The role of endothelial-mesenchymal transition in development and pathological process

IUBMB Life

Volumn 64, Issue 9, 2012, Pages 717-723

  Lin, Feng ^a   Wang, Nan ^a   Zhang, Tong Cun ^a,b  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

cancer fibrosis; cancer associated fibroblasts; endothelial mesenchymal transition; epithelial mesenchymal transition

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; NOTCH RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

CELL DIFFERENTIATION; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HEART DEVELOPMENT; HEART MUSCLE FIBROSIS; METASTASIS; REVIEW;

ANIMALS; CELL TRANSDIFFERENTIATION; DISEASE PROGRESSION; EMBRYONIC DEVELOPMENT; FIBROSIS; HEART DISEASES; HUMANS; NEOPLASMS; REGENERATION; SIGNAL TRANSDUCTION;

EID: 84865345444     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1059     Document Type: Review

References (48)

1. Kalluri, R., and, Zeisberg, M., (2006) Fibroblasts in cancer. Nat. Rev. Cancer 6, 392-401.
2. Nakajima, Y., Yamagishi, T., Hokari, S., and, Nakamura, H., (2000) Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor-beta and bone morphogenetic protein. Anat. Rec. 258, 119-127. (Pubitemid 30082904)
3. Armstrong, E. J., and, Bischoff, J., (2004) Heart valve development: endothelial cell signaling and differentiation. Circ. Res. 95, 459-470. (Pubitemid 39180926)
4. Zeisberg, M., Potenta, S., and, Xie, L., (2007) Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67, 10123-10128. (Pubitemid 350070783)
5. Kinsella, M. G., and, Fitzharris, T. P., (1980) Origin of cushion tissue in the developing chick heart: cinematographic recordings of in situ formation. Science 207, 1359-1360. (Pubitemid 10111126)
6. Eisenberg, L. M., and, Markwald, R. R., (1995) Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77, 1-6.
7. Zhang, J., Lin, Y., Zhang, Y., Lan, Y., Lin, C., et al. (2008) Frs2α-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 135, 3611-3622.
8. Arciniegas, E., Sutton, A. B., Allen, T. D., and, Schor, A. M., (1992) Transforming growth factor beta 1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro. J. Cell Sci. 103, 521-529.
9. Arciniegas, E., Neves, C. Y., Carrillo, L. M., Zambrano, E. A., and, Ramírez, R., (2005) Endothelial-mesenchymal transition occurs during embryonic pulmonary artery development. Endothelium 12, 193-200. (Pubitemid 41600864)
10. Markwald, R. R., Fitzharris, T. P., and, Manasek, F. J., (1977) Structural development of endocardial cushions. Am. J. Anat. 148, 85-119. (Pubitemid 8034351)
11. Moonen, J. R., Krenning, G., Brinker, M. G., Koerts, J. A., van Luyn, M. J., et al. (2010) Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny. Cardiovasc. Res. 86, 506-515.
12. Armulik, A., Abramsson, A., and, Betsholtz, C., (2005) Endothelial/pericyte interactions. Circ. Res. 97, 512-523. (Pubitemid 41361741)
13. Coultas, L., Chawengsaksophak, K., and, Rossant, J., (2005) Endothelial cells and VEGF in vascular development. Nature 438, 937-945. (Pubitemid 43093959)
14. Rieder, F., Kessler, S. P., West, G. A., Bhilocha, S., de la Motte, C., et al. (2011) Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am. J. Pathol. 179, 2660-2673.
15. Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., et al. (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961. (Pubitemid 47222040)
16. Zeisberg, E. M., Potenta, S. E., Sugimoto, H., Zeisberg, M., and, Kalluri, R., (2008) Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J. Am. Soc. Nephrol. 19, 2282-2287.
17. Piera-Velazquez, S., Li, Z., and, Jimenez, S. A., (2011) Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am. J. Pathol. 179, 1074-1080.
18. Antman, E. M., and, Braunwald, E., (2001) Acute myocardial infarction. In Harrison's Principles of Internal Medicine. (, Fauci, A. S., Braunwald, E., Isselbacher, K. J., Wilson, J. D., Martin, J. B., et al., eds.). pp. 1386-1399, McGraw-Hill, New York.
19. Aisagbonhi, O., Rai, M., Ryzhov, S., Atria, N., Feoktistov, I., et al. (2011) Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis. Model Mech. 4, 469-483.
20. Limana, F., Zacheo, A., Mocini, D., Mangoni, A., Borsellino, G., et al. (2007) Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ. Res. 101, 1255-1265. (Pubitemid 350294642)
21. Medici, D., Shore, E. M., Lounev, V. Y., Kaplan, F. S., Kalluri, R., et al. (2010) Conversion of vascular endothelial cells into multipotent stem-like cells. Nat. Med. 16, 1400-1406.
22. Li, J., Qu, X., and, Bertram, J. F., (2009) Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am. J. Pathol. 175, 1380-1388.
23. Xu, H., Zaidi, M., Struve, J., Jones, D. W., Krolikowski, J. G., et al. (2011) Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. Am. J. Physiol. Cell Physiol. 300, C550-C556.
24. Takahashi, K., Ghatei, M. A., Lam, H. C., O'Halloran, D. J., and, Bloom, S. R., (1990) Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia 33, 306-310. (Pubitemid 20161886)
25. Widyantoro, B., Emoto, N., Nakayama, K., Anggrahini, D. W., Adiarto, S., et al. (2010) Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 121, 2407-2418.
26. Potenta, S., Zeisberg, E., and, Kalluri, R., (2008) The role of endothelial-to-mesenchymal transition in cancer. Br. J. Cancer 99, 1375-1379.
27. Cheng, F., Pekkonen, P., Laurinavicius, S., Sugiyama, N., Henderson, S., et al. (2010) KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host Microbe 10, 577-590.
28. Gasperini, P., Espigol-Frigole, G., McCormick, P. J., Salvucci, O., Maric, D., et al. (2012) Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling. Cancer Res. 72, 1157-1169.
29. Massagué, J., (2000) How cells read TGF-β signals. Nat. Rev. Mol. Cell Biol. 1, 169-178.
30. Attisano, L., and, Wrana, J. L., (2000) Smads as transcriptional co-modulators. Curr. Opin. Cell Biol. 12, 235-243. (Pubitemid 30142572)
31. Wu, L., Sun, T., Kobayashi, K., Gao, P., and, Griffin, J. D., (2002) Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol. Cell Biol. 22, 7688-7700.
32. Feng, X. H., and, Derynck, R., (2005) Specificity and versatility in TGF-β signaling through smads. Annu. Rev. Cell Dev. Biol. 21, 659-693. (Pubitemid 41740650)
33. Massagué, J., Seoane, J., and, Wotton, D., (2005) Smad transcription factors. Genes Dev. 19, 2783-2810. (Pubitemid 41739965)
34. Goumans, M. J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., et al. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol. Cell 12, 817-828. (Pubitemid 37352776)
35. Camenisch, T. D., Molin, D. G., Person, A., Runyan, R. B., Gittenberger-de Groot, A. C., et al. (2002) Temporal and distinct TGF-β ligand requirements during mouse and avian endocardial cushion morphogenesis. Dev. Biol. 248, 170-181.
36. Kokudo, T., Suzuki, Y., Yoshimatsu, Y., Yamazaki, T., Watabe, T., et al. (2008) Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J. Cell Sci. 121, 3317-3324.
37. Timmerman, L. A., Grego-Bessa, J., and, Raya, A., (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 18, 99-115. (Pubitemid 38090691)
38. Westin, J., and, Lardelli, M., (1997) Three novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function. Dev. Genes Evol. 207, 51-63. (Pubitemid 27272008)
39. Medici, D., Potenta, S., and, Kalluri, R., (2011) Transforming growth factor-β2 promotes snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem. J. 437, 515-520.
40. Kumarswamy, R., Volkmann, I., Jazbutyte, V., Dangwal, S., Park, D. H., et al. (2012) Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21. Arterioscler. Thromb. Vasc. Biol. 32, 361-369.
41. Artavanis-Tsakonas, S., Rand, M. D., and, Lake, R. J., (1999) Notch signaling: cell fate control and signal integration in development. Science 284, 770-776. (Pubitemid 29291335)
42. Bray, S., and, Furriols, M., (2001) Notch pathway: making sense of suppressor of hairless. Curr. Biol. 6, R217-R221. (Pubitemid 32241508)
43. Nam, Y., Weng, A. P., Aster, J. C., and, Blacklow, S. C., (2003) Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J. Biol. Chem. 278, 21232-21239. (Pubitemid 36806438)
44. Nam, Y., Sliz, P., Song, L., Aster, J. C., and, Blacklow, S. C., (2006) Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124, 973-983. (Pubitemid 43344237)
45. Noseda, M., McLean, G., Niessen, K., Chang, L., Pollet, I., et al. (2004) Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ. Res. 94, 910-917. (Pubitemid 38490068)
46. Liebner, S., Cattelino, A., Gallini, R., Rudini, N., Iurlaro, M., et al. (2004) Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J. Cell Biol. 166, 359-367. (Pubitemid 39031239)
47. Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., and, Brown, R. A., (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat. Rev. Mol. Cell Biol. 3, 349-363. (Pubitemid 34619269)
48. Yang, Y. A., (2002) Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. J. Clin. Invest. 109, 1607-1615.