Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases

Fibrogenesis and Tissue Repair

Volumn 5, Issue SUPPL.1, 2012, Pages

  Piera Velazquez, Sonsoles ^a   Jimenez, Sergio A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; TRANSFORMING GROWTH FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL TRANSFORMATION; ENDOTHELIAL TO MESENCHYMAL CELL TRANSITION; ENDOTHELIUM CELL; FIBROSIS; HEART MUSCLE FIBROSIS; HUMAN; KIDNEY FIBROSIS; LUNG FIBROSIS; MOLECULAR MECHANICS; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION;

EID: 84872694870     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/1755-1536-5-S1-S7     Document Type: Article

References (44)

1. Hinz B, Gabbiani G. Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives. F1000 Biol Rep 2010, 11:2-78.
2. Neilson EG. Mechanisms of disease: Fibroblasts--a new look at an old problem. Nat Clin Pract Nephrol 2006, 2:101-8. 10.1038/ncpneph0093, 16932401.
3. Abraham DJ, Eckes B, Rajkumar V, Krieg T. New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma. Curr Rheumatol Rep 2007, 9:136-43. 10.1007/s11926-007-0008-z, 17502044.
4. Heinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G. The myofibroblast: one function, multiple origins. Am J Pathol 2007, 170:1807-16. 10.2353/ajpath.2007.070112, 1899462, 17525249.
5. Rosenbloom J, Castro SV, Jimenez SA. Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann Intern Med 2010, 152:159-66.
6. Wei J, Bhattacharyya S, Tourtellotte WG, Varga J. Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy. Autoimmun Rev 2011, 10:267-275. 10.1016/j.autrev.2010.09.015, 20863909.
7. McAnulty RJ. Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 2007, 39:666-71. 10.1016/j.biocel.2006.11.005, 17196874.
8. Postlethwaite AE, Shigemitsu H, Kanangat S. Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis. Curr Opin Rheumatol 2004, 16:733-8. 10.1097/01.bor.0000139310.77347.9c, 15577612.
9. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-90. 10.1016/j.cell.2009.11.007, 19945376.
10. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003, 112:1776-84. 297008, 14679171.
11. Willis BC, Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 2007, 293:L525-34. 10.1152/ajplung.00163.2007, 17631612.
12. Willis BC, duBois RM, Borok Z. Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc 2006, 3:377-82. 10.1513/pats.200601-004TK, 2658689, 16738204.
13. Rastaldi MP. Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis. J Nephrol 2006, 19:407-12.
14. Zeisberg M, Kalluri R. Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis. Front Biosci 2008, 13:6991-8.
15. Herzog EL, Bucala R. Fibrocytes in health and disease. Exp Hematol 2010, 38:548-56. 10.1016/j.exphem.2010.03.004, 3136351, 20303382.
16. Bellini A, Mattoli S. The role of the fibrocytes, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007, 87:858-70. 10.1038/labinvest.3700654, 17607298.
17. Arciniegas E, Sutton AB, Allen TD, Schor AM. Transforming growth factor beta 1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro. J Cell Sci 1992, 103:521-9.
18. Li J, Bertram JF. Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis. Nephrology (Carlton) 2010, 15:507-12. 10.1111/j.1440-1797.2010.01319.x, 20649869.
19. Piera-Velazquez S, Li Z, Jimenez SA. Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders. Am J Pathol 2011, 179:1074-1084. 10.1016/j.ajpath.2011.06.001, 21763673.
20. Arciniegas E, Neves CY, Carrillo LM, Zambrano EA, Ramirez R. Endothelial-mesenchymal transition occurs during embryonic pulmonary artery development. Endothelium 2005, 12:193-200. 10.1080/10623320500227283, 16162442.
21. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 2007, 13:952-61. 10.1038/nm1613, 17660828.
22. Goumans M, van Zonneveld AJ, ten Dijke P. Transforming growth factor β-Induced endothelial-to-mesenchymal transition: A switch to cardiac fibrosis?. Trends Cardiovasc Med 2008, 18:293-8. 10.1016/j.tcm.2009.01.001, 19345316.
23. Widyantoro B, Emoto N, Nakayama K, Anggrahini DW, Adiarto S, Iwasa N, Yagi K, Miyagawa K, Rikitake Y, Suzuki T, Kisanuki YY, Yanagisawa M, Hirata K. Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 2010, 121:2407-18. 10.1161/CIRCULATIONAHA.110.938217, 20497976.
24. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008, 19:2282-7. 10.1681/ASN.2008050513, 2588112, 18987304.
25. Li J, Qu X, Bertram JF. Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice. Am J Pathol 2009, 175:1380-8. 10.2353/ajpath.2009.090096, 2751535, 19729486.
26. Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y. Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 2010, 43:161-72. 10.1165/rcmb.2009-0031OC, 2937229, 19767450.
27. Nieto MA. Epithelial-mesenchymal transitions in development and disease: Old views and new perspectives. Int J Dev Biol 2009, 53:1541-1547. 10.1387/ijdb.072410mn, 19247945.
28. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000, 2:76-83. 10.1038/35000025, 10655586.
29. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7:131-42. 10.1038/nrm1835, 16493418.
30. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC. Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004, 6:931-940. 10.1038/ncb1173, 15448698.
31. Doble BW, Woodgett JR. Role of glycogen synthase kinase-3 in cell fate and epithelial- mesenchymal transitions. Cells Tissues Organs 2007, 185:73-84. 10.1159/000101306, 17587811.
32. Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, Gopalan B, Stylianou E, Fiocchi C. Inflammation-Induced Endothelial-to-Mesenchymal Transition A Novel Mechanism of Intestinal Fibrosis. Am J Pathol 2011, 179:2660-73. 10.1016/j.ajpath.2011.07.042, 21945322.
33. Mendoza F, Piera-Velazquez S, Farber JL, Jimenez SA. Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of systemic sclerosis associated pulmonary fibroproliferative vasculopathy. Arthritis Rheum 63:S171-172. Abstract.
34. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008, 214:199-210. 10.1002/path.2277, 2693329, 18161745.
35. Varga J, Abraham D. Systemic Sclerosis: A prototypic multi-system fibrotic disorder. J Clin Invest 2007, 117:557-67. 10.1172/JCI31139, 1804347, 17332883.
36. Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol 2011, 8:42-54. 10.1038/nrrheum.2011.149, 22025123.
37. Varga J, Whitfield ML. Transforming growth factor-beta in systemic sclerosis (scleroderma). Front Biosci (Schol Ed) 2009, 1:226-35.
38. Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Watabe T, Miyazono K. Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci 2008, 121:3317-3324. 10.1242/jcs.028282, 18796538.
39. Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 2010, 16:1400-6. 10.1038/nm.2252, 3209716, 21102460.
40. Li J, Qu X, Yao J, Caruana G, Ricardo SD, Yamamoto Y, Yamamoto H, Bertram JF. Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes 2010, 59:2612-24. 10.2337/db09-1631, 3279546, 20682692.
41. Li Z, Jimenez SA. Protein kinase C delta and the c-abl kinase are required for transforming growth factor-beta induction of endothelial-mesenchymal transition in vitro. Arthritis Rheum 2011, 63:2473-2483. 10.1002/art.30317, 3134600, 21425122.
42. Medici D, Potenta S, Kalluri R. Transforming growth factor-b2 promotes Snail-mediated endothelia-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem J 2011, 437:515-520. 10.1042/BJ20101500, 21585337.
43. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech 2011, 4:469-483. 10.1242/dmm.006510, 3124051, 21324930.
44. Zhu P, Huang L, Ge X, Yan F, Wu R, Ao Q. Transdifferentiation of pulmonary arteriolar endothelial cells into smooth muscle-like cells regulated by myocardin involved in hypoxia-induced pulmonary vascular remodelling. Int J Exp Pathol 2006, 87:463-74. 10.1111/j.1365-2613.2006.00503.x, 2517388, 17222214.