Pathogenesis of scleroderma. Collagen

Rheumatic Disease Clinics of North America

Volumn 22, Issue 4, 1996, Pages 647-674

  Jimenez, S A ^a   Hitraya, E ^a   Varga, J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CYTOKINE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

COLLAGEN SYNTHESIS; CONNECTIVE TISSUE; ENHANCER REGION; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; GENE EXPRESSION; HUMAN; MONONUCLEAR CELL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SCLERODERMA; TRANSCRIPTION INITIATION;

EID: 0029957278     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-857X(05)70294-5     Document Type: Article

References (196)

1. D. Abraham S. Lupoli A. McWhirter Expression and function of surface antigens on scleroderma fibroblasts Arthritis Rheum 34 1991 1164
2. S.L. Adams Collagen gene expression Am J Respir Cell Mol Biol 1 1989 161
3. E. Amento A. Bhan K. McCullagh Influences of gamma interferon on synovial fibroblast-like cells: Ia induction and inhibition of collagen synthesis J Clin Invest 76 1985 837
4. J. Armendariz-Borunda K. Katayama J. Seyer Transcriptional mechanisms of type I collagen gene expression are differentially regulated by IL-1α, TNF-α, and TGFβ in Ito cells J Biol Chem 267 1992 14316
5. M. Aumailley K. Mann H. von der Mark Cell attachment properties of collagen type VI and Arg-Gly-Asp dependent binding to its α2(VI) and α3(VI) chains Exp Cell Res 181 1989 463
6. E. Avvedimento Y. Yamada E. Lovelace Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts Nucleic Acids Res 9 1981 1123
7. G. Barsh C. Roush R. Gelinas DNA and chromatin structure of the human α1(I) collagen gene J Biol Chem 259 1984 14906
8. L.S. Beck L. DeGuzman W.P. Lee One systemic administration of transforming growth factor-β1 reverses age- or glucocorticoid-impaired wound healing J Clin Invest 92 1993 2841
9. B. Berman M. Duncan Short-term keloid treatment in vivo with interferon alpha-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro J Am Acad Dermatol 21 1989 694
10. S. Boast M.-W. Su F. Ramirez Functional analysis of cis -acting DNA sequences controlling transcription of the human type I collagen genes J Biol Chem 265 1990 13351
11. W. Border E. Ruoslahti Transforming growth factor-β in disease: The dark side of tissue repair J Clin Invest 90 1992 1
12. P. Bornstein J. McKay D.J. Liska Interactions between the promoter and first intron are involved in transcriptional control of α1(I) collagen gene expression Mol Cell Biol 8 1988 4851
13. P. Bornstein J. McKay J.K. Morishima Regulatory elements in the first intron contribute to transcriptional control of the human α1(I) collagen gene Proc Natl Acad Sci USA 84 1987 8869
14. P. Bornstein J. McKay The first intron of the α1(I) collagen gene contains several transcriptional regulatory elements J Biol Chem 263 1988 1603
15. P. Bornstein H. Sage Structurally distinct collagen types Annu Rev Biochem 49 1980 957
16. P. Bornstein H. Sage Regulation of collagen gene expression Prog Nucleic Acid Res Mol Biol 37 1989 67
17. L. Bounaguro G. Barillari H.K. Chang Effects of the human immunodeficiency virus type I Tat protein on the expression of inflammatory cytokines J Virol 66 1992 7159
18. D. Brenner M. O'Hara P. Angel Prolonged activation of jun and collagenase genes by tumor necrosis factor alpha Nature 337 1989 661
19. R.R. Bruns W. Press E. Engvall Type VI collagen in extracellular, 100 nm periodic filaments and fibrils. Identification by immunoelectron microscopy J Cell Biol 103 1986 393
20. R.B. Buckingham R.K. Prince G.P. Rodnan Increased collagen accumulation in dermal fibroblast cultures from patients with progressive systemic sclerosis (scleroderma) J Lab Clin Med 92 1978 5
21. R.E. Burgeson M.E. Nimni Collagen types. Molecular structure and tissue distribution Clin Orthop 282 1992 250
22. M.-L. Chu W. de Wet M. Bernard Fine structural analysis of the human pro α1(I) collagen gene J Biol Chem 260 1985 2315
23. H.N. Claman R.C. Giorno J.R. Seibold Endothelial and fibroblast activation in scleroderma The myth of the “uninvolved skin.” Arthritis Rheum 34 1991 1495
24. J. Clark T. Dedon E. Wayner Effects of interferon gamma on cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts J Clin Invest 83 1989 1505
25. C. Cupp J. Taylor K. Khalili Evidence for stimulation of the transforming growth factor-β1 promoter by HIV-1 Tat in cells derived from CNS Oncogene 8 1993 2231
26. M. Czaja F. Weiner M. Eghbali Differential effects of γ-interferon on collagen and fibronectin gene expression J Biol Chem 262 1987 13348
27. M. Czaja F. Weiner S. Takahashi Gamma-interferon treatment inhibits collagen deposition in murine schistosomiasis Hepatology 10 1989 795
28. W.A. D'Angelo J.F. Fries A.T. Masi Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls Am J Med 46 1969 428
29. H. Dang M. Dauphinee N. Talal Serum antibodies to retroviral gag protein in systemic sclerosis Arthritis Rheum 34 1991 1336
30. 2 production by human synovial cells J Clin Invest 77 1986 645
31. Y. Deguchi Spontaneous increase of transforming growth factor-β production by bronchoalveolar mononuclear cells of patients with systemic autoimmune diseases affecting the lung Ann Rheum Dis 51 1992 362
32. W. DeWet M. Bernard V. Benson-Chanda Organization of the human pro-α2(I) collagen gene J Biol Chem 262 1987 16032
33. Diaz A, Jimenez SA. Interferon-γ regulates collagen and fibronectin gene expression by transcriptional and posttranscriptional mechanisms. Int J Biochem Cell Biol, in press
34. 2 J Biol Chem 268 1993 10364
35. M. Duncan B. Berman Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin-1 α and β and tumor necrosis factor α and β J Invest Dermatol 92 1989 699
36. M. Duncan B. Berman Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation J Exp Med 162 1985 516
37. M. Duncan B. Berman Persistence of reduced collagen-producing phenotype in cultured scleroderma fibroblasts after short-term exposure to interferons J Clin Invest 79 1987 1318
38. B. Eckes K. Mauch G. Hüppe Differential regulation of transcription and transcript stability of pro-α1(I) collagen and fibronectin in activated fibroblasts derived from patients with systemic scleroderma Biochem J 315 1996 549
39. S.C. Elgin Anatomy of hypersensitive sites Nature 309 1984 213
40. 3 human skin collagen: Release by pepsin digestion and preponderance in fetal life J Biol Chem 249 1974 3225
41. V. Falanga S. Tiegs S. Alstadt Transforming growth factor-β: Selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis J Invest Dermatol 89 1987 100
42. M. Ferrarini V. Steen T. Medsger Jr Functional and phenotypic analysis of T lymphocytes cloned from the skin of patients with systemic sclerosis Clin Exp Immunol 79 1990 346
43. R. Fleischmajer V. Damiano A. Nedwich Scleroderma and the subcutaneous tissue Science 171 1971 1019
44. R. Fleischmajer W. Dessau R. Timpl Immunofluorescence analysis of collagen, fibronectin, and basement membrane protein in scleroderma skin J Invest Dermatol 75 1980 270
45. R. Fleischmajer J. Perlish R.E. Burgeson Type I and type III collagen interactions during fibrillogenesis Ann N Y Acad Sci 580 1990 161
46. R. Fleischmajer J. Perlish J. Reeves Cellular infiltrates in scleroderma Arthritis Rheum 20 1977 775
47. R. Fleischmajer J. Perlish T. Krieg Variability in collagen and fibronectin synthesis by scleroderma fibroblasts in primary culture J Invest Dermatol 76 1981 400
48. L. Fouser E.H. Sage J. Clark Feedback regulation of collagen gene expression: A Trojan horse approach Proc Natl Acad Sci USA 88 1991 10158
49. A.D. Frankel Activation of HIV transcription by Tat Curr Opin Genet Dev 2 1992 293
50. B. Freundlich S. Jimenez V. Steen Treatment of systemic sclerosis with recombinant interferon-γ Arthritis Rheum 35 1992 1134
51. A. Gabrielli C. Di Loreto R. Taborro Immunohistochemical localization of intracellular and extracellular associated TGFβ in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon Clin Immunol Immunopathol 68 1993 340
52. P. Galera M. Musso P. Ducy c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin Proc Natl Acad Sci USA 91 1994 9372
53. S. Gay A. Tranbadt L. Moreland Growth factors, extracellular matrix, and oncogenes in scleroderma Arthritis Rheum 35 1992 304
54. P. Gillery F.-X. Maquart Y. Le Corre Variability in the retraction of collagen lattices by scleroderma fibroblasts—relationship to protein synthesis and clinical data Clin Exp Dermatol 16 1991 324
55. P. Gillery H. Serpier M. Polette Gamma interferon inhibits extracellular matrix synthesis and remodelling in collagen lattice cultures of normal and scleroderma fibroblasts Eur J Cell Biol 57 1992 244
56. S.N. Giri D.M. Hyde M.A. Hollinger Effect of antibody to transforming growth factor-β on bleomycin induced accumulation of lung collagen in mice Thorax 48 1993 953
57. S.N. Giri D.M. Hyde B. Marafino Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice Biochemical Medicine Metabolic Biology 36 1986 194
58. M. Goldring S. Krane Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells J Biol Chem 262 1987 16724
59. M. Goldring L. Sandell M. Stephenson Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes J Biol Chem 261 1986 9049
60. R. Granstein G. Murphy R. Margolis Gamma interferon inhibits collagen synthesis in vivo in the mouse J Clin Invest 79 1987 1254
61. M. Gruschwitz P. Driesch I. Kellner Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosis J Am Acad Dermatol 27 1992 169
62. M. Gruschwitz S. Moorman G. Kromer Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen, and thymocytes in early avian scleroderma J Autoimmun 4 1991 577
63. M. Gruschwitz P. Muller N. Sepp Transcription and expression of transforming growth factor β in the skin of progressive systemic sclerosis: A mediator of fibrosis? J Invest Dermatol 94 1990 197
64. M. Gruschwitz N. Sepp H. Kofler Expression of class II-MHC antigens in the dermis of patients with progressive systemic sclerosis Immunobiology 182 1991 234
65. R. Gustaffson T. Totterman L. Klareskog Increase in activated T cells and reduction in suppressor inducer T cells in systemic sclerosis Ann Rheum Dis 49 1990 40
66. J. Harrison S. Vargas D. Petersen Interleukin-1 and phorbol ester inhibits collagen synthesis in osteoblastic MC3T3-E1 cells by a transcriptional mechanism Mol Endocrinol 4 1990 184
67. K. Herrmann M. Heckmann M. Kulozik Steady-state mRNA levels of collagens I, III, fibronectin, and collagenase in skin biopsies of systemic sclerosis patients J Invest Dermatol 97 1991 219
68. H. Higley K. Persichitte S. Chu Immunocytochemical localization and serologic detection of transforming growth factor β1: Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon Arthritis Rheum 37 1994 278
69. E.G. Hitraya S.A. Jimenez Transcriptional regulation of the α1(I) procollagen gene in systemic sclerosis dermal fibroblasts: Role of intronic sequences Arthritis Rheum 39 1996 1347
70. B.H. Howard S.L. Adams M.E. Sobel Decreased levels of collagen mRNA in Rous sarcoma virus-transformed chick embryo fibroblasts J Biol Chem 253 1978 5869
71. R. Ignotz J. Massague Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix J Biol Chem 261 1986 4337
72. R. Ignotz T. Endo J. Massague Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor β J Biol Chem 262 1987 6443
73. Y. Inagaki S. Truter F. Ramirez Transforming growth factor β stimulates α2(I) collagen gene expression through a cis -acting element that contains an Sp1-binding site J Biol Chem 269 1994 14828
74. Y. Isaka Y. Fujiwara N. Ueda Glomerulosclerosis induced by in vivo transfection of transforming growth factor β or platelet-derived growth factor gene into rat kidney J Clin Invest 92 1993 2597
75. O. Ishikawa H. Ishikawa Macrophage infiltration in the skin of patients with systemic sclerosis J Rheumatol 19 1992 1202
76. S.A. Jimenez Cellular immune dysfunction in the pathogenesis of scleroderma Semin Arthritis Rheum 13 1983 104
77. S.A. Jimenez R.I. Bashey Collagen synthesis by scleroderma fibroblasts in culture Arthritis Rheum 20 1977 902
78. S.A. Jimenez A. Diaz K. Khalili Retroviruses and the pathogenesis of systemic sclerosis Int Rev Immunol 12 1995 159
79. S.A. Jimenez G. Feldman R. Bashey Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts Biochem J 237 1986 837
80. S.A. Jimenez B. Freundlich J. Rosenbloom Selective inhibition of human diploid fibroblast collagen synthesis by interferons J Clin Invest 74 1984 1112
81. S.A. Jimenez A. Martinez Fibroblasts Roitt I.M. Delves P.J. Encyclopedia of Immunology 1991 Saunders Scientific Publications London 562
82. S.A. Jimenez W. McArthur J. Rosenbloom Inhibition of collagen synthesis by mononuclear cell supernates J Exp Med 150 1979 1421
83. S.A. Jimenez J. Varga A. Olsen Functional analysis of human α1(I) procollagen gene promoter. Differential activity in collagen-producing and -nonproducing cells and response to transforming growth factor-β1 J Biol Chem 269 1994 12684
84. S.A. Jimenez R.I. Yankowski P.M. Frontino Biosynthetic heterogeneity of sclerodermatous skin in organ cultures J Mol Med 2 1977 423
85. R. Johnson M. Ziff Lymphokine stimulation of collagen accumulation J Clin Invest 58 1976 240
86. V. Kahari T. Vuorio K. Nanto-Salonen Increased type I collagen mRNA levels in cultured scleroderma fibroblasts Biochem Biophys Acta 781 1984 183
87. V.-M. Kahari Y. Chen M. Su Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor β1 J Clin Invest 86 1990 1489
88. V.-M. Kahari J. Heino H. Larjava Alterations in scleroderma fibroblast surface glycoproteins associated with increased collagen synthesis Acta Derm Venereol 67 1987 199
89. V.-M. Kahari J. Heino T. Vuorio Interferon-γ and -α reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture Biochem Biophys Acta 968 1988 45
90. V.-M. Kahari M. Sandberg H. Kalimo Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization J Invest Dermatol 90 1988 664
91. V.-M. Kahari P. Multimaki E. Vuorio Elevated pro-α2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene FEBS Lett 215 1987 331
92. G. Karsenty R. Ravazzolo B. deCrombrugghe Purification and functional characterization of a DNA-binding protein that interacts with a negative element in the mouse α1(I) collagen promoter J Biol Chem 266 1992 24842
93. G. Karsenty B. de Crombrugghe Two different negative and one positive regulatory factors interact with a short promoter segment of the α1(I) collagen gene J Biol Chem 265 1990 9934
94. G. Karsenty P. Rang-Woon Regulation of type I collagen gene expression Int Rev Immunol 12 1995 177
95. H. Katai J.D. Stephenson C.P. Simkevich An AP-1-like motif in the first intron of human pro-α1(I) collagen gene is a critical determinant of its transcriptional activity Mol Cell Biochem 118 1992 119
96. K. Katayama J. Seyer R. Raghow Regulation of extracellular matrix production by chemically synthesized subfragments of type I collagen carboxy-propeptide Biochemistry 30 1991 7097
97. Y. Kawaguchi M. Harigan K. Suzuki Interleukin-1 receptor on fibroblasts from systemic sclerosis patients induces excessive functional responses to interleukin-1β Biochem Biophys Res Commun 190 1993 154
98. E.C. Keystone C. Lok B. Appleton Elevated serum levels of transforming growth factor-β in patients with scleroderma (SSc) (abstract) Arthritis Rheum 35 1992 S206
99. K. Kikuchi E.A. Smith E.C. LeRoy M. Trojanowska Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts Biochem Biophys Res Commun 187 1992 45 50
100. K. Kikuchi C. Hartl E. Smith Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGF-β1 stimulation Biochem Biophys Res Commun 187 1992 45
101. K. Kikuchi A. Yamakage E. Smith Differential modulation of bFGF receptors by TGF-β in adult skin, scleroderma skin, and newborn foreskin fibroblasts J Invest Dermatol 99 1992 201
102. S.J. Kim P. Angee R. Latyatis Autoinduction of transforming growth factor-β1 is mediated by the AP-1 complex Mol Cell Biol 10 1990 1492
103. D.M. Kingsley The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms Genes Dev 8 1994 133
104. B.M. Kräling G.G. Maul S.A. Jimenez Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages Pathobiology 63 1995 48
105. S. Krane J.-M. Dayer L. Simon Mononuclear cell-conditioned medium contains mononuclear cell factor (MCF) homologous with interleukin-1, stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells Collagen Related Res 5 1985 99
106. T. Krieg R. Hein A. Hatamochi Molecular and clinical aspects of connective tissue Eur J Clin Invest 18 1988 105
107. M. Kulozik A. Hogg B. Lankat-Buttgereit T. Krieg Co-localization of transforming growth factor-β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis J Clin Invest 86 1990 917
108. R. Lawrence D.J. Hartmann G.E. Sonenshein Transforming growth factor beta stimulates type V collagen expression in bovine vascular smooth muscle cells J Biol Chem 269 1994 9603
109. E.C. LeRoy Connective tissue synthesis by scleroderma skin fibroblasts in cell culture J Exp Med 135 1972 1351
110. E.C. LeRoy Increased collagen synthesis by scleroderma skin fibroblasts in vitro: A possible defect in the regulation or activation of the scleroderma fibroblasts J Clin Invest 54 1974 880
111. E.C. LeRoy E. Smith M. Kahaleh A strategy for determining the pathogenesis of scleroderma: Is transforming growth factor-β the answer? Arthritis Rheum 32 1989 817
112. G. Liau D. Szapary C. Setoyama B. deCrombrugghe Restriction enzyme digestions identify discrete domains in the chromatin around the promoter of the mouse α2(I) collagen gene J Biol Chem 261 1986 11362
113. C.Q. Lin M.J. Bissell Multifaceted regulation of cell differentiation by extracellular matrix FASEB J 7 1993 737
114. D.J. Liska J.L. Slack P. Bornstein A highly conserved intronic sequence is involved in transcriptional regulation of the α1(I) collagen gene Cell Regulation 1 1990 487
115. C. Lovell A. Nicholls V. Duance Characterization of dermal collagen in systemic sclerosis Br J Dermatol 100 1979 359
116. G.P. Lunstrum L.Y. Sakai D.R. Keene Complex globular domains of type VII procollagen: The structure of anchoring fibrils J Biol Chem 261 1986 9042
117. S.N. Maity P.T. Golumbek G. Karsenty Selective activation of transcription by a novel CCAAT binding factor Science 241 1988 582
118. S. Majewski M. Hunzelmann C. Schirren Increased adhesion of fibroblasts from patients with scleroderma to extracellular matrix components: In vitro modulation by IFN-γ but not by TGF-β J Invest Dermatol 98 1992 86
119. S. Majewski N. Hunzelmann J. Johnson Expression of the intercellular adhesion molecule-1 (ICAM-1) in the skin of patients with systemic sclerosis J Invest Dermatol 97 1991 667
120. J. Massague The transforming growth factor-β family Annu Rev Cell Biol 6 1990 597
121. C. Maul S. Jimenez E. Riggs Determination of an epitope of the diffuse systemic sclerosis marker DNA topoisomerase-1: Sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis Proc Natl Acad Sci USA 86 1989 8492
122. A. Mauviel M. Daireaux F. Dini Tumor necrosis factor-α inhibits collagen and fibronectin synthesis in human dermal fibroblasts FEBS Lett 236 1988 47
123. A. Mauviel J. Heino V.-M. Kahari Comparative effects of IL-1 and TNF-α on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts J Invest Dermatol 96 1991 243
124. A. Mauviel N. Temime D. Charron Induction of interleukin-1 β production in human dermal fibroblasts by interleukin-1 α and tumor necrosis factor-α. Involvement of protein kinase-dependent and adenylate cyclase dependent regulatory pathways J Cell Biochem 47 1991 174
125. E.R. McCabe J.H. Kersey P.J. Vandersteen Reverse transcriptase in patients with scleroderma Biochemical Medicine 21 1979 47
126. C. McKeon H. Ohkubo I. Pastan Unusual methylation pattern of the α2(I) collagen gene Cell 29 1982 203
127. T.A. Medsger Systemic sclerosis (scleroderma), localized scleroderma, eosinophilic fasciitis, and calcinosis D.J. McCarty W.J. Koopman Arthritis and Allied Conditions. 1993 Lea & Febiger Philadelphia 1253
128. E. Munoz D. Suri S. Amini Stimulation of α1(I) procollagen gene expression in NIH-3T3 cells by the human T cell leukemia virus type I (HTLV-1) tax gene J Clin Invest 96 1995 2413
129. T. Mustoe G. Pierce A. Thomason Accelerated healing of incisional wounds in rats induced by TGF-β Science 237 1987 1333
130. E.G. Nabel L. Shum V.J. Pompili Direct transfer of transforming growth factor-β 1 gene into arteries stimulates fibrocellular hyperplasia Proc Natl Acad Sci USA 90 1993 10759
131. A. Narayanan R. Page J. Swanson Collagen synthesis by human fibroblasts: Regulation by TGFβ in the presence of other inflammatory mediators Biochem J 260 1989 463
132. A. Narayanan J. Whitey A. Souza Effect of γ-interferon on collagen synthesis by normal and fibrotic human lung fibroblasts Chest 101 1992 1326
133. B. Needleman Increased expression of intercellular adhesion molecule 1 on the fibroblasts of scleroderma patients Arthritis Rheum 33 1990 1847
134. B. Needleman J. Choi A. Burrows-Mezu Secretion and binding of transforming growth factor β by scleroderma and normal dermal fibroblasts Arthritis Rheum 33 1990 650
135. M. Nehls M. Grapilon D. Brenner NF-1/Sp-1 switch elements regulate collagen α1(I) gene expression DNA Cell Biol 11 1992 443
136. M. Nehls R. Rippe L. Veloz Transcription factors nuclear factor I and Sp1 interact with the murine collagen α1(I) promoter Mol Cell Biol 11 1991 4065
137. E. Neilson S. Phillips S. Jimenez Lymphokine modulation of fibroblast proliferation J Immunol 128 1982 1484
138. B.R. Olsen The next frontier: Molecular biology of extracellular matrix Connect Tissue Res 23 1989 115
139. D. Olsen J. Peltonen S. Jaakkola Collagen gene expression by cultured human skin fibroblasts: Abundant steady-state levels of Type VI procollagen mRNAs J Clin Invest 83 1989 791
140. J. Peltonen L. Kahari J. Uitto Increased expression of type VI collagen genes in systemic sclerosis Arthritis Rheum 33 1990 1829
141. J. Peltonen L. Kahari S. Jaakkola Evaluation of transforming growth factor β 1 and type I procollagen gene expression in fibrotic skin diseases by in situ hybridization J Invest Dermatol 94 1989 365
142. R. Pentinnen S. Kobayashi P. Bornstein Transforming growth factor β increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability Proc Natl Acad Sci USA 85 1988 1105
143. J. Perlish G. Lemlich R. Fleischmajer Identification of collagen fibrils in scleroderma skin J Invest Dermatol 90 1988 48
144. J. Perlish R. Timpl R. Fleischmajer Collagen synthesis regulation by the amino propeptide of procollagen I in normal and scleroderma fibroblasts Arthritis Rheum 28 1985 647
145. P. Piguet C. Vesin G. Grau Interleukin-1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica Cytokines 5 1993 57
146. A.E. Postlethwaite R. Raghow G.P. Stricklin Modulation of fibroblast functions by interleukin 1: Increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin α1 J Cell Biol 106 1988 311
147. A. Postlethwaite R. Snyderman A. Kang The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor J Exp Med 144 1976 1188
148. E. Priel S. Showalter M. Roberts Topoisomerase I activity associated with human immunodeficiency virus (HIV) particles and equine infectious anemia virus core EMBO J 9 1990 4167
149. D.J. Prockop K.I. Kivirikko Collagens: Molecular biology, diseases, and potentials for therapy Annu Rev Biochem 64 1995 403
150. D. Quaglino Jr L.B. Nanney J.A. Ditesheim Transforming growth factor β stimulates wound healing and modulates extracellular matrix gene expression in pig skin incisional wound model J Invest Dermatol 97 1991 34
151. R. Raghow J. Thompson Molecular mechanisms of collagen gene expression Mol Cell Biochem 86 1989 5
152. R. Raghow A. Postlethwaite J. Keski-Oja Transforming growth factor-β increases the steady-state levels of type I procollagen and fibronectin mRNA posttranscriptionally in cultured human dermal fibroblasts J Clin Invest 79 1987 1285
153. A. Razin H. Cedar DNA methylation and gene expression Microbiol Rev 55 1991 451
154. K. Rhodes M. Breindl Developmental changes in the methylation status of regulatory elements in the murine α1(I) collagen gene Gene Expr 2 1992 59
155. J. Ritzenthaler R.A. Goldstein A. Fine Transforming growth factor-β activation elements in the distal promoter region of the rat α1 type I collagen gene Biochem J 280 1991 157
156. J. Ritzenthaler R. Goldstein A. Fine Regulation of the α1(I) collagen promoter via a transforming growth factor-β activation element J Biol Chem 268 1993 13625
157. A. Roberts M. Sporn R. Assoian Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and collagen formation in vitro Proc Natl Acad Sci USA 83 1986 4167
158. G. Rodnan E. Lipinski J. Luksick Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma Arthritis Rheum 22 1979 130
159. J. Rosenbloom G. Feldman B. Freundlich Transcriptional control of human diploid fibroblast collagen synthesis by γ-interferon Biochem Biophys Res Commun 123 1984 365
160. J. Rosenbloom G. Feldman B. Freundlich Inhibition of excessive scleroderma fibroblasts collagen synthesis by recombinant γ interferon Arthritis Rheum 29 1986 851
161. P. Rossi G. Karsenty A.B. Roberts A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β Cell 52 1988 405
162. C.M. Rossouw W.P. Vergeer S.J.D. du Plooy DNA sequences in the first intron of the human pro-α1 (I) collagen gene enhance transcription J Biol Chem 262 1987 15151
163. A. Roumm T. Whiteside T. Medsger Jr Lymphocytes in the skin of patients with progressive systemic sclerosis Arthritis Rheum 27 1984 645
164. L. Rudnicka J. Varga A.M. Christiano Elevated expression of type VII collagen in the skin of patients with systemic sclerosis: Regulation by transforming growth factor-β J Clin Invest 93 1994 1709
165. E. Ruoslahti Y. Yamaguchi A. Hilderbrand Extracellular matrix/growth factor interactions Cold Spring Harb Symp Quant Biol 57 1992 309
166. M.A. Sackner Scleroderma, Modern Medical Monographs 1966 Grune and Stratton New York
167. H. Sage Collagens of the basement membrane J Invest Dermatol 79 1982 515
168. E.H. Sage P. Bornstein Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin J Biol Chem 266 1991 14831
169. P. Savagner P.H. Krebsbach O. Hatano Collagen II promoter and enhancer interact synergistically through Sp1 and distinct nuclear factors DNA Cell Biol 14 1995 501
170. J.R. Seibold Scleroderma Kelly W.N. Textbook of Rheumatology 1993 WB Saunders Company Philadelphia 1113
171. J. Seyer A. Kang G. Rodnan Investigation of type III collagen of the lung in progressive systemic sclerosis (scleroderma) Arthritis Rheum 24 1981 625
172. P.P. Sfikakis B.K. McCune M. Tsokos Immunohistologic demonstration of transforming growth factor-β isoforms in the skin of patients with systemic sclerosis Clin Immunol Immunopathol 69 1993 1991
173. 1 Lancet 339 1992 213
174. A.L. Sherwood P. Bornstein Transcriptional control of the α1(I) collagen gene involves orientation- and position-specific intronic sequences Biochem J 265 1990 895
175. M. Siekevitz M.G. Feinberg N. Holbrook Activation of interleukin-2 and interleukin-2 receptor (Tac) promoter expression by the transactivator (tat) gene product of human T-cell leukemia virus, type I Proc Natl Acad Sci USA 84 1987 5389
176. J.L. Slack D.J. Liska P. Bornstein Regulation of expression of the type I collagen genes Am J Med Genet 45 1993 140
177. E.A. Smith E.C. LeRoy A possible role for transforming growth factor-beta in systemic sclerosis J Invest Dermatol 95 1990 1255
178. M.E. Sobel T. Yamamoto B. de Crombrugghe Regulation of procollagen messenger ribonucleic acid levels in Rous sarcoma virus–transformed chick embryo fibroblasts Biochemistry 20 1981 2678
179. J. Solis-Herruzo D. Brenner M. Chojkier Tumor necrosis factor α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts J Biol Chem 263 1986 5841
180. S. Sollberg J. Peltonen J. Uitto Elevated expression of β1 and β2 integrins, intercellular adhesion molecule 1, and endothelial leukocyte adhesion molecule 1 in the skin of patients with systemic sclerosis of recent onset Arthritis Rheum 35 1992 290
181. M.B. Sporn A.B. Roberts Transforming growth factor-β: Recent progress and new challenges J Cell Biol 119 1992 1017
182. W. Stevens R. Vancheeswaran C. Black Alpha interferon-2a (Roferon-A) in the treatment of diffuse cutaneous systemic sclerosis: A pilot study Br J Rheumatol 31 1992 683
183. J.P. Taylor C. Cupp A. Diaz Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells Proc Natl Acad Sci USA 89 1992 9617
184. J. Uitto P. Helin O. Rasmussen Skin collagen in patients with scleroderma: Biosynthesis and maturation in vitro and the effect of D-penicillamine Annals of Clinical Research 2 1970 228
185. J. Uitto E.A. Bauer A.Z. Eisen Scleroderma. Increased biosynthesis of triple-helical type I and type III procollagens associated with unaltered expression of collagenase by skin fibroblasts in culture J Clin Invest 64 1979 921
186. J. Van de Water L. Haapanen R. Boyd Identification of T cells in early lymphocytic infiltrates in avian scleroderma Arthritis Rheum 32 1989 1031
187. J. Varga A. Olsen J. Herhal Interferon-γ reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor-β in normal human fibroblasts Eur J Clin Invest 20 1990 487
188. J. Varga J. Rosenbloom S. Jimenez Transforming growth factor-β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts Biochem J 247 1987 597
189. J. Vilcek T. Lee Tumor necrosis factor: New insights into the molecular mechanisms of its multiple actions J Biol Chem 266 1991 7313
190. T. Vuorio V.-M. Kahari C. Black Expression of osteonectin, decorin, and transforming growth factor-β1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea J Rheumatol 28 1991 247
191. L.M. Wakefield D.M. Smith K.C. Flaunders Latent transforming growth factor-β from human platelets. A high molecular weight complex containing precursor sequences J Biol Chem 263 1988 7646
192. G. Wantzin E. Ralfkiaer L. Steen The role of intercellular adhesion molecules in inflammatory skin reactions Br J Dermatol 119 1988 141
193. F. Weiner A. Shah P. Smith Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor α Biochemistry 28 1989 4094
194. Y.G. Wolf L.M. Rasmussen E. Ruoslahti Antibodies against transforming growth factor-β1 suppress intimal hyperplasia in a rat model J Clin Invest 93 1994 1172
195. J.L. Wrana L. Attisano R. Wieser Mechanism of activation of the TGF-β receptor Nature 370 1994 341
196. A. Yamakage L. Kikuchi A. Smith Selective up-regulation of PDGFα receptors by TGF-β in scleroderma fibroblasts J Exp Med 175 1992 1227