srivastava, S.P.2    Kanasaki, M.3    He, J.4    Kitada, M.5    Nagai, T.6    Takagi, S.7    Kanasaki, K.8    Koya, D.9
  • 87
    • 84861987033 scopus 로고    scopus 로고
    • Notch and disease: A growing field
    • [CrossRef] [PubMed]
    • Louvi, A.; Artavanis-Tsakonas, S. Notch and disease: A growing field. Semin. Cell. Dev. Biol. 2012, 23, 473-480. [CrossRef] [PubMed]
    • (2012) Semin. Cell. Dev. Biol , vol.23 , pp. 473-480
    • Louvi, A.1    Artavanis-Tsakonas, S.2
  • 88
    • 84920266745 scopus 로고    scopus 로고
    • Sonic hedgehog signaling in the lung. From development to disease
    • [CrossRef] [PubMed]
    • Kugler, M. C.; Joyner, A. L.; Loomis, C. A.; Munger, J. S. Sonic hedgehog signaling in the lung. From development to disease. Am. J. Respir. Cell Mol. Biol. 2015, 52, 1-13. [CrossRef] [PubMed]
    • (2015) Am. J. Respir. Cell Mol. Biol , vol.52 , pp. 1-13
    • Kugler, M.C.1    Joyner, A.L.2    Loomis, C.A.3    Munger, J.S.4
  • 89
    • 84899925204 scopus 로고    scopus 로고
    • Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability
    • [CrossRef] [PubMed]
    • Distler, A.; Lang, V.; Del Vecchio, T.; Huang, J.; Zhang, Y.; Beyer, C.; Lin, N. Y.; Palumbo-Zerr, K.; Distler, O.; Schett, G.; et al. Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability. Ann. Rheum. Dis. 2014, 73, 1264-1268. [CrossRef] [PubMed]
    • (2014) Ann. Rheum. Dis , vol.73 , pp. 1264-1268
    • Distler, A.1    Lang, V.2    Del Vecchio, T.3    Huang, J.4    Zhang, Y.5    Beyer, C.6    Lin, N.Y.7    Palumbo-Zerr, K.8    Distler, O.9    Schett, G.10
  • 90
    • 11144354703 scopus 로고    scopus 로고
    • Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation
    • [CrossRef] [PubMed]
    • Noseda, M.; McLean, G.; Niessen, K.; Chang, L.; Pollet, I.; Montpetit, R.; Shahidi, R.; Dorovini-Zis, K.; Li, L.; Beckstead, B.; et al. Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ. Res. 2004, 94, 910-917. [CrossRef] [PubMed]
    • (2004) Circ. Res , vol.94 , pp. 910-917
    • Noseda, M.1    McLean, G.2    Niessen, K.3    Chang, L.4    Pollet, I.5    Montpetit, R.6    Shahidi, R.7    Dorovini-Zis, K.8    Li, L.9    Beckstead, B.10
  • 91
    • 48249103470 scopus 로고    scopus 로고
    • Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    • [CrossRef] [PubMed]
    • Niessen, K.; Fu, Y.; Chang, L.; Hoodless, P. A.; McFadden, D.; Karsan, A. Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 2008, 182, 315-325. [CrossRef] [PubMed]
    • (2008) J. Cell Biol , vol.182 , pp. 315-325
    • Niessen, K.1    Fu, Y.2    Chang, L.3    Hoodless, P.A.4    McFadden, D.5    Karsan, A.6
  • 92
    • 79961240429 scopus 로고    scopus 로고
    • Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase
    • [CrossRef] [PubMed]
    • Chang, A. C.; Fu, Y.; Garside, V. C.; Niessen, K.; Chang, L.; Fuller, M.; Setiadi, A.; Smrz, J.; Kyle, A.; Minchinton, A.; et al. Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Dev. Cell 2011, 21, 288-300. [CrossRef] [PubMed]
    • (2011) Dev. Cell , vol.21 , pp. 288-300
    • Chang, A.C.1    Fu, Y.2    Garside, V.C.3    Niessen, K.4    Chang, L.5    Fuller, M.6    Setiadi, A.7    Smrz, J.8    Kyle, A.9    Minchinton, A.10
  • 93
    • 67749104045 scopus 로고    scopus 로고
    • Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells
    • [CrossRef] [PubMed]
    • Fu, Y.; Chang, A.; Chang, L.; Niessen, K.; Eapen, S.; Setiadi, A.; Karsan, A. Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells. J. Biol. Chem. 2009, 284, 19452-19462. [CrossRef] [PubMed]
    • (2009) J. Biol. Chem , vol.284 , pp. 19452-19462
    • Fu, Y.1    Chang, A.2    Chang, L.3    Niessen, K.4    Eapen, S.5    Setiadi, A.6    Karsan, A.7
  • 94
    • 84860633548 scopus 로고    scopus 로고
    • Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis
    • [CrossRef] [PubMed]
    • Ding, H.; Zhou, D.; Hao, S.; Zhou, L.; He, W.; Nie, J.; Hou, F. F.; Liu, Y. Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis. J. Am. Soc. Nephrol. 2012, 23, 801-813. [CrossRef] [PubMed]
    • (2012) J. Am. Soc. Nephrol , vol.23 , pp. 801-813
    • Ding, H.1    Zhou, D.2    Hao, S.3    Zhou, L.4    He, W.5    Nie, J.6    Hou, F.F.7    Liu, Y.8
  • 95
    • 70349436007 scopus 로고    scopus 로고
    • Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Syn, W. K.; Jung, Y.; Omenetti, A.; Abdelmalek, M.; Guy, C. D.; Yang, L.; Wang, J.; Witek, R. P.; Fearing, C. M.; Pereira, T. A.; et al. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology 2009, 137, 1478-1488. [CrossRef] [PubMed]
    • (2009) Gastroenterology , vol.137 , pp. 1478-1488
    • Syn, W.K.1    Jung, Y.2    Omenetti, A.3    Abdelmalek, M.4    Guy, C.D.5    Yang, L.6    Wang, J.7    Witek, R.P.8    Fearing, C.M.9    Pereira, T.A.10
  • 99
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • [CrossRef] [PubMed]
    • Clevers, H.; Nusse, R. Wnt/β-catenin signaling and disease. Cell 2012, 149, 1192-1205. [CrossRef] [PubMed]
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 100
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signaling
    • [CrossRef] [PubMed]
    • Niehrs, C. The complex world of WNT receptor signaling. Nat. Rev. Mol. Cell Biol. 2012, 13, 767-779. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 101
    • 84955603885 scopus 로고    scopus 로고
    • Canonical Wnt signaling in systemic sclerosis
    • [CrossRef] [PubMed]
    • Bergmann, C.; Distler, J. H. Canonical Wnt signaling in systemic sclerosis. Lab. Invest. 2016. [CrossRef] [PubMed]
    • (2016) Lab. Invest
    • Bergmann, C.1    Distler, J.H.2
  • 102
    • 84863923526 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
    • [CrossRef] [PubMed]
    • Wei, J.; Fang, F.; Lam, A. P.; Sargent, J. L.; Hamburg, E.; Hinchcliff, M. E.; Gottardi, C. J.; Atit, R.; Whitfield, M. L.; Varga, J. Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum. 2012, 64, 2734-2745. [CrossRef] [PubMed]
    • (2012) Arthritis Rheum , vol.64 , pp. 2734-2745
    • Wei, J.1    Fang, F.2    Lam, A.P.3    Sargent, J.L.4    Hamburg, E.5    Hinchcliff, M.E.6    Gottardi, C.J.7    Atit, R.8    Whitfield, M.L.9    Varga, J.10
  • 105
    • 79959628679 scopus 로고    scopus 로고
    • Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition
    • [CrossRef] [PubMed]
    • Aisagbonhi, O.; Rai, M.; Ryzhov, S.; Atria, N.; Feoktistov, I.; Hatzopoulos, A. K. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis. Model. Mech. 2011, 4, 469-483. [CrossRef] [PubMed]
    • (2011) Dis. Model. Mech , vol.4 , pp. 469-483
    • Aisagbonhi, O.1    Rai, M.2    Ryzhov, S.3    Atria, N.4    Feoktistov, I.5    Hatzopoulos, A.K.6
  • 106
    • 84925371635 scopus 로고    scopus 로고
    • C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease
    • [CrossRef] [PubMed]
    • Li, L.; Chen, L.; Zang, J.; Tang, X.; Liu, Y.; Zhang, J.; Bai, L.; Yin, Q.; Lu, Y.; Cheng, J.; et al. C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease. Metabolism 2015, 64, 597-610. [CrossRef] [PubMed]
    • (2015) Metabolism , vol.64 , pp. 597-610
    • Li, L.1    Chen, L.2    Zang, J.3    Tang, X.4    Liu, Y.5    Zhang, J.6    Bai, L.7    Yin, Q.8    Lu, Y.9    Cheng, J.10
  • 107
    • 84879123915 scopus 로고    scopus 로고
    • Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells
    • [CrossRef] [PubMed]
    • Cheng, S. L.; Shao, J. S.; Behrmann, A.; Krchma, K.; Towler, D. A. Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2013, 33, 1679-1689. [CrossRef] [PubMed]
    • (2013) Arterioscler. Thromb. Vasc. Biol , vol.33 , pp. 1679-1689
    • Cheng, S.L.1    Shao, J.S.2    Behrmann, A.3    Krchma, K.4    Towler, D.A.5
  • 108
    • 0035794218 scopus 로고    scopus 로고
    • Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    • [CrossRef] [PubMed]
    • Razani, B.; Zhang, X. L.; Bitzer, M.; von Gersdorff, G.; Böttinger, E. P.; Lisanti, M. P. Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J. Biol. Chem. 2001, 276, 6727-6738. [CrossRef] [PubMed]
    • (2001) J. Biol. Chem , vol.276 , pp. 6727-6738
    • Razani, B.1    Zhang, X.L.2    Bitzer, M.3    von Gersdorff, G.4    Böttinger, E.P.5    Lisanti, M.P.6
  • 109
    • 56249093843 scopus 로고    scopus 로고
    • Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis
    • [CrossRef] [PubMed]
    • Del Galdo, F.; Lisanti, M. P.; Jimenez, S. A. Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis. Curr. Opin. Rheumatol. 2008, 20, 713-719. [CrossRef] [PubMed]
    • (2008) Curr. Opin. Rheumatol , vol.20 , pp. 713-719
    • Del Galdo, F.1    Lisanti, M.P.2    Jimenez, S.A.3
  • 110
    • 84882616856 scopus 로고    scopus 로고
    • Role of caveolin-1 in fibrotic diseases
    • [CrossRef] [PubMed]
    • Gvaramia, D.; Blaauboer, M. E.; Hanemaaijer, R.; Everts, V. Role of caveolin-1 in fibrotic diseases. Matrix Biol. 2013, 32, 307-315. [CrossRef] [PubMed]
    • (2013) Matrix Biol , vol.32 , pp. 307-315
    • Gvaramia, D.1    Blaauboer, M.E.2    Hanemaaijer, R.3    Everts, V.4
  • 111
    • 51849169053 scopus 로고    scopus 로고
    • Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis
    • [CrossRef] [PubMed]
    • Del Galdo, F.; Sotgia, F.; de Almeida, C. J.; Jasmin, J. F.; Musick, M.; Lisanti, M. P.; Jiménez, S. A. Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum. 2008, 58, 2854-2865. [CrossRef] [PubMed]
    • (2008) Arthritis Rheum , vol.58 , pp. 2854-2865
    • Del Galdo, F.1    Sotgia, F.2    de Almeida, C.J.3    Jasmin, J.F.4    Musick, M.5    Lisanti, M.P.6    Jiménez, S.A.7
  • 114
    • 33748369338 scopus 로고    scopus 로고
    • Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy
    • [CrossRef] [PubMed]
    • Jasmin, J. F.; Mercier, I.; Dupuis, J.; Tanowitz, H. B.; Lisanti, M. P. Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. Circulation 2006, 114, 912-920. [CrossRef] [PubMed]
    • (2006) Circulation , vol.114 , pp. 912-920
    • Jasmin, J.F.1    Mercier, I.2    Dupuis, J.3    Tanowitz, H.B.4    Lisanti, M.P.5
  • 115
    • 84872717683 scopus 로고    scopus 로고
    • Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro
    • [CrossRef] [PubMed]
    • Li, Z.; Wermuth, P. J.; Benn, B. S.; Lisanti, M. P.; Jimenez, S. A. Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro. Am. J. Pathol. 2013, 182, 325-331. [CrossRef] [PubMed]
    • (2013) Am. J. Pathol , vol.182 , pp. 325-331
    • Li, Z.1    Wermuth, P.J.2    Benn, B.S.3    Lisanti, M.P.4    Jimenez, S.A.5
  • 118
    • 77953364227 scopus 로고    scopus 로고
    • Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition
    • [CrossRef] [PubMed]
    • Widyantoro, B.; Emoto, N.; Nakayama, K.; Anggrahini, D. W.; Adiarto, S.; Iwasa, N.; Yagi, K.; Miyagawa, K.; Rikitake, Y.; Suzuki, T.; et al. Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 2010, 121, 2407-2418. [CrossRef] [PubMed]
    • (2010) Circulation , vol.121 , pp. 2407-2418
    • Widyantoro, B.1    Emoto, N.2    Nakayama, K.3    Anggrahini, D.W.4    Adiarto, S.5    Iwasa, N.6    Yagi, K.7    Miyagawa, K.8    Rikitake, Y.9    Suzuki, T.10
  • 120
    • 84943229214 scopus 로고    scopus 로고
    • The endothelial-mesenchymal transition in systemic sclerosis is induced by endothelin-1 and transforming growth factor-β and may be blocked by macitentan, a dual endothelin-1 receptor antagonist
    • [CrossRef] [PubMed]
    • Cipriani, P.; Di Benedetto, P.; Ruscitti, P.; Capece, D.; Zazzeroni, F.; Liakouli, V.; Pantano, I.; Berardicurti, O.; Carubbi, F.; Pecetti, G.; et al. The endothelial-mesenchymal transition in systemic sclerosis is induced by endothelin-1 and transforming growth factor-β and may be blocked by macitentan, a dual endothelin-1 receptor antagonist. J. Rheumatol. 2015, 42, 1808-1816. [CrossRef] [PubMed]
    • (2015) J. Rheumatol , vol.42 , pp. 1808-1816
    • Cipriani, P.1    Di Benedetto, P.2    Ruscitti, P.3    Capece, D.4    Zazzeroni, F.5    Liakouli, V.6    Pantano, I.7    Berardicurti, O.8    Carubbi, F.9    Pecetti, G.10
  • 121
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • [CrossRef] [PubMed]
    • Semenza, G. L. Hypoxia-inducible factors in physiology and medicine. Cell 2012, 148, 399-408. [CrossRef] [PubMed]
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 122
    • 84860424872 scopus 로고    scopus 로고
    • Hypoxia and hypoxia signaling in tissue repair and fibrosis
    • [PubMed]
    • Lokmic, Z.; Musyoka, J.; Hewitson, T. D.; Darby, I. A. Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int. Rev. Cell Mol. Biol. 2012, 296, 139-185. [PubMed]
    • (2012) Int. Rev. Cell Mol. Biol , vol.296 , pp. 139-185
    • Lokmic, Z.1    Musyoka, J.2    Hewitson, T.D.3    Darby, I.A.4
  • 123
    • 70350389951 scopus 로고    scopus 로고
    • Pathophysiological consequences of HIF activation; HIF as a modulator of fibrosis
    • [CrossRef] [PubMed]
    • Hasse, V. H. Pathophysiological consequences of HIF activation; HIF as a modulator of fibrosis. Ann. N. Y. Acad. Sci. 2009, 1177, 57-65. [CrossRef] [PubMed]
    • (2009) Ann. N.Y. Acad. Sci , vol.1177 , pp. 57-65
    • Hasse, V.H.1
  • 124
    • 67651162069 scopus 로고    scopus 로고
    • Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis
    • [CrossRef] [PubMed]
    • Beyer, C.; Schett, G.; Gay, S.; Distler, O.; Distler, J. H. Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis. Arthritis Res. Ther. 2009, 11, 220. [CrossRef] [PubMed]
    • (2009) Arthritis Res. Ther , vol.11 , pp. 220
    • Beyer, C.1    Schett, G.2    Gay, S.3    Distler, O.4    Distler, J.H.5
  • 126
    • 0035914297 scopus 로고    scopus 로고
    • Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
    • [CrossRef] [PubMed]
    • Sánchez-Elsner, T.; Botella, L. M.; Velasco, B.; Corbí, A.; Attisano, L.; Bernabéu, C. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J. Biol. Chem. 2001, 276, 38527-38535. [CrossRef] [PubMed]
    • (2001) J. Biol. Chem , vol.276 , pp. 38527-38535
    • Sánchez-Elsner, T.1    Botella, L.M.2    Velasco, B.3    Corbí, A.4    Attisano, L.5    Bernabéu, C.6
  • 128
    • 84936802418 scopus 로고    scopus 로고
    • Snail is a direct target of hypoxia-inducible factor 1α (HIF1α) in hypoxia-induced endothelial to mesenchymal transition of human coronary endothelial cells
    • [CrossRef] [PubMed]
    • Xu, X.; Tan, X.; Tampe, B.; Sanchez, E.; Zeisberg, M.; Zeisberg, E. M. Snail is a direct target of hypoxia-inducible factor 1α (HIF1α) in hypoxia-induced endothelial to mesenchymal transition of human coronary endothelial cells. J. Biol. Chem. 2015, 290, 16653-16664. [CrossRef] [PubMed]
    • (2015) J. Biol. Chem , vol.290 , pp. 16653-16664
    • Xu, X.1    Tan, X.2    Tampe, B.3    Sanchez, E.4    Zeisberg, M.5    Zeisberg, E.M.6
  • 129
    • 84942892712 scopus 로고    scopus 로고
    • A Hypoxia-induced vascular endothelial-to-mesenchymal transition in development of radiation-induced pulmonary fibrosis
    • [CrossRef] [PubMed]
    • Choi, S. H.; Hong, Z. Y.; Nam, J. K.; Lee, H. J.; Jang, J.; Yoo, R. J.; Lee, Y. J.; Lee, C. Y.; Kim, K. H.; Park, S.; et al. A Hypoxia-induced vascular endothelial-to-mesenchymal transition in development of radiation-induced pulmonary fibrosis. Clin. Cancer Res. 2015, 21, 3716-3726. [CrossRef] [PubMed]
    • (2015) Clin. Cancer Res , vol.21 , pp. 3716-3726
    • Choi, S.H.1    Hong, Z.Y.2    Nam, J.K.3    Lee, H.J.4    Jang, J.5    Yoo, R.J.6    Lee, Y.J.7    Lee, C.Y.8    Kim, K.H.9    Park, S.10
  • 130
    • 84944906108 scopus 로고    scopus 로고
    • Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis
    • [CrossRef] [PubMed]
    • Liu, R. M.; Desai, L. P. Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox. Biol. 2015, 6, 565-577. [CrossRef] [PubMed]
    • (2015) Redox. Biol , vol.6 , pp. 565-577
    • Liu, R.M.1    Desai, L.P.2
  • 131
    • 84940483315 scopus 로고    scopus 로고
    • Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences
    • [CrossRef] [PubMed]
    • Richter, K.; Konzack, A.; Pihlajaniemi, T.; Heljasvaara, R.; Kietzmann, T. Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences. Redox. Biol. 2015, 6, 344-352. [CrossRef] [PubMed]
    • (2015) Redox. Biol , vol.6 , pp. 344-352
    • Richter, K.1    Konzack, A.2    Pihlajaniemi, T.3    Heljasvaara, R.4    Kietzmann, T.5
  • 133
    • 77955092333 scopus 로고    scopus 로고
    • Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis
    • [CrossRef] [PubMed]
    • Kliment, C. R.; Oury, T. D. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic. Biol. Med. 2010, 49, 707-717. [CrossRef] [PubMed]
    • (2010) Free Radic. Biol. Med , vol.49 , pp. 707-717
    • Kliment, C.R.1    Oury, T.D.2
  • 134
    • 84904415350 scopus 로고    scopus 로고
    • Myofibroblast differentiation: Main features, biomedical relevance, and the role of reactive oxygen species
    • [CrossRef] [PubMed]
    • Siani, A.; Tirelli, N. Myofibroblast differentiation: Main features, biomedical relevance, and the role of reactive oxygen species. Antioxid. Redox. Signal 2014, 21, 768-785. [CrossRef] [PubMed]
    • (2014) Antioxid. Redox. Signal , vol.21 , pp. 768-785
    • Siani, A.1    Tirelli, N.2
  • 135
    • 79954570719 scopus 로고    scopus 로고
    • Myofibroblast differentiation during fibrosis: Role of NAD(P)H oxidases
    • [CrossRef] [PubMed]
    • Barnes, J. L.; Gorin, Y. Myofibroblast differentiation during fibrosis: Role of NAD(P)H oxidases. Kidney Int. 2011, 79, 944-956. [CrossRef] [PubMed]
    • (2011) Kidney Int , vol.79 , pp. 944-956
    • Barnes, J.L.1    Gorin, Y.2
  • 136
    • 84893415235 scopus 로고    scopus 로고
    • NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses
    • [CrossRef] [PubMed]
    • Jiang, F.; Liu, G. S.; Dusting, G. J.; Chan, E. C. NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses. Redox. Biol. 2014, 2, 267-272. [CrossRef] [PubMed]
    • (2014) Redox. Biol , vol.2 , pp. 267-272
    • Jiang, F.1    Liu, G.S.2    Dusting, G.J.3    Chan, E.C.4
  • 137
    • 77956036249 scopus 로고    scopus 로고
    • NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts
    • [CrossRef] [PubMed]
    • Amara, N.; Goven, D.; Prost, F.; Muloway, R.; Crestani, B.; Boczkowski, J. NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts. Thorax 2010, 65, 733-738. [CrossRef] [PubMed]
    • (2010) Thorax , vol.65 , pp. 733-738
    • Amara, N.1    Goven, D.2    Prost, F.3    Muloway, R.4    Crestani, B.5    Boczkowski, J.6
  • 139
    • 27644456575 scopus 로고    scopus 로고
    • NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts
    • [CrossRef] [PubMed]
    • Cucoranu, I.; Clempus, R.; Dikalova, A.; Phelan, P. J.; Ariyan, S.; Dikalov, S.; Sorescu, D. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ. Res. 2005, 97, 900-907. [CrossRef] [PubMed]
    • (2005) Circ. Res , vol.97 , pp. 900-907
    • Cucoranu, I.1    Clempus, R.2    Dikalova, A.3    Phelan, P.J.4    Ariyan, S.5    Dikalov, S.6    Sorescu, D.7
  • 140
    • 79958764508 scopus 로고    scopus 로고
    • Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis
    • [CrossRef] [PubMed]
    • Crestani, B.; Besnard, V.; Boczkowski, J. Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis. Int. J. Biochem. Cell Biol. 2011, 43, 1086-1089. [CrossRef] [PubMed]
    • (2011) Int. J. Biochem. Cell Biol , vol.43 , pp. 1086-1089
    • Crestani, B.1    Besnard, V.2    Boczkowski, J.3
  • 143
    • 84929902758 scopus 로고    scopus 로고
    • A reactive oxygen species-mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis
    • [CrossRef] [PubMed]
    • Spadoni, T.; Svegliati Baroni, S.; Amico, D.; Albani, L.; Moroncini, G.; Avvedimento, E. V.; Gabrielli, A. A reactive oxygen species-mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis. Arthritis Rheumatol. 2015, 67, 1611-1622. [CrossRef] [PubMed]
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1611-1622
    • Spadoni, T.1    Svegliati Baroni, S.2    Amico, D.3    Albani, L.4    Moroncini, G.5    Avvedimento, E.V.6    Gabrielli, A.7
  • 144
    • 84947125109 scopus 로고    scopus 로고
    • Increased expression of NADPH Oxidase 4 (NOX4) in Systemic Sclerosis dermal fibroblasts: Regulation of Transforming Growth Factor β
    • [CrossRef] [PubMed]
    • Piera-Velazquez, S.; Makul, A.; Jimenez, S. A. Increased expression of NADPH Oxidase 4 (NOX4) in Systemic Sclerosis dermal fibroblasts: Regulation of Transforming Growth Factor β. Arthritis Rheumatol. 2015, 67, 2749-2758. [CrossRef] [PubMed]
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2749-2758
    • Piera-Velazquez, S.1    Makul, A.2    Jimenez, S.A.3
  • 145
    • 33847007102 scopus 로고    scopus 로고
    • Mirna: Past and present
    • [CrossRef] [PubMed]
    • Wang, Y.; Stricker, H. M.; Gou, D.; Liu, L. miRNA: Past and present. Front. Biosci. 2007, 12, 2316-2329. [CrossRef] [PubMed]
    • (2007) Front. Biosci , vol.12 , pp. 2316-2329
    • Wang, Y.1    Stricker, H.M.2    Gou, D.3    Liu, L.4
  • 146
    • 77951219188 scopus 로고    scopus 로고
    • MicroRNAs and the regulation of fibrosis
    • [CrossRef] [PubMed]
    • Jiang, X.; Tsitsiou, E.; Herrick, S. E.; Lindsay, M. A. MicroRNAs and the regulation of fibrosis. FEBS J. 2010, 277, 2015-2021. [CrossRef] [PubMed]
    • (2010) FEBS J , vol.277 , pp. 2015-2021
    • Jiang, X.1    Tsitsiou, E.2    Herrick, S.E.3    Lindsay, M.A.4
  • 147
    • 84878242170 scopus 로고    scopus 로고
    • Mirnas regulate expression and function of extracellular matrix molecules
    • [CrossRef] [PubMed]
    • Rutnam, Z. J.; Wight, T. N.; Yang, B. miRNAs regulate expression and function of extracellular matrix molecules. Matrix Biol. 2013, 32, 74-85. [CrossRef] [PubMed]
    • (2013) Matrix Biol , vol.32 , pp. 74-85
    • Rutnam, Z.J.1    Wight, T.N.2    Yang, B.3
  • 148
    • 84871099822 scopus 로고    scopus 로고
    • MicroRNAs, transforming growth factor beta-1, and tissue fibrosis
    • [CrossRef] [PubMed]
    • Bowen, T.; Jenkins, R. H.; Fraser, D. J. MicroRNAs, transforming growth factor beta-1, and tissue fibrosis. J. Pathol. 2013, 229, 274-285. [CrossRef] [PubMed]
    • (2013) J. Pathol , vol.229 , pp. 274-285
    • Bowen, T.1    Jenkins, R.H.2    Fraser, D.J.3
  • 149
    • 84886723147 scopus 로고    scopus 로고
    • The role of microRNAs in skin fibrosis
    • [CrossRef] [PubMed]
    • Babalola, O.; Mamalis, A.; Lev-Tov, H.; Jagdeo, J. The role of microRNAs in skin fibrosis. Arch. Dermatol. Res. 2013, 305, 763-776. [CrossRef] [PubMed]
    • (2013) Arch. Dermatol. Res , vol.305 , pp. 763-776
    • Babalola, O.1    Mamalis, A.2    Lev-Tov, H.3    Jagdeo, J.4
  • 150
    • 84885100164 scopus 로고    scopus 로고
    • MicroRNAs: Their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma
    • [CrossRef] [PubMed]
    • Zhu, H.; Luo, H.; Zuo, X. MicroRNAs: Their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma. Exp. Mol. Med. 2013, 45, e41. [CrossRef] [PubMed]
    • (2013) Exp. Mol. Med , vol.45
    • Zhu, H.1    Luo, H.2    Zuo, X.3
  • 151
    • 84964296861 scopus 로고    scopus 로고
    • MicroRNA regulatory networks in idiopathic pulmonary fibrosis
    • [CrossRef] [PubMed]
    • Pandit, K. V.; Milosevic, J. MicroRNA regulatory networks in idiopathic pulmonary fibrosis. Biochem. Cell Biol. 2015, 93, 129-137. [CrossRef] [PubMed]
    • (2015) Biochem. Cell Biol , vol.93 , pp. 129-137
    • Pandit, K.V.1    Milosevic, J.2
  • 152
    • 84908160751 scopus 로고    scopus 로고
    • Noncoding RNAs and myocardial fibrosis
    • [CrossRef] [PubMed]
    • Thum, T. Noncoding RNAs and myocardial fibrosis. Nat. Rev. Cardiol. 2014, 11, 655-663. [CrossRef] [PubMed]
    • (2014) Nat. Rev. Cardiol , vol.11 , pp. 655-663
    • Thum, T.1
  • 153
    • 84865654208 scopus 로고    scopus 로고
    • The potential of microRNAs in liver fibrosis
    • [CrossRef] [PubMed]
    • He, Y.; Huang, C.; Zhang, S. P.; Sun, X.; Long, X. R.; Li, J. The potential of microRNAs in liver fibrosis. Cell Signal 2012, 24, 2268-2272. [CrossRef] [PubMed]
    • (2012) Cell Signal , vol.24 , pp. 2268-2272
    • He, Y.1    Huang, C.2    Zhang, S.P.3    Sun, X.4    Long, X.R.5    Li, J.6
  • 154
    • 84884853106 scopus 로고    scopus 로고
    • MicroRNAs in kidney fibrosis and diabetic nephropathy: Roles on EMT and EndMT
    • [CrossRef] [PubMed]
    • Srivastava, S. P.; Koya, D.; Kanasaki, K. MicroRNAs in kidney fibrosis and diabetic nephropathy: Roles on EMT and EndMT. Biomed. Res. Int. 2013, 2013, 125469. [CrossRef] [PubMed]
    • (2013) Biomed. Res. Int , vol.2013 , pp. 125469
    • Srivastava, S.P.1    Koya, D.2    Kanasaki, K.3
  • 155
    • 84857111170 scopus 로고    scopus 로고
    • Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT
    • [CrossRef] [PubMed]
    • Ghosh, A. K.; Nagpal, V.; Covington, J. W.; Michaels, M. A.; Vaughan, D. E. Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT. Cell Signal 2012, 24, 1031-1036. [CrossRef] [PubMed]
    • (2012) Cell Signal , vol.24 , pp. 1031-1036
    • Ghosh, A.K.1    Nagpal, V.2    Covington, J.W.3    Michaels, M.A.4    Vaughan, D.E.5
  • 156
    • 84955693617 scopus 로고    scopus 로고
    • MiR-125b is critical for fibroblast0to-myofibroblast transition and cardiac fibrosis
    • [PubMed]
    • Nagpal, V.; Rai, R.; Place, A. T.; Murphy, S. B.; Verma, S. K.; Ghosh, A. K.; Vaughan, D. E. MiR-125b is critical for fibroblast0to-myofibroblast transition and cardiac fibrosis. Circulation 2016, 133, 291-301. [PubMed]
    • (2016) Circulation , vol.133 , pp. 291-301
    • Nagpal, V.1    Rai, R.2    Place, A.T.3    Murphy, S.B.4    Verma, S.K.5    Ghosh, A.K.6    Vaughan, D.E.7
  • 157
    • 84892665702 scopus 로고    scopus 로고
    • Microrna 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway
    • [CrossRef] [PubMed]
    • Zhang, J.; Zhang, Z.; Zhang, D. Y.; Zhu, J.; Zhang, T.; Wang, C. microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS ONE 2013, 8, e83294. [CrossRef] [PubMed]
    • (2013) PLoS ONE , vol.8
    • Zhang, J.1    Zhang, Z.2    Zhang, D.Y.3    Zhu, J.4    Zhang, T.5    Wang, C.6
  • 158
    • 84856171521 scopus 로고    scopus 로고
    • Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21
    • [CrossRef] [PubMed]
    • Kumarswamy, R.; Volkmann, I.; Jazbutyte, V.; Dangwal, S.; Park, D. H.; Thum, T. Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21. Arterioscler. Thromb. Vasc. Biol. 2012, 32, 361-369. [CrossRef] [PubMed]
    • (2012) Arterioscler. Thromb. Vasc. Biol , vol.32 , pp. 361-369
    • Kumarswamy, R.1    Volkmann, I.2    Jazbutyte, V.3    Dangwal, S.4    Park, D.H.5    Thum, T.6
  • 159
    • 84939575336 scopus 로고    scopus 로고
    • Kallistatin inhibits TGF-β-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression
    • [CrossRef] [PubMed]
    • Guo, Y.; Li, P.; Bledsoe, G.; Yang, Z. R.; Chao, L.; Chao, J. Kallistatin inhibits TGF-β-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression. Exp. Cell Res. 2015, 337, 103-110. [CrossRef] [PubMed]
    • (2015) Exp. Cell Res , vol.337 , pp. 103-110
    • Guo, Y.1    Li, P.2    Bledsoe, G.3    Yang, Z.R.4    Chao, L.5    Chao, J.6
  • 160
    • 84914106428 scopus 로고    scopus 로고
    • Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: Mechanosensitive athero-miRs
    • [CrossRef] [PubMed]
    • Kumar, S.; Kim, C. W.; Simmons, R. D.; Jo, H. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: Mechanosensitive athero-miRs. Arterioscler. Thromb. Vasc. Biol. 2014, 34, 2206-2216. [CrossRef] [PubMed]
    • (2014) Arterioscler. Thromb. Vasc. Biol , vol.34 , pp. 2206-2216
    • Kumar, S.1    Kim, C.W.2    Simmons, R.D.3    Jo, H.4
  • 161
    • 84955365536 scopus 로고    scopus 로고
    • MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β
    • [CrossRef] [PubMed]
    • Katsura, A.; Suzuki, H. I.; Ueno, T.; Mihira, H.; Yamazaki, T.; Yasuda, T.; Watabe, T.; Mano, H.; Yamada, Y.; Miyazono, K. MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β. Genes Cells 2016, 21, 99-116. [CrossRef] [PubMed]
    • (2016) Genes Cells , vol.21 , pp. 99-116
    • Katsura, A.1    Suzuki, H.I.2    Ueno, T.3    Mihira, H.4    Yamazaki, T.5    Yasuda, T.6    Watabe, T.7    Mano, H.8    Yamada, Y.9    Miyazono, K.10
  • 162
    • 84871676561 scopus 로고    scopus 로고
    • FGF regulates TGF-β signaling and endothelial-to mesenchymal transition via control of let-7 miRNA expression
    • [CrossRef] [PubMed]
    • Chen, P. Y.; Qin, L.; Barnes, C.; Charisse, K.; Yi, T.; Zhang, X.; Ali, R.; Medina, P. P.; Yu, J.; Slack, F. J.; et al. FGF regulates TGF-β signaling and endothelial-to mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012, 2, 1684-1696. [CrossRef] [PubMed]
    • (2012) Cell Rep , vol.2 , pp. 1684-1696
    • Chen, P.Y.1    Qin, L.2    Barnes, C.3    Charisse, K.4    Yi, T.5    Zhang, X.6    Ali, R.7    Medina, P.P.8    Yu, J.9    Slack, F.J.10
  • 163
    • 84899528177 scopus 로고    scopus 로고
    • N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Nagai, T.; Kanasaki, M.; Srivastava, S. P.; Nakamura, Y.; Ishigaki, Y.; Kitada, M.; Shi, S.; Kanasaki, K.; Koya, D. N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition. Biomed. Res. Int. 2014, 2014, 696475. [CrossRef] [PubMed]
    • (2014) Biomed. Res. Int , vol.2014 , pp. 696475
    • Nagai, T.1    Kanasaki, M.2    Srivastava, S.P.3    Nakamura, Y.4    Ishigaki, Y.5    Kitada, M.6    Shi, S.7    Kanasaki, K.8    Koya, D.9
  • 164
    • 84901309585 scopus 로고    scopus 로고
    • Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen
    • [CrossRef] [PubMed]
    • Kanasaki, K.; Shi, S.; Kanasaki, M.; He, J.; Nagai, T.; Nakamura, Y.; Ishigaki, Y.; Kitada, M.; Srivastava, S. P.; Koya, D. Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen. Diabetes 2014, 63, 2120-2131. [CrossRef] [PubMed]
    • (2014) Diabetes , vol.63 , pp. 2120-2131
    • Kanasaki, K.1    Shi, S.2    Kanasaki, M.3    He, J.4    Nagai, T.5    Nakamura, Y.6    Ishigaki, Y.7    Kitada, M.8    Srivastava, S.P.9    Koya, D.10
  • 166
    • 73549092294 scopus 로고    scopus 로고
    • Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice
    • [CrossRef] [PubMed]
    • Li, J.; Qu, X.; Bertram, J. F. Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am. J. Pathol. 2009, 175, 1380-1388. [CrossRef] [PubMed]
    • (2009) Am. J. Pathol , vol.175 , pp. 1380-1388
    • Li, J.1    Qu, X.2    Bertram, J.F.3
  • 167
    • 84883296447 scopus 로고    scopus 로고
    • Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease
    • [CrossRef] [PubMed]
    • He, J.; Xu, Y.; Koya, D.; Kanasaki, K. Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease. Clin. Exp. Nephrol. 2013, 17, 488-497. [CrossRef] [PubMed]
    • (2013) Clin. Exp. Nephrol , vol.17 , pp. 488-497
    • He, J.1    Xu, Y.2    Koya, D.3    Kanasaki, K.4
  • 169
    • 84876697769 scopus 로고    scopus 로고
    • Interferonpromotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2
    • [CrossRef] [PubMed]
    • Chrobak, I.; Lenna, S.; Stawski, L.; Trojanowska, M. Interferonpromotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2. J. Cell Physiol. 2013, 228, 1774-1783. [CrossRef] [PubMed]
    • (2013) J. Cell Physiol , vol.228 , pp. 1774-1783
    • Chrobak, I.1    Lenna, S.2    Stawski, L.3    Trojanowska, M.4
  • 170
    • 84942088525 scopus 로고    scopus 로고
    • Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis
    • [CrossRef] [PubMed]
    • Xu, X.; Tan, X.; Tampe, B.; Nyamsuren, G.; Liu, X.; Maier, L. S.; Sossalla, S.; Kalluri, R.; Zeisberg, M.; Hasenfuss, G.; et al. Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis. Cardiovasc. Res. 2015, 105, 279-291. [CrossRef] [PubMed]
    • (2015) Cardiovasc. Res , vol.105 , pp. 279-291
    • Xu, X.1    Tan, X.2    Tampe, B.3    Nyamsuren, G.4    Liu, X.5    Maier, L.S.6    Sossalla, S.7    Kalluri, R.8    Zeisberg, M.9    Hasenfuss, G.10
  • 171
    • 84906322326 scopus 로고    scopus 로고
    • Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease
    • [CrossRef] [PubMed]
    • Charytan, D. M.; Padera, R.; Helfand, A. M.; Zeisberg, M.; Xu, X.; Liu, X.; Himmelfarb, J.; Cinelli, A.; Kalluri, R.; Zeisberg, E. M. Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease. Int. J. Cardiol. 2014, 176, 99-109. [CrossRef] [PubMed]
    • (2014) Int. J. Cardiol , vol.176 , pp. 99-109
    • Charytan, D.M.1    Padera, R.2    Helfand, A.M.3    Zeisberg, M.4    Xu, X.5    Liu, X.6    Himmelfarb, J.7    Cinelli, A.8    Kalluri, R.9    Zeisberg, E.M.10
  • 172
    • 34447504987 scopus 로고    scopus 로고
    • Perspectives on endothelial-to-mesenchymal transition: Potential contribution to vascular remodeling in chronic pulmonary hypertension
    • [CrossRef] [PubMed]
    • Arciniegas, E.; Frid, M. G.; Douglas, I. S.; Stenmark, K. R. Perspectives on endothelial-to-mesenchymal transition: Potential contribution to vascular remodeling in chronic pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 293, L1-L8. [CrossRef] [PubMed]
    • (2007) Am. J. Physiol. Lung Cell Mol. Physiol , vol.293 , pp. L1-L8
    • Arciniegas, E.1    Frid, M.G.2    Douglas, I.S.3    Stenmark, K.R.4
  • 173
    • 84904854851 scopus 로고    scopus 로고
    • Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis
    • [CrossRef] [PubMed]
    • Jimenez, S. A. Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN. Rheumatol. 2013, 2013, 835948. [CrossRef] [PubMed]
    • (2013) ISRN. Rheumatol , vol.2013 , pp. 835948
    • Jimenez, S.A.1
  • 174
    • 84879102821 scopus 로고    scopus 로고
    • Cytokine-induced chromatin modifications of the type I collagen alpha 2 gene during intestinal endothelial-to-mesenchymal transition
    • [CrossRef] [PubMed]
    • Sadler, T.; Scarpa, M.; Rieder, F.; West, G.; Stylianou, E. Cytokine-induced chromatin modifications of the type I collagen alpha 2 gene during intestinal endothelial-to-mesenchymal transition. Inflamm. Bowel Dis. 2013, 19, 1354-1364. [CrossRef] [PubMed]
    • (2013) Inflamm. Bowel Dis , vol.19 , pp. 1354-1364
    • Sadler, T.1    Scarpa, M.2    Rieder, F.3    West, G.4    Stylianou, E.5
  • 175
    • 84957900315 scopus 로고    scopus 로고
    • Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?
    • [CrossRef] [PubMed]
    • Jimenez, S. A.; Piera-Velazquez, S. Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? Matrix Biol. 2016. [CrossRef] [PubMed]
    • (2016) Matrix Biol
    • Jimenez, S.A.1    Piera-Velazquez, S.2
  • 176
    • 84956574004 scopus 로고    scopus 로고
    • In Brief: Endothelial-to-mesenchymal transition
    • [CrossRef] [PubMed]
    • Sanchez-Duffhues, G.; Orlova, V.; Ten Dijke, P. In Brief: Endothelial-to-mesenchymal transition. J. Pathol. 2016, 238, 378-380. [CrossRef] [PubMed]
    • (2016) J. Pathol , vol.238 , pp. 378-380
    • Sanchez-Duffhues, G.1    Orlova, V.2    Ten Dijke, P.3


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