Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1- 13C]pyruvate

NMR in Biomedicine

Volumn 24, Issue 8, 2011, Pages 980-987

  Schroeder, Marie A ^a   Atherton, Helen J ^a,b   Heather, Lisa C ^a   Griffin, Julian L ^b   Clarke, Kieran ^a   Radda, George K ^a   Tyler, Damian J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cardiac metabolism; Hyperpolarisation; Metabolic regulation; MRS; Pyruvate dehydrogenase

Indexed keywords

ACETYL-COA; ASSESSMENT METHODS; CARDIAC TISSUES; ENZYME COMPLEXES; FEEDBACK INHIBITION; H NMR SPECTROSCOPY; HYPERPOLARISATION; IN-VITRO; IN-VIVO; KEY REGULATORS; METABOLIC FATE; METABOLIC REGULATION; MRS; NICOTINAMIDE ADENINE DINUCLEOTIDES; PROTEIN LEVEL; PYRUVATE DEHYDROGENASE KINASE; PYRUVATES; RELATIVE CONTRIBUTION; SUBSTRATE SELECTION; UP-REGULATION;

AMIDES; HEART; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; RATS; TISSUE;

ENZYME INHIBITION;

1 PYRUVIC ACID C 13; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; ENZYME ACTIVITY; ENZYME REGULATION; HEART; HEART MUSCLE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; CARBON ISOTOPES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MYOCARDIUM; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; RATS; RATS, WISTAR;

RATTUS;

EID: 80052855442     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1668     Document Type: Article

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