Cardiac steatosis and left ventricular function in men with metabolic syndrome

Journal of Cardiovascular Magnetic Resonance

Volumn 15, Issue 1, 2013, Pages

  Nyman, Kristofer ^a   Granér, Marit ^a   Pentikäinen, Markku O ^a   Lundbom, Jesper ^a   Hakkarainen, Antti ^a   Sirén, Reijo ^a   Nieminen, Markku S ^a   Taskinen, Marja Riitta ^a   Lundbom, Nina ^a   Lauerma, Kirsi ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cardiac steatosis; Cardiovascular magnetic resonance; Diastolic dysfunction; Epicardial fat; Metabolic syndrome; Myocardial triglyceride content; Obesity; Pericardial fat; Proton magnetic resonance spectroscopy

Indexed keywords

TRIACYLGLYCEROL;

ADULT; ARTICLE; CARDIAC STEATOSIS; CARDIOVASCULAR MAGNETIC RESONANCE; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLE; DISEASE ASSOCIATION; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE FUNCTION; HUMAN; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LIPID STORAGE; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STEATOSIS;

ADIPOSE TISSUE; ADIPOSITY; ADULT; CARDIOMYOPATHIES; CASE-CONTROL STUDIES; DIASTOLE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MYOCARDIUM; SEVERITY OF ILLNESS INDEX; SEX FACTORS; TRIGLYCERIDES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84887340400     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/1532-429X-15-103     Document Type: Article

References (36)

1. American heart association obesity committee of the council on nutrition, physical activity and metabolism, council on arteriosclerosis, thrombosis and vascular biology, council on cardiovascular disease in the young, council on cardiovascular radiology and intervention, council on cardiovascular nursing, council on epidemiology and prevention, council on the kidney in cardiovascular disease, and stroke council: assessing adiposity: a scientific statement from the american heart association. Cornier MA, Despres JP, Davis N, Grossniklaus DA, Klein S, Lamarche B, Lopez-Jimenez F, Rao G, St-Onge MP, Towfighi A, Poirier P, Circulation 2011 124 18 1996 2019 10.1161/CIR.0b013e318233bc6a 21947291
2. Body fat distribution and risk of cardiovascular disease: an update. Despres JP, Circulation 2012 126 10 1301 13 10.1161/CIRCULATIONAHA.111.067264 22949540
3. Ectopic fat depots and cardiovascular disease. Britton KA, Fox CS, Circulation 2011 124 24 837 41 10.1161/CIRCULATIONAHA.111.077602 22156000
4. Myocardial, perivascular, and epicardial fat. Iozzo P, Diabetes Care 2011 34 Suppl 2 371 9 21525485
5. Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method. Reingold JS, McGavock JM, Kaka S, Tillery T, Victor RG, Szczepaniak LS, Am J Physiol Endocrinol Metab 2005 289 5 935 9 10.1152/ajpendo.00095.2005 15972271 (Pubitemid 41504396)
6. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. Kankaanpaa M, Lehto HR, Parkka JP, Komu M, Viljanen A, Ferrannini E, Knuuti J, Nuutila P, Parkkola R, Iozzo P, J Clin Endocrinol Metab 2006 91 11 4689 95 10.1210/jc.2006-0584 16926257 (Pubitemid 44833458)
7. Contribution of glucose tolerance and gender to cardiac adiposity. Iozzo P, Lautamaki R, Borra R, Lehto HR, Bucci M, Viljanen A, Parkka J, Lepomaki V, Maggio R, Parkkola R, Knuuti J, Nuutila P, J Clin Endocrinol Metab 2009 94 11 4472 82 10.1210/jc.2009-0436 19820028
8. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szczepaniak LS, Circulation 2007 116 10 1170 5 10.1161/CIRCULATIONAHA.106.645614 17698735 (Pubitemid 47360218)
9. Lipotoxicity in the heart. Wende AR, Abel ED, Biochim Biophys Acta 2010 1801 3 311 9 10.1016/j.bbalip.2009.09.023 19818871
10. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. Rijzewijk LJ, van der Meer RW, Smit JW, Diamant M, Bax JJ, Hammer S, Romijn JA, de Roos A, Lamb HJ, J Am Coll Cardiol 2008 52 22 1793 9 10.1016/j.jacc.2008.07.062 19022158
11. Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve. Korosoglou G, Humpert PM, Ahrens J, Oikonomou D, Osman NF, Gitsioudis G, Buss SJ, Steen H, Schnackenburg B, Bierhaus A, Nawroth PP, Katus HA, J Magn Reson Imaging 2012 35 4 804 11 10.1002/jmri.22879 22068959
12. Left ventricular diastolic dysfunction as assessed by echocardiography in metabolic syndrome. Masugata H, Senda S, Goda F, Yoshihara Y, Yoshikawa K, Fujita N, Daikuhara H, Nakamura H, Taoka T, Kohno M, Hypertens Res 2006 29 11 897 903 10.1291/hypres.29.897 17345790 (Pubitemid 46068954)
13. Effects of isolated obesity on left and right ventricular function: a tissue Doppler and strain rate imaging study. Orhan AL, Uslu N, Dayi SU, Nurkalem Z, Uzun F, Erer HB, Hasdemir H, Emre A, Karakus G, Soran O, Gorcsan J 3rd, Eren M, Echocardiography 2010 27 3 236 43 10.1111/j.1540-8175.2009.01024.x 20070359
14. Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Rider OJ, Francis JM, Ali MK, Holloway C, Pegg T, Robson MD, Tyler D, Byrne J, Clarke K, Neubauer S, Circulation 2012 125 12 1511 9 10.1161/CIRCULATIONAHA.111.069518 22368152
15. Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese women. Utz W, Engeli S, Haufe S, Kast P, Hermsdorf M, Wiesner S, Pofahl M, Traber J, Luft FC, Boschmann M, Schulz-Menger J, Jordan J, Heart 2011 97 19 1585 9 10.1136/hrt.2011.224451 21775510
16. International diabetes federation task force on epidemiology and prevention, hational heart, lung, and blood institute, American heart association, world heart federation, international atherosclerosis society, international association for the study of obesity: harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, Circulation 2009 120 16 1640 5 10.1161/CIRCULATIONAHA.109.192644 19805654
17. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Friedewald WT, Levy RI, Fredrickson DS, Clin Chem 1972 18 6 499 502 4337382
18. Use and abuse of HOMA modeling. Wallace TM, Levy JC, Matthews DR, Diabetes Care 2004 27 6 1487 95 10.2337/diacare.27.6.1487 15161807 (Pubitemid 38680001)
19. Left ventricular global function index by magnetic resonance imaging - a novel marker for assessment of cardiac performance for the prediction of cardiovascular events: the multi-ethnic study of atherosclerosis. Mewton N, Opdahl A, Choi EY, Almeida AL, Kawel N, Wu CO, Burke GL, Liu S, Liu K, Bluemke DA, Lima JA, Hypertension 2013 61 4 770 8 10.1161/HYPERTENSIONAHA.111.198028 23424238
20. CMR for assessment of diastolic function. Westenberg JJ, Curr Cardiovasc Imaging Rep 2011 4 2 149 58 10.1007/s12410-011-9070-z 21475412
21. Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D, Comput Biol Med 2001 31 4 269 86 10.1016/S0010-4825(01)00006-3 11334636 (Pubitemid 32378728)
22. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. Vanhamme L, van den Boogaart A, Van Huffel S, J Magn Reson 1997 129 1 35 43 10.1006/jmre.1997.1244 9405214 (Pubitemid 127454051)
23. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. Graner M, Siren R, Nyman K, Lundbom J, Hakkarainen A, Pentikainen MO, Lauerma K, Lundbom N, Adiels M, Nieminen MS, Taskinen MR, J Clin Endocrinol Metab 2013 98 3 1189 97 10.1210/jc.2012-3190 23418318
24. Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity. Mandry D, Eschalier R, Kearney-Schwartz A, Rossignol P, Joly L, Djaballah W, Bohme P, Escanye JM, Vuissoz PA, Fay R, Zannad F, Marie PY, J Hypertens 2012 30 3 567 73 10.1097/HJH.0b013e32834f6f3f 22227821
25. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O'Donnell CJ, Fox CS, Circulation 2008 117 5 605 13 10.1161/CIRCULATIONAHA. 107.743062 18212276
26. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. Tamarappoo B, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, Friedman JD, Hayes SW, Thomson LE, Slomka PJ, Rozanski A, Berman DS, JACC Cardiovasc Imaging 2010 3 11 1104 12 10.1016/j.jcmg.2010.07.014 21070997
27. Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction. Cavalcante JL, Tamarappoo BK, Hachamovitch R, Kwon DH, Alraies MC, Halliburton S, Schoenhagen P, Dey D, Berman DS, Marwick TH, Am J Cardiol 2012 110 12 1793 8 10.1016/j.amjcard.2012.07.045 22980968
28. Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro. Marchington JM, Pond CM, Int J Obes 1990 14 12 1013 22 2086494
29. Human epicardial fat: what is new and what is missing? Sacks HS, Fain JN, Clin Exp Pharmacol Physiol 2011 38 12 879 87 10.1111/j.1440-1681.2011.05601.x 21895738
30. Human epicardial adipose tissue: a review. Sacks HS, Fain JN, Am Heart J 2007 153 6 907 17 10.1016/j.ahj.2007.03.019 17540190 (Pubitemid 46809849)
31. Impact of increased visceral and cardiac fat on cardiometabolic risk and disease. Sironi AM, Petz R, De Marchi D, Buzzigoli E, Ciociaro D, Positano V, Lombardi M, Ferrannini E, Gastaldelli A, Diabet Med 2012 29 5 622 7 10.1111/j.1464-5491.2011.03503.x 22023514
32. Insulin resistance is not associated with myocardial steatosis in women. Krssak M, Winhofer Y, Gobl C, Bischof M, Reiter G, Kautzky-Willer A, Luger A, Krebs M, Anderwald C, Diabetologia 2011 54 7 1871 8 10.1007/s00125-011-2146-0 21491158
33. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H, Meinders EA, Romijn JA, de Roos A, Smit JW, J Am Coll Cardiol 2008 52 12 1006 12 10.1016/j.jacc.2008.04.068 18786482
34. Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. van Loon LJ, Goodpaster BH, Pflugers Arch 2006 451 5 606 16 10.1007/s00424-005-1509-0 16155759 (Pubitemid 43042172)
35. Lipid metabolism and toxicity in the heart. Goldberg IJ, Trent CM, Schulze PC, Cell Metab 2012 15 6 805 12 10.1016/j.cmet.2012.04.006 22682221
36. Cardiac energy metabolism in obesity. Lopaschuk GD, Folmes CD, Stanley WC, Circ Res 2007 101 4 335 47 10.1161/CIRCRESAHA.107.150417 17702980 (Pubitemid 47267702)