메뉴 건너뛰기




Volumn 33, Issue , 2015, Pages 3-7

Systemic sclerosis: From pathogenesis to targeted therapy

Author keywords

Cytokine; Fibrosis; Growth factor; Scleroderma; Systemic sclerosis; Vasculopathy

Indexed keywords

ABATACEPT; ADALIMUMAB; AMBRISENTAN; AZATHIOPRINE; BASILIXIMAB; BOSENTAN; CYCLOPHOSPHAMIDE; DASATINIB; DISITERTIDE; EFALIZUMAB; ETANERCEPT; FRESOLIMUMAB; IMATINIB; INFLIXIMAB; INTERLEUKIN 6; LYSOPHOSPHATIDIC ACID; MACITENTAN; METELIMUMAB; METHOTREXATE; MYCOPHENOLATE MOFETIL; NILOTINIB; NORLEUCINE; PAMREVLUMAB; PIRFENIDONE; RIOCIGUAT; RITUXIMAB; SELEXIPAG; TOCILIZUMAB; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; AUTACOID; IMMUNOSUPPRESSIVE AGENT;

EID: 84953343033     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (90)

References (26)
  • 1
    • 77950261786 scopus 로고    scopus 로고
    • Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study
    • NIHTYANOVA SI, TANG EC, COGHLAN JG, WELLS AU, BLACK CM, DENTON CP: Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study. QJM 2010; 103: 109-15.
    • (2010) QJM , vol.103 , pp. 109-115
    • Nihtyanova, S.I.1    Tang, E.C.2    Coghlan, J.G.3    Wells, A.U.4    Black, C.M.5    Denton, C.P.6
  • 3
    • 84881138875 scopus 로고    scopus 로고
    • Targeted therapies for systemic sclerosis
    • DENTON CP, ONG VH: Targeted therapies for systemic sclerosis. Nat Rev Rheumatol 2013; 9: 451-64.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 451-464
    • Denton, C.P.1    Ong, V.H.2
  • 4
    • 84902844800 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial
    • van LAAR JM, FARGE D, SONT JK et al.: EBMT/EULAR Scleroderma Study Group. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. JAMA 2014; 311: 2490-8.
    • (2014) JAMA , vol.311 , pp. 2490-2498
    • Van Laar, J.M.1    Farge, D.2    Sont, J.K.3
  • 5
    • 84898775777 scopus 로고    scopus 로고
    • Prediction of pulmonary complications and long-term survival in systemic sclerosis
    • NIHTYANOVA SI, SCHREIBER BE, ONG VH et al.: Prediction of pulmonary complications and long-term survival in systemic sclerosis. Arthritis Rheum 2014; 66: 1625-35.
    • (2014) Arthritis Rheum , vol.66 , pp. 1625-1635
    • Nihtyanova, S.I.1    Schreiber, B.E.2    Ong, V.H.3
  • 6
    • 84896506258 scopus 로고    scopus 로고
    • Groupe Français de Recherche sur la Sclérodermie. Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey
    • NGUYEN C, RANQUE B, BAUBET T et al.: Groupe Français de Recherche sur la Sclérodermie. Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey. PLoS One 2014; 9: e90484.
    • (2014) PLoS One , vol.9
    • Nguyen, C.1    Ranque, B.2    Baubet, T.3
  • 7
    • 84898799747 scopus 로고    scopus 로고
    • Current management strategies for systemic sclerosis
    • NIHTYANOVA SI, ONG VH, DENTON CP: Current management strategies for systemic sclerosis. Clin Exp Rheumatol 2014; 32 (Suppl. 81): 156-64.
    • (2014) Clin Exp Rheumatol , vol.32 , pp. 156-164
    • Nihtyanova, S.I.1    Ong, V.H.2    Denton, C.P.3
  • 8
    • 84928719391 scopus 로고    scopus 로고
    • Twenty-two points to consider for clinical trials in systemic sclerosis, based on EULAR standards?
    • KHANNA D, FURST DE, ALLANORE Y et al.: Twenty-two points to consider for clinical trials in systemic sclerosis, based on EULAR standards. Rheumatology 2015; 54; 144-51.
    • (2015) Rheumatology , vol.54 , pp. 144-151
    • Khanna, D.1    Furst, D.E.2    Allanore, Y.3
  • 9
    • 73649119523 scopus 로고    scopus 로고
    • Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis
    • HERRICK AL, LUNT M, WHIDBY N et al.: Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis. J Rheumatol 2010; 37: 116-24.
    • (2010) J Rheumatol , vol.37 , pp. 116-124
    • Herrick, A.L.1    Lunt, M.2    Whidby, N.3
  • 10
    • 76649085510 scopus 로고    scopus 로고
    • Autoantibodies as predictive tools in systemic sclerosis
    • NIHTYANOVA SI, DENTON CP: Autoantibodies as predictive tools in systemic sclerosis. Nat Rev Rheumatol 2010; 6: 112-6.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 112-116
    • Nihtyanova, S.I.1    Denton, C.P.2
  • 11
    • 84899925204 scopus 로고    scopus 로고
    • Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability
    • DISTLER A, LANG V, DEL VECCHIO T et al.: Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability. Ann Rheum Dis 2014; 73: 1264-8.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1264-1268
    • Distler, A.1    Lang, V.2    Del Vecchio, T.3
  • 12
    • 70349826650 scopus 로고    scopus 로고
    • Animal models of scleroderma: lessons from transgenic and knockout mice
    • DERRETT-SMITH EC, DENTON CP, SONNYLAL S: Animal models of scleroderma: lessons from transgenic and knockout mice. Curr Opin Rheumatol 2009; 21: 630-5.
    • (2009) Curr Opin Rheumatol , vol.21 , pp. 630-635
    • Derrett-Smith, E.C.1    Denton, C.P.2    Sonnylal, S.3
  • 13
    • 42449125545 scopus 로고    scopus 로고
    • Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model
    • HOYLES RK, KHAN K, SHIWEN X et al.: Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model. Arthritis Rheum 2008; 58: 1175-88.
    • (2008) Arthritis Rheum , vol.58 , pp. 1175-1188
    • Hoyles, R.K.1    Khan, K.2    Shiwen, X.3
  • 14
    • 84886801549 scopus 로고    scopus 로고
    • Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension
    • DERRETT-SMITH EC, DOOLEY A, GILBANE AJ et al.: Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum 2013; 65: 2928-39.
    • (2013) Arthritis Rheum , vol.65 , pp. 2928-2939
    • Derrett-Smith, E.C.1    Dooley, A.2    Gilbane, A.J.3
  • 15
    • 84924758403 scopus 로고    scopus 로고
    • Impaired bone morphogenetic protein receptor II signaling in a transforming growth factor-β-dependent mouse model of pulmonary hypertension and in systemic sclerosis
    • GILBANE AJ, DERRETT-SMITH E, TRINDER SL et al.: Impaired bone morphogenetic protein receptor II signaling in a transforming growth factor-β-dependent mouse model of pulmonary hypertension and in systemic sclerosis. Am J Respir Crit Care Med 2015; 191: 665-77.
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 665-677
    • Gilbane, A.J.1    Derrett-Smith, E.2    Trinder, S.L.3
  • 16
    • 33846250366 scopus 로고    scopus 로고
    • Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
    • DENTON CP, MERKEL PA, FURST DE et al.: Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 2007; 56: 323-33.
    • (2007) Arthritis Rheum , vol.56 , pp. 323-333
    • Denton, C.P.1    Merkel, P.A.2    Furst, D.E.3
  • 17
    • 84936791793 scopus 로고    scopus 로고
    • Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
    • RICE LM, PADILLA CM, McLAUGHLIN SR et al.: Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest 2015; 125: 2795-807.
    • (2015) J Clin Invest , vol.125 , pp. 2795-2807
    • Rice, L.M.1    Padilla, C.M.2    Mclaughlin, S.R.3
  • 18
    • 84889677536 scopus 로고    scopus 로고
    • Treatment of diffuse systemic sclerosis with hyperimmune caprine serum (AIMSPRO): a phase II double-blind placebo-controlled trial
    • QUILLINAN NP, McINTOSH D, VERNES J, HAQ S, DENTON CP: Treatment of diffuse systemic sclerosis with hyperimmune caprine serum (AIMSPRO): a phase II double-blind placebo-controlled trial. Ann Rheum Dis 2014; 73: 56-61.
    • (2014) Ann Rheum Dis , vol.73 , pp. 56-61
    • Quillinan, N.P.1    Mcintosh, D.2    Vernes, J.3    Haq, S.4    Denton, C.P.5
  • 19
    • 84868331821 scopus 로고    scopus 로고
    • Autotaxin emerges as a therapeutic target for idiopathic pulmonary fibrosis: limiting fibrosis by limiting lysophosphatidic acid synthesis
    • TAGER AM: Autotaxin emerges as a therapeutic target for idiopathic pulmonary fibrosis: limiting fibrosis by limiting lysophosphatidic acid synthesis. Am J Respir Cell Mol Biol 2012; 47: 563-5.
    • (2012) Am J Respir Cell Mol Biol , vol.47 , pp. 563-565
    • Tager, A.M.1
  • 20
    • 79955559412 scopus 로고    scopus 로고
    • Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma
    • CASTELINO FV, SEIDERS J, BAIN G et al.: Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum 2011; 63: 1405-15.
    • (2011) Arthritis Rheum , vol.63 , pp. 1405-1415
    • Castelino, F.V.1    Seiders, J.2    Bain, G.3
  • 21
    • 38049091636 scopus 로고    scopus 로고
    • The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    • TAGER AM, LACAMERA P, SHEA BS et al.: The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 2008; 14: 45-54.
    • (2008) Nat Med , vol.14 , pp. 45-54
    • Tager, A.M.1    Lacamera, P.2    Shea, B.S.3
  • 22
    • 84875861264 scopus 로고    scopus 로고
    • Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis
    • de LAURETIS A, SESTINI P, PANTELIDIS P et al.: Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis. J Rheumatol 2013; 40: 435-46.
    • (2013) J Rheumatol , vol.40 , pp. 435-446
    • De Lauretis, A.1    Sestini, P.2    Pantelidis, P.3
  • 23
    • 84862520877 scopus 로고    scopus 로고
    • Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis
    • KHAN K, XU S, NIHTYANOVA S et al.: Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis. Ann Rheum Dis 2012; 71: 1235-42.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1235-1242
    • Khan, K.1    Xu, S.2    Nihtyanova, S.3
  • 24
    • 84887463104 scopus 로고    scopus 로고
    • Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors
    • MAURER B, DISTLER A, DEES C et al.: Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Ann Rheum Dis 2013; 72: 2039-46.
    • (2013) Ann Rheum Dis , vol.72 , pp. 2039-2046
    • Maurer, B.1    Distler, A.2    Dees, C.3
  • 25
    • 84865814629 scopus 로고    scopus 로고
    • Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy
    • KEIR GJ, MAHER TM, HANSELL DM et al.: Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy. Eur Respir J 2012; 40: 641-8.
    • (2012) Eur Respir J , vol.40 , pp. 641-648
    • Keir, G.J.1    Maher, T.M.2    Hansell, D.M.3
  • 26
    • 84925537240 scopus 로고    scopus 로고
    • Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
    • PLUMBO-ZERR K, ZERR P, DISTLER A et al.: Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat Med 2015; 21: 150-8.
    • (2015) Nat Med , vol.21 , pp. 150-158
    • Plumbo-Zerr, K.1    Zerr, P.2    Distler, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.