C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease

Metabolism: Clinical and Experimental

Volumn 64, Issue 5, 2015, Pages 597-610

  Li, Ling ^a   Chen, Lijia ^a   Zang, Jing ^a   Tang, Xi ^a   Liu, Yan ^b   Zhang, Jie ^a   Bai, Lin ^a   Yin, Qinghua ^a   Lu, Yanrong ^a   Cheng, Jingqiu ^a   Fu, Ping ^a   Liu, Fang ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

C3a receptor antagonists; C5a receptor antagonists; Diabetic kidney disease; Endothelial myofibroblast transition; Wnt catenin signaling pathway

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A RECEPTOR; GLUCOSE; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; C5AR1 PROTEIN, HUMAN; COMPLEMENT C3A RECEPTOR; COMPLEMENT COMPONENT C5A; COMPLEMENT RECEPTOR; WNT1 PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENDOTHELIUM CELL; FEMALE; GLOMERULUS; HUMAN; HUMAN CELL; KIDNEY BIOPSY; KIDNEY FIBROSIS; MALE; MIDDLE AGED; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ADULT; ANIMALS; BLOTTING, WESTERN; CELL LINE; COMPLEMENT C3A; COMPLEMENT C5A; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOFIBROBLASTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; SIGNAL TRANSDUCTION; WNT1 PROTEIN;

EID: 84925371635     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.01.014     Document Type: Article

References (36)

1. A. Dei Cas, and L. Gnudi VEGF and angiopoietins in diabetic glomerulopathy: how far for a new treatment? Metabolism 61 12 2012 1666 1673
2. E.M. Zeisberg, S.E. Potenta, H. Sugimoto, M. Zeisberg, and R. Kalluri Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition J Am Soc Nephrol 19 2008 2282 2287
3. J.A. Lindquist, and P.R. Mertens Myofibroblasts, regeneration or renal fibrosis - is there a decisive hint? Nephrol Dial Transplant 28 2013 2678 2681
4. J. He, Y. Xu, D. Koya, and K. Kanasaki Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease Clin Exp Nephrol 17 2013 488 497
5. F. Strutz, and M. Zeisberg Renal fibroblasts and myofibroblasts in chronic kidney disease J Am Soc Nephrol 17 2006 2992 2998
6. L.M. Eisenberg, and R.R. Markwald Molecular regulation of atrioventricular valvuloseptal morphogenesis Circ Res 77 1995 1 6
7. F. Lin, N. Wang, and T.C. Zhang The role of endothelial-mesenchymal transition in development and pathological process IUBMB Life 64 2012 717 723
8. J. Li, X. Qu, and J.F. Bertram Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice Am J Pathol 175 2009 1380 1388
9. J.F. Navarro-González, and C. Mora-Fernández The role of inflammatory cytokines in diabetic nephropathy J Am Soc Nephrol 19 2008 433 442
10. M. Saraheimo, A.M. Teppo, C. Forsblom, J. Fagerudd, and P.H. Groop Diabetic nephropathy is associated with low-grade inflammation in type 1 diabetic patients Diabetologia 46 2003 1402 1407
11. K.R. Tuttle Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease J Am Soc Nephrol 16 2005 1537 1538
12. K. Kanasaki, G. Taduri, and D. Koya Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis Front Endocrinol (Lausanne) 4 2013 [article 7, 1-15]
13. S.P. Berger, A. Roos, and M.R. Daha Complement and the kidney: what the nephrologist needs to know in 2006? Nephrol Dial Transplant 20 2005 2613 2619
14. P. Boor, A. Konieczny, L. Villa, A.L. Schult, E. Bücher, and S. Rong Complement C5 mediates experimental tubulointerstitial fibrosis J Am Soc Nephrol 18 2007 1508 1515
15. L. Bao, I. Osawe, T. Puri, J.D. Lambris, M. Haas, and R.J. Quigg C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist Eur J Immunol 35 2005 2496 2506
16. M. Mizuno, S. Blanchin, P. Gasque, K. Nishikawa, and S. Matsuo High levels of complement C3a receptor in the glomeruli in lupus nephritis Am J Kidney Dis 49 2007 598 606
17. R. Suetsugu-Maki, N. Maki, T.P. Fox, K. Nakamura, R. Cowper Solari, and C.R. Tomlinson A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice Mol Vis 17 2011 949 964
18. F. Liu, R. Gou, J. Huang, P. Fu, F. Chen, and W.X. Fan Effect of anaphylatoxin C3a, C5a on the tubular epithelial-myofibroblast transdifferentiation in vitro Chin Med J (Engl) 124 2011 4039 4045
19. O. Aisagbonhi, M. Rai, S. Ryzhov, N. Atria, I. Feoktistov, and A.K. Hatzopoulos Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition Dis Model Mech 4 2011 469 483
20. C. Ho, P.H. Lee, Y.C. Hsu, F.S. Wang, Y.T. Huang, and C.L. Lin Sustained Wnt/β-catenin signaling rescues high glucose induction of transforming growth factor-β1-mediated renal fibrosis Am J Med Sci 344 2012 374 382
21. L.M. Proctor, A.J. Strachan, T.M. Woodruff, I.B. Mahadevan, H.M. Williams, and I.A. Shiels Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats Int Immunopharmacol 6 2006 1224 1232
22. B. Rooney, H. O'Donovan, A. Gaffney, M. Browne, N. Faherty, and S.P. Curran CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy FEBS Lett 585 2011 531 538
23. J. Li, X. Qu, J. Yao, G. Caruana, S.D. Ricardo, and Y. Yamamoto Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy Diabetes 59 2010 2612 2624
24. M.C. Braun, R.Y. Reins, T.B. Li, T.J. Hollmann, R. Dutta, and W.A. Rick Renal expression of the c3a receptor and functional responses of primary human proximal tubular epithelial cells J Immunol 173 2004 4190 4196
25. R. Zahedi, M. Braun, R.A. Wetsel, B.H. Ault, A. Khan, and T.R. Welch The C5a receptor is expressed by human renal proximal tubular epithelial cells Clin Exp Immunol 121 2000 226 233
26. T. Monsinjon, P. Gasque, P. Chan, A. Ischenko, J.J. Brady, and M.C. Fontaine Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells FASEB J 17 2003 1003 1014
27. I.U. Schraufstatter, K. Trieu, L. Sikora, P. Sriramarao, and R. DiScipio Complement c3a and c5a induce different signal transduction cascades in endothelial cells J Immunol 169 2002 2102 2110
28. K. Abe, M. Miyazaki, T. Koji, A. Furusu, T. Nakamura-Kurashige, and T. Nishino Enhanced expression of complement C5a receptor mRNA in human diseased kidney assessed by in situ hybridization Kidney Int 60 2001 137 146
29. C.L. Lin, J.Y. Wang, Y.T. Huang, Y.H. Kuo, K. Surendran, and F.S. Wang Wnt/β-catenin signaling modulates survival of high glucose-stressed mesangial cells J Am Soc Nephrol 17 2006 2812 2820
30. C.L. Lin, J.Y. Wang, J.Y. Ko, K. Surendran, Y.T. Huang, and Y.H. Kuo Superoxide destabilization of β-catenin augments apoptosis of high-glucose-stressed mesangial cells Endocrinology 149 2008 2934 2942
31. Z. Li, J. Xu, P. Xu, S. Liu, and Z. Yang Wnt/β-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes Cell Prolif 46 2013 76 85
32. W. He, Y.S. Kang, C. Dai, and Y. Liu Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury J Am Soc Nephrol 22 2011 90 103
33. Y.J. Lee, and H.J. Han Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3β, Snail1, and β-catenin in renal proximal tubule cells Am J Physiol Renal Physiol 298 2010 F1263 F1275
34. Y. Liu New insights into epithelial-mesenchymal transition in kidney ibrosis J Am Soc Nephrol 21 2010 212 222
35. S. Liebner, A. Cattelino, R. Gallini, N. Rudini, M. Iurlaro, and S. Piccolo Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in themouse J Cell Biol 166 2004 359 367
36. C.L. Lin, J.Y. Wang, J.Y. Ko, Y.T. Huang, Y.H. Kuo, and F.S. Wang Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction J Am Soc Nephrol 21 2010 124 135