Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes

JACC: Basic to Translational Science

Volumn 3, Issue 4, 2018, Pages 485-498

  Dodd, Michael S ^a   Sousa Fialho, Maria da Luz ^a   Montes Aparicio, Claudia N ^a   Kerr, Matthew ^a   Timm, Kerstin N ^a   Griffin, Julian L ^b   Luiken, Joost J F P ^c   Glatz, Jan F C ^c   Tyler, Damian J ^a   Heather, Lisa C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

cardiovascular disease; diabetes; fatty acids; HIF 1 ; hypoxia; metabolism

Indexed keywords

DIMETHYLOXALYLGLYCINE; FATTY ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITOR; OXYGENASE; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; ENZYME INHIBITION; FATTY ACID METABOLISM; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION;

EID: 85053829816     PISSN: 2452302X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacbts.2018.04.005     Document Type: Article

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