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Volumn 10, Issue MAY, 2019, Pages

Metabolic profiling of the diabetic heart: Toward a richer picture

Author keywords

Animal models; Diabetic cardiomyopathy; Heart failure; Lipidomics; Metabolomics; Mitochondria

Indexed keywords

BIOLOGICAL MARKER; KETONE; PHOSPHATE; TRIACYLGLYCEROL;

EID: 85068261529     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2019.00639     Document Type: Review
Times cited : (30)

References (151)
  • 1
    • 84946409554 scopus 로고    scopus 로고
    • Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance
    • Abdesselam, I., Pepino, P., Troalen, T., Macia, M., Ancel, P., Masi, B., et al. (2015). Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 17:95. doi: 10.1186/s12968-015-0198-x
    • (2015) J. Cardiovasc. Magn. Reson. , vol.17 , pp. 95
    • Abdesselam, I.1    Pepino, P.2    Troalen, T.3    Macia, M.4    Ancel, P.5    Masi, B.6
  • 2
    • 84910067714 scopus 로고    scopus 로고
    • Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo
    • Abdurrachim, D., Ciapaite, J., Wessels, B., Nabben, M., Luiken, J. J., Nicolay, K., et al. (2014). Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1841, 1525-1537. doi: 10.1016/j.bbalip.2014.07.016
    • (2014) Biochim. Biophys. Acta Mol. Cell Biol. Lipids , vol.1841 , pp. 1525-1537
    • Abdurrachim, D.1    Ciapaite, J.2    Wessels, B.3    Nabben, M.4    Luiken, J.J.5    Nicolay, K.6
  • 3
    • 85031718578 scopus 로고    scopus 로고
    • Diabetic db/db mice do not develop heart failure upon pressure overload: A longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations
    • Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., et al. (2017). Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc. Res. 113, 1148-1160. doi: 10.1093/cvr/cvx100
    • (2017) Cardiovasc. Res. , vol.113 , pp. 1148-1160
    • Abdurrachim, D.1    Nabben, M.2    Hoerr, V.3    Kuhlmann, M.T.4    Bovenkamp, P.5    Ciapaite, J.6
  • 4
    • 84936889159 scopus 로고    scopus 로고
    • Current state and future challenges of mass spectrometry imaging for clinical research
    • Addie, R. D., Balluff, B., Bovée, J. V., Morreau, H., and McDonnell, L. A. (2015). Current state and future challenges of mass spectrometry imaging for clinical research. Anal. Chem. 87, 6426-6433. doi: 10.1021/acs.analchem.5b00416
    • (2015) Anal. Chem. , vol.87 , pp. 6426-6433
    • Addie, R.D.1    Balluff, B.2    Bovée, J.V.3    Morreau, H.4    McDonnell, L.A.5
  • 5
    • 84959431623 scopus 로고    scopus 로고
    • A diet rich in medium-chain fatty acids improves systolic function and alters the lipidomic profile in patients with type 2 diabetes: A pilot study
    • Airhart, S., Cade, W. T., Jiang, H., Coggan, A. R., Racette, S. B., Korenblat, K., et al. (2016). A diet rich in medium-chain fatty acids improves systolic function and alters the lipidomic profile in patients with type 2 diabetes: a pilot study. J. Clin. Endocrinol. Metab. 101, 504-512. doi: 10.1210/jc.2015-3292
    • (2016) J. Clin. Endocrinol. Metab. , vol.101 , pp. 504-512
    • Airhart, S.1    Cade, W.T.2    Jiang, H.3    Coggan, A.R.4    Racette, S.B.5    Korenblat, K.6
  • 6
    • 84921732687 scopus 로고    scopus 로고
    • Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart
    • Ashmore, T., Fernandez, B. O., Branco-Price, C., West, J. A., Cowburn, A. S., Heather, L. C., et al. (2014). Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. J. Physiol. 592, 4715-4731. doi: 10.1113/jphysiol.2014.275263
    • (2014) J. Physiol. , vol.592 , pp. 4715-4731
    • Ashmore, T.1    Fernandez, B.O.2    Branco-Price, C.3    West, J.A.4    Cowburn, A.S.5    Heather, L.C.6
  • 7
    • 79951820751 scopus 로고    scopus 로고
    • Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS
    • Atherton, H. J., Schroeder, M. A., Dodd, M. S., Heather, L. C., Carter, E. E., Cochlin, L. E., et al. (2011). Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS. NMR Biomed. 24, 201-208. doi: 10.1002/nbm.1573
    • (2011) NMR Biomed , vol.24 , pp. 201-208
    • Atherton, H.J.1    Schroeder, M.A.2    Dodd, M.S.3    Heather, L.C.4    Carter, E.E.5    Cochlin, L.E.6
  • 8
    • 84975775560 scopus 로고    scopus 로고
    • The failing heart relies on ketone bodies as a fuel
    • Aubert, G., Martin, O. J., Horton, J. L., Lai, L., Vega, R. B., Leone, T. C., et al. (2016). The failing heart relies on ketone bodies as a fuel. Circulation 133, 698-705. doi: 10.1161/CIRCULATIONAHA.115.017355
    • (2016) Circulation , vol.133 , pp. 698-705
    • Aubert, G.1    Martin, O.J.2    Horton, J.L.3    Lai, L.4    Vega, R.B.5    Leone, T.C.6
  • 9
    • 0025266282 scopus 로고
    • Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease
    • Avogaro, A., Nosadini, R., Doria, A., Fioretto, P., Velussi, M., Vigorito, C., et al. (1990). Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease. Am. J. Physiol. Endocrinol. Metab. 258, E606-E618. doi: 10.1152/ajpendo.1990.258.4.E606
    • (1990) Am. J. Physiol. Endocrinol. Metab. , vol.258 , pp. E606-E618
    • Avogaro, A.1    Nosadini, R.2    Doria, A.3    Fioretto, P.4    Velussi, M.5    Vigorito, C.6
  • 10
    • 73149086391 scopus 로고    scopus 로고
    • Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide
    • Baranowski, M., Blachnio-Zabielska, A., Hirnle, T., Harasiuk, D., Matlak, K., Knapp, M., et al. (2010). Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide. J. Lipid Res. 51, 74-80. doi: 10.1194/jlr.M900002-JLR200
    • (2010) J. Lipid Res. , vol.51 , pp. 74-80
    • Baranowski, M.1    Blachnio-Zabielska, A.2    Hirnle, T.3    Harasiuk, D.4    Matlak, K.5    Knapp, M.6
  • 11
    • 72249100585 scopus 로고    scopus 로고
    • Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
    • Basu, R., Oudit, G. Y., Wang, X., Zhang, L., Ussher, J. R., Lopaschuk, G. D., et al. (2009). Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am. J. Physiol. Heart Circ. Physiol. 297, H2096-H2108. doi: 10.1152/ajpheart.00452.2009
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297 , pp. H2096-H2108
    • Basu, R.1    Oudit, G.Y.2    Wang, X.3    Zhang, L.4    Ussher, J.R.5    Lopaschuk, G.D.6
  • 12
    • 84975775436 scopus 로고    scopus 로고
    • Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure
    • Bedi, K. C. Jr., Snyder, N. W., Brandimarto, J., Aziz, M., Mesaros, C., Worth, A. J., et al. (2016). Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation 133, 706-716. doi: 10.1161/CIRCULATIONAHA.115.017545
    • (2016) Circulation , vol.133 , pp. 706-716
    • Bedi, K.C.1    Snyder, N.W.2    Brandimarto, J.3    Aziz, M.4    Mesaros, C.5    Worth, A.J.6
  • 13
    • 0141669148 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy
    • Bell, D. S. H. (2003). Diabetic cardiomyopathy. Diabetes Care 26, 2949-2951. doi: 10.2337/diacare.26.10.2949
    • (2003) Diabetes Care , vol.26 , pp. 2949-2951
    • Bell, D.S.H.1
  • 14
  • 15
    • 50449119332 scopus 로고
    • Metabolism of the human heart: II. Studies on fat, ketone and amino acid metabolism
    • Bing, R. J., Siegel, A., Ungar, I., and Gilbert, M. (1954). Metabolism of the human heart: II. Studies on fat, ketone and amino acid metabolism. Am. J. Med. 16, 504-515. doi: 10.1016/0002-9343(54)90365-4
    • (1954) Am. J. Med. , vol.16 , pp. 504-515
    • Bing, R.J.1    Siegel, A.2    Ungar, I.3    Gilbert, M.4
  • 16
    • 85042096322 scopus 로고    scopus 로고
    • Diabetes and branched-chain amino acids: What is the link?
    • Bloomgarden, Z. (2018). Diabetes and branched-chain amino acids: what is the link? J. Diabetes 10, 350-352. doi: 10.1111/1753-0407.12645
    • (2018) J. Diabetes , vol.10 , pp. 350-352
    • Bloomgarden, Z.1
  • 17
    • 85033215915 scopus 로고    scopus 로고
    • Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load
    • Boardman, N. T., Hafstad, A. D., Lund, J., Rossvoll, L., and Aasum, E. (2017). Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load. Am. J. Physiol. Heart Circ. Physiol. 313, H1054-H1062. doi: 10.1152/ajpheart.00382.2017
    • (2017) Am. J. Physiol. Heart Circ. Physiol. , vol.313 , pp. H1054-H1062
    • Boardman, N.T.1    Hafstad, A.D.2    Lund, J.3    Rossvoll, L.4    Aasum, E.5
  • 18
    • 33751255379 scopus 로고    scopus 로고
    • Cardiac remodeling rather than disturbed myocardial energy metabolism is associated with cardiac dysfunction in diabetic rats
    • Bollano, E., Omerovic, E., Svensson, H., Waagstein, F., and Fu, M. (2007). Cardiac remodeling rather than disturbed myocardial energy metabolism is associated with cardiac dysfunction in diabetic rats. Int. J. Cardiol. 114, 195-201. doi: 10.1016/j.ijcard.2006.01.027
    • (2007) Int. J. Cardiol. , vol.114 , pp. 195-201
    • Bollano, E.1    Omerovic, E.2    Svensson, H.3    Waagstein, F.4    Fu, M.5
  • 19
    • 84930874656 scopus 로고
    • Heart failure: An overview
    • A. Fishman New York, NY: McGraw Hill
    • Braunwald, E. (1978). “Heart failure: an overview,” in Heart Failure, ed. A. P. Fishman (New York, NY: McGraw Hill), 55-70.
    • (1978) Heart Failure , pp. 55-70
    • Braunwald, E.1
  • 20
    • 84869081812 scopus 로고    scopus 로고
    • Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans
    • Bucci, M., Borra, R., Någren, K., Pärkkä, J. P., Ry, S. D., Maggio, R., et al. (2012). Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans. Cardiovasc. Ther. 30, 333-341. doi: 10.1111/j.1755-5922.2011.00275.x
    • (2012) Cardiovasc. Ther. , vol.30 , pp. 333-341
    • Bucci, M.1    Borra, R.2    Någren, K.3    Pärkkä, J.P.4    Ry, S.D.5    Maggio, R.6
  • 21
    • 34248393099 scopus 로고    scopus 로고
    • High-fat diets: Modeling the metabolic disorders of human obesity in rodents
    • Buettner, R., Schölmerich, J., and Bollheimer, L. C. (2007). High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity 15, 798-808. doi: 10.1038/oby.2007.608
    • (2007) Obesity , vol.15 , pp. 798-808
    • Buettner, R.1    Schölmerich, J.2    Bollheimer, L.C.3
  • 22
    • 70450211783 scopus 로고    scopus 로고
    • Rodent models of diabetic cardiomyopathy
    • Bugger, H., and Abel, E. D. (2009). Rodent models of diabetic cardiomyopathy. Dis. Model. Mech. 2, 454-466. doi: 10.1242/dmm.001941
    • (2009) Dis. Model. Mech. , vol.2 , pp. 454-466
    • Bugger, H.1    Abel, E.D.2
  • 23
    • 77956572071 scopus 로고    scopus 로고
    • Mitochondria in the diabetic heart
    • Bugger, H., and Abel, E. D. (2010). Mitochondria in the diabetic heart. Cardiovasc. Res. 88, 229-240. doi: 10.1093/cvr/cvq239
    • (2010) Cardiovasc. Res. , vol.88 , pp. 229-240
    • Bugger, H.1    Abel, E.D.2
  • 24
    • 0027330056 scopus 로고
    • A 13C-NMR study of glucose oxidation in the intact functioning rat heart following diabetes-induced cardiomyopathy
    • Chatham, J. C., and Forder, J. R. (1993). A 13C-NMR study of glucose oxidation in the intact functioning rat heart following diabetes-induced cardiomyopathy. J. Mol. Cell. Cardiol. 25, 1203-1213. doi: 10.1006/jmcc.1993.1133
    • (1993) J. Mol. Cell. Cardiol. , vol.25 , pp. 1203-1213
    • Chatham, J.C.1    Forder, J.R.2
  • 25
    • 0010288836 scopus 로고    scopus 로고
    • Relationship between cardiac function and substrate oxidation in hearts of diabetic rats
    • Chatham, J. C., and Forder, J. R. (1997). Relationship between cardiac function and substrate oxidation in hearts of diabetic rats. Am. J. Physiol. Heart Circ. Physiol. 273, H52-H58. doi: 10.1152/ajpheart.1997.273.1.H52
    • (1997) Am. J. Physiol. Heart Circ. Physiol. , vol.273 , pp. H52-H58
    • Chatham, J.C.1    Forder, J.R.2
  • 26
    • 0032848847 scopus 로고    scopus 로고
    • Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation
    • Chatham, J. C., Gao, Z.-P., and Forder, J. R. (1999). Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation. Am. J. Physiol. Endocrinol. Metab. 277, E342-E351. doi: 10.1152/ajpendo.1999.277.2.E342
    • (1999) Am. J. Physiol. Endocrinol. Metab. , vol.277 , pp. E342-E351
    • Chatham, J.C.1    Gao, Z.-P.2    Forder, J.R.3
  • 27
    • 0036274119 scopus 로고    scopus 로고
    • Cardiac carbohydrate metabolism in Zucker diabetic fatty rats
    • Chatham, J. C., and Seymour, A.-M. (2002). Cardiac carbohydrate metabolism in Zucker diabetic fatty rats. Cardiovasc. Res. 55, 104-112. doi: 10.1016/s0008-6363(02)00399-1
    • (2002) Cardiovasc. Res. , vol.55 , pp. 104-112
    • Chatham, J.C.1    Seymour, A.-M.2
  • 28
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-495. doi: 10.1016/s0092-8674(00)81294-5
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6
  • 29
    • 84862137804 scopus 로고    scopus 로고
    • Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
    • Chokshi, A., Drosatos, K., Cheema, F. H., Ji, R., Khawaja, T., Yu, S., et al. (2012). Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. Circulation 125, 2844-2853. doi: 10.1161/CIRCULATIONAHA.111.060889
    • (2012) Circulation , vol.125 , pp. 2844-2853
    • Chokshi, A.1    Drosatos, K.2    Cheema, F.H.3    Ji, R.4    Khawaja, T.5    Yu, S.6
  • 30
    • 85019616260 scopus 로고    scopus 로고
    • Metabolic remodelling in diabetic cardiomyopathy
    • Chong, C.-R., Clarke, K., and Levelt, E. (2017). Metabolic remodelling in diabetic cardiomyopathy. Cardiovasc. Res. 113, 422-430. doi: 10.1093/cvr/cvx018
    • (2017) Cardiovasc. Res. , vol.113 , pp. 422-430
    • Chong, C.-R.1    Clarke, K.2    Levelt, E.3
  • 31
    • 79955537175 scopus 로고    scopus 로고
    • A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart
    • Cole, M. A., Murray, A. J., Cochlin, L. E., Heather, L. C., McAleese, S., Knight, N. S., et al. (2011). A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart. Basic Res. Cardiol. 106, 447-457. doi: 10.1007/s00395-011-0156-1
    • (2011) Basic Res. Cardiol. , vol.106 , pp. 447-457
    • Cole, M.A.1    Murray, A.J.2    Cochlin, L.E.3    Heather, L.C.4    McAleese, S.5    Knight, N.S.6
  • 32
    • 3042739406 scopus 로고    scopus 로고
    • Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats
    • Coort, S. L. M., Hasselbaink, D. M., Koonen, D. P. Y., Willems, J., Coumans, W. A., Chabowski, A., et al. (2004). Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats. Diabetes 53, 1655-1663. doi: 10.2337/diabetes.53.7.1655
    • (2004) Diabetes , vol.53 , pp. 1655-1663
    • Coort, S.L.M.1    Hasselbaink, D.M.2    Koonen, D.P.Y.3    Willems, J.4    Coumans, W.A.5    Chabowski, A.6
  • 33
    • 15444366991 scopus 로고    scopus 로고
    • Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    • Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P., and Garg, R. (2005). Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111, 1448-1454. doi: 10.1161/01.CIR.0000158483.13093.9D
    • (2005) Circulation , vol.111 , pp. 1448-1454
    • Dandona, P.1    Aljada, A.2    Chaudhuri, A.3    Mohanty, P.4    Garg, R.5
  • 34
    • 8644285092 scopus 로고    scopus 로고
    • The role of glimepiride in the effective management of Type 2 diabetes
    • Davis, S. N. (2004). The role of glimepiride in the effective management of Type 2 diabetes. J. Diabetes Complicat. 18, 367-376. doi: 10.1016/j.jdiacomp.2004.07.001
    • (2004) J. Diabetes Complicat. , vol.18 , pp. 367-376
    • Davis, S.N.1
  • 35
    • 80054695683 scopus 로고    scopus 로고
    • Single dose streptozotocin induced diabetes: Considerations for study design in islet transplantation models
    • Deeds, M., Anderson, J., Armstrong, A., Gastineau, D., Hiddinga, H., Jahangir, A., et al. (2011). Single dose streptozotocin induced diabetes: considerations for study design in islet transplantation models. Lab. Anim. 45, 131-140. doi: 10.1258/la.2010.010090
    • (2011) Lab. Anim. , vol.45 , pp. 131-140
    • Deeds, M.1    Anderson, J.2    Armstrong, A.3    Gastineau, D.4    Hiddinga, H.5    Jahangir, A.6
  • 36
    • 0014116416 scopus 로고
    • Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion
    • Denton, R. M., and Randle, P. J. (1967). Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion. Biochem. J. 104, 416-422. doi: 10.1042/bj1040416
    • (1967) Biochem. J. , vol.104 , pp. 416-422
    • Denton, R.M.1    Randle, P.J.2
  • 38
    • 85002781495 scopus 로고    scopus 로고
    • Evidence of glycolysis up-regulation and pyruvate mitochondrial oxidation mismatch during mechanical unloading of the failing human heart: Implications for cardiac reloading and conditioning
    • Diakos, N. A., Navankasattusas, S., Abel, E. D., Rutter, J., McCreath, L., Ferrin, P., et al. (2016). Evidence of glycolysis up-regulation and pyruvate mitochondrial oxidation mismatch during mechanical unloading of the failing human heart: implications for cardiac reloading and conditioning. JACC Basic Transl. Sci. 1, 432-444. doi: 10.1016/j.jacbts.2016.06.009
    • (2016) JACC Basic Transl. Sci. , vol.1 , pp. 432-444
    • Diakos, N.A.1    Navankasattusas, S.2    Abel, E.D.3    Rutter, J.4    McCreath, L.5    Ferrin, P.6
  • 39
    • 0038488294 scopus 로고    scopus 로고
    • Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus
    • Diamant, M., Lamb, H. J., Groeneveld, Y., Endert, E. L., Smit, J. W. A., Bax, J. J., et al. (2003). Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J. Am. Coll. Cardiol. 42, 328-335. doi: 10.1016/s0735-1097(03)00625-9
    • (2003) J. Am. Coll. Cardiol. , vol.42 , pp. 328-335
    • Diamant, M.1    Lamb, H.J.2    Groeneveld, Y.3    Endert, E.L.4    Smit, J.W.A.5    Bax, J.J.6
  • 40
    • 85053829816 scopus 로고    scopus 로고
    • Fatty acids prevent hypoxia-inducible factor-1α signaling through decreased succinate in diabetes
    • Dodd, M. S., Sousa Fialho, M., da, L., Montes Aparicio, C. N., Kerr, M., Timm, K. N., et al. (2018). Fatty acids prevent hypoxia-inducible factor-1α signaling through decreased succinate in diabetes. JACC Basic Transl. Sci. 3, 485-498. doi: 10.1016/j.jacbts.2018.04.005
    • (2018) JACC Basic Transl. Sci. , vol.3 , pp. 485-498
    • Dodd, M.S.1    Sousa Fialho, M.2    Da, L.3    Montes Aparicio, C.N.4    Kerr, M.5    Timm, K.N.6
  • 41
    • 85025078604 scopus 로고    scopus 로고
    • Changes of myocardial lipidomics profiling in a rat model of diabetic cardiomyopathy using UPLC/Q-TOF/MS analysis
    • Dong, S., Zhang, R., Liang, Y., Shi, J., Li, J., Shang, F., et al. (2017). Changes of myocardial lipidomics profiling in a rat model of diabetic cardiomyopathy using UPLC/Q-TOF/MS analysis. Diabetol. Metab. Syndr. 9:56. doi: 10.1186/s13098-017-0249-6
    • (2017) Diabetol. Metab. Syndr. , vol.9 , pp. 56
    • Dong, S.1    Zhang, R.2    Liang, Y.3    Shi, J.4    Li, J.5    Shang, F.6
  • 42
    • 85054932478 scopus 로고    scopus 로고
    • Berberine could ameliorate cardiac dysfunction via interfering myocardial lipidomic profiles in the rat model of diabetic cardiomyopathy
    • Dong, S., Zhang, S., Chen, Z., Zhang, R., Tian, L., Cheng, L., et al. (2018). Berberine could ameliorate cardiac dysfunction via interfering myocardial lipidomic profiles in the rat model of diabetic cardiomyopathy. Front. Physiol. 9:1042. doi: 10.3389/fphys.2018.01042
    • (2018) Front. Physiol. , vol.9 , pp. 1042
    • Dong, S.1    Zhang, S.2    Chen, Z.3    Zhang, R.4    Tian, L.5    Cheng, L.6
  • 43
    • 78650315006 scopus 로고    scopus 로고
    • Systems level studies of mammalian metabolomes: The roles of mass spectrometry and nuclear magnetic resonance spectroscopy
    • Dunn, W. B., Broadhurst, D. I., Atherton, H. J., Goodacre, R., and Griffin, J. L. (2011). Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem. Soc. Rev. 40, 387-426. doi: 10.1039/B906712B
    • (2011) Chem. Soc. Rev. , vol.40 , pp. 387-426
    • Dunn, W.B.1    Broadhurst, D.I.2    Atherton, H.J.3    Goodacre, R.4    Griffin, J.L.5
  • 44
    • 84861601268 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Myth or reality?
    • Ernande, L., and Derumeaux, G. (2012). Diabetic cardiomyopathy: myth or reality? Arch. Cardiovasc. Dis. 105, 218-225. doi: 10.1016/j.acvd.2011.11.007
    • (2012) Arch. Cardiovasc. Dis. , vol.105 , pp. 218-225
    • Ernande, L.1    Derumeaux, G.2
  • 45
    • 84964608804 scopus 로고    scopus 로고
    • Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
    • Ferrannini, E., Baldi, S., Frascerra, S., Astiarraga, B., Heise, T., Bizzotto, R., et al. (2016). Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes 65, 1190-1195. doi: 10.2337/db15-1356
    • (2016) Diabetes , vol.65 , pp. 1190-1195
    • Ferrannini, E.1    Baldi, S.2    Frascerra, S.3    Astiarraga, B.4    Heise, T.5    Bizzotto, R.6
  • 46
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • Finck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., et al. (2003). A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc. Natl. Acad. Sci. U.S.A. 100, 1226-1231. doi: 10.1073/pnas.0336724100
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5    Kovacs, A.6
  • 47
    • 0026331625 scopus 로고
    • Molecular mapping of the mouse ob mutation
    • Friedman, J. M., Leibel, R. L., Siegel, D. S., Walsh, J., and Bahary, N. (1991). Molecular mapping of the mouse ob mutation. Genomics 11, 1054-1062. doi: 10.1016/0888-7543(91)90032-A
    • (1991) Genomics , vol.11 , pp. 1054-1062
    • Friedman, J.M.1    Leibel, R.L.2    Siegel, D.S.3    Walsh, J.4    Bahary, N.5
  • 48
    • 61749086774 scopus 로고    scopus 로고
    • Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes
    • Girard, C. A., Wunderlich, F. T., Shimomura, K., Collins, S., Kaizik, S., Proks, P., et al. (2009). Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes. J. Clin. Invest. 119, 80-90. doi: 10.1172/JCI35772
    • (2009) J. Clin. Invest. , vol.119 , pp. 80-90
    • Girard, C.A.1    Wunderlich, F.T.2    Shimomura, K.3    Collins, S.4    Kaizik, S.5    Proks, P.6
  • 50
    • 80055026433 scopus 로고    scopus 로고
    • Metabolomics as a tool for cardiac research
    • Griffin, J. L., Atherton, H., Shockcor, J., and Atzori, L. (2011). Metabolomics as a tool for cardiac research. Nat. Rev. Cardiol. 8, 630-643. doi: 10.1038/nrcardio.2011.138
    • (2011) Nat. Rev. Cardiol. , vol.8 , pp. 630-643
    • Griffin, J.L.1    Atherton, H.2    Shockcor, J.3    Atzori, L.4
  • 51
    • 85012072430 scopus 로고    scopus 로고
    • Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
    • Hall, Z., Bond, N. J., Ashmore, T., Sanders, F., Ament, Z., Wang, X., et al. (2017). Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hepatology 65, 1165-1180. doi: 10.1002/hep.28953
    • (2017) Hepatology , vol.65 , pp. 1165-1180
    • Hall, Z.1    Bond, N.J.2    Ashmore, T.3    Sanders, F.4    Ament, Z.5    Wang, X.6
  • 52
    • 53149114140 scopus 로고    scopus 로고
    • Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus
    • Hammer, S., van der Meer, R. W., Lamb, H. J., de Boer, H. H., Bax, J. J., de Roos, A., et al. (2008a). Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 295, E714-E718. doi: 10.1152/ajpendo.90413.2008
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , pp. E714-E718
    • Hammer, S.1    Van Der Meer, R.W.2    Lamb, H.J.3    De Boer, H.H.4    Bax, J.J.5    De Roos, A.6
  • 53
    • 39049116617 scopus 로고    scopus 로고
    • Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men
    • Hammer, S., van der Meer, R. W., Lamb, H. J., Schär, M., de Roos, A., Smit, J. W. A., et al. (2008b). Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men. J. Clin. Endocrinol. Metab. 93, 497-503. doi: 10.1210/jc.2007-2015
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 497-503
    • Hammer, S.1    Van Der Meer, R.W.2    Lamb, H.J.3    Schär, M.4    De Roos, A.5    Smit, J.W.A.6
  • 54
    • 29244477536 scopus 로고    scopus 로고
    • Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction
    • Han, X., Yang, J., Cheng, H., Yang, K., Abendschein, D. R., and Gross, R. W. (2005). Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction. Biochemistry 44, 16684-16694. doi: 10.1021/bi051908a
    • (2005) Biochemistry , vol.44 , pp. 16684-16694
    • Han, X.1    Yang, J.2    Cheng, H.3    Yang, K.4    Abendschein, D.R.5    Gross, R.W.6
  • 55
    • 34249672811 scopus 로고    scopus 로고
    • Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes:? A shotgun lipidomics study
    • Han, X., Yang, J., Yang, K., Zhao, Z., Abendschein, D. R., and Gross, R. W. (2007). Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes:? a shotgun lipidomics study. Biochemistry 46, 6417-6428. doi: 10.1021/bi7004015
    • (2007) Biochemistry , vol.46 , pp. 6417-6428
    • Han, X.1    Yang, J.2    Yang, K.3    Zhao, Z.4    Abendschein, D.R.5    Gross, R.W.6
  • 56
    • 31644445201 scopus 로고    scopus 로고
    • Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus
    • Herrero, P., Peterson, L. R., McGill, J. B., Matthew, S., Lesniak, D., Dence, C., et al. (2006). Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus. J. Am. Coll. Cardiol. 47, 598-604. doi: 10.1016/j.jacc.2005.09.030
    • (2006) J. Am. Coll. Cardiol. , vol.47 , pp. 598-604
    • Herrero, P.1    Peterson, L.R.2    McGill, J.B.3    Matthew, S.4    Lesniak, D.5    Dence, C.6
  • 57
    • 33947237562 scopus 로고
    • The chemical nature of heart failure
    • Herrmann, G., and Decherd, G. M. Jr. (1939). The chemical nature of heart failure. Ann. Intern. Med. 12, 1233-1244. doi: 10.7326/0003-4819-12-8-1233
    • (1939) Ann. Intern. Med. , vol.12 , pp. 1233-1244
    • Herrmann, G.1    Decherd, G.M.2
  • 58
    • 79953214035 scopus 로고    scopus 로고
    • A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects
    • Holloway, C. J., Cochlin, L. E., Emmanuel, Y., Murray, A., Codreanu, I., Edwards, L. M., et al. (2011). A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. Am. J. Clin. Nutr. 93, 748-755. doi: 10.3945/ajcn.110.002758
    • (2011) Am. J. Clin. Nutr. , vol.93 , pp. 748-755
    • Holloway, C.J.1    Cochlin, L.E.2    Emmanuel, Y.3    Murray, A.4    Codreanu, I.5    Edwards, L.M.6
  • 59
    • 85007240955 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Does the type of diabetes matter?
    • Hölscher, M. E., Bode, C., and Bugger, H. (2016). Diabetic cardiomyopathy: does the type of diabetes matter? Int. J. Mol. Sci. 17:2136. doi: 10.3390/ijms17122136
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 2136
    • Hölscher, M.E.1    Bode, C.2    Bugger, H.3
  • 60
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • How, O.-J., Aasum, E., Severson, D. L., Chan, W. Y. A., Essop, M. F., and Larsen, T. S. (2006). Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 55, 466-473. doi: 10.2337/diabetes.55.02.06.db05-1164
    • (2006) Diabetes , vol.55 , pp. 466-473
    • How, O.-J.1    Aasum, E.2    Severson, D.L.3    Chan, W.Y.A.4    Essop, M.F.5    Larsen, T.S.6
  • 61
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • Hummel, K. P., Dickie, M. M., and Coleman, D. L. (1966). Diabetes, a new mutation in the mouse. Science 153, 1127-1128. doi: 10.1126/science.153.3740.1127
    • (1966) Science , vol.153 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 62
    • 84964253599 scopus 로고    scopus 로고
    • Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo
    • Ilaiwy, A., Liu, M., Parry, T. L., Bain, J. R., Newgard, C. B., Schisler, J. C., et al. (2016). Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo. Metabolomics 12:95. doi: 10.1007/s11306-016-1022-9
    • (2016) Metabolomics , vol.12 , pp. 95
    • Ilaiwy, A.1    Liu, M.2    Parry, T.L.3    Bain, J.R.4    Newgard, C.B.5    Schisler, J.C.6
  • 63
    • 0028873551 scopus 로고
    • Elevated lipid peroxidation and Vitamin E-quinone levels in heart ventricles of streptozotocin-treated diabetic rats
    • Jain, S. K., and Levine, S. N. (1995). Elevated lipid peroxidation and vitamin E-quinone levels in heart ventricles of streptozotocin-treated diabetic rats. Free Radic. Biol. Med. 18, 337-341. doi: 10.1016/0891-5849(94)00114-Y
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 337-341
    • Jain, S.K.1    Levine, S.N.2
  • 64
    • 84870663187 scopus 로고    scopus 로고
    • Effects of insulin therapy on myocardial lipid content and cardiac geometry in patients with type-2 diabetes mellitus
    • Jankovic, D., Winhofer, Y., Promintzer-Schifferl, M., Wohlschläger-Krenn, E., Anderwald, C. H., Wolf, P., et al. (2012). Effects of insulin therapy on myocardial lipid content and cardiac geometry in patients with type-2 diabetes mellitus. PLoS One 7:e50077. doi: 10.1371/journal.pone.0050077
    • (2012) PLoS One , vol.7
    • Jankovic, D.1    Winhofer, Y.2    Promintzer-Schifferl, M.3    Wohlschläger-Krenn, E.4    Anderwald, C.H.5    Wolf, P.6
  • 65
    • 0028793745 scopus 로고
    • Substrate selection in the isolated working rat heart: Effects of reperfusion, afterload, and concentration
    • Jeffrey, F. M., Diczku, V., Sherry, A. D., and Malloy, C. R. (1995). Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration. Basic Res. Cardiol. 90, 388-396. doi: 10.1007/BF00788500
    • (1995) Basic Res. Cardiol. , vol.90 , pp. 388-396
    • Jeffrey, F.M.1    Diczku, V.2    Sherry, A.D.3    Malloy, C.R.4
  • 66
    • 85044730815 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity
    • Jia, G., Hill, M. A., and Sowers, J. R. (2018). Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ. Res. 122, 624-638. doi: 10.1161/CIRCRESAHA.117.311586
    • (2018) Circ. Res. , vol.122 , pp. 624-638
    • Jia, G.1    Hill, M.A.2    Sowers, J.R.3
  • 67
    • 85013469521 scopus 로고    scopus 로고
    • Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure
    • Kaimoto, S., Hoshino, A., Ariyoshi, M., Okawa, Y., Tateishi, S., Ono, K., et al. (2017). Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure. Am. J. Physiol. Heart Circ. Physiol. 312, H305-H313. doi: 10.1152/ajpheart.00553.2016
    • (2017) Am. J. Physiol. Heart Circ. Physiol. , vol.312 , pp. H305-H313
    • Kaimoto, S.1    Hoshino, A.2    Ariyoshi, M.3    Okawa, Y.4    Tateishi, S.5    Ono, K.6
  • 68
    • 33751546348 scopus 로고    scopus 로고
    • Myocardial triglyceride content and epicardial fat mass in human obesity: Relationship to left ventricular function and serum free fatty acid levels
    • Kankaanpää, M., Lehto, H.-R., Pärkkä, J. P., Komu, M., Viljanen, A., Ferrannini, E., et al. (2006). Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J. Clin. Endocrinol. Metab. 91, 4689-4695. doi: 10.1210/jc.2006-0584
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4689-4695
    • Kankaanpää, M.1    Lehto, H.-R.2    Pärkkä, J.P.3    Komu, M.4    Viljanen, A.5    Ferrannini, E.6
  • 69
    • 0026343898 scopus 로고
    • Quantitation of acyl-CoA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation
    • Kler, R. S., Jackson, S., Bartlett, K., Bindoff, L. A., Eaton, S., Pourfarzam, M., et al. (1991). Quantitation of acyl-CoA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation. J. Biol. Chem. 266, 22932-22938.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22932-22938
    • Kler, R.S.1    Jackson, S.2    Bartlett, K.3    Bindoff, L.A.4    Eaton, S.5    Pourfarzam, M.6
  • 70
    • 0020626828 scopus 로고
    • Defective oxidative metabolism of heart mitochondria from genetically diabetic mice
    • Kuo, T. H., Moore, K. H., Giacomelli, F., and Wiener, J. (1983). Defective oxidative metabolism of heart mitochondria from genetically diabetic mice. Diabetes 32, 781-787. doi: 10.2337/diab.32.9.781
    • (1983) Diabetes , vol.32 , pp. 781-787
    • Kuo, T.H.1    Moore, K.H.2    Giacomelli, F.3    Wiener, J.4
  • 71
    • 0030846522 scopus 로고    scopus 로고
    • Changes in microsomal membrane phospholipids and fatty acids and in activities of membrane-bound enzyme in diabetic rat heart
    • Kuwahara, Y., Yanagishita, T., Konno, N., and Katagiri, T. (1997). Changes in microsomal membrane phospholipids and fatty acids and in activities of membrane-bound enzyme in diabetic rat heart. Basic Res. Cardiol. 92, 214-222. doi: 10.1007/BF00788516
    • (1997) Basic Res. Cardiol. , vol.92 , pp. 214-222
    • Kuwahara, Y.1    Yanagishita, T.2    Konno, N.3    Katagiri, T.4
  • 72
    • 65449179559 scopus 로고    scopus 로고
    • Functional assessment of isolated mitochondria in vitro
    • Lanza, I. R., and Nair, K. S. (2009). Functional assessment of isolated mitochondria in vitro. Methods Enzymol. 457, 349-372. doi: 10.1016/S0076-6879(09)05020-4
    • (2009) Methods Enzymol , vol.457 , pp. 349-372
    • Lanza, I.R.1    Nair, K.S.2
  • 73
    • 42549169797 scopus 로고    scopus 로고
    • Metabolic (In)flexibility of the diabetic heart
    • Larsen, T. S., and Aasum, E. (2008). Metabolic (In)flexibility of the diabetic heart. Cardiovasc. Drugs Ther. 22, 91-95. doi: 10.1007/s10557-008-6083-1
    • (2008) Cardiovasc. Drugs Ther. , vol.22 , pp. 91-95
    • Larsen, T.S.1    Aasum, E.2
  • 74
    • 84977838083 scopus 로고    scopus 로고
    • Increasing pyruvate dehydrogenase flux as a treatment for diabetic cardiomyopathy: A combined 13C hyperpolarized magnetic resonance and echocardiography study
    • Le Page, L. M., Rider, O. J., Lewis, A. J., Ball, V., Clarke, K., Johansson, E., et al. (2015). Increasing pyruvate dehydrogenase flux as a treatment for diabetic cardiomyopathy: a combined 13C hyperpolarized magnetic resonance and echocardiography study. Diabetes 64, 2735-2743. doi: 10.2337/db14-1560
    • (2015) Diabetes , vol.64 , pp. 2735-2743
    • Le Page, L.M.1    Rider, O.J.2    Lewis, A.J.3    Ball, V.4    Clarke, K.5    Johansson, E.6
  • 76
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- And streptozotocin-induced diabetes
    • Lenzen, S. (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51, 216-226. doi: 10.1007/s00125-007-0886-7
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 77
    • 84962173633 scopus 로고    scopus 로고
    • Relationship between left ventricular structural and metabolic remodeling in type 2 diabetes
    • Levelt, E., Mahmod, M., Piechnik, S. K., Ariga, R., Francis, J. M., Rodgers, C. T., et al. (2016a). Relationship between left ventricular structural and metabolic remodeling in type 2 diabetes. Diabetes 65, 44-52. doi: 10.2337/db15-0627
    • (2016) Diabetes , vol.65 , pp. 44-52
    • Levelt, E.1    Mahmod, M.2    Piechnik, S.K.3    Ariga, R.4    Francis, J.M.5    Rodgers, C.T.6
  • 78
    • 85015953289 scopus 로고    scopus 로고
    • Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus
    • Levelt, E., Rodgers, C. T., Clarke, W. T., Mahmod, M., Ariga, R., Francis, J. M., et al. (2016b). Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus. Eur. Heart J. 37, 3461-3469. doi: 10.1093/eurheartj/ehv442
    • (2016) Eur. Heart J. , vol.37 , pp. 3461-3469
    • Levelt, E.1    Rodgers, C.T.2    Clarke, W.T.3    Mahmod, M.4    Ariga, R.5    Francis, J.M.6
  • 79
    • 50949096938 scopus 로고    scopus 로고
    • Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition
    • Lewin, T. M., de Jong, H., Schwerbrock, N. J. M., Hammond, L. E., Watkins, S. M., Combs, T. P., et al. (2008). Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1781, 352-358. doi: 10.1016/j.bbalip.2008.05.001
    • (2008) Biochim. Biophys. Acta Mol. Cell Biol. Lipids , vol.1781 , pp. 352-358
    • Lewin, T.M.1    De Jong, H.2    Schwerbrock, N.J.M.3    Hammond, L.E.4    Watkins, S.M.5    Combs, T.P.6
  • 80
    • 84929094858 scopus 로고    scopus 로고
    • Triptolide improves systolic function and myocardial energy metabolism of diabetic cardiomyopathy in streptozotocin-induced diabetic rats
    • Liang, Z., Leo, S., Wen, H., Ouyang, M., Jiang, W., and Yang, K. (2015). Triptolide improves systolic function and myocardial energy metabolism of diabetic cardiomyopathy in streptozotocin-induced diabetic rats. BMC Cardiovasc. Disord. 15:42. doi: 10.1186/s12872-015-0030-4
    • (2015) BMC Cardiovasc. Disord. , vol.15 , pp. 42
    • Liang, Z.1    Leo, S.2    Wen, H.3    Ouyang, M.4    Jiang, W.5    Yang, K.6
  • 81
    • 84868095524 scopus 로고    scopus 로고
    • Overview of animal models of obesity
    • Lutz, T. A., and Woods, S. C. (2012). Overview of animal models of obesity. Curr. Protoc. Pharmacol. 58, 5.61.1-5.61.18. doi: 10.1002/0471141755.ph0561s58
    • (2012) Curr. Protoc. Pharmacol. , vol.58 , pp. 5611-56118
    • Lutz, T.A.1    Woods, S.C.2
  • 82
    • 84884680593 scopus 로고    scopus 로고
    • Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin
    • Mansor, L. S., Gonzalez, E. R., Cole, M. A., Tyler, D. J., Beeson, J. H., Clarke, K., et al. (2013). Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin. Cardiovasc. Diabetol. 12:136. doi: 10.1186/1475-2840-12-136
    • (2013) Cardiovasc. Diabetol. , vol.12 , pp. 136
    • Mansor, L.S.1    Gonzalez, E.R.2    Cole, M.A.3    Tyler, D.J.4    Beeson, J.H.5    Clarke, K.6
  • 83
    • 0030902933 scopus 로고    scopus 로고
    • Increased oxysterol contents in diabetic rat hearts: Their involvement in diabetic cardiomyopathy
    • Matsui, H., Okumura, K., Mukawa, H., Hibino, M., Toki, Y., and Ito, T. (1997). Increased oxysterol contents in diabetic rat hearts: their involvement in diabetic cardiomyopathy. Can. J. Cardiol. 13, 373-379.
    • (1997) Can. J. Cardiol. , vol.13 , pp. 373-379
    • Matsui, H.1    Okumura, K.2    Mukawa, H.3    Hibino, M.4    Toki, Y.5    Ito, T.6
  • 84
    • 34548385838 scopus 로고    scopus 로고
    • Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study
    • McGavock, J. M., Lingvay, I., Zib, I., Tillery, T., Salas, N., Unger, R., et al. (2007). Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation 116, 1170-1175. doi: 10.1161/CIRCULATIONAHA.106.645614
    • (2007) Circulation , vol.116 , pp. 1170-1175
    • McGavock, J.M.1    Lingvay, I.2    Zib, I.3    Tillery, T.4    Salas, N.5    Unger, R.6
  • 85
    • 84855968181 scopus 로고    scopus 로고
    • MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model
    • Menger, R. F., Stutts, W. L., Anbukumar, D. S., Bowden, J. A., Ford, D. A., and Yost, R. A. (2012). MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model. Anal. Chem. 84, 1117-1125. doi: 10.1021/ac202779h
    • (2012) Anal. Chem. , vol.84 , pp. 1117-1125
    • Menger, R.F.1    Stutts, W.L.2    Anbukumar, D.S.3    Bowden, J.A.4    Ford, D.A.5    Yost, R.A.6
  • 87
    • 4143091440 scopus 로고    scopus 로고
    • Myocardial insulin resistance associated with chronic hypertriglyceridemia and increased FFA levels in type 2 diabetic patients
    • Monti, L. D., Landoni, C., Setola, E., Galluccio, E., Lucotti, P., Sandoli, E. P., et al. (2004). Myocardial insulin resistance associated with chronic hypertriglyceridemia and increased FFA levels in type 2 diabetic patients. Am. J. Physiol. Heart Circ. Physiol. 287, H1225-H1231. doi: 10.1152/ajpheart.00629.2003
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.287 , pp. H1225-H1231
    • Monti, L.D.1    Landoni, C.2    Setola, E.3    Galluccio, E.4    Lucotti, P.5    Sandoli, E.P.6
  • 88
    • 85079121634 scopus 로고    scopus 로고
    • Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 44 million participants
    • NCD Risk Factor Collaboration (NCD-RisC) (2016). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 44 million participants. Lancet 387, 1513-1530. doi: 10.1016/s0140-6736(16)00618-8
    • (2016) Lancet , vol.387 , pp. 1513-1530
  • 89
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart - An engine out of fuel
    • Neubauer, S. (2007). The failing heart - an engine out of fuel. N. Engl. J. Med. 356, 1140-1151. doi: 10.1056/NEJMra063052
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 90
    • 0030819144 scopus 로고    scopus 로고
    • Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy
    • Neubauer, S., Horn, M., Cramer, M., Harre, K., Newell, J. B., Peters, W., et al. (1997). Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96, 2190-2196. doi: 10.1161/01.CIR.96.7.2190
    • (1997) Circulation , vol.96 , pp. 2190-2196
    • Neubauer, S.1    Horn, M.2    Cramer, M.3    Harre, K.4    Newell, J.B.5    Peters, W.6
  • 91
    • 78650683294 scopus 로고    scopus 로고
    • Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus
    • Ng, A. C. T., Delgado, V., Bertini, M., van der Meer, R. W., Rijzewijk, L. J., Hooi Ewe, S., et al. (2010). Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus. Circulation 122, 2538-2544. doi: 10.1161/CIRCULATIONAHA.110.955542
    • (2010) Circulation , vol.122 , pp. 2538-2544
    • Ng, A.C.T.1    Delgado, V.2    Bertini, M.3    Van Der Meer, R.W.4    Rijzewijk, L.J.5    Hooi Ewe, S.6
  • 93
    • 84946544768 scopus 로고    scopus 로고
    • Mitochondrial responses to extreme environments: Insights from metabolomics
    • O'Brien, K. A., Griffin, J. L., Murray, A. J., and Edwards, L. M. (2015). Mitochondrial responses to extreme environments: insights from metabolomics. Extrem Physiol. Med. 4:7. doi: 10.1186/s13728-015-0026-9
    • (2015) Extrem Physiol. Med. , vol.4 , pp. 7
    • O'Brien, K.A.1    Griffin, J.L.2    Murray, A.J.3    Edwards, L.M.4
  • 94
    • 33645093211 scopus 로고    scopus 로고
    • Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage
    • O'Donnell, J. M., Zampino, M., Alpert, N. M., Fasano, M. J., Geenen, D. L., and Lewandowski, E. D. (2006). Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage. Am. J. Physiol. Endocrinol. Metab. 290, E448-E455. doi: 10.1152/ajpendo.00139.2005
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290 , pp. E448-E455
    • O'Donnell, J.M.1    Zampino, M.2    Alpert, N.M.3    Fasano, M.J.4    Geenen, D.L.5    Lewandowski, E.D.6
  • 96
    • 84896545275 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Pathophysiology, diagnostic evaluation and management
    • Pappachan, J. M., Varughese, G. I., Sriraman, R., and Arunagirinathan, G. (2013). Diabetic cardiomyopathy: pathophysiology, diagnostic evaluation and management. World J. Diabetes 4, 177-189. doi: 10.4239/wjd.v4.i5.177
    • (2013) World J. Diabetes , vol.4 , pp. 177-189
    • Pappachan, J.M.1    Varughese, G.I.2    Sriraman, R.3    Arunagirinathan, G.4
  • 97
    • 34249903324 scopus 로고    scopus 로고
    • Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance
    • Perseghin, G., Ntali, G., Cobelli, F. D., Lattuada, G., Esposito, A., Belloni, E., et al. (2007). Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance. Diabetes Care 30, 1520-1526. doi: 10.2337/dc06-2429
    • (2007) Diabetes Care , vol.30 , pp. 1520-1526
    • Perseghin, G.1    Ntali, G.2    Cobelli, F.D.3    Lattuada, G.4    Esposito, A.5    Belloni, E.6
  • 98
    • 2442492971 scopus 로고    scopus 로고
    • Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women
    • Peterson, L. R., Herrero, P., Schechtman, K. B., Racette, S. B., Waggoner, A. D., Kisrieva-Ware, Z., et al. (2004). Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109, 2191-2196. doi: 10.1161/01.CIR.0000127959.28627.F8
    • (2004) Circulation , vol.109 , pp. 2191-2196
    • Peterson, L.R.1    Herrero, P.2    Schechtman, K.B.3    Racette, S.B.4    Waggoner, A.D.5    Kisrieva-Ware, Z.6
  • 99
    • 50549202600 scopus 로고
    • The glucose fatty acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle, P. J., Garland, P. B., Hales, C. N., and Newsholme, E. A. (1963). The glucose fatty acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 281, 785-789. doi: 10.1016/S0140-6736(63)91500-9
    • (1963) Lancet , vol.281 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 100
    • 17144404203 scopus 로고    scopus 로고
    • Animal models of diabetes mellitus
    • Rees, D. A., and Alcolado, J. C. (2005). Animal models of diabetes mellitus. Diabet. Med. 22, 359-370. doi: 10.1111/j.1464-5491.2005.01499.x
    • (2005) Diabet. Med. , vol.22 , pp. 359-370
    • Rees, D.A.1    Alcolado, J.C.2
  • 101
    • 0014852350 scopus 로고
    • Effect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart
    • Reid, J. V. O., Lochner, A., and Brink, A. J. (1970). Effect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart. J. Mol. Cell. Cardiol. 1, 209-220. doi: 10.1016/0022-2828(70)90002-7
    • (1970) J. Mol. Cell. Cardiol. , vol.1 , pp. 209-220
    • Reid, J.V.O.1    Lochner, A.2    Brink, A.J.3
  • 102
    • 27144543513 scopus 로고    scopus 로고
    • Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: Reproducibility and sensitivity of the method
    • Reingold, J. S., McGavock, J. M., Kaka, S., Tillery, T., Victor, R. G., and Szczepaniak, L. S. (2005). Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method. Am. J. Physiol. Endocrinol. Metab. 289, E935-E939. doi: 10.1152/ajpendo.00095.2005
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289 , pp. E935-E939
    • Reingold, J.S.1    McGavock, J.M.2    Kaka, S.3    Tillery, T.4    Victor, R.G.5    Szczepaniak, L.S.6
  • 103
    • 84893662844 scopus 로고    scopus 로고
    • Effects of weight loss on myocardial energetics and diastolic function in obesity
    • Rider, O. J., Francis, J. M., Tyler, D., Byrne, J., Clarke, K., and Neubauer, S. (2013). Effects of weight loss on myocardial energetics and diastolic function in obesity. Int. J. Cardiovasc. Imaging 29, 1043-1050. doi: 10.1007/s10554-012-0174-6
    • (2013) Int. J. Cardiovasc. Imaging , vol.29 , pp. 1043-1050
    • Rider, O.J.1    Francis, J.M.2    Tyler, D.3    Byrne, J.4    Clarke, K.5    Neubauer, S.6
  • 104
    • 70350459556 scopus 로고    scopus 로고
    • Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: Studies with cardiac positron emission tomography and magnetic resonance imaging
    • Rijzewijk, L. J., van der Meer, R. W., Lamb, H. J., de Jong, H. W. A. M., Lubberink, M., Romijn, J. A., et al. (2009). Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging. J. Am. Coll. Cardiol. 54, 1524-1532. doi: 10.1016/j.jacc.2009.04.074
    • (2009) J. Am. Coll. Cardiol. , vol.54 , pp. 1524-1532
    • Rijzewijk, L.J.1    Van Der Meer, R.W.2    Lamb, H.J.3    De Jong, H.W.A.M.4    Lubberink, M.5    Romijn, J.A.6
  • 105
    • 55949119360 scopus 로고    scopus 로고
    • Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    • Rijzewijk, L. J., van der Meer, R. W., Smit, J. W. A., Diamant, M., Bax, J. J., Hammer, S., et al. (2008). Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J. Am. Coll. Cardiol. 52, 1793-1799. doi: 10.1016/j.jacc.2008.07.062
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 1793-1799
    • Rijzewijk, L.J.1    Van Der Meer, R.W.2    Smit, J.W.A.3    Diamant, M.4    Bax, J.J.5    Hammer, S.6
  • 106
    • 85047767414 scopus 로고    scopus 로고
    • Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidemia
    • Rohm, M., Savic, D., Ball, V., Curtis, M. K., Bonham, S., Fischer, R., et al. (2018). Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidemia. Diabetes 67, 1057-1067. doi: 10.2337/db17-1195
    • (2018) Diabetes , vol.67 , pp. 1057-1067
    • Rohm, M.1    Savic, D.2    Ball, V.3    Curtis, M.K.4    Bonham, S.5    Fischer, R.6
  • 107
    • 77956586695 scopus 로고    scopus 로고
    • Mitochondria in heart failure
    • Rosca, M. G., and Hoppel, C. L. (2010). Mitochondria in heart failure. Cardiovasc. Res. 88, 40-50. doi: 10.1093/cvr/cvq240
    • (2010) Cardiovasc. Res. , vol.88 , pp. 40-50
    • Rosca, M.G.1    Hoppel, C.L.2
  • 109
    • 0038677068 scopus 로고    scopus 로고
    • Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes
    • Scheuermann-Freestone, M., Madsen, P. L., Manners, D., Blamire, A. M., Buckingham, R. E., Styles, P., et al. (2003). Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation 107, 3040-3046. doi: 10.1161/01.CIR.0000072789.89096.10
    • (2003) Circulation , vol.107 , pp. 3040-3046
    • Scheuermann-Freestone, M.1    Madsen, P.L.2    Manners, D.3    Blamire, A.M.4    Buckingham, R.E.5    Styles, P.6
  • 110
    • 0028604486 scopus 로고
    • STZ transport and cytotoxicity: Specific enhancement in GLUT2-expressing cells
    • Schnedl, W. J., Ferber, S., Johnson, J. H., and Newgard, C. B. (1994). STZ transport and cytotoxicity: specific enhancement in GLUT2-expressing cells. Diabetes 43, 1326-1333. doi: 10.2337/diab.43.11.1326
    • (1994) Diabetes , vol.43 , pp. 1326-1333
    • Schnedl, W.J.1    Ferber, S.2    Johnson, J.H.3    Newgard, C.B.4
  • 111
    • 84872051718 scopus 로고    scopus 로고
    • Acylcarnitines: Reflecting or inflicting insulin resistance?
    • Schooneman, M. G., Vaz, F. M., Houten, S. M., and Soeters, M. R. (2013). Acylcarnitines: reflecting or inflicting insulin resistance? Diabetes 62, 1-8. doi: 10.2337/db12-0466
    • (2013) Diabetes , vol.62 , pp. 1-8
    • Schooneman, M.G.1    Vaz, F.M.2    Houten, S.M.3    Soeters, M.R.4
  • 112
    • 68849099655 scopus 로고    scopus 로고
    • Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy
    • Schroeder, M. A., Atherton, H. J., Ball, D. R., Cole, M. A., Heather, L. C., Griffin, J. L., et al. (2009). Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J. 23, 2529-2538. doi: 10.1096/fj.09-129171
    • (2009) FASEB J , vol.23 , pp. 2529-2538
    • Schroeder, M.A.1    Atherton, H.J.2    Ball, D.R.3    Cole, M.A.4    Heather, L.C.5    Griffin, J.L.6
  • 113
    • 80052855442 scopus 로고    scopus 로고
    • Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate
    • Schroeder, M. A., Atherton, H. J., Heather, L. C., Griffin, J. L., Clarke, K., Radda, G. K., et al. (2011). Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate. NMR Biomed. 24, 980-987. doi: 10.1002/nbm.1668
    • (2011) NMR Biomed , vol.24 , pp. 980-987
    • Schroeder, M.A.1    Atherton, H.J.2    Heather, L.C.3    Griffin, J.L.4    Clarke, K.5    Radda, G.K.6
  • 114
    • 50149105620 scopus 로고    scopus 로고
    • In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance
    • Schroeder, M. A., Cochlin, L. E., Heather, L. C., Clarke, K., Radda, G. K., and Tyler, D. J. (2008). In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc. Natl. Acad. Sci. U.S.A. 105, 12051-12056. doi: 10.1073/pnas.0805953105
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 12051-12056
    • Schroeder, M.A.1    Cochlin, L.E.2    Heather, L.C.3    Clarke, K.4    Radda, G.K.5    Tyler, D.J.6
  • 115
    • 0028603590 scopus 로고
    • Genetic and pathogenic basis of autoimmune diabetes in NOD mice
    • Serreze, D. V., and Leiter, E. H. (1994). Genetic and pathogenic basis of autoimmune diabetes in NOD mice. Curr. Opin. Immunol. 6, 900-906. doi: 10.1016/0952-7915(94)90011-6
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 900-906
    • Serreze, D.V.1    Leiter, E.H.2
  • 116
    • 84929103952 scopus 로고    scopus 로고
    • In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy
    • Seymour, A.-M. L., Giles, L., Ball, V., Miller, J. J., Clarke, K., Carr, C. A., et al. (2015). In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy. Cardiovasc. Res. 106, 249-260. doi: 10.1093/cvr/cvv101
    • (2015) Cardiovasc. Res. , vol.106 , pp. 249-260
    • Seymour, A.-M.L.1    Giles, L.2    Ball, V.3    Miller, J.J.4    Clarke, K.5    Carr, C.A.6
  • 117
    • 50349127453 scopus 로고
    • Necrosis of islets of langerhans produced experimentally
    • Shaw Dunn, J., Sheehan, H. L., and Mcletchie, N. G. B. (1943). Necrosis of islets of langerhans produced experimentally. Lancet 241, 484-487. doi: 10.1016/s0140-6736(00)42072-6
    • (1943) Lancet , vol.241 , pp. 484-487
    • Shaw Dunn, J.1    Sheehan, H.L.2    Mcletchie, N.G.B.3
  • 118
    • 84934434996 scopus 로고    scopus 로고
    • Diabetes in zucker diabetic fatty rat
    • eds H.-G. Joost, H. Al-Hasani, and A. Schürmann Totowa, NJ: Humana Press
    • Shiota, M., and Printz, R. L. (2012). “Diabetes in zucker diabetic fatty rat,” in Animal Models in Diabetes Research Methods in Molecular Biology, eds H.-G. Joost, H. Al-Hasani, and A. Schürmann (Totowa, NJ: Humana Press), 103-123. doi: 10.1007/978-1-62703-068-7_8
    • (2012) Animal Models in Diabetes Research Methods in Molecular Biology , pp. 103-123
    • Shiota, M.1    Printz, R.L.2
  • 119
    • 48749113999 scopus 로고    scopus 로고
    • Time course of alterations in myocardial glucose utilization in the zucker diabetic fatty rat with correlation to gene expression of glucose transporters: A small-animal PET investigation
    • Shoghi, K. I., Gropler, R. J., Sharp, T., Herrero, P., Fettig, N., Su, Y., et al. (2008). Time course of alterations in myocardial glucose utilization in the zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation. J. Nucl. Med. 49, 1320-1327. doi: 10.2967/jnumed.108.051672
    • (2008) J. Nucl. Med. , vol.49 , pp. 1320-1327
    • Shoghi, K.I.1    Gropler, R.J.2    Sharp, T.3    Herrero, P.4    Fettig, N.5    Su, Y.6
  • 120
    • 0033399059 scopus 로고    scopus 로고
    • Altered creatine kinase enzyme kinetics in diabetic cardiomyopathy. A 31P NMR magnetization transfer study of the intact beating rat heart
    • Spindler, M., Saupe, K. W., Tian, R., Ahmed, S., Matlib, M. A., and Ingwall, J. S. (1999). Altered creatine kinase enzyme kinetics in diabetic cardiomyopathy. A 31P NMR magnetization transfer study of the intact beating rat heart. J. Mol. Cell. Cardiol. 31, 2175-2189. doi: 10.1006/jmcc.1999.1044
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 2175-2189
    • Spindler, M.1    Saupe, K.W.2    Tian, R.3    Ahmed, S.4    Matlib, M.A.5    Ingwall, J.S.6
  • 121
    • 23844504364 scopus 로고    scopus 로고
    • Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening
    • Srinivasan, K., Viswanad, B., Asrat, L., Kaul, C. L., and Ramarao, P. (2005). Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol. Res. 52, 313-320. doi: 10.1016/j.phrs.2005.05.004
    • (2005) Pharmacol. Res. , vol.52 , pp. 313-320
    • Srinivasan, K.1    Viswanad, B.2    Asrat, L.3    Kaul, C.L.4    Ramarao, P.5
  • 122
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley, W. C., Recchia, F. A., and Lopaschuk, G. D. (2005). Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 85, 1093-1129. doi: 10.1152/physrev.00006.2004
    • (2005) Physiol. Rev. , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 123
    • 16344395330 scopus 로고    scopus 로고
    • Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium:? Identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics
    • Su, X., Han, X., Mancuso, D. J., Abendschein, D. R., and Gross, R. W. (2005). Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium:? identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics. Biochemistry 44, 5234-5245. doi: 10.1021/bi047773a
    • (2005) Biochemistry , vol.44 , pp. 5234-5245
    • Su, X.1    Han, X.2    Mancuso, D.J.3    Abendschein, D.R.4    Gross, R.W.5
  • 124
  • 126
    • 0037371754 scopus 로고    scopus 로고
    • Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
    • Szczepaniak, L. S., Dobbins, R. L., Metzger, G. J., Sartoni-D'Ambrosia, G., Arbique, D., Vongpatanasin, W., et al. (2003). Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn. Reson. Med. 49, 417-423. doi: 10.1002/mrm.10372
    • (2003) Magn. Reson. Med. , vol.49 , pp. 417-423
    • Szczepaniak, L.S.1    Dobbins, R.L.2    Metzger, G.J.3    Sartoni-D'Ambrosia, G.4    Arbique, D.5    Vongpatanasin, W.6
  • 128
    • 84938589054 scopus 로고    scopus 로고
    • In vivo targeted molecular magnetic resonance imaging of free radicals in diabetic cardiomyopathy within mice
    • Towner, R. A., Smith, N., Saunders, D., Carrizales, J., Lupu, F., Silasi-Mansat, R., et al. (2015). In vivo targeted molecular magnetic resonance imaging of free radicals in diabetic cardiomyopathy within mice. Free Radic. Res. 49, 1140-1146. doi: 10.3109/10715762.2015.1050587
    • (2015) Free Radic. Res. , vol.49 , pp. 1140-1146
    • Towner, R.A.1    Smith, N.2    Saunders, D.3    Carrizales, J.4    Lupu, F.5    Silasi-Mansat, R.6
  • 129
    • 0033694535 scopus 로고    scopus 로고
    • Lipotoxic diseases of nonadipose tissues in obesity
    • Unger, R., and Orci, L. (2000). Lipotoxic diseases of nonadipose tissues in obesity. Int. J. Obes. 24, S28-S32. doi: 10.1038/sj.ijo.0801498
    • (2000) Int. J. Obes. , vol.24 , pp. S28-S32
    • Unger, R.1    Orci, L.2
  • 130
    • 84880923169 scopus 로고    scopus 로고
    • Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women
    • Utz, W., Engeli, S., Haufe, S., Kast, P., Böhnke, J., Haas, V., et al. (2013). Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women. Int. J. Cardiol. 167, 905-909. doi: 10.1016/j.ijcard.2012.03.104
    • (2013) Int. J. Cardiol. , vol.167 , pp. 905-909
    • Utz, W.1    Engeli, S.2    Haufe, S.3    Kast, P.4    Böhnke, J.5    Haas, V.6
  • 131
    • 68949215755 scopus 로고    scopus 로고
    • Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: Studies using positron emission tomography
    • van den Brom, C. E., Huisman, M. C., Vlasblom, R., Boontje, N. M., Duijst, S., Lubberink, M., et al. (2009). Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. Cardiovasc. Diabetol. 8:39. doi: 10.1186/1475-2840-8-39
    • (2009) Cardiovasc. Diabetol. , vol.8 , pp. 39
    • Van Den Brom, C.E.1    Huisman, M.C.2    Vlasblom, R.3    Boontje, N.M.4    Duijst, S.5    Lubberink, M.6
  • 132
    • 65449182043 scopus 로고    scopus 로고
    • Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus
    • van der Meer, R. W., Rijzewijk, L. J., de Jong, H. W. A. M., Lamb, H. J., Lubberink, M., Romijn, J. A., et al. (2009). Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus. Circulation 119, 2069-2077. doi: 10.1161/CIRCULATIONAHA.108.803916
    • (2009) Circulation , vol.119 , pp. 2069-2077
    • Van Der Meer, R.W.1    Rijzewijk, L.J.2    De Jong, H.W.A.M.3    Lamb, H.J.4    Lubberink, M.5    Romijn, J.A.6
  • 133
    • 84948129560 scopus 로고    scopus 로고
    • Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart
    • Vazquez, E. J., Berthiaume, J. M., Kamath, V., Achike, O., Buchanan, E., Montano, M. M., et al. (2015). Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart. Cardiovasc. Res. 107, 453-465. doi: 10.1093/cvr/cvv183
    • (2015) Cardiovasc. Res. , vol.107 , pp. 453-465
    • Vazquez, E.J.1    Berthiaume, J.M.2    Kamath, V.3    Achike, O.4    Buchanan, E.5    Montano, M.M.6
  • 134
    • 80052800016 scopus 로고    scopus 로고
    • The creatine kinase system and pleiotropic effects of creatine
    • Wallimann, T., Tokarska-Schlattner, M., and Schlattner, U. (2011). The creatine kinase system and pleiotropic effects of creatine. Amino Acids 40, 1271-1296. doi: 10.1007/s00726-011-0877-3
    • (2011) Amino Acids , vol.40 , pp. 1271-1296
    • Wallimann, T.1    Tokarska-Schlattner, M.2    Schlattner, U.3
  • 135
    • 84925228644 scopus 로고    scopus 로고
    • Leptin- And leptin receptor-deficient rodent models: Relevance for human type 2 diabetes
    • Wang, B., Chandrasekera, P. C., and Pippin, J. J. (2014). Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr. Diabetes Rev. 10, 131-145. doi: 10.2174/1573399810666140508121012
    • (2014) Curr. Diabetes Rev. , vol.10 , pp. 131-145
    • Wang, B.1    Chandrasekera, P.C.2    Pippin, J.J.3
  • 136
    • 0032918044 scopus 로고    scopus 로고
    • A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse
    • Wang, J., Takeuchi, T., Tanaka, S., Kubo, S.-K., Kayo, T., Lu, D., et al. (1999). A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse. J. Clin. Invest. 103, 27-37. doi: 10.1172/JCI4431
    • (1999) J. Clin. Invest. , vol.103 , pp. 27-37
    • Wang, J.1    Takeuchi, T.2    Tanaka, S.3    Kubo, S.-K.4    Kayo, T.5    Lu, D.6
  • 137
    • 18044389144 scopus 로고    scopus 로고
    • Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats
    • Wang, P., Lloyd, S. G., Zeng, H., Bonen, A., and Chatham, J. C. (2005). Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats. Am. J. Physiol. Heart Circ. Physiol. 288, H2102-H2110. doi: 10.1152/ajpheart.00935.2004
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288 , pp. H2102-H2110
    • Wang, P.1    Lloyd, S.G.2    Zeng, H.3    Bonen, A.4    Chatham, J.C.5
  • 138
    • 84947262080 scopus 로고    scopus 로고
    • Comprehensive metabolic profiling of age-related mitochondrial dysfunction in the high-fat-fed ob/ob mouse heart
    • Wang, X., West, J. A., Murray, A. J., and Griffin, J. L. (2015). Comprehensive metabolic profiling of age-related mitochondrial dysfunction in the high-fat-fed ob/ob mouse heart. J. Proteome Res. 14, 2849-2862. doi: 10.1021/acs.jproteome.5b00128
    • (2015) J. Proteome Res. , vol.14 , pp. 2849-2862
    • Wang, X.1    West, J.A.2    Murray, A.J.3    Griffin, J.L.4
  • 139
    • 33745070330 scopus 로고    scopus 로고
    • Assessment of myocardial metabolism in diabetic rats using small-animal PET: A feasibility study
    • Welch, M. J., Lewis, J. S., Kim, J., Sharp, T. L., Dence, C. S., Gropler, R. J., et al. (2006). Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study. J. Nucl. Med. 47, 689-697.
    • (2006) J. Nucl. Med. , vol.47 , pp. 689-697
    • Welch, M.J.1    Lewis, J.S.2    Kim, J.3    Sharp, T.L.4    Dence, C.S.5    Gropler, R.J.6
  • 140
    • 0023240892 scopus 로고
    • Genetic control of diabetes and insulitis in the nonobese diabetic (n.d.) mouse
    • Wicker, L. S., Miller, B. J., Coker, L. Z., McNally, S. E., Scott, S., Mullen, Y., et al. (1987). Genetic control of diabetes and insulitis in the nonobese diabetic (n.d.) mouse. J. Exp. Med. 165, 1639-1654. doi: 10.1084/jem.165.6.1639
    • (1987) J. Exp. Med. , vol.165 , pp. 1639-1654
    • Wicker, L.S.1    Miller, B.J.2    Coker, L.Z.3    McNally, S.E.4    Scott, S.5    Mullen, Y.6
  • 143
    • 84936942895 scopus 로고    scopus 로고
    • Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity
    • Wu, J., and Yan, L.-J. (2015). Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity. Diabetes Metab. Syndr. Obes. 8, 181-188. doi: 10.2147/DMSO.S82272
    • (2015) Diabetes Metab. Syndr. Obes. , vol.8 , pp. 181-188
    • Wu, J.1    Yan, L.-J.2
  • 144
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 o chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka, M., Kayo, T., Ikeda, T., and Koizuni, A. (1997). A novel locus, Mody4, distal to D7Mit189 o chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894. doi: 10.2337/diab.46.5.887
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizuni, A.4
  • 145
    • 84874672555 scopus 로고    scopus 로고
    • Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload
    • Zhabyeyev, P., Gandhi, M., Mori, J., Basu, R., Kassiri, Z., Clanachan, A., et al. (2013). Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload. Cardiovasc. Res. 97, 676-685. doi: 10.1093/cvr/cvs424
    • (2013) Cardiovasc. Res. , vol.97 , pp. 676-685
    • Zhabyeyev, P.1    Gandhi, M.2    Mori, J.3    Basu, R.4    Kassiri, Z.5    Clanachan, A.6
  • 146
    • 78650481257 scopus 로고    scopus 로고
    • Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation
    • Zhang, L., Ussher, J. R., Oka, T., Cadete, V. J. J., Wagg, C., and Lopaschuk, G. D. (2011). Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation. Cardiovasc. Res. 89, 148-156. doi: 10.1093/cvr/cvq266
    • (2011) Cardiovasc. Res. , vol.89 , pp. 148-156
    • Zhang, L.1    Ussher, J.R.2    Oka, T.3    Cadete, V.J.J.4    Wagg, C.5    Lopaschuk, G.D.6
  • 147
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432. doi: 10.1038/372425a0
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 148
    • 85052467314 scopus 로고    scopus 로고
    • Identification of energy metabolism changes in diabetic cardiomyopathy rats using a metabonomic approach
    • Zhao, L., Dong, M., Xu, C., Zheng, H., Wei, T., Liu, K., et al. (2018). Identification of energy metabolism changes in diabetic cardiomyopathy rats using a metabonomic approach. Cell. Physiol. Biochem. 48, 934-946. doi: 10.1159/000491960
    • (2018) Cell. Physiol. Biochem. , vol.48 , pp. 934-946
    • Zhao, L.1    Dong, M.2    Xu, C.3    Zheng, H.4    Wei, T.5    Liu, K.6
  • 149
    • 0015336896 scopus 로고
    • Insulin and obesity in the zucker genetically obese rat “Fatty
    • Zucker, L. M., and Antoniades, H. N. (1972). Insulin and obesity in the zucker genetically obese rat “Fatty.”. Endocrinology 90, 1320-1330. doi: 10.1210/endo-90-5-1320
    • (1972) Endocrinology , vol.90 , pp. 1320-1330
    • Zucker, L.M.1    Antoniades, H.N.2
  • 150
    • 77957216320 scopus 로고
    • Fatty, a new mutation in the rat
    • Zucker, L. M., and Zucker, T. F. (1961). Fatty, a new mutation in the rat. J. Hered. 52, 275-278. doi: 10.1093/oxfordjournals.jhered.a107093
    • (1961) J. Hered. , vol.52 , pp. 275-278
    • Zucker, L.M.1    Zucker, T.F.2
  • 151
    • 84880343712 scopus 로고    scopus 로고
    • Preparative gas chromatography and its applications
    • Zuo, H.-L., Yang, F.-Q., Huang, W.-H., and Xia, Z.-N. (2013). Preparative gas chromatography and its applications. J. Chromatogr. Sci. 51, 704-715. doi: 10.1093/chromsci/bmt040
    • (2013) J. Chromatogr. Sci. , vol.51 , pp. 704-715
    • Zuo, H.-L.1    Yang, F.-Q.2    Huang, W.-H.3    Xia, Z.-N.4


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