-
2
-
-
33847348491
-
Systemic sclerosis: A prototypic multisystem fibrotic disorder
-
Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007;117:557-567.
-
(2007)
J Clin Invest
, vol.117
, pp. 557-567
-
-
Varga, J.1
Abraham, D.2
-
3
-
-
84894042138
-
Mortality in systemic sclerosis: Lessons learned from population-based and observational cohort studies
-
Nikpour M, Baron M. Mortality in systemic sclerosis: lessons learned from population-based and observational cohort studies. Curr Opin Rheumatol 2014;26:131-137.
-
(2014)
Curr Opin Rheumatol
, vol.26
, pp. 131-137
-
-
Nikpour, M.1
Baron, M.2
-
5
-
-
84939237107
-
From pathogenesis to therapy-Perspective on treatment strategies in fibrotic diseases
-
Ramming A, Dees C, Distler JH. From pathogenesis to therapy-Perspective on treatment strategies in fibrotic diseases. Pharmacol Res 2015;100:93-100.
-
(2015)
Pharmacol Res
, vol.100
, pp. 93-100
-
-
Ramming, A.1
Dees, C.2
Distler, J.H.3
-
6
-
-
0015359850
-
Connective tissue synthesis by scleroderma skin fibroblasts in cell culture
-
Leroy EC. Connective tissue synthesis by scleroderma skin fibroblasts in cell culture. J Exp Med 1972;135:1351-1362.
-
(1972)
J Exp Med
, vol.135
, pp. 1351-1362
-
-
Leroy, E.C.1
-
7
-
-
84859179083
-
Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis
-
Akhmetshina A, Palumbo K, Dees C et al. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat Commun 2012;3:735.
-
(2012)
Nat Commun
, vol.3
, pp. 735
-
-
Akhmetshina, A.1
Palumbo, K.2
Dees, C.3
-
8
-
-
84859500585
-
Beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
-
Beyer C, Schramm A, Akhmetshina A et al. beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 2012;71:761-767.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 761-767
-
-
Beyer, C.1
Schramm, A.2
Akhmetshina, A.3
-
9
-
-
84859500859
-
Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
-
Reich N, Tomcik M, Zerr P et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis 2012;71:737-745.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 737-745
-
-
Reich, N.1
Tomcik, M.2
Zerr, P.3
-
10
-
-
82755197822
-
Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway
-
Bergmann C, Akhmetshina A, Dees C et al. Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis 2011;70:2191-2198.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 2191-2198
-
-
Bergmann, C.1
Akhmetshina, A.2
Dees, C.3
-
11
-
-
65249134946
-
Wnt/beta-catenin signaling promotes renal interstitial fibrosis
-
He W, Dai C, Li Y et al. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009;20:765-776.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 765-776
-
-
He, W.1
Dai, C.2
Li, Y.3
-
12
-
-
65249088418
-
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
-
Konigshoff M, Kramer M, Balsara N et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 2009;119:772-787.
-
(2009)
J Clin Invest
, vol.119
, pp. 772-787
-
-
Konigshoff, M.1
Kramer, M.2
Balsara, N.3
-
13
-
-
58149333154
-
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
-
Kobayashi K, Luo M, Zhang Y et al. Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol 2009;11:46-55.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 46-55
-
-
Kobayashi, K.1
Luo, M.2
Zhang, Y.3
-
14
-
-
79957637197
-
Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
-
Dees C, Tomcik M, Zerr P et al. Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Ann Rheum Dis 2011;70:1304-1310.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1304-1310
-
-
Dees, C.1
Tomcik, M.2
Zerr, P.3
-
15
-
-
84862207240
-
Three decades of Wnts: A personal perspective on how a scientific field developed
-
Nusse R, Varmus H. Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J 2012;31:2670-2684.
-
(2012)
EMBO J
, vol.31
, pp. 2670-2684
-
-
Nusse, R.1
Varmus, H.2
-
17
-
-
67650230896
-
Wnt/beta-catenin signaling: Components, mechanisms, and diseases
-
MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009;17:9-26.
-
(2009)
Dev Cell
, vol.17
, pp. 9-26
-
-
Macdonald, B.T.1
Tamai, K.2
He, X.3
-
18
-
-
70449356831
-
Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells
-
Gao Z, Xu Z, Hung MS et al. Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells. Oncol Rep 2009;22:1479-1484.
-
(2009)
Oncol Rep
, vol.22
, pp. 1479-1484
-
-
Gao, Z.1
Xu, Z.2
Hung, M.S.3
-
19
-
-
84861990875
-
Methylation and aberrant expression of the Wnt antagonist secreted Frizzled-related protein 1 in bladder cancer
-
Wang X, Wang H, Bu R et al. Methylation and aberrant expression of the Wnt antagonist secreted Frizzled-related protein 1 in bladder cancer. Oncol Lett 2012;4:334-338.
-
(2012)
Oncol Lett
, vol.4
, pp. 334-338
-
-
Wang, X.1
Wang, H.2
Bu, R.3
-
20
-
-
84899914231
-
The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
-
Dees C, Schlottmann I, Funke R et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis 2014;73:1232-1239.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 1232-1239
-
-
Dees, C.1
Schlottmann, I.2
Funke, R.3
-
21
-
-
84861986053
-
Wnt/beta-catenin signaling and disease
-
Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell 2012;149:1192-1205.
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
22
-
-
84860765166
-
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
-
Hao HX, Xie Y, Zhang Y et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 2012;485:195-200.
-
(2012)
Nature
, vol.485
, pp. 195-200
-
-
Hao, H.X.1
Xie, Y.2
Zhang, Y.3
-
23
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
-
Huang SM, Mishina YM, Liu S et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 2009;461:614-620.
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
-
24
-
-
84907576727
-
Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis
-
Svegliati S, Marrone G, Pezone A et al. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. Sci Signal 2014;7:ra84.
-
(2014)
Sci Signal
, vol.7
, pp. ra84
-
-
Svegliati, S.1
Marrone, G.2
Pezone, A.3
-
25
-
-
79958077377
-
Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation
-
Lam AP, Flozak AS, Russell S et al. Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol 2011;45:915-922.
-
(2011)
Am J Respir Cell Mol Biol
, vol.45
, pp. 915-922
-
-
Lam, A.P.1
Flozak, A.S.2
Russell, S.3
-
26
-
-
84863133508
-
Axin pathway activity regulates in vivo pY654-beta-catenin accumulation and pulmonary fibrosis
-
Ulsamer A, Wei Y, Kim KK et al. Axin pathway activity regulates in vivo pY654-beta-catenin accumulation and pulmonary fibrosis. J Biol Chem 2012;287:5164-5172.
-
(2012)
J Biol Chem
, vol.287
, pp. 5164-5172
-
-
Ulsamer, A.1
Wei, Y.2
Kim, K.K.3
-
27
-
-
84866393033
-
Sustained beta-catenin activity in dermal fibroblasts is sufficient for skin fibrosis
-
Hamburg EJ, Atit RP. Sustained beta-catenin activity in dermal fibroblasts is sufficient for skin fibrosis. J Invest Dermatol 2012;132: 2469-2472.
-
(2012)
J Invest Dermatol
, vol.132
, pp. 2469-2472
-
-
Hamburg, E.J.1
Atit, R.P.2
-
28
-
-
84924623581
-
Sustained beta-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes
-
Hamburg-Shields E, DiNuoscio GJ, Mullin NK et al. Sustained beta-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes. J Pathol 2015;235:686-697.
-
(2015)
J Pathol
, vol.235
, pp. 686-697
-
-
Hamburg-Shields, E.1
Dinuoscio, G.J.2
Mullin, N.K.3
-
29
-
-
84872867267
-
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
-
Ren S, Johnson BG, Kida Y et al. LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci USA 2013;110: 1440-1445.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 1440-1445
-
-
Ren, S.1
Johnson, B.G.2
Kida, Y.3
-
30
-
-
84863923526
-
Wnt/beta-catenin signaling is hyper-activated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
-
Wei J, Fang F, Lam AP et al. Wnt/beta-catenin signaling is hyper-activated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum 2012;64:2734-2745.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2734-2745
-
-
Wei, J.1
Fang, F.2
Lam, A.P.3
-
31
-
-
84893767540
-
Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling
-
Distler A, Ziemer C, Beyer C et al. Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling. Ann Rheum Dis 2014;73: 624-627.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 624-627
-
-
Distler, A.1
Ziemer, C.2
Beyer, C.3
-
32
-
-
84903767326
-
Can we safely target the WNT pathway?
-
Kahn M. Can we safely target the WNT pathway? Nat Rev Drug Discov 2014;13:513-532.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 513-532
-
-
Kahn, M.1
-
33
-
-
84878406860
-
Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis
-
Beyer C, Reichert H, Akan H et al. Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis. Ann Rheum Dis 2013;72: 1255-1258.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 1255-1258
-
-
Beyer, C.1
Reichert, H.2
Akan, H.3
-
34
-
-
77956288500
-
Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
-
Henderson Jr WR, Chi EY, Ye X et al. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA 2010;107:14309-14314.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14309-14314
-
-
Henderson, W.R.1
Chi, E.Y.2
Ye, X.3
-
35
-
-
80052335469
-
Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis
-
Hao S, He W, Li Y et al. Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 2011;22:1642-1653.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 1642-1653
-
-
Hao, S.1
He, W.2
Li, Y.3
-
36
-
-
84881480768
-
Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
-
Distler A, Deloch L, Huang J et al. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis 2013;72:1575-1580.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 1575-1580
-
-
Distler, A.1
Deloch, L.2
Huang, J.3
-
37
-
-
0037829660
-
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
-
Pinto D, Gregorieff A, Begthel H et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 2003;17:1709-1713.
-
(2003)
Genes Dev
, vol.17
, pp. 1709-1713
-
-
Pinto, D.1
Gregorieff, A.2
Begthel, H.3
-
38
-
-
0346458662
-
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
-
Kuhnert F, Davis CR, Wang HT et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci USA 2004;101: 266-271.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 266-271
-
-
Kuhnert, F.1
Davis, C.R.2
Wang, H.T.3
-
39
-
-
84899925204
-
Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability
-
Distler A, Lang V, Del Vecchio T et al. Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability. Ann Rheum Dis 2014;73:1264-1268.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 1264-1268
-
-
Distler, A.1
Lang, V.2
Del Vecchio, T.3
|